scholarly journals Nonspecific Aortoarteritis (Takayasu’s Arteritis) in Children: A Description of Cases at the New Coronavirus Infection COVID-19

2021 ◽  
Vol 7 (11) ◽  
pp. 153-169
Keyword(s):  
Differential Diagnosis ◽  
Children And Adolescents ◽  
Takayasu’S Arteritis ◽  
Clinical Manifestations ◽  
Takayasu's Arteritis ◽  
Coronavirus Infection

A description of two cases of the Takayasu’s arteritis in children, who were under our observation, enrolled in the Department of Cardiology and Rheumatology of the National Center Maternity and Childhood Protection during the pandemic period of the new coronavirus infection in 2021 were presented. The Takayasu’s arteritis should be included in the structure of the differential diagnosis in children and adolescents with clinical manifestations characteristic of post-COVID syndrome.

scholarly journals Takayasu’s Arteritis: An Uncommon Cause of Renal Artery Stenosis and Therapeutic Considerations

2013 ◽  
Vol 6 (1) ◽  
pp. 14-19
Author(s):  
Mary Virmani1 ◽  
Luis Ortega ◽  
Loay Salman ◽  
Tushar Vachharajani ◽  
Arif Asif ◽  
...  
Keyword(s):  
Takayasu’S Arteritis ◽  
Treatment Options ◽  
Clinical Manifestations ◽  
Treatment Strategies ◽  
Specific Treatment ◽  
Transluminal Angioplasty ◽  
Cytotoxic Agents ◽  
Takayasu's Arteritis ◽  
Revascularization Procedures ◽  
Therapeutic Considerations

Takayasu’s arteritis is a rare disorder characterized by granulomatous and necro-inflammatory disease of the aorta and its major branches. Its etiology remains unknown. We report a young woman with Takayasu’s arteritis affecting the aortic arch, carotid, mesenteric, celiac and bilateral renal arteries resulting in severe hypertension, unilateral renal atrophy and renal insufficiency. The immunosuppressive therapy did not halt the progression of her vascular disease, which required revascularization procedures on numerous occasions. Here, the clinical manifestations and histopathological features of Takayasu’s arteritis are reviewed. In addition, the available medical treatment options including glucocorticoids, cytotoxic agents and TNF-alpha inhibitors are discussed. Furthermore, current revascularization procedures such as percutaneous transluminal angioplasty and reconstructive vascular surgery in the treatment of occlusive vasculopathy due to Takayasu’s arteritis are discussed. Although the prognosis of this debilitating disease has improved over the past two decades, a better understanding of its etiology and pathogenesis will facilitate the discovery of effective target-specific treatment strategies with a narrow adverse effects profile.

scholarly journals Folgoration as an Example of Pathergy in a Patient Affected by Pyoderma Gangrenosum and Takayasu's Arteritis

2009 ◽  
Vol 2009 ◽  
pp. 1-3 ◽  
Author(s):  
A. G. Richetta ◽  
S. D'Epiro ◽  
C. Mattozzi ◽  
S. Giancristoforo ◽  
S. Calvieri
Keyword(s):  
Rheumatoid Arthritis ◽  
Ulcerative Colitis ◽  
Pyoderma Gangrenosum ◽  
Monoclonal Gammopathy ◽  
Takayasu’S Arteritis ◽  
Clinical Manifestations ◽  
Neutrophilic Dermatosis ◽  
Minor Trauma ◽  
Takayasu's Arteritis ◽  
Unknown Aetiology

Pyoderma gangrenosum (PG) is a neutrophilic dermatosis of unknown aetiology. Clinical manifestations of PG are characterized by destructive, necrotizing, and noninfective ulceration of the skin. 20–30% of cases are initiated and aggravated by minor trauma or surgery, a phenomenon named pathergy. PG is related to several autoimmune diseases including ulcerative colitis, Crohn's disease, rheumatoid arthritis, and monoclonal gammopathy. The association with Takayasu's arteritis (TA), a chronic inflammatory and stenotic disease of large and medium-sized arteries, is instead less common. We report a case of PG associated with TA that was induced by an accident with folgoration of the skin; in this case the folgoration can be considered as an exemple of Pathergy, that is, a characteristic feature of PG.

scholarly journals Takayasu’s Arteritis with Subcutaneous Nodules in a 4-year -old Child: A Case Report

2020 ◽  
Vol 58 (231) ◽  
Author(s):  
Sunil Kumar Das ◽  
Aakrit Dahal ◽  
Nikhil Shrestha ◽  
Sajal Tnawanasu ◽  
Subash Sharma
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Acute Phase ◽  
Takayasu Arteritis ◽  
Oral Corticosteroid ◽  
Takayasu’S Arteritis ◽  
Subcutaneous Nodule ◽  
Takayasu's Arteritis ◽  
Acute Phase Reactants ◽  
Subcutaneous Nodules

A 4-year-old girl who presented with pain in the abdomen, subcutaneous nodule, fever and was later diagnosed with Takayasu arteritis . Oral corticosteroid and methotrexate were started. Childhood TA should be kept in differential diagnosis when presented with subcutaneous nodules and increased acute phase reactants.

scholarly journals Is prolonged febrile syndrome associated with reactive thrombocytosis a possible association in the diagnosis of Takayasu’s arteritis? A case report

2021 ◽  
Vol 49 (11) ◽  
pp. 030006052110553
Author(s):  
Victoria Birlutiu ◽  
Rares-Mircea Birlutiu ◽  
Mariana Sandu ◽  
Emmanuel Mihali-Oniga
Keyword(s):  
Weight Loss ◽  
Blood Vessels ◽  
Takayasu’S Arteritis ◽  
Clinical Manifestations ◽  
Vascular Lesions ◽  
Takayasu's Arteritis ◽  
Childbearing Age ◽  
Reactive Thrombocytosis ◽  
Inflammatory Phase ◽  
Febrile Syndrome

Takayasu’s arteritis is a rare, systemic, inflammatory vasculitis of large blood vessels with an unknown aetiology that more frequently affects women of childbearing age with progression to stenosis, fibrosis or thrombogenesis. Clinical manifestations are associated either with inflammation of the vascular wall (including fever, myalgia, arthralgia, weight loss) or the development of aneurysms and extensive vascular lesions, which creates challenges for a differential diagnosis. This current report presents the case of a female Caucasian patient, aged 23 years, that presented herself repetitively at the hospital reporting symptoms including fever, productive cough, myalgia associated with physical effort, arthralgia, inconstant headache, weight loss and altered general condition. The patient was diagnosed with Takayasu’s arteritis in the context of a prolonged febrile syndrome associated with reactive thrombocytosis. This association results in the need to exclude multiple differential diagnoses. Nonspecific management was initiated, which included antibiotic treatment, antifungal medication, anticoagulants, steroidal anti-inflammatory drugs and correction of anaemia. The patient slowly improved. Takayasu’s arteritis in the inflammatory phase associated with a prolonged febrile syndrome and reactive thrombocytosis is a rare diagnosis of exclusion of a multitude of inflammatory diseases of large blood vessels, infectious diseases and neurofibromatosis, which requires multiple investigations for an accurate diagnosis and management.

scholarly journals Поражение пищеварительного тракта как проявление COVID-19 у ребенка 4 лет

Doctor Ru ◽  
2021 ◽  
Vol 20 (3) ◽  
pp. 56-59
Author(s):  
I.M. Osmanov ◽  
◽  
O.N. Solodovnikova ◽  
S.N. Borzakova ◽  
T.V. Sbrodova ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Abdominal Pain ◽  
Bacterial Infections ◽  
Clinical Manifestations ◽  
Enteric Infection ◽  
The Novel ◽  
Key Points ◽  
Enteric Infections ◽  
Coronavirus Infection ◽  
Novel Coronavirus

Objective of the Paper: To represent a case of the novel coronavirus infection COVID-19 in a 4-year-old child with isolated bowel damage. Key Points. COVID-19 impacts several systems and organs. Usually, children have mild or asymptomatic disease. Clinical manifestations of COVID-19 in children can be damage not only of respiratory tract, but also of GIT, requiring differential diagnosis of enteric infections (both viral and bacterial). Prompt diagnosis of COVID-19 is essential for antiepidemic measures and suppression an infectious process. The case shows challenges faced by clinicians when diagnosing COVID-19 in patients with isolated GIT damages without catarrhal signs. Course of the disease in this patient was characterised by a number of features indicative of a bacterial enteric infection: abdominal pain, diarrhoea, increased CRP, colitis syndrome in stool test, warranting differential diagnosis of acute enteric bacterial infections. Negative bacterial culture, detection of SARS-CoV2 RNA in oropharynx and nasopharynx mucous, fast stool normalisation and dyspeptic events arrest allowed diagnosing that the diarrhoea was associated with COVID-19. One month of metabolic and probiotic therapy normalised stool, arrested abdominal pain, and improved exercise tolerance. Conclusion. GIT damage in paediatric COVID-19 patients is essential and unexplored. COVID-19 should be added to differential diagnosis in case of clinical manifestations of an acute enteric infection. Keywords: children, novel coronavirus infection, COVID-19, GIT.

Comparison of Clinical Features at the Onset of Takayasu’s Arteritis According to Age and Sex

2019 ◽  
Vol 18 (1) ◽  
pp. 80-86
Author(s):  
Jin Wan ◽  
Shuying Qi ◽  
Hua Liao ◽  
Weiping Ci ◽  
Yanqiu Guo ◽  
...  
Keyword(s):  
Chest Pain ◽  
Takayasu’S Arteritis ◽  
Age At Onset ◽  
Clinical Manifestations ◽  
Aortic Insufficiency ◽  
Predisposing Factors ◽  
Takayasu's Arteritis ◽  
Aortic Lesion ◽  
Patient Groups ◽  
Male Patients

Background: Takayasu’s arteritis (TA) is a large-vessel vasculitis that predominantly affects the aorta, pulmonary artery, and its main branches. The cause of TA is still unclear. Objective: To identify the clinical characteristics of TA at onset in different patient groups. Methods: The clinical manifestations, laboratory, and angiographic findings of 53 patients with TA based on age at onset and sex were retrospectively analysed. Results: The ratio of the incidence of TA in males and females was 1:4. Chest pain, reduced glomerular filtration rate (GFR), and multivessel involvement were the most common symptoms at TA onset in male patients. 17% of patients had an onset age >40 years, and the percentage of TA patients >40 years old with chest pain was significantly higher [6 (66.7%) vs 13 (29.5%) and p=0.031] than that in TA patients <40 years old. However, their renal artery involvement [1 (11.1%) vs 21 (47.7%)), p=0.042], abdominal aorta lesion [0 (0.0%) vs 16 (38.1%), p=0.030], and multiple vessel involvement [2 (22.2%) vs. 32 (72.7%), p=0.004] were significantly less evident. Multivariate analysis showed that hypertension and thoracic aortic lesion were predisposing factors for TA diagnosis [odds ratio (OR)=3.918, 95% confidence interval (CI)=1.616-1566.185, p=0.026]. For patients with aortic insufficiency (OR=3.674, 95% CI=2.734-567.621, p=0.007) or aneurysm formation (OR=7.255, 95% CI=1.23-1628.614, p=0.044), ascending aortic lesion was an independent risk factor. Furthermore, patients >40 years with chest pain but no brachial pulse should be suspected to have TA. Conclusion: Hypertension and thoracic aortic lesion are predisposing factors for the diagnosis of TA. Male with TA was more prone to present with chest pain, multivessel involvement, and reduced GFR.

Sign in / Sign up

Export Citation Format

Share Document