scholarly journals Incidence and Risk Factors of Hypogonadism in Male Patients With Latent Autoimmune Diabetes and Classic Type 2 Diabetes

2021 ◽  
Vol 12 ◽  
Author(s):  
Meili Cai ◽  
Ran Cui ◽  
Peng Yang ◽  
Jingyang Gao ◽  
Xiaoyun Cheng ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Uric Acid ◽  
Diabetes Management ◽  
Autoimmune Diabetes ◽  
Glycosylated Hemoglobin ◽  
Diabetic Patients ◽  
Latent Autoimmune Diabetes ◽  
Male Patients

ObjectivesThis study aimed to compare the prevalence of hypogonadism between male patients with latent autoimmune diabetes (LADA) and type 2 diabetes (T2DM) and investigate the risk factors for hypogonadism in these patients.MethodsThis cross-sectional study evaluated 367 male patients with LADA (n=73) and T2DM (n=294) who visited the endocrinology department of Shanghai Tenth People’s Hospital between January 2016 and October 2019 for diabetes management. Sex hormones, lipid profiles, sex hormone-binding globulin (SHBG), glycosylated hemoglobin A1c, beta-cell function, uric acid, and osteocalcin were determined in serum samples. Hypogonadism was defined as calculated free testosterone (cFT) less than 220 pmol/L along with the presence of symptoms (positive ADAM score).ResultsThe rate of hypogonadism in the LADA and T2DM group were 8.2, and 21.7%, respectively (p=0.017). After adjusting possible confounders, the rate of hypogonadism in the LADA group was comparable to those of the T2DM group. Univariate logistic regressions demonstrated that age, BMI, fasting C-peptide, triglycerides, total cholesterol and uric acid were associated with hypogonadism in men with diabetes, BMI, triglycerides and estradiol were independent risk for hypogonadism in men with diabetes.ConclusionThis is the first evidence to explore the rate of hypogonadism in male patients with latent autoimmune diabetes (LADA). In the population requiring admission to a large urban hospital in China, the rate of hypogonadism was comparable to those of the T2DM group after adjusting for possible confounders. BMI, triglycerides and estradiol were independently associated with the presence of HH in male diabetic patients.

1639-P: Correlates and Prevalence of Hypogonadism in Male Patients with Latent Autoimmune Diabetes, Classic Type 1 Diabetes, and Classic Type 2 Diabetes

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1639-P
Author(s):  
MEILI CAI ◽  
JINGYANG GAO ◽  
CHUNJUN SHENG ◽  
HONG LI ◽  
HUI SHENG ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Autoimmune Diabetes ◽  
Latent Autoimmune Diabetes ◽  
Male Patients

scholarly journals Interleukin-18 serum level is elevated in type 2 diabetes and latent autoimmune diabetes

2018 ◽  
Vol 7 (1) ◽  
pp. 179-185 ◽  
Author(s):  
Emanuela Zaharieva ◽  
Zdravko Kamenov ◽  
Tsvetelina Velikova ◽  
Adelina Tsakova ◽  
Yosif El-Darawish ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Serum Level ◽  
Autoimmune Diabetes ◽  
Enzyme Linked Immunosorbent Assay ◽  
Diabetic Patients ◽  
Interleukin 18 ◽  
Control Subjects ◽  
Latent Autoimmune Diabetes ◽  
Hs Crp

Background Interleukin-18 (IL-18) is an inflammatory cytokine found to be elevated in obesity, metabolic syndrome and type 2 diabetes (T2D) as a part of the chronic low-grade inflammatory process in these states. The aim of the study was to evaluate the interleukin level in patients with latent autoimmune diabetes of the adults (LADA) in comparison to that in T2D subjects. Materials and methods IL-18 was analyzed through enzyme-linked immunosorbent assay in 76 participants with T2D and 24 with LADA and 14 control subjects. Evaluation was also carried out in body mass index (BMI)- and glycemic control-matched diabetic patients. Results The serum concentration of IL-18 was higher in patients with T2D (389.04 ± 203.44 pg/mL) and LADA (327.04 ± 144.48 pg/mL) than that in control subjects (219.88 ± 91.03 pg/mL), P < 0.05. However, it was not significantly different between both diabetic groups (P = 0.255) despite higher IL-6 (4.78 ± 5.84 vs 1.79 ± 0.96 pg/mL, P < 0.001) and hs-CRP (2.60 ± 1.70 vs 1.29 ± 1.20 mg/L, P = 0.002) level in T2D patients. The results were persistent in BMI-matched subjects with diabetes (IL-18 = 403.48 ± 226.32 vs 329.30 ± 146.30 pg/mL, respectively for T2D and LADA, P = 0.391). The correlations in T2D group concerning HDL cholesterol (r = −0.377, P = 0.001), postprandial glucose (r = 0.244, P = 0.043), IL-6 (r = 0.398, P < 0.001) and hs-CRP (r = 0.427, P = 0.001) were not confirmed in LADA and control subjects. Conclusion The IL-18 serum level was higher in T2D and LADA than that in control subjects, but did not differ between both diabetic groups, even when they were BMI matched. Correlations with lipid, glycemic and inflammatory parameters were present in T2D only.

scholarly journals LADA (latent autoimmune diabetes in adults) in Norway – occurrence, risk factors, treatment and complications

2013 ◽  
Vol 23 (1) ◽  
Author(s):  
Sofia Carlsson ◽  
Kristian Midthjell ◽  
Valdemar Grill
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Autoimmune Diabetes ◽  
Well Being ◽  
Optimal Treatment ◽  
Family History Of Diabetes ◽  
Latent Autoimmune Diabetes ◽  
Incident Cases

LADA (latent autoimmune diabetes in adults) may be the most common form of autoimmune diabetes and thus encompasses a significant proportion of the diabetic population. Still, knowledge about this common form of diabetes is limited. In this paper we give an overview of some aspects of LADA, primarily using data from the Nord-Trøndelag Health Study (HUNT). In HUNT, LADA accounts for 7% of all incident cases of diabetes in adults. Data from HUNT indicate that risk factors for LADA include overweight, physical inactivity, family history of diabetes and low psychosocial well-being. Risk factors thus seem to be largely similar to those of type 2 diabetes which suggests a partially shared pathogenesis, in spite of the autoimmune nature of LADA. With regard to genetic factors LADA may be a genetic mix of type 1 and type 2 diabetes, as LADA patients seem to have an increased prevalence of HLA haplotypes linked to type 1 diabetes, and possibly also genes associated with type 2 diabetes. Patients with LADA are at increased mortality risk, primarily from cardiovascular disease. The excess risk seems to be linked to poor glycemic control rather than metabolic risk factors. These results emphasise the importance of optimal treatment modalities to improve survival in LADA. Documentation of optimal treatment for LADA is still lacking and there is an urgent need for studies in this field.

RELATIONSHIP BETWEEN PLASMA TESTOSTERONE LEVELS AND RISK FACTORS IN MALE PATIENTS WITH TYPE 2 DIABETES

2013 ◽  
pp. 57-63
Author(s):  
Thi Bach Oanh Nguyen ◽  
Hai Thuy Nguyen ◽  
Cuu Loi Nguyen
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Plasma Testosterone ◽  
Diabetic Patients ◽  
Testosterone Levels ◽  
Age Related ◽  
Male Patients ◽  
Type 2 Diabetic

Background: Testosterone is vital hormone for men’s health and a keyplayer in glucose homeostasis, lipid metabolism, and cardiovascular pathology. Testosterone deficiency is associated with age, many chronic health conditions and other metabolic disorders. Objectives: Of this study to assess the concentration of plasma testosterone in male patients with type 2 diabetes, and evaluate the relationship between plasma testosterone levels and the assosiated risk factors. Methods: 54 male patients with type 2 diabetes and 31 non diabetes subjects over 45 years old, were assessed plasma tetosterone and lipidemia concentration and risk factore including age, BMI, waist circumference, blood pressure. Results: The concentration of plasma testosterone in type 2 diabetic male patients was lower than that in normal male subjects (4.5± 1.59 vs 5.27± 1.59 ng/ml, p< 0.05). There was significantly difference of plasma tetosterone levels between diabetic patients and controls of < 60 ages and ≥ 60 ages were respectively (4.07± 1.19 vs 5.36± 1.89 ng/ml) and (4.76± 1.76 vs 5.22 ±1.39 ng/ml, p <0.05). There was correlation between plasma testosterone levels with WC (r = - 0.4242, p< 0.01) and BMI (r = -0.37, p<0.01) and no relationship significatively between plasma testosterone concentration with blood pressure and lipidemia in diabetic patients. Conclusions: Concentration of plasma testosterone in type 2 diabetic male patients was lower than that in healthy subjects of similar age, related with age, VB and BMI. Key words: Testosterone, diabetes, risk factors.

Rheumatoid Factor in Type 2 Male Diabetes Mellitus Patients in a Tertiary Care Hospital of Bangladesh

2018 ◽  
Vol 4 (2) ◽  
pp. 58-62
Author(s):  
Roksana Yeasmin ◽  
MA Muttalib ◽  
Kazi Nazneen Sultana ◽  
Nizamul Hoque Bhuiyan ◽  
Md Jamil Hasan Karami ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Rheumatoid Factor ◽  
Serum Uric Acid ◽  
Control Group ◽  
Healthy Male ◽  
Male Patients

Background: Type 2 diabetes mellitus is a chronic disease characterized by relative or absolute deficiency of insulin, resulting in glucose intolerance.Objectives: The present study was planned to see the associations of serum uric acid with positive Rheumatoid factor in type 2 male diabetes mellitus patients. Methodology: This case control study was carried out at the department of Biochemistry at Ibrahim Medical College, Dhaka, Bangladesh. The duration of the study was from June 2015 to June 2016 for a period of one year. In this present study, male patients with type 2 diabetes mellitus were taken as case group and age and sex matched healthy male were taken as control group. Rheumatoid factor was measured from the blood of all case and control group respondents. Others blood para meters were also measured for the correlation with the diabetes mellitus patients.Results: In this present study, 110 male patients presented with type 2 diabetes mellitus were recruited as case and age and sex matched healthy male were recruited as control. More rheumatoid factor positive in type 2 DM male patients with the uric acid range between 6.5 to 9.5 mg/dL. The number of patients was 5 out of total 9 rheumatoid factor positive cases. In this study serum uric acid was significantly correlated with rheumatoid factor in type 2 male diabetic patients. Rheumatoid factor positive cases were taking insulin among 9 and it was statistically significantly associated (p<0.001). Conclusion: In this study serum uric acid is significantly associated with positive rheumatoid factor in type 2 male diabetic patients.Journal of Current and Advance Medical Research 2017;4(2):58-62

Type 1 Diabetes-related Autoantibodies in Different Forms of Diabetes

2019 ◽  
Vol 15 (3) ◽  
pp. 199-204 ◽  
Author(s):  
Elin Pettersen Sørgjerd
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Autoimmune Diabetes ◽  
Acid Decarboxylase ◽  
Adult Onset ◽  
Latent Autoimmune Diabetes ◽  
Childhood Type 1 Diabetes ◽  
Childhood Type

Autoantibodies against Glutamic Acid Decarboxylase (GADA), insulinoma antigen-2 (IA- 2A), insulin (IAA) and the most recently Zinc Transporter 8 (ZnT8A) are one of the most reliable biomarkers for autoimmune diabetes in both children and adults. They are today the only biomarkers that can distinguish Latent Autoimmune Diabetes in Adults (LADA) from phenotypically type 2 diabetes. As the frequency of autoantibodies at diagnosis in childhood type 1 diabetes depends on age, GADA is by far the most common in adult onset autoimmune diabetes, especially LADA. Being multiple autoantibody positive have also shown to be more common in childhood diabetes compared to adult onset diabetes, and multiple autoantibody positivity have a high predictive value of childhood type 1 diabetes. Autoantibodies have shown inconsistent results to predict diabetes in adults. Levels of autoantibodies are reported to cause heterogeneity in LADA. Reports indicate that individuals with high levels of autoantibodies have a more type 1 diabetes like phenotype and individuals with low levels of autoantibody positivity have a more type 2 diabetes like phenotype. It is also well known that autoantibody levels can fluctuate and transient autoantibody positivity in adult onset autoimmune diabetes have been reported to affect the phenotype.

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