scholarly journals Treatment of premenstrual dysphoric disorders with combined oral contraceptives

2019 ◽  
Vol 2 (14) ◽  
pp. 23-26
Author(s):  
K. B. Loginova ◽  
G. M. Dyukova ◽  
Yu. V. Dobrokhotova ◽  
A. B. Danilov
Keyword(s):  
Emotional Disorders ◽  
Oral Contraceptives ◽  
Premenstrual Syndrome ◽  
Sleep Disturbances ◽  
Ethinyl Estradiol ◽  
Physical Symptoms ◽  
Severe Form ◽  
Reproductive Period ◽  
Emotional Symptoms ◽  
Combined Oral Contraceptives

Premenstrual dysphoric disorder (PMDD) is a severe form of premenstrual syndrome (PMS) with severe psycho-emotional disorders. The frequency of occurrence of PMDD in women of the reproductive period of the Russian Federation is estimated at an average of 15.6 %. The development of PMDD is based on the individual sensitivity of neurotransmitters and neuropeptides to fluctuations in the levels of sex steroid hormones of the ovulatory menstrual cycle, therefore, hormone therapy drugs are used for PMDD therapy — combined oral contraceptives (COC) that suppress ovulation.The purpose of this study was to evaluate the effectiveness of COC containing drospirenone in the treatment of PMDD.Materials and methods. 78 women of the reproductive period underwent a comprehensive examination and treatment of PMDD symptoms with contraceptives containing 30 mg of ethinyl estradiol and 3 mg of drospirenone (Midian).Results of the study. The age of patients with PMDD averaged 33.7 years; 55 % of women were between 25–34 years old; 97 % needed contraception; all women represented in the group had higher education, normal menstrual function and body mass index. After 3 months of treatment, there was a statistically significant decrease in pain of various localization, problems with appetite, difficulties in communicating with others, sleep disturbances, and an increase in productivity at work, at home and in school. After 6 months of treatment, COC psycho-emotional symptoms, such as depression, anger, irritation, emotional lability, anxiety, tension, loss of control, significantly regressed, while the effectiveness of therapy reached 50 % relative to the original background. Physical symptoms of PMS, such as swelling of the mammary glands, pain of various locations, sleep disturbances, were stopped on average by 70 %.Conclusions. COC containing drospirenone can be used to treat severe premenstrual syndrome, i. e. PMDD.

scholarly journals Ethinyl Estradiol/Drospirenone for the Treatment of the Emotional and Physical Symptoms of Premenstrual Dysphoric Disorder

2007 ◽  
Vol 3 (4) ◽  
pp. 395-408 ◽  
Author(s):  
Andrea J Rapkin ◽  
Michelle McDonald ◽  
Sharon A Winer
Keyword(s):  
Premenstrual Syndrome ◽  
Ethinyl Estradiol ◽  
Oral Contraceptive Pill ◽  
Premenstrual Dysphoric Disorder ◽  
Physical Symptoms ◽  
Severe Form ◽  
Steroid Production ◽  
Combined Oral Contraceptive ◽  
Free Interval ◽  
Affective Symptoms

A combined oral contraceptive pill containing 20 μg of ethinyl estradiol and 3 mg of the progestin drospirenone in a novel dose regimen (24 active pills followed by 4 placebo pills), has demonstrated efficacy for the symptoms of premenstrual dysphoric disorder, a severe form of premenstrual syndrome, with an emphasis on the affective symptoms. Drospirenone has progestagenic, anti-androgenic and anti-aldosterone properties, which differ from earlier generations of progestins, and reducing the hormone pill-free interval allows for better suppression of ovarian steroid production.

Combined oral contraceptives and treatment of new coronavirus infection (COVID-19): aspects of drug interactions

2021 ◽  
Vol 19 (1) ◽  
pp. 149-158
Author(s):  
O.A. Limanova ◽  
◽  
L.E. Fedotova ◽  
O.A. Gromova ◽  
◽  
...  
Keyword(s):  
Drug Interactions ◽  
Oral Contraceptives ◽  
Ethinyl Estradiol ◽  
Antihypertensive Drugs ◽  
Efficacy And Safety ◽  
Antiinflammatory Drugs ◽  
Combined Oral Contraceptives ◽  
Chlormadinone Acetate ◽  
Coronavirus Infection ◽  
Oral Hypoglycemic Drugs

This article discusses the problem of drug interactions between combined oral contraceptives on the example of Belara® (30 μg of ethinyl estradiol + 2 mg of chlormadinone acetate; Gedeon Richter, Hungary) and medications recommended for the treatment of new coronavirus infection (COVID-19) and concomitant disorders at the pharmacodynamic and pharmacokinetic levels with an assessment of the efficacy and safety of therapy for females. We described safe, potentially dangerous, and dangerous combinations of these drugs. Key words: new coronavirus infection (CAVID-19), combined oral contraceptives, antiviral drugs, antibacterial drugs, antiinflammatory drugs, anticoagulants, migraine drugs, antihypertensive drugs, oral hypoglycemic drugs, essential micronutrients, pharmacodynamic and pharmacokinetic interactions

More Contraindications to the Pill

PEDIATRICS ◽  
1980 ◽  
Vol 66 (4) ◽  
pp. 644-645
Author(s):  
Janet P. Realini
Keyword(s):  
Oral Contraceptives ◽  
Animal Studies ◽  
Ethinyl Estradiol ◽  
Combined Oral Contraceptives ◽  
Excellent Review ◽  
Ovulation Inhibition ◽  
Relative Potencies

I read with interest the excellent review by Drs Greydanus and McAnarney.1 Several of their points concerning combined oral contraceptives deserve discussion, however. The relative potencies of the progestins and estrogens contained in oral contraceptives are controversial. Progestin potency is difficult to measure reliably, and comparisons among progestins can be misleading.2 While animal studies have suggested that mestranol is a weaker estrogen than ethinyl estradiol, a study of human ovulation inhibition suggested that ethinyl estradiol may be weaker than mestranol.3

Does Adding Fluoxetine to Combined Oral Contraceptives Containing Drospirenone Improve the Management of Severe Premenstrual Syndrome? A 6-Month Randomized Double-Blind Placebo-Controlled Three-Arm Trial

2020 ◽  
Vol 27 (2) ◽  
pp. 743-750
Author(s):  
Nesreen AbdelFattah AbdAllah Shehata ◽  
Ghada Abdel Fattah Abdel Moety ◽  
Hamada Ashry Abd El Wahed ◽  
Ashraf Samir Fahim ◽  
Maha Ali Katta ◽  
...  
Keyword(s):  
Oral Contraceptives ◽  
Premenstrual Syndrome ◽  
Double Blind ◽  
Combined Oral Contraceptives ◽  
Double Blind Placebo

Changes in Psychological Symptoms in Women Taking Oral Contraceptives

1970 ◽  
Vol 116 (531) ◽  
pp. 161-164 ◽  
Author(s):  
Brenda Herzberg ◽  
Alec Coppen
Keyword(s):  
Oral Contraceptives ◽  
Premenstrual Syndrome ◽  
Psychological Symptoms ◽  
Physical Symptoms

The premenstrual syndrome first described by Frank (1931) includes a number of psychological and physical symptoms appearing in the week before menstruation and relieved by the onset of the period. The aetiology is still obscure.

scholarly journals Hormonal effects of drosperinone and ethinyl estradiol based combined oral contraceptives on polycystic ovarian syndrome

2021 ◽  
Vol 10 (5) ◽  
pp. 1824
Author(s):  
Madhusmita S. Nayak ◽  
Deepa D. Kala ◽  
Amit Agarwal
Keyword(s):  
Oral Contraceptives ◽  
Polycystic Ovarian Syndrome ◽  
Ethinyl Estradiol ◽  
Effective Means ◽  
Free Testosterone ◽  
Sex Hormone Binding Globulin ◽  
Combined Oral Contraceptives ◽  
Serum Luteinizing Hormone ◽  
Hospital Patients ◽  
Ovarian Syndrome

Background: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder treated with combined oral contraceptives (COCs). The androgenic potential of any type of COC is in part determined by the progestin present. A newer form of progestin, drospirenone, has been recently introduced, and is available in combination with ethinyl estradiol.Methods: The study was conducted on 60 patients fulfilling inclusion criteria, in the department of obstetrics and gynecology, Terna Medical College and Hospital. Patients were diagnosed as PCOS according to Rotterdam criteria. After initial evaluation, blood samples were sent for levels of serum luteinizing hormone (LH), follicle stimulating hormone (FSH), dehydroepiandrosterone-sulphate (DHEA-S), free testosterone, sex hormone binding globulin (SHBG). Each patient was advised to take a combination of EE (30 mcg) + drosperinone (3 mg), 1 tablet daily from the second day of her menstruation for 21 days then a 7 days gap and again for 21 days and so on cyclically for 3 cycles, then to repeat the tests as done at the beginning.  Hirsutism was assessed clinically using the Ferriman-Gallwey scale at initial visit and three months later.Results: We found a significant improvement in the Serum LH, FSH levels and a significant fall in free testosterone levels accompanied by a rise in SHBG levels. There is also overall improvement in the hirsutism scores.Conclusions: Drosperinone based COCs are a good and effective means of treatment of PCOS. Treatment duration of three months was found to be effective in our study.

scholarly journals THE CORRELATION BETWEEN NUTRITIONAL STATUS AND CALCIUM ADEQUACE LEVEL ON THE INCIDENCE OF PREMENSTRUAL SYNDROME (PMS) IN FEMALE STUDENTS AT THE FACULTY OF PUBLIC HEALTH UNIVERSITAS AIRLANGGA

2021 ◽  
Vol 16 (3) ◽  
pp. 426
Author(s):  
Lailatul Masruroh ◽  
Lailatul Muniroh
Keyword(s):  
Public Health ◽  
Nutritional Status ◽  
Calcium Intake ◽  
Premenstrual Syndrome ◽  
Statistical Tests ◽  
Simple Random Sampling ◽  
Physical Symptoms ◽  
Female Students ◽  
Emotional Symptoms ◽  
Cross Sectional

ABSTRACTPremenstrual syndrome (PMS) is a series of symptoms consisting of physical symptoms, emotional symptoms, and behavioral symptoms experienced by women before menstruation. PMS is caused by several factors, including nutritional status and calcium intake. This study was conducted to analyze the correlation between nutritional status and adequacy levels of calcium with the incidence of PMS in female students at the Faculty of Public Health, Universitas Airlangga. This research used a cross sectional design. The sample consisted of 83 female students at the Faculty of Public Health, Airlangga University class of 2015-2017, chosen through simple random sampling. Data and methods used in the study included measurements of body weight and height to get nutritional status variable, the food recall 2x24 hours form to record adequacy levels of the calcium variable, and the Shortened Premenstrual Assessment Form (SPAF) questionnaire to get incidence of the PMS variable. Data were analyzed using the Chi-square test. The results of statistical tests showed that there was a correlation between nutritional status (p = 0.012) and PMS, but there was no correlation between calcium intake (p = 0.878) and the incidence of PMS. The conclusion of this study is women were overweight were more likely to experience more severe PMS and women who had low calcium did not experience notable patterns in their incidence or severity of PMS. Keywords: nutritional status, calcium, premenstrual syndrome

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