Vitamin D Receptor TaqI Polymorphism Is Associated With Reduced Follicle Number in Women Utilizing Assisted Reproductive Technologies

In late 2019, the new Coronavirus has been identified in the city of Wuhan (China) then COVID-19 spreads like wildfire in the rest of the world. Pregnant women represent a risk category for increased abortion rates and vertical transmission with adverse events on the newborns has been recently confirmed. The scientific world is struggling for finding an effective cure for counteracting symptomatology. Today, there are many therapeutic proposes but none of them can effectively counteract the infection. Moreover, many of these compounds show important side effects not justifying their use. Scientific literature reports an immune system over-reaction through interleukins- 6 activation. In this regard, the possibility to control the immune system represents a possible strategy for counteracting the onset of COVID-19 symptomatology. Vitamin D deficiency shows increased susceptibility to acute viral respiratory infections. Moreover, Vitamin D seems involved in host protection from different virus species by modulating activation and release of cytokines. Myo-inositol down-regulates the expression of IL-6 by phosphatidyl-inositol-3-kinase pathway. Furthermore, myo-inositol is the precursor of phospholipids in the surfactant and it is applied for inducing surfactant synthesis in infants for treating respiratory distress syndrome. This review aims to summarize the evidence about COVID-19 infection in pregnant women and to encourage the scientific community to investigate the use of Vitamin D and Myo-inositol which could represent a possible preventive treatment for pregnant women or women undergoing assisted reproductive technologies.

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Vitamin D receptor (VDR) TaqI polymorphism in primary biliary cirrhosis (PBC)

Journal of Hepatology ◽

10.1016/s0168-8278(01)81646-9 ◽

2001 ◽

Vol 34 ◽

pp. 209 ◽

Cited By ~ 1

Author(s):

A.M. Baragiotta ◽

A. Floreani ◽

O. James ◽

C. Venturi ◽

A. Craggs ◽

...

Keyword(s):

Vitamin D ◽

Primary Biliary Cirrhosis ◽

Vitamin D Receptor ◽

Biliary Cirrhosis ◽

Taqi Polymorphism

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Vitamin D receptor gene methylation is associated with ethnicity, tuberculosis, and TaqI polymorphism

Human Immunology ◽

10.1016/j.humimm.2010.12.010 ◽

2011 ◽

Vol 72 (3) ◽

pp. 262-268 ◽

Cited By ~ 50

Author(s):

Charlene Andraos ◽

Gerrit Koorsen ◽

Julian C. Knight ◽

Liza Bornman

Keyword(s):

Vitamin D ◽

Vitamin D Receptor ◽

Receptor Gene ◽

Vitamin D Receptor Gene ◽

Gene Methylation ◽

Taqi Polymorphism

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Frequency of fokI and taqI polymorphism of vitamin D receptor gene in Indian population and its association with 25-hydroxyvitamin D levels

Indian Journal of Human Genetics ◽

10.4103/0971-6866.60186 ◽

2009 ◽

Vol 15 (3) ◽

pp. 108 ◽

Cited By ~ 40

Author(s):

BibhuR Das ◽

AparnaA Bhanushali ◽

Namrata Lajpal ◽

SmitaS Kulkarni ◽

SandeepS Chavan ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Receptor ◽

Indian Population ◽

Receptor Gene ◽

Vitamin D Receptor Gene ◽

Hydroxyvitamin D ◽

Taqi Polymorphism ◽

25 Hydroxyvitamin D

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Vitamin D Receptor Gene Polymorphisms in Childhood Brucellosis in Turkish Children

Journal of Pediatric Infectious Diseases ◽

10.1055/s-0041-1732471 ◽

2021 ◽

Author(s):

Ayse Kaman ◽

Fatma Nur Öz ◽

Gülseren Sahin ◽

Özge Metin Akcan

Keyword(s):

Vitamin D ◽

Vitamin D Receptor ◽

Gene Polymorphisms ◽

Receptor Gene ◽

Vitamin D Receptor Gene ◽

Genotype Distribution ◽

Healthy Controls ◽

Vdr Gene ◽

Taqi Polymorphism ◽

Vdr Gene Polymorphisms

Abstract Objective The vitamin D receptor gene (VDR) polymorphisms and the risk of various infections have been studied. An association with brucellosis and vitamin D levels has been investigated but not yet with VDR gene polymorphisms. We aimed to examine the association between VDR gene polymorphisms and susceptibility to childhood brucellosis. Methods This case–control study included patients with brucellosis and healthy controls. After extracting genomic DNA using a Qiagen blood DNA isolation kit, five VDR single nucleotide polymorphisms (SNPs), including Cdx-2, FokI, BsmI, ApaI, and TaqI gene, were amplified. Genetic distribution of these SNPs of VDR gene in patient and control groups were compared. Results A total of 38 patients with brucellosis and 89 healthy controls were evaluated. The genotype distribution of Cdx2, FokI, BsmI, and ApaI polymorphisms were similar between patients and healthy controls. However, the CC homozygous genotype for VDR gene TaqI was significantly overexpressed in patients compared with controls (23.7 vs. 7.9%; p = 0.042). The frequency of the C allele of the TaqI genotype was significantly different between patients and controls (p = 0.018). On the other hand, presence of the A allele in the BsmI was associated considerably with an increased risk of brucellosis (p = 0.037). VDR polymorphism distribution was similar according to age, presence of complicated disease, and presence of bacteremia. The heterozygote TaqI polymorphism was more common in patients presented as subacute and chronic symptoms (p = 0.036). Conclusion Our results indicated the possible role in TaqI polymorphism of the VDR gene for the risk of brucellosis at the time of exposure to infection.

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Familial Calcium Stone Disease: TaqI Polymorphism and the Vitamin D Receptor

Journal of Endourology ◽

10.1089/end.1999.13.313 ◽

1999 ◽

Vol 13 (4) ◽

pp. 313-316 ◽

Cited By ~ 44

Author(s):

STEPHEN V. JACKMAN ◽

ADAM S. KIBEL ◽

CYRIL A. OVUWORIE ◽

ROBERT G. MOORE ◽

LOUIS R. KAVOUSSI ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Receptor ◽

Stone Disease ◽

Calcium Stone ◽

Taqi Polymorphism

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Association of select vitamin D receptor gene polymorphisms with the risk of tobacco-related cancers – a meta-analysis

Scientific Reports ◽

10.1038/s41598-019-52519-5 ◽

2019 ◽

Vol 9 (1) ◽

Author(s):

Lukasz Laczmanski ◽

Izabela Laczmanska ◽

Felicja Lwow

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Vitamin D Receptor ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Receptor Gene ◽

P Value ◽

Vdr Gene ◽

Taqi Polymorphism ◽

Vdr Gene Polymorphisms

Abstract The observed increase in morbidity and mortality due to tobacco-related cancers, especially those in the respiratory system and esophagus, is becoming a public health challenge. Smoking cigarettes is one of the main risk factors predisposing individuals to many types of cancers. The aim of this study was to determine the role of select vitamin D receptor (VDR) gene polymorphisms as risk factors in tobacco-related cancers. The MEDLINE and ResearchGate databases were used to search for articles up to June 2017, and 12 articles including 26 studies concerning FokI, ApaI, TaqI and BsmI polymorphisms and lung, neck, head, esophageal and oral cancers were chosen. In total, 5 113 cases and 5 657 controls were included in the pooled analysis. We found a significant relationship between tobacco-related cancers and the occurrence of the “t” allele in the TaqI polymorphism of VDR. The occurrence of the “t” allele reduced the risk of tobacco-related cancers by 17% (OR = 0.83, 0.72–0.96 95% CI, p-value = 0.0114). Our analysis revealed that there is a correlation between the TaqI polymorphism of VDR and the risk of tobacco-related cancers.

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Vitamin D and reproductive health

Problems of Endocrinology ◽

10.14341/probl12468 ◽

2020 ◽

Vol 66 (5) ◽

pp. 96-101

Author(s):

I. V. Gorelova ◽

P. V. Popova ◽

M. V. Rulev

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Pregnancy Rate ◽

Clinical Studies ◽

Assisted Reproductive Technologies ◽

Reproductive Technologies ◽

Male Rats ◽

Vitamin D Levels

Vitamin D insufficiency and deficiency in women with infertility is more common than in the population. However, we still do not know the exact mechanisms for the participation of vitamin D in the regulation of reproductive function. The purpose of this study is to analyze actual literature data on the role of vitamin D in the regulation of reproductive system and its influence on using of assisted reproductive technologies for the treatment of infertility. A search was carried out for literary sources published in the NSBI database PubMed, Medline, and others with a search depth of up to 20 years. 135 sources on this topic were studied, of which 54 were included in the analysis. The review presents data obtained in animal studies, in vitro and in clinical studies. Thus, the absence of vitamin D resulted in a dramatical decrease in fertility in both female and male rats and mice, due to the development of hypocalcemia. In vitro studies describe its involvement in the receptive transformation of the endometrium and in the regulation of the immune response during embryo implantation. However, clinical studies often show conflicting results. There is no unequivocal data on the effect of vitamin D levels on spermogram parameters, but a decrease in the pregnancy rate was shown when ovulation was induced in pairs, where a vitamin D deficiency was revealed in men. A meta-analysis published in 2017 showed a decrease in the pregnancy and live birth rate in women with low levels of vitamin D after the use of assisted reproductive technologies (ART). It was not possible to establish whether this decrease depends on oocyte quality or endometrium. There is an opportunity that the effect of vitamin D deficiency on fertility will not come with all forms of infertility. For example, in women with anovulation due to polycystic ovary syndrome, vitamin D deficiency is demonstrated to decrease pregnancy rate in ovulation induction cycles and in ART. Such relationship was not found in women with unexplained infertility.Thus, the role of vitamin D in the pathogenesis of infertility requires further study, as well as the possibilities of therapy in order to increase the effectiveness of infertility treatment methods and assisted reproductive technology programs.

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