scholarly journals Currently Available Strategies for Target Identification of Bioactive Natural Products

2021 ◽  
Vol 9 ◽  
Author(s):  
Gen Li ◽  
Xuling Peng ◽  
Yajing Guo ◽  
Shaoxuan Gong ◽  
Shijie Cao ◽  
...  
Keyword(s):  
Natural Products ◽  
Pharmaceutical Industry ◽  
Drug Research ◽  
Target Identification ◽  
Biologically Active ◽  
Bioactive Natural Products ◽  
Target Sites ◽  
Wide Availability ◽  
Research Findings ◽  
Active Natural

In recent years, biologically active natural products have gradually become important agents in the field of drug research and development because of their wide availability and variety. However, the target sites of many natural products are yet to be identified, which is a setback in the pharmaceutical industry and has seriously hindered the translation of research findings of these natural products as viable candidates for new drug exploitation. This review systematically describes the commonly used strategies for target identification via the application of probe and non-probe approaches. The merits and demerits of each method were summarized using recent examples, with the goal of comparing currently available methods and selecting the optimum techniques for identifying the targets of bioactive natural products.

scholarly journals 2-Hydroxysorangiadenosine: Structure and Biosynthesis of a Myxobacterial Sesquiterpene–Nucleoside

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2676 ◽  
Author(s):  
Dorothy A. Okoth ◽  
Joachim J. Hug ◽  
Ronald Garcia ◽  
Cathrin Spröer ◽  
Jörg Overmann ◽  
...  
Keyword(s):  
Natural Products ◽  
Pharmaceutical Industry ◽  
Structure Elucidation ◽  
Biosynthetic Pathway ◽  
Biologically Active ◽  
Full Structure ◽  
Potential Applications ◽  
Active Natural

Myxobacteria represent an under-investigated source for biologically active natural products featuring intriguing structural moieties with potential applications, e.g., in the pharmaceutical industry. Sorangiadenosine and the here-discovered 2-hydroxysorangiadenosine are myxobacterial sesquiterpene–nucleosides with an unusual structural moiety, a bicyclic eudesmane-type sesquiterpene. As the biosynthesis of these rare terpene–nucleoside hybrid natural products remains elusive, we investigated secondary metabolomes and genomes of several 2-hydroxysorangiadenosine-producing myxobacteria. We report the isolation and full structure elucidation of 2-hydroxysorangiadenosine and its cytotoxic and antibiotic activities and propose a biosynthetic pathway in the myxobacterium Vitiosangium cumulatum MCy10943T.

scholarly journals Bioprospecting of Microbes for Valuable Compounds to Mankind

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Nurul-Syakima Ab Mutalib ◽  
Sunny Hei Wong ◽  
Hooi-Leng Ser ◽  
Acharaporn Duangjai ◽  
Jodi Woan-Fei Law ◽  
...  
Keyword(s):  
Natural Products ◽  
Pharmaceutical Industry ◽  
Secondary Metabolites ◽  
Ecological Niche ◽  
Chemical Structure ◽  
Biological Activities ◽  
Biologically Active ◽  
Critical Insight ◽  
Valuable Compounds ◽  
Active Natural

The most biological multiplicity on this planet is almost certainly concealed in soils. Many valuable bacteria had been extensively dispersed in soils worldwide, with soils from terrestrial, desserts and Antarctic. Hence, soils become an intensively utilized ecological niche for the inhabitants to generate various useful biologically active natural products such asantibiotics, antifungal, antiviral, antioxidant, neuroprotection, anticancer and other important compounds. Bacteria including Actinobacteria have been exceptionally valuable for the pharmaceutical industry due to their limitless capability to generate secondary metabolites with various biological activities and chemical structure. Therefore, this article aims to provide critical insight of bioprospecting of microbes for valuable compounds to mankind.

Biologically active natural products from Cassine viburnifolia

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
T Grkovic ◽  
R Akee ◽  
J Evans ◽  
JM Collins ◽  
B O'Keefe
Keyword(s):  
Natural Products ◽  
Biologically Active ◽  
Active Natural

Synthetic studies on biologically active natural products by a chemicoenzymatic approach

Tetrahedron ◽  
1984 ◽  
Vol 40 (1) ◽  
pp. 145-152 ◽  
Author(s):  
Masaji Ohno ◽  
Yukishige Ito ◽  
Masafumi Arita ◽  
Tomoyuki Shibata ◽  
Kunitomo Adachi ◽  
...  
Keyword(s):  
Natural Products ◽  
Biologically Active ◽  
Synthetic Studies ◽  
Active Natural

Back to the Roots: Prediction of Biologically Active Natural Products from Ayurveda Traditional Medicine

2011 ◽  
Vol 30 (2-3) ◽  
pp. 181-187 ◽  
Author(s):  
Honey Polur ◽  
Tejal Joshi ◽  
Christopher T. Workman ◽  
Gandhidas Lavekar ◽  
Irene Kouskoumvekaki
Keyword(s):  
Natural Products ◽  
Traditional Medicine ◽  
Biologically Active ◽  
Active Natural

The Exploitation of Enzymatically-Derivedcis-1,2-Dihydrocatechols and Related Compounds in the Synthesis of Biologically Active Natural Products

2017 ◽  
Vol 18 (2) ◽  
pp. 239-264 ◽  
Author(s):  
Ehab S. Taher ◽  
Martin G. Banwell ◽  
Joshua N. Buckler ◽  
Qiao Yan ◽  
Ping Lan
Keyword(s):  
Natural Products ◽  
Biologically Active ◽  
Related Compounds ◽  
Active Natural

scholarly journals Palladium-Catalyzed Coupling Reactions on Functionalized 2-Trifluoromethyl-4-chromenone Scaffolds: Synthesis of Highly Functionalized Trifluoromethyl Heterocycles

Synthesis ◽  
2018 ◽  
Vol 51 (06) ◽  
pp. 1342-1352 ◽  
Author(s):  
Javier Izquierdo ◽  
Atul Jain ◽  
Sarki Abdulkadir ◽  
Gary Schiltz
Keyword(s):  
Natural Products ◽  
Organic Synthesis ◽  
Biological Activities ◽  
Structural Complexity ◽  
Biologically Active ◽  
Coupling Reactions ◽  
Trifluoromethyl Group ◽  
Palladium Catalyzed ◽  
Active Natural

The chromenone core is an ubiquitous group in biologically active natural products and has been extensively used in organic synthesis. Fluorine-derived compounds, including those with a trifluoromethyl group (CF3), have shown enhanced biological activities in numerous pharmaceuticals compared with their non-fluorinated analogues. 2-Trifluoromethylchromenones can be readily functionalized at the 8- and 7-positions, providing chromenones cores of high structural complexity, which are excellent precursors for numerous trifluoromethyl heterocycles.

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