scholarly journals Vitamin E Acetate Determination in Vaping Liquids and Non-targeted Analysis of Vaping Emissions of Diluents of Concern, Vitamin E Acetate and Medium-Chain Triglycerides Oil

2021 ◽  
Vol 9 ◽  
Author(s):  
Ivana Kosarac ◽  
Cariton Kubwabo ◽  
Guru Prasad Katuri ◽  
Dora Petraccone ◽  
Trevor K. Mischki
Keyword(s):  
Vitamin E ◽  
Method Detection Limit ◽  
Quadrupole Mass ◽  
Medium Chain Triglycerides ◽  
Limit Of Quantification ◽  
High Association ◽  
Targeted Analysis ◽  
Vitamin E Acetate ◽  
Flavour Profile ◽  
Sample Dilution

During the summer of 2019, cases of lung injury associated with vaping emerged in North America, including among individuals who reported exclusive use of nicotine vaping liquids. Once vitamin E acetate was identified as a potential causative agent a quantitative method based on a simple sample dilution, separation by gas chromatography and analysis by triple quadrupole mass spectrometry (GC MSMS) was developed. Method detection limit (MDL) and limit of quantification (LOQ) were determined at 0.159 µg/mL and 0.505 µg/mL, respectively. The analysis was performed on a subset of 203 commercially sourced nicotine containing vaping liquids of various flavour profile and nicotine range (nicotine free-59 mg/mL) from an internal inventory. The target analyte, Vitamin E Acetate, was not detected in any samples analyzed, as expected, given the reported detection in literature and high association of the chemical with cannabis and not nicotine containing vaping products.

scholarly journals Pulmonary Toxicity and Inflammatory Response of Vape Cartridges Containing Medium-Chain Triglycerides Oil and Vitamin E Acetate: Implications in the Pathogenesis of EVALI

Toxics ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 46 ◽  
Author(s):  
Thivanka Muthumalage ◽  
Joseph H. Lucas ◽  
Qixin Wang ◽  
Thomas Lamb ◽  
Matthew D. McGraw ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Vitamin E ◽  
Inflammatory Response ◽  
Pulmonary Toxicity ◽  
Oxygen Species ◽  
Medium Chain Triglycerides ◽  
Barrier Dysfunction ◽  
Vitamin E Acetate

Recently, there has been an outbreak of a condition named e-cigarette or vaping products-associated lung injury (EVALI). The primary components of vaping products include tetrahydrocannabinol (THC), vitamin E acetate (VEA) and medium-chain triglycerides (MCT), may be responsible for acute lung toxicity. Currently, little information is available on the physiological and biological effects of exposure to these products. We hypothesized that these CBD/counterfeit vape cartridges and their constituents (VEA and MCT) induce pulmonary toxicity, mediated by oxidative damage and inflammatory responses, leading to acute lung injury. We studied the potential mechanisms of CBD/counterfeit vape cartridge aerosol induced inflammatory response by evaluating the generation of reactive oxygen species by MCT, VEA, and cartridges and their effects on the inflammatory state of pulmonary epithelium and immune cells both in vitro and in vivo. Cells exposed to these aerosols generated reactive oxygen species, caused cytotoxicity, induced epithelial barrier dysfunction, and elicited an inflammatory response. Using a murine model, the parameters of acute toxicity to aerosol inhalation were assessed. Infiltration of neutrophils and lymphocytes was accompanied by significant increases in IL-6, eotaxin, and G-CSF in the bronchoalveolar lavage fluid (BALF). In mouse BALF, eicosanoid inflammatory mediators, leukotrienes, were significantly increased. Plasma from e-cig users also showed increased levels of hydroxyeicosatetraenoic acid (HETEs) and various eicosanoids. Exposure to CBD/counterfeit vape cartridge aerosols showed the most significant effects and toxicity compared to MCT and VEA. In addition, we determined SARS-CoV-2 related proteins and found no impact associated with aerosol exposures from these tested cartridges. Overall, this study demonstrates acute exposure to specific CBD/counterfeit vape cartridges induces in vitro cytotoxicity, barrier dysfunction, and inflammation and in vivo mouse exposure induces acute inflammation with elevated proinflammatory markers in the pathogenesis of EVALI.

scholarly journals Metabolism of vitamin E acetate by reconstituted human gingival and buccal epithelium

2007 ◽  
Vol 57 ◽  
pp. 135-139 ◽  
Author(s):  
A.E. Scott ◽  
J. Alcock ◽  
M.J. Carlile ◽  
H.R. Griffiths
Keyword(s):  
Vitamin E ◽  
Buccal Epithelium ◽  
Vitamin E Acetate

scholarly journals Topical Vitamin E Acetate for the Treatment of Cheilitis: A Multicentre Experience

2003 ◽  
Vol 1 (3) ◽  
pp. 125-128 ◽  
Author(s):  
N. Cassano ◽  
M. De Benedittis ◽  
M. Petruzzi ◽  
M. Carbonara ◽  
C. Agnusdei ◽  
...  
Keyword(s):  
Vitamin E ◽  
Adverse Reactions ◽  
Contact Allergy ◽  
Response To Treatment ◽  
Vitamin E Acetate ◽  
Frequent Form ◽  
Oral Isotretinoin ◽  
Safe Approach ◽  
Symptoms And Signs ◽  
Overall Effectiveness

Treatment of cheilitis is usually difficult and often disappointing. We evaluated the effects of a topical preparation containing vitamin E acetate (VEA® lipogel) in 254 patients (mean age, 29.5) with cheilitis of various nature and etiology, involving the vermilion region and/or the perioral skin. The most frequent form of cheilitis was that induced by oral isotretinoin; other forms were irritant contact dermatitis, atopic cheilitis, and contact allergy. Patients were instructed to apply VEA® lipogel daily; the number of daily applications was modulated on the basis of the severity of symptoms (two or three times a day in the majority of cases). After 4 weeks of treatment, clinical examination showed that the severity of symptoms and signs significantly improved (P<0.001). The response to treatment was reported as particularly rapid by 32% of patients. Patient's assessment of overall effectiveness and acceptability was positive in the majority of cases. Treatment was well tolerated; local adverse reactions were observed in 2.75% of patients and were mostly transient and mild. Our experience suggests that VEA® lipogel is an effective and safe approach to cheilitis. The safety of this preparation is also due to the presence of only a few excipients and the absence of fragrances, preservatives and colouring agents.

Gas-Liquid Chromatographic Determination of Vitamin D2 in Multiple Vitamin Tablets Containing Minerals and Vitamin E Acetate

1974 ◽  
Vol 57 (5) ◽  
pp. 1089-1091
Author(s):  
David O Edlund ◽  
Florido A Filippini ◽  
James K Datson
Keyword(s):  
Vitamin E ◽  
Chromatographic Determination ◽  
Vitamin D2 ◽  
Vitamin E Acetate ◽  
Chromatographic Procedure ◽  
Ether Solution ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic ◽  
Column Chromatographic

Abstract A gas-liquid chromatographic procedure used to determine vitamin D2 in multiple vitamin tablets has been modified to make it applicable for analysis of multiple vitamin tablets containing minerals and vitamin E acetate. The procedure modifications involve pre-extraction with ether, solution in an alcoholic sulfuric acid-pyridine mixture, and column chromatographic separation on phosphate-treated alumina. The modified procedure has been statistically evaluated. A 2.2% coefficient of variation and 100.3% average recovery were obtained for the samples evaluated.

scholarly journals Vitamin E Acetate in Bronchoalveolar-Lavage Fluid Associated with EVALI

2020 ◽  
Vol 382 (8) ◽  
pp. 697-705 ◽  
Author(s):  
Benjamin C. Blount ◽  
Mateusz P. Karwowski ◽  
Peter G. Shields ◽  
Maria Morel-Espinosa ◽  
Liza Valentin-Blasini ◽  
...  
Keyword(s):  
Vitamin E ◽  
Bronchoalveolar Lavage ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Vitamin E Acetate

Culprit or correlate? An application of the Bradford Hill criteria to Vitamin E acetate

2020 ◽  
Vol 94 (6) ◽  
pp. 2249-2254 ◽  
Author(s):  
Ryan Feldman ◽  
Jonathan Meiman ◽  
Matthew Stanton ◽  
David D. Gummin
Keyword(s):  
Vitamin E ◽  
Vitamin E Acetate ◽  
Bradford Hill ◽  
Bradford Hill Criteria ◽  
Hill Criteria
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