scholarly journals Autophagy in Staphylococcus aureus Infection

2021 ◽  
Vol 11 ◽  
Author(s):  
Mengyao Wang ◽  
Ziyao Fan ◽  
Hongbing Han
Keyword(s):  
Staphylococcus Aureus ◽  
Immune System ◽  
Infection Control ◽  
Regulatory System ◽  
Intracellular Pathogen ◽  
Host Immune System ◽  
Accessory Gene ◽  
Aureus Infection ◽  
Gene Regulatory System ◽  
Gene Regulatory

Staphylococcus aureus is an invasive, facultative intracellular pathogen that can colonize niches in various host organisms, making it difficult for the host immune system to completely eliminate. Host autophagy is an intracellular clearance pathway involved in degrading S. aureus. Whereas the accessory gene regulatory system of S. aureus that controls virulence factors could resist the host immune defenses by evading and even utilizing autophagy. This article reviews the interaction between autophagy and S. aureus, providing insights on how to use these mechanisms to improve S. aureus infection control.

scholarly journals Role of the Accessory Gene Regulatoragrin Community-Associated Methicillin-Resistant Staphylococcus aureus Pathogenesis

2011 ◽  
Vol 79 (5) ◽  
pp. 1927-1935 ◽  
Author(s):  
Gordon Y. C. Cheung ◽  
Rong Wang ◽  
Burhan A. Khan ◽  
Daniel E. Sturdevant ◽  
Michael Otto
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistance ◽  
Regulatory System ◽  
Accessory Gene ◽  
Methicillin Resistant ◽  
Content Type ◽  
Fibrinogen Binding ◽  
Gene Regulatory System ◽  
Differential Gene ◽  
Mrsa Strains

ABSTRACTThe molecular basis underlying the pathogenic success of community-associated methicillin-resistantStaphylococcus aureus(CA-MRSA) is not completely understood, but differential gene expression has been suggested to account at least in part for the high virulence of CA-MRSA strains. Here, we show that theagrgene regulatory system has a crucial role in the development of skin infections in the most prevalent CA-MRSA strain USA300. Importantly, our data indicate that this is due to discrepancies between theagrregulon of CA-MRSA and those of hospital-associated MRSA and laboratory strains. In particular,agrregulation in strain USA300 led to exceptionally strong expression of toxins and exoenzymes, upregulation of fibrinogen-binding proteins, increased capacity to bind fibrinogen, and increased expression of methicillin resistance genes. Our findings demonstrate thatagrfunctionality is critical for CA-MRSA disease and indicate that an adaptation of theagrregulon contributed to the evolution of highly pathogenic CA-MRSA.

Impact of the accessory gene regulatory system (Agr) on extracellular proteins,codY expression and amino acid metabolism inStaphylococcus epidermidis

PROTEOMICS ◽  
2006 ◽  
Vol 6 (12) ◽  
pp. 3602-3613 ◽  
Author(s):  
Christoph F. Batzilla ◽  
Shwan Rachid ◽  
Susanne Engelmann ◽  
Michael Hecker ◽  
Jörg Hacker ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Regulatory System ◽  
Extracellular Proteins ◽  
Accessory Gene ◽  
Gene Regulatory System ◽  
Gene Regulatory

scholarly journals Role of the PhoP–PhoQ gene regulatory system in adaptation of Yersinia pestis to environmental stress in the flea digestive tract

Microbiology ◽  
2015 ◽  
Vol 161 (6) ◽  
pp. 1198-1210 ◽  
Author(s):  
Viveka Vadyvaloo ◽  
Austin K. Viall ◽  
Clayton O. Jarrett ◽  
Angela K. Hinz ◽  
Daniel E. Sturdevant ◽  
...  
Keyword(s):  
Environmental Stress ◽  
Yersinia Pestis ◽  
Digestive Tract ◽  
Regulatory System ◽  
Gene Regulatory System ◽  
Gene Regulatory

scholarly journals Investigating the Roles of Listeria monocytogenes Peroxidases in Growth and Virulence

2021 ◽  
Author(s):  
Monica R. Cesinger ◽  
Nicole H. Schwardt ◽  
Cortney R. Halsey ◽  
Maureen K. Thomason ◽  
Michelle L. Reniere
Keyword(s):  
Reactive Oxygen Species ◽  
Immune System ◽  
Listeria Monocytogenes ◽  
Causative Agent ◽  
Foodborne Illness ◽  
Intracellular Pathogen ◽  
Host Immune System ◽  
Oxygen Species ◽  
Aerobic Growth ◽  
Content Type

Listeria monocytogenes is a facultative intracellular pathogen and the causative agent of the foodborne illness listeriosis. L. monocytogenes must contend with reactive oxygen species generated extracellularly during aerobic growth and intracellularly by the host immune system. However, the mechanisms by which L. monocytogenes defends against peroxide toxicity have not yet been defined.

Abstract 782: A network approach to study the effect of chemical exposures on gene regulatory system in rats

2016 ◽  
Author(s):  
Francesca Petralia ◽  
Vasily Aushev ◽  
Kalpana Gopalakrishnan ◽  
Susan Teitelbaum ◽  
Jia Chen ◽  
...  
Keyword(s):  
Regulatory System ◽  
Network Approach ◽  
Chemical Exposures ◽  
Gene Regulatory System ◽  
Gene Regulatory
Sign in / Sign up

Export Citation Format

Share Document