Analysis of Sustainability In Livestock Production Systems In Cordoba, Colombia.

The concept of sustainability is usually broad; it refers to the ability of the system to meet the current demand for livestock products without compromising the use of resources by future generations. Therefore, this study has been conducted to provide an overview of rotational, intensive, and regenerative livestock models to evaluate and measure their level of sustainability in the environmental, social, and economic dimensions to guide livestock guilds, professionals and stakeholders to transform their agricultural systems by adopting the concept of sustainability. The results show that the regenerative livestock system has a high association with the economic dimension in the Almost Good category, in the environmental dimension in the Moderate category, and in the social dimension in the Almost Good and Very Good categories. On the other hand, the rotational livestock system and the intensive livestock system have an association with the environmental dimension categorized as good; however, the association of the intensive livestock system is not as strong as that of the rotational livestock system.

Intake of MPRO3 over 4 Weeks Reduces Glucose Levels and Improves Gastrointestinal Health and Metabolism

Human gut microbiota are involved in different metabolic processes, such as digestion and nutrient synthesis, among others. For the elderly, supplements are a major means of maintaining health and improving intestinal homeostasis. In this study, 51 elderly women were administered MPRO3 (n = 17), a placebo (n = 16), or both (MPRO3: 1 week, placebo: 3 weeks; n = 18) for 4 weeks. The fecal microbiota were analyzed by sequencing the 16S rRNA gene V3–V4 super-variable region. The dietary fiber intake increased, and glucose levels decreased with 4-week MPRO3 intake. Reflux, indigestion, and diarrhea syndromes gradually improved with MPRO3 intake, whereas constipation was maintained. The stool shape also improved. Bifidobacterium animalis, B. pseudolongum, Lactobacillus plantarum, and L. paracasei were relatively more abundant after 4 weeks of MPRO3 intake than in those subjects after a 1-week intake. Bifidobacterium and B. longum abundances increased after 1 week of MPRO3 intake but decreased when the intake was discontinued. Among different modules and pathways, all 10 modules analyzed showed a relatively high association with 4-week MPRO3 intake. The mineral absorption pathway and cortisol biosynthesis and secretion pathways correlated with the B. animalis and B. pseudolongum abundances at 4 weeks. Therefore, 4-week MPRO3 intake decreased the fasting blood glucose level and improved intestinal health and metabolism.

Simultaneous Bicompartmental Bucket Handle Injury Associated With a Chronic Anterior Cruciate Ligament Rupture: Case Report and Literature Review

Introduction: Simultaneously locked bucket handle injury of both menisci is a rare phenomenon. Clinically the knee is locked in flexion with pain in both joint lines. It has a high association rate with instability generated by an anterior cruciate ligament injury (ACL). There are a few reports regarding this association or without any associated injury treated either in one-stage or two-stage surgery.Objetive: To report a patient with a simultaneous bicompartmental locked bucket handle, highlighting the challenges of the surgical technique and a literature review.Case Report: We present the case of a 42-year-old male with a simultaneous bicompartmental locked bucket handle injury associated with chronic ACL deficiency. Treated in one stage by bilateral partial meniscectomy and ACL reconstruction. We discuss the MRI findings, treatment options and performed an up-to date review.Conclusions: Although partial meniscectomy is a common procedure, when performed in an unusual patient and in the absence of therapeutic guidelines or consensus when dealing with this association, an appropriate preoperative plan should be followed. This case provides a perioperative approach focused on a review of the most recent literature.

Non-Suicidal Self-Injury in the Decompensation of Personality Disorder in Adolescents During the COVID-19 Pandemic in 2020–2021

The aim of the study was to determine the clinical and psychopathological characteristics of non-suicidal self-injury (NSSI) in personality disorder (PD) in the comparative age-related aspect during the coronavirus infection (COVID-19) pandemic. Patients and methods: a total of 230 patients (177 males and 53 females) aged 16–25, diagnosed with PD and NSSI behavior manifestations, were studied retrospectively in mental hospital and outpatintly by using clinical-psychopathological method. All patients were divided into two equal groups of 115 people each. Group I was examined in 2017–2019, Group II — in 2020–2021 during the coronavirus infection (COVID-19) pandemic. Results: common features established in both groups were as follows: affective instability, alexithymia, conflict relations with significant others, and current traumatic experience. For a comparative assessment of NSSI in patients of both groups, we used the NSSI typology in adolescent PD, previously developed by the authors. Impulsive, demonstrative, addictive, depersonalizing and self-destructive types of NSSI were recognized as significant for the diagnostic assessment. In the second group of patients, that is, during the period of the COVID-19 pandemic, a change in the selected variants of NSSI was found, that is, in borderline and narcissistic PD the impulsive type was replaced by a demonstrative type, and in schizoid and anxious PD it turned into an addictive one. For a comparative assessment of NSSI in patients of both groups, we used the NSSI typology in PD in adolescence, previously developed by the authors. When assessing suicidality in group II, it was revealed that in most types of PD, with a decrease in the number of suicidal attempts, there was a noticeable increase in the incidence of NSSI with demonstrative suicidality, which correlated with the trajectories of the identified variants of NSSI. Conclusions: the study underlined the role of personality pathology in in adolescence in the development of psychopathological disorders with NSSI and their high association with suicidal activity. The modification of various NSSI variants in the context of a coronavirus infection (COVID-19) pandemic may be due to the unique characteristics of the psychotraumatic factor. With the same strength of impact, the multidirectional influence on various personality types and comorbid psychopathological disorders in adolescence should be taken into account, when creating new models of therapeutic and socio-rehabilitation interventions for the adolescent contingent of patients.

Sudden Onset of Vestibular Migraine Complicated with BPPV and Mal de Debarquement Syndrome – a Diagnostic Dilemma

Vestibular migraine is combination of migraine and vestibular symptoms. In clinical examination it can be replaced with benign paroxysmal positional vertigo (BPPV) cupulolithiasis, but also BPPV is common comorbidity in migraine patients. There is also high association between vestibular migraine and Mal de Debarquement syndrome. Patient came to hospital with vertigo that was diagnosed as left PC-BPPV canalolithiasis. After first Epley's maneuver symptoms didn't resolved. Week after, at second Epley's maneuver performed patient developed left PC-BPPV cupulolithiasis. Month after, at third Epley's maneuver BPPV resolved but patient developed Mal de Debarquement syndrome. Laboratory testing showed hyperhomocisteinemia and homozygous MTHFR C677T and PAI, with low vitamin D. After reviewing the vestibular symptoms in the first attack which was misdiagnosed as BPPV canalolithiasis, and history of migraine, patient was diagnosed with vestibular migraine. Patient well responded to migraine diet and supplementation with B complex. Vestibular disorders are similar to each other and they can overlap. More attention in taking detailed medical history should be given to patients with vertigo or dizziness.

Vitamin E Acetate Determination in Vaping Liquids and Non-targeted Analysis of Vaping Emissions of Diluents of Concern, Vitamin E Acetate and Medium-Chain Triglycerides Oil

During the summer of 2019, cases of lung injury associated with vaping emerged in North America, including among individuals who reported exclusive use of nicotine vaping liquids. Once vitamin E acetate was identified as a potential causative agent a quantitative method based on a simple sample dilution, separation by gas chromatography and analysis by triple quadrupole mass spectrometry (GC MSMS) was developed. Method detection limit (MDL) and limit of quantification (LOQ) were determined at 0.159 µg/mL and 0.505 µg/mL, respectively. The analysis was performed on a subset of 203 commercially sourced nicotine containing vaping liquids of various flavour profile and nicotine range (nicotine free-59 mg/mL) from an internal inventory. The target analyte, Vitamin E Acetate, was not detected in any samples analyzed, as expected, given the reported detection in literature and high association of the chemical with cannabis and not nicotine containing vaping products.

Mucormycosis: Why Incidence Rate is more in Covid -19 patients

This article aims to review existing evidence and evaluate the documented reasons of high association of Mucormycosis with Covis-19 patients. A literature search was conducted using CDC, MedlinePlus, PubMed, Medscape and Researchgate databases.

The Impact of COVID-19 on NO2 and PM2.5 Levels and Their Associations with Human Mobility Patterns in Singapore

The decline in NO2 and PM2.5 pollutant levels were observed during COVID-19 around the world, especially during lockdowns. Previous studies explained such observed decline with the decrease in human mobility, whilst overlooking the meteorological changes (e.g., rainfall, wind speed) that could mediate air pollution level simultaneously. This pitfall could potentially lead to over-or under-estimation of the effect of COVID-19 on air pollution. Consequently, this study aims to re-evaluate the impact of COVID-19 on NO2 and PM2.5 pollutant level in Singapore, by incorporating the effect of meteorological parameters in predicting NO2 and PM2.5 baseline in 2020 using machine learning methods. The results found that NO2 and PM2.5 declined by a maximum of 38% and 36%, respectively, during lockdown period. As two proxies for change in human mobility, taxi availability and carpark availability were found to increase and decrease by a maximum of 12.6% and 9.8%, respectively, in 2020 from 2019 during lockdown. To investigate how human mobility influenced air pollutant level, two correlation analyses were conducted: one between PM2.5 and carpark availability changes at regional scale and the other between NO2 and taxi availability changes at a spatial resolution of 0.01°. The NO2 variation was found to be more associated with the change in human mobility, with the correlation coefficients vary spatially across Singapore. A cluster of stronger correlations were found in the South and East Coast of Singapore. Contrarily, PM2.5 and carpark availability had a weak correlation, which could be due to the limit of regional analyses. Drawing to the wider context, the high association between human mobility and NO2 in the South and East Coast area can provide insights into future NO2 reduction policy in Singapore.Graphical Abstract

Prognostic Matrisomal Gene Panel and Its Association with Immune Cell Infiltration in Head and Neck Carcinomas

Squamous cell carcinoma of the head and neck (SCCHN) is common worldwide and related to several risk factors including smoking, alcohol consumption, poor dentition and human papillomavirus (HPV) infection. Different etiological factors may influence the tumor microenvironment and play a role in dictating response to therapeutics. Here, we sought to investigate whether an early-stage SCCHN-specific prognostic matrisome-derived gene signature could be identified for HPV-negative SCCHN patients (n = 168), by applying a bioinformatics pipeline to the publicly available SCCHN-TCGA dataset. We identified six matrisome-derived genes with high association with prognostic outcomes in SCCHN. A six-gene risk score, the SCCHN TMI (SCCHN-tumor matrisome index: composed of MASP1, EGFL6, SFRP5, SPP1, MMP8 and P4HA1) was constructed and used to stratify patients into risk groups. Using machine learning-based deconvolution methods, we found that the risk groups were characterized by a differing abundance of infiltrating immune cells. This work highlights the key role of immune infiltration cells in the overall survival of patients affected by HPV-negative SCCHN. The identified SCCHN TMI represents a genomic tool that could potentially aid patient stratification and selection for therapy in these patients.

Confining the Inner Space of Strained Carbon Nanorings

Strained aromatic macrocycles based on cycloparaphenylenes (CPPs) are the shortest repeating units of armchair single-walled carbon nanotubes. Since the development of several new synthetic methodologies for accessing these structures, their properties have been extensively studied. Besides the fundamental interest in these novel molecular scaffolds, their application in the field of materials science is an ongoing topic of research. Most of the reported CPP-type macrocycles display strong binding toward fullerenes, due to the perfect match between the convex and concave π-surfaces of fullerenes and CPPs, respectively. Highly functionalized CPP derivatives capable of supramolecular binding with other molecules are rarely reported. The synthesis of highly functionalized [n]cyclo-2,7-pyrenylenes leads to CPP-type macrocycles with a defined cavity capable of binding non-fullerene guests with high association constants.