scholarly journals Exploring the Interplay Between Oral Diseases, Microbiome, and Chronic Diseases Driven by Metabolic Dysfunction in Childhood

2021 ◽  
Vol 2 ◽  
Author(s):  
Fernanda Maria Sabella ◽  
Simone Nataly Busato de Feiria ◽  
Apoena de Aguiar Ribeiro ◽  
Letícia Helena Theodoro ◽  
José Francisco Höfling ◽  
...  
Keyword(s):  
Chronic Diseases ◽  
Type I Diabetes ◽  
Oral Microbiome ◽  
Entire Body ◽  
Type I ◽  
Metabolic Dysfunction ◽  
Oral Diseases ◽  
Future Health ◽  
Childhood Diseases ◽  
Inflammatory State

Oral childhood diseases, such as caries and gingivitis, have much more than a local impact on the dentition and tooth surrounding tissues, which can affect systemic conditions. While the mouth is frequently exposed to microbial stressors that can contribute to an inflammatory state in the entire body, chronic disorders can also interfere with oral health. Sharing common risk factors, a dynamic interplay can be driven between 1. dental caries, gingivitis, and type I diabetes mellitus, 2. early childhood caries and obesity, and 3. caries and cardiovascular diseases. Considering that there are ~2.2 billion children worldwide and that childhood provides unique opportunities for intervention targeting future health promotion, this review is of prime importance and aimed to explore the relationship between the oral microbiome and oral chronic diseases driven by metabolic dysfunction in childhood.

A School Nurse Application of the ECHO Model

2019 ◽  
pp. 105984051986174
Author(s):  
Suzuho Shimasaki ◽  
Pamela Brunner Nii ◽  
Lisa Davis ◽  
Erin Bishop ◽  
Cari Berget ◽  
...  
Keyword(s):  
Diabetes Care ◽  
Chronic Conditions ◽  
Type I Diabetes ◽  
Models Of Care ◽  
School Nurses ◽  
Type I ◽  
Colorado School ◽  
Childhood Diseases ◽  
Survey Results

Type I diabetes (T1D) is one of the most common childhood diseases and Type 2 diabetes (T2D) is increasing at alarming rates. Given that children spend a great percentage of their time in school, this setting is a critical environment for models of care that lead to better management of this and other health conditions. The School Nurses Managing Diabetes Care ECHO was offered to Colorado school nurses to build their capacity in providing evidence-based management of T1D. The purpose of this effort was to (1) determine whether or not the model could be used as a tool of collaboration and dissemination for school nurses across Colorado and (2) assess the effectiveness of the “School Nurses Managing Diabetes Care” ECHO learning series. Post-series survey results demonstrated a 25% increase in self-efficacy ratings, moving learners from “average among my peers” toward “competent.” Additionally, all respondents planned to make one or more practice changes to improve care for students with T1D. Expanding the use of the ECHO model to implement intensive management of children and youth with T1D is critically important as rates of this and other chronic conditions continue to increase.

Quality of Care of Children With Chronic Diseases in Alexandria, Egypt: The Models of Asthma, Type I Diabetes, Epilepsy, and Rheumatic Heart Disease

PEDIATRICS ◽  
2000 ◽  
Vol 106 (1) ◽  
pp. e12-e12 ◽  
Author(s):  
Amal Bassili ◽  
Adel Zaki ◽  
Salah R. Zaher ◽  
Ihab H. El-Sawy ◽  
Mona Hassan Ahmed ◽  
...  
Keyword(s):  
Heart Disease ◽  
Quality Of Care ◽  
Chronic Diseases ◽  
Rheumatic Heart Disease ◽  
Type I Diabetes ◽  
Type I ◽  
Rheumatic Heart

Electron microscopy analysis of degenerating pancreatic ß cells in transgenic mice expressing the MHC Class I antigen Dd

1990 ◽  
Vol 48 (3) ◽  
pp. 548-549
Author(s):  
T. A. Stewart ◽  
D. Liggitt ◽  
S. Pitts ◽  
L. Martin ◽  
M. Siegel ◽  
...  
Keyword(s):  
Type I Diabetes ◽  
Disease Process ◽  
Class Ii ◽  
Class I ◽  
Type I ◽  
Aberrant Expression ◽  
Mhc Molecules ◽  
Endogenous Insulin ◽  
Class Ii Mhc ◽  
Ifn Γ

Insulin-dependant (Type I) diabetes mellitus (IDDM) is a metabolic disorder resulting from the lack of endogenous insulin secretion. The disease is thought to result from the autoimmune mediated destruction of the insulin producing ß cells within the islets of Langerhans. The disease process is probably triggered by environmental agents, e.g. virus or chemical toxins on a background of genetic susceptibility associated with particular alleles within the major histocompatiblity complex (MHC). The relation between IDDM and the MHC locus has been reinforced by the demonstration of both class I and class II MHC proteins on the surface of ß cells from newly diagnosed patients as well as mounting evidence that IDDM has an autoimmune pathogenesis. In 1984, a series of observations were used to advance a hypothesis, in which it was suggested that aberrant expression of class II MHC molecules, perhaps induced by gamma-interferon (IFN γ) could present self antigens and initiate an autoimmune disease. We have tested some aspects of this model and demonstrated that expression of IFN γ by pancreatic ß cells can initiate an inflammatory destruction of both the islets and pancreas and does lead to IDDM.

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