Characteristics of Acute Kidney Injury in the Intensive Care Unit of Dr. Soetomo General Hospital, Surabaya

Acute Kidney Injury (AKI) is one of the causes of morbidity and mortality among people in both developing and developed countries in the intensive care unit (ICU). In Indonesia, the incidence rate is 0.2% while for the Surabaya, AKI research has not been widely carried out and published. This study aims to determine the characteristics of AKI patients in ICU of Dr. Soetomo hospital covers the data distribution of sociodemographic, risk factors, and mortality. This descriptive study involving 23 inpatients at the ICU with AKI as the sample. Samples were selected using total sampling method. Data were collected from medical records with data collection sheets. The results were then analyzed descriptively and tested bivariate using logistic regression. The results showed that 82.6% of the patients were male with the highest age range of 50-56 years old (30.43%). AKI mortality rate in the intensive care unit was 30.43%. The primary diagnosis was diabetes mellitus (34.78%) and the highest exposure factor was a septic shock (38.70%). Factors associated with AKI mortality were diabetes mellitus (p = 0.000) and exposure to septic shock (p = 0.005). Keywords: acute kidney injury; intensive care unit

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The Effects of Serum Phosphate on 28-day Mortality in Patients Hospitalized in the Intensive Care Unit, Treated with Mechanical Ventilator Therapy and Treated with CRRT for Septic Shock-Induced Acute Kidney Injury

Journal of Cardio-Vascular-Thoracic Anaesthesia and Intensive Care Society ◽

10.5222/gkdad.2020.76993 ◽

2020 ◽

Author(s):

Cem Kıvılcım Kaçar ◽

Osman Uzundere ◽

Deniz Kandemir ◽

Ümit Akol ◽

Abdulkadir Yektaş

Keyword(s):

Intensive Care Unit ◽

Septic Shock ◽

Acute Kidney Injury ◽

Intensive Care ◽

Kidney Injury ◽

Serum Phosphate ◽

Mechanical Ventilator ◽

Ventilator Therapy

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Circulating Proenkephalin, Acute Kidney Injury, and Its Improvement in Patients with Severe Sepsis or Shock

Clinical Chemistry ◽

10.1373/clinchem.2018.288068 ◽

2018 ◽

Vol 64 (9) ◽

pp. 1361-1369 ◽

Cited By ~ 8

Author(s):

Pietro Caironi ◽

Roberto Latini ◽

Joachim Struck ◽

Oliver Hartmann ◽

Andreas Bergmann ◽

...

Keyword(s):

Intensive Care Unit ◽

Septic Shock ◽

Acute Kidney Injury ◽

Renal Function ◽

Intensive Care ◽

Serum Creatinine ◽

Odds Ratio ◽

Adjusted Odds Ratio ◽

Kidney Injury ◽

Baseline Serum

Abstract BACKGROUND Acute kidney injury (AKI) occurs in many critically ill patients and is associated with high mortality. We examined whether proenkephalin could predict incident AKI and its improvement in septic patients. METHODS Plasma proenkephalin A 119–159 (penKid) was assayed in 956 patients with sepsis or septic shock enrolled in the multicenter Albumin Italian Outcome Sepsis (ALBIOS) trial to test its association with incident AKI, improvement of renal function, need for renal replacement therapy (RRT), and mortality. RESULTS Median [Q1–Q3] plasma penKid concentration on day 1 [84 (20–159) pmol/L[ was correlated with serum creatinine concentration (r = 0.74); it was higher in patients with chronic renal failure and rose progressively with the renal Sequential Organ Failure Assessment subscore. It predicted incident AKI within 48 h (adjusted odds ratio, 3.3; 95% CI, 2.1–5.1; P < 0.0001) or 1 week [adjusted hazard ratio, 2.1 (1.7–2.8); P < 0.0001] and future RRT during the intensive care unit stay [odds ratio, 4.0 (3.0–5.4)]. PenKid was also associated with improvements in renal function in patients with baseline serum creatinine >2 mg/dL, both within the next 48 h [adjusted odds ratio, 0.31 (0.18–0.54), P < 0.0001] and 1 week [0.23 (0.12–0.45)]. The time course of penKid concentrations predicted AKI and 90-day mortality. CONCLUSIONS Early measurement and the trajectory of penKid predict incident AKI, improvement of renal function, and the need for RRT in the acute phase after intensive care unit admission during sepsis or septic shock. PenKid measurement may be a valuable tool to test early therapies aimed at preventing the risk of AKI in sepsis.

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Impact on mortality of the timing of renal replacement therapy in patients with severe acute kidney injury in septic shock: the IDEAL-ICU study (initiation of dialysis early versus delayed in the intensive care unit): study protocol for a randomized controlled trial

Trials ◽

10.1186/1745-6215-15-270 ◽

2014 ◽

Vol 15 (1) ◽

Cited By ~ 60

Author(s):

Saber Davide Barbar ◽

Christine Binquet ◽

Mehran Monchi ◽

Rémi Bruyère ◽

Jean-Pierre Quenot

Keyword(s):

Intensive Care Unit ◽

Septic Shock ◽

Acute Kidney Injury ◽

Randomized Controlled Trial ◽

Intensive Care ◽

Controlled Trial ◽

Kidney Injury ◽

Randomized Controlled ◽

Initiation Of Dialysis ◽

The Ideal

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Efficacy of HA330 Hemoperfusion Adsorbent in Patients Followed in the Intensive Care Unit for Septic Shock and Acute Kidney Injury and Treated with Continuous Venovenous Hemodiafiltration as Renal Replacement Therapy

Blood Purification ◽

10.1159/000505565 ◽

2020 ◽

Vol 49 (4) ◽

pp. 448-456 ◽

Cited By ~ 1

Author(s):

Cem Kıvılcım Kaçar ◽

Osman Uzundere ◽

Deniz Kandemir ◽

Abdulkadir Yektaş

Keyword(s):

Intensive Care Unit ◽

Septic Shock ◽

Acute Kidney Injury ◽

Intensive Care ◽

Renal Replacement Therapy ◽

Replacement Therapy ◽

Clinical Status ◽

Kidney Injury ◽

Continuous Venovenous Hemodiafiltration ◽

Cell Counts

Introduction: Blood purification is an option for treatment of the source of sepsis when correcting patients’ septic shock-induced clinical status. We investigated the efficacy of HA330 hemoperfusion adsorbent application with renal replacement therapy in patients with septic shock and acute kidney injury. Methods: This prospective observational study involved 23 patients diagnosed with sepsis who underwent continuous venovenous hemodiafiltration and HA330 hemoperfusion for 2 h once daily for 3 days. The patients’ demographic data, comorbidities, lengths of intensive care unit and hospital stays, blood cell counts, blood biochemistry values, coagulation values, blood gas values, inflammatory markers, hemodynamic parameters, and inotropic medication use before and after each application of HA330 hemoperfusion were recorded. The effectiveness of HA330 hemoperfusion was evaluated by comparing the parameters on days 0 and 1, 1 and 2, and 2 and 3. Results: The pH increased significantly following the first application of HA330 hemoperfusion (p = 0.001), the C-reactive protein (CRP) and procalcitonin levels decreased significantly after the second application (p = 0.002 and 0.018, respectively), and the CRP level decreased significantly following the third application (p = 0.046). Conclusions: The application of HA330 hemoperfusion 2 h daily for 3 consecutive days improved level of CRP and heart rate, but had no effect on others or on the prognosis.

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