scholarly journals Association Between Vitamin D and Resistin in Postmenopausal Females With Altered Bone Health

2021 ◽  
Vol 11 ◽  
Author(s):  
Sundus Tariq ◽  
Saba Tariq ◽  
Saba Khaliq ◽  
Mukhtiar Baig ◽  
Manal Abdulaziz Murad ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Serum Vitamin ◽  
Significant Negative Correlation ◽  
Enzyme Linked Immunosorbent Assay ◽  
Mineral Density ◽  
Serum Vitamin D ◽  
Vitamin D Levels

BackgroundResistin is a relatively novel adipokine that has a role in bone remodeling and may regulate bone mineral density (BMD). Vitamin D and adipokines have a dynamic role in the body’s various metabolic processes, including bone metabolism, and may alter bone metabolism in relation to each other. This study aimed to investigate the association between vitamin D and serum resistin levels in postmenopausal non-osteoporotic and osteoporotic females.MethodsThis correlational analytical study was conducted on 161 postmenopausal females, divided into two groups, non-osteoporotic and osteoporotic, between 50–70 years. Bone mineral density (BMD) was assessed by dual-energy X-ray absorptiometry (DXA) scan. Serum resistin and vitamin D levels were analyzed by enzyme-linked immunosorbent assay (ELISA) method. Serum calcium, phosphate, and alkaline phosphatase with spectrophotometry. A correlation was checked using spearman’s rho correlation coefficient, and multivariate stepwise regression analysis was used to predict serum resistin levels.ResultsPostmenopausal females (n=161) having sufficient, insufficient and deficient levels of vitamin D were 87 (54.0%), 64 (39.8%), and 10 (6.2%), respectively. Lumbar spine BMD (p < 0.001), total hip BMD (p < 0.001), and serum resistin levels (p < 0.001) were significantly different between the two groups. There was a significant negative correlation between serum resistin and vitamin D in postmenopausal females (rho = -0.182, p = 0.021) and osteoporotic group (rho = -0.253, p = 0.019) but non-significant in non-osteoporotic group (rho = -0.077, p = 0.509). Serum vitamin D was found to be independent predictor of serum resistin levels, accounting for only 3% variance.ConclusionSerum vitamin D levels were low while serum resistin levels were high in postmenopausal osteoporotic females and vitamin D is a negative predictor of serum resistin levels.

Bone mineral density and its influencing factors in children with idiopathic nephrotic syndrome: a prospective observational study

2019 ◽  
Vol 49 (4) ◽  
pp. 292-298
Author(s):  
Indar K Sharawat ◽  
Lesa Dawman ◽  
Merabhai V Kumkhaniya ◽  
Kusum Devpura ◽  
Amarjeet Mehta
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Nephrotic Syndrome ◽  
Bone Mineral ◽  
Idiopathic Nephrotic Syndrome ◽  
Serum Vitamin ◽  
Z Score ◽  
Mineral Density ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Glucocorticoids are first-line therapy for children with idiopathic nephrotic syndrome (INS). These children are at risk of deranged bone metabolism and low bone mineral density (BMD). We studied 60 children with INS and divided them into two groups. Group 1 included 21 children (initial and infrequent relapsing) and group 2 included 39 children (frequent relapsing, steroid dependent and steroid resistant). Dual-energy X-ray absorptiometry of the lumbar spine was performed to assess BMD. Mean BMD Z-score was compared in both groups; this correlated significantly on univariate analysis with cumulative steroid dose, serum vitamin D levels and calcium supplementation. However, on multivariate analysis, serum vitamin D level was the only factor significantly predictive of low z-score.

scholarly journals STUDY OF BONE MINERAL DENSITY AND SERUM VITAMIN D LEVELS IN HEALTHY POSTMENOPAUSAL WOMEN

2016 ◽  
Vol 3 (64) ◽  
pp. 3515-3519
Author(s):  
Selvapandian Kirubaharan S ◽  
Arshiya Begum ◽  
Priya Anbarasan ◽  
Latha Jeyasubramanian ◽  
Santhi Natesan ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Serum Vitamin ◽  
Mineral Density ◽  
Serum Vitamin D ◽  
Vitamin D Levels

scholarly journals Levetiracetam monotherapy effect on serum calcium and serum vitamin D in patient of epilepsy

2017 ◽  
Vol 5 (2) ◽  
pp. 503 ◽  
Author(s):  
Anubha Garg ◽  
Surekha Dabla ◽  
Sandeep Nagenhalli ◽  
Sanjay Fotedar
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Mineral ◽  
Serum Calcium ◽  
Serum Vitamin ◽  
Total Leukocyte Count ◽  
Mineral Density ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
One Year

Background: Objective of the study was to determine the Levetiracetam monotherapy effect on serum calcium and serum vitamin D levels in tertiary care hospital in Haryana, India.Methods: A total of 110 patients with epilepsy, were enrolled to the study for one year between April 2013 to August 2014. All male patients aged 15-60 years and premenopausal females with epilepsy were included in the study. The study was a interventional prospective study design. The antiepileptic drug levetiracetam was administered starting from a dose of 20 mg/kg and dose was titrated according to the clinical response. During the follow up period, the subjects were asked about the seizure frequency and other side effects. The patients were be subjected to questionnaires based proforma. Baseline investigations, Hemogram, renal and liver function tests, calcium, phosphate, vitamin D and bone mineral density and T scores were noted. All investigations were repeated after one year of levetiracetam monotherapy.Results: The mean age of onset of seizures in the study group was 23.22±6.62 years. 58% (n=29) were seizure free after 1 year of levetiracetam monotherapy, 28% patients had adequate control and 14% patients had poor control of their seizure episodes. There was an insignificant change in Hemoglobin, total leukocyte count, platelet count, renal parameters and Liver enzymes from baseline over a year of levetiracetam therapy. Serum calcium levels increased insignificantly from baseline levels of 9.68±0.59 mg/dl to 9.72±0.56mg/dl. Vitamin D levels increased from baseline of 39.35±14.91ng/ml to 39.84±14.07 ng/ml. Bone mineral density increased insignificantly from baseline of 0.92±0.13 g/cm2 to 0.93±0.13 g/cm2.Conclusions: Present study has shown an overall beneficial effect on serum calcium, Vitamin D level, bone mineral density and T scores on DEXA scan.

Bone mineral density and serum vitamin D status in Parkinson's disease: Are the stage and clinical features of the disease important?

2020 ◽  
Vol 68 (2) ◽  
pp. 394 ◽  
Author(s):  
ErhanArif Ozturk ◽  
Ibrahim Gundogdu ◽  
Burak Tonuk ◽  
Ebru Umay ◽  
BilgeGonenli Kocer ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Parkinson’S Disease ◽  
Vitamin D ◽  
Parkinson's Disease ◽  
Clinical Features ◽  
Bone Mineral ◽  
Serum Vitamin ◽  
Vitamin D Status ◽  
Mineral Density ◽  
Serum Vitamin D

scholarly journals Bone Metabolism In Patients With Type 1 Neurofibromatosis: Key Role of Sun Exposure and Physical Activity

2021 ◽  
Author(s):  
Ursula Pia Ferrara ◽  
Cristina Tortora ◽  
Carmen Rosano BD ◽  
Antonia Assunto BD ◽  
Alessandro Rossi ◽  
...  
Keyword(s):  
Physical Activity ◽  
Vitamin D ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Linear Regression Analysis ◽  
Serum Vitamin ◽  
Sun Exposure ◽  
Mineral Density ◽  
Vitamin D Levels ◽  
Cholecalciferol Supplementation

Abstract Bone metabolism has been rarely investigated in children affected by Neurofibromatosis (NF1). Aim of the present study was to assess bone mineral metabolism in children and adults NF1 patients, to determine the relevant factors potentially involved in the development of reduced bone mineral density (BMD), and provide possible therapeutic intervention in NF1 patients. 114 NF1 patients and sex and age matched controls were enrolled into the study. Clinical and biochemical factors reflecting bone metabolism were evaluated. Factors potentially affecting BMD were also investigated including: physical activity, sun exposure, vitamin D intake. Whenever the presence of vitamin D deficiency was recorded, cholecalciferol supplementation was started and BMD data obtained during supplementation were compared with previous ones. NF1 patients showed lower Z-scores at Dual-Energy X-ray Absorptiometry (DXA) than controls. Physical activity was significantly reduced in NF1 patients than in controls. Sun exposure was significantly lower in NF1 compared to control subjects. At linear regression analysis vitamin D was the most predictive factor of reduced BMD (p = 0.0001). Cholecalciferol supplementation significantly increased BMD z.score (p = 0.000). We speculated that a combination of different factors, including reduced sun exposure, possibly associated with reduced serum vitamin D levels, and poor physical activity, concur to the impaired bone status in NF1 patients. We also demonstrated that treatment with vitamin D can be effective in improving BMD in NF1 patients, including children. In conclusion, the findings of the current study are expected to have important implications for the follow-up and prevention of osteopenia/osteoporosis in this common genetic disease.

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