scholarly journals Potential therapeutic applications of anti-inflammatory porous PLGA/Mg(OH)2 scaffolds for kidney regeneration

2016 ◽  
Vol 4 ◽  
Author(s):  
Park Ki Wan ◽  
Lih Eugene ◽  
Park Kwang-Sook ◽  
Chun So Young ◽  
Joung Yoon Ki ◽  
...  
Keyword(s):  
Kidney Regeneration ◽  
Therapeutic Applications ◽  
Anti Inflammatory

Heparin and proteoglycans as anti-inflammatory drugs

1996 ◽  
Vol 16 (01) ◽  
pp. 56-59
Author(s):  
D. J. Tyrrell ◽  
C. P. Page
Keyword(s):  
Inflammatory Diseases ◽  
Therapeutic Applications ◽  
Wide Range ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

SummaryEvidence continues to accumulate that the pleiotropic nature of heparin (beyond its anticoagulant potency) includes anti-inflammatory activities at a number of levels. It is clear that drugs exploiting these anti-inflammatory activities of heparin may offer exciting new therapeutic applications to the treatment of a wide range of inflammatory diseases.

Adiponectin in health and disease

2016 ◽  
Vol 88 (12) ◽  
pp. 126-132
Author(s):  
I V Tereshchenko ◽  
Ya A Kamenskikh ◽  
A A Suslina
Keyword(s):  
Clinical Practice ◽  
Literature Review ◽  
Therapeutic Applications ◽  
The Past ◽  
Health And Disease ◽  
Anti Inflammatory ◽  
The Given

Over the past 20 years after the discovery of adiponectin, much knowledge about its effect in health and disease has been gained. Adiponectin has antidiabetic, antiatherogenic, anti-inflammatory, immunomodulatory, metabolic, vasoprotective, and antiapoptotic properties. However, an understanding stems from the given literature review that much remains to be explored. Adiponectin has not yet commonly used in clinical practice, but cardiologists, endocrinologists, pediatricians, oncologists, and physicians of many specialties are interested in its preventive and therapeutic applications.

scholarly journals Chondroitin sulphate structure affects its immunological activities on murine splenocytes sensitized with ovalbumin

2004 ◽  
Vol 382 (1) ◽  
pp. 269-278 ◽  
Author(s):  
Hiroshi AKIYAMA ◽  
Shinobu SAKAI ◽  
Robert J. LINHARDT ◽  
Yukihiro GODA ◽  
Toshihiko TOIDA ◽  
...  
Keyword(s):  
Immune Response ◽  
Chondroitin Sulphate ◽  
Specific Ige ◽  
Dextran Sulphate ◽  
Animal Tissues ◽  
Murine Splenocytes ◽  
Therapeutic Applications ◽  
Anti Inflammatory ◽  
Th1 Immune Response

Chondroitin sulphate (CS) is a glycosaminoglycan widely distributed in animal tissues, which has anti-inflammatory and chondroprotective properties. We reported previously that chondroitin 4-sulphate (CS-A) up-regulates the antigen-specific Th1 immune response of murine splenocytes sensitized with ovalbumin in vitro, and that CS suppresses the antigen-specific IgE responses. We now demonstrate that a specific sulphation pattern of the CS polysaccharide is required for the Th1-promoted activity, as other polysaccharides such as dextran and dextran sulphate do not significantly induce this activity. While the presence of some O-sulpho groups appear to be essential for activity, CS-A, and synthetically prepared, partially O-sulphonated CS, induce higher Th1-promoted activity than synthetically prepared, fully O-sulphonated CS. CS-A induces an activity greater than chondroitin sulphate B (CS-B) or chondroitin 6-sulphate (CS-C). In addition, chondroitin sulphate E (CS-E) induces greater activity than CS-A or CS-D. These results suggest that the GlcA(β1-3)GalNAc(4,6-O-disulpho) sequence in CS-E is important for Th1-promoted activity. Furthermore, rat anti-mouse CD62L antibody, an antibody to L-selectin, inhibits the Th1-promoting activity of CS. These results suggest that the Th1-promoted activity could be associated with L-selectin on lymphocytes. These findings describe a new mechanism for the anti-inflammatory and chondroprotective properties of CS that may be useful in designing new therapeutic applications for CS used in the treatment of immediate-type hypersensitivity.

scholarly journals Piperidine nucleus in the field of drug discovery

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Mennatallah Mahmoud Abdelshaheed ◽  
Iten Mamdouh Fawzy ◽  
Hussein Ibrahim El-Subbagh ◽  
Khairia Mohamed Youssef
Keyword(s):  
Drug Discovery ◽  
Heterocyclic System ◽  
Review Article ◽  
Main Text ◽  
Therapeutic Applications ◽  
Anticoagulant Agents ◽  
Anti Inflammatory

Abstract Background Piperidine is an essential heterocyclic system and a pivotal cornerstone in the production of drugs. Piperidine byproducts showed several important pharmacophoric features and are being utilized in different therapeutic applications. Main text Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents. Conclusions This review article sheds a light on the most recent studies proving the importance of piperidine nucleus in the field of drug discovery.

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