scholarly journals Can Four Score Replace GCS For Assessing Neurological Status Of Critically Ill Patients –An Indian Study.

2103 ◽  
Vol 9 (2) ◽  
Author(s):  
Anita Mercy S ◽  
Ramesh Thakur ◽  
Sandhya Yaddanpudi ◽  
Hemant Bhagat
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Neurological Status ◽  
Indian Study ◽  
Four Score

scholarly journals E.04 Coma and delirium are associated with low levels of brain tissue oxygen in critically ill patients

2016 ◽  
Vol 43 (S2) ◽  
pp. S17-S17
Author(s):  
MD Wood ◽  
D Maslove ◽  
J Muscedere ◽  
JG Boyd
Keyword(s):  
Brain Tissue ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Near Infrared ◽  
Neurological Status ◽  
Confusion Assessment Method ◽  
Assessment Method ◽  
Brain Tissue Oxygenation ◽  
Low Levels ◽  
Icu Delirium

Background: The cause of ICU delirium is unknown. We used near infrared spectroscopy (NIRS) to measure brain tissue oxygenation (BtO2) in critically ill patients, to test the hypothesis that poor cerebral oxygen delivery contributes to ICU delirium. Methods: Adult patients were enrolled if they required mechanical ventilation for >24 hours, and/or vasoactive agents. Patients were excluded if they had previous cognitive dysfunction, brain injury on admission, or a life expectancy <24 hours. BtO2 was measured for the first 24 hours of ICU admission. The confusion assessment method-ICU (CAM-ICU) was used to screen for delirium. Participants were designated to one of three groups on the basis of their predominant neurological status (comatose, delirious, or intact). Results: To date, 47 patients have been recruited. Both delirious and comatose patients’ had significantly lower BtO2 levels compared to intact patients (P<0.001). There was a significant correlation between hemoglobin and BtO2 (R2=0.347, P<0.01). However, when correlation analysis was conducted separately amongst the three groups, the delirious patients (R2=0.485, P<0.05) were the strongest contributors to this positive correlation. Conclusions: Delirious patients exhibited the lowest BtO2 recordings and demonstrated a significant association between Hb and BtO2. This study offers potential insight into the pathophysiology of ICU delirium.

scholarly journals Host-Microbiome Interactions Mediated by Phenolic Metabolites in Chronically Critically Ill Patients

Metabolites ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 122
Author(s):  
Ekaterina Chernevskaya ◽  
Natalia Klimenko ◽  
Alisa Pautova ◽  
Irina Buyakova ◽  
Alexander Tyakht ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Brain Function ◽  
Serum Levels ◽  
Neurological Status ◽  
Metabolic Potential ◽  
Fecal Samples ◽  
Phenolic Metabolites ◽  
Chronically Critically Ill

The community structure and metabolic potential of gut microbiome is not well investigated, especially in chronically critically ill patients with prolonged dependence on support systems after severe brain disorders. Microbial phenolic metabolites can target the brain function by the direct and indirect modulation of inflammation. The aim of this study was to investigate the features of the gut microbiota and profile of certain metabolites in the progression and reversibility of neurological disorders in chronically critically ill patients. Fecal samples were collected in dynamics from such patients (n = 44) and analyzed using 16S rRNA sequencing. Serum microbial and mitochondrial metabolites were measured by GC-MS and compared with the biomarkers and clinical neurological scores. The identified associations between specific bacterial taxa in fecal samples, neurological status and serum levels of metabolites suggest that impacts on specific members of the gut microbiota and their metabolism might be a promising tool for regulating brain function in future.

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