scholarly journals Use of a Network-Based Method to Identify Latent Genes Associated with Hearing Loss in Children

2021 ◽  
Vol 9 ◽  
Author(s):  
Feng Liang ◽  
Xin Fu ◽  
ShiJian Ding ◽  
Lin Li
Keyword(s):  
Hearing Loss ◽  
Otitis Media ◽  
Emotional Development ◽  
Congenital Deafness ◽  
Random Walk With Restart ◽  
Clinical Screening ◽  
Protein Protein Interaction ◽  
New Genes ◽  
Childhood Deafness ◽  
Novel Biomarkers

Hearing loss is a total or partial inability to hear. Approximately 5% of people worldwide experience this condition. Hearing capacity is closely related to language, social, and basic emotional development; hearing loss is particularly serious in children. The pathogenesis of childhood hearing loss remains poorly understood. Here, we sought to identify new genes potentially associated with two types of hearing loss in children: congenital deafness and otitis media. We used a network-based method incorporating a random walk with restart algorithm, as well as a protein-protein interaction framework, to identify genes potentially associated with either pathogenesis. A following screening procedure was performed and 18 and 87 genes were identified, which potentially involved in the development of congenital deafness or otitis media, respectively. These findings provide novel biomarkers for clinical screening of childhood deafness; they contribute to a genetic understanding of the pathogenetic mechanisms involved.

Cytomegalovirus Isolation from a Human Inner Ear

1979 ◽  
Vol 88 (3) ◽  
pp. 424-426 ◽  
Author(s):  
Larry E. Davis ◽  
Charles G. James ◽  
Frederick Fiber ◽  
Leroy C. McLaren
Keyword(s):  
Hearing Loss ◽  
Inner Ear ◽  
Congenital Deafness ◽  
Cmv Infection ◽  
Human Inner Ear ◽  
Congenital Cmv

Cytomegalovirus (CMV) infection of the fetus has been associated with congenital deafness or hearing loss. This association has previously been based on clinical or pathological studies. We report an infant who died with the congenital CMV syndrome in which CMV was isolated from the perilymph of the inner ear providing additional evidence that this virus can infect the labyrinth.

Antimicrobial Treatment of Acute Otitis Media

1994 ◽  
Vol 103 (5_suppl) ◽  
pp. 11-14 ◽  
Author(s):  
Daniel M. Canafax ◽  
G. Scott Giebink
Keyword(s):  
Hearing Loss ◽  
Otitis Media ◽  
Antimicrobial Agents ◽  
Acute Otitis Media ◽  
Antimicrobial Treatment ◽  
Speech Delay ◽  
Significant Morbidity ◽  
Antimicrobial Drugs ◽  
Etiologic Role ◽  
History Of

Episodes of acute otitis media frequently occur in childhood and are attended by significant morbidity, such as hearing loss and possible speech delay. Bacteria play an important etiologic role in the pathogenesis of otitis media; therefore, antimicrobial agents are the cornerstone in the treatment of this disease. Many antimicrobial choices are available for treating children with acute otitis media. To choose an antimicrobial for each patient, consideration must be given to the patient's age, history of otitis media episodes, and responses to previously used antimicrobial drugs, and the regional antimicrobial susceptibility of the otitis media pathogens.

THE UNIVERSALITY OF OTITIS MEDIA IN 50 INFANTS WITH CLEFT PALATE

PEDIATRICS ◽  
1969 ◽  
Vol 44 (1) ◽  
pp. 35-42
Author(s):  
Jack L. Paradise ◽  
Charles D. Bluestone ◽  
Herman Felder
Keyword(s):  
Adverse Effects ◽  
Cleft Palate ◽  
Otitis Media ◽  
Middle Ear ◽  
Emotional Development ◽  
Well Being ◽  
Suppurative Otitis Media ◽  
Middle Ear Disease ◽  
And Function ◽  
Irreparable Damage

Bilateral secretory (serous) or suppurative otitis media was found without exception in 50 infants with cleft palate who were 20 months of age or younger. Middle ear disease probably develops in all cleft palate infants during the first few months of life, and appears to be best managed by myringotomy with insertion of plastic tubes. Unless drainage and aeration of the middle ear are accomplished, irreparable damage to middle ear structures may develop in some patients; and, in all of them, hearing impairment will probably persist throughout infancy or longer, with adverse effects on well-being and function and with serious implications for intellectual, speech, and emotional development. Further studies are required to assess the long-range effectiveness of surgical management.

Purulent Otitis Media: Differences Between Populations in Different Environments

PEDIATRICS ◽  
1974 ◽  
Vol 53 (2) ◽  
pp. 135-136
Author(s):  
Patrick Manning ◽  
Mary Ellen Avery ◽  
Alan Ross
Keyword(s):  
Hearing Loss ◽  
Adverse Effects ◽  
Language Development ◽  
Otitis Media ◽  
Early Life ◽  
Educational Programs ◽  
Previous Issue ◽  
High Incidence ◽  
History Of ◽  
Tympanic Membranes

The paper by Kaplan and colleagues in a previous issue starts by emphasizing the unusually high incidence of otitis media among Eskimo children. Forty-one percent of their cohort of 489 Alaskan Eskimo children, followed for ten years, had perforations or scars of the tympanic membranes; significant hearing losses were present in 16% of the group. Among the 374 children with a history of otorrhea, 291 (78%) had their first attack before their second birthday. The adverse effects of hearing loss in early life on language development were underscored by the authors, who quite properly point out the need for special educational programs.

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