scholarly journals Mitochondrial DNA 4977 bp Deletion in Peripheral Blood Is Associated With Polycystic Ovary Syndrome

2021 ◽  
Vol 12 ◽  
Author(s):  
Mujin Ye ◽  
Bin Hu ◽  
Weihui Shi ◽  
Fei Guo ◽  
Chenming Xu ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Polycystic Ovary Syndrome ◽  
Peripheral Blood ◽  
Polycystic Ovary ◽  
Follicle Stimulating Hormone ◽  
The Body ◽  
Mtdna Copy Number ◽  
Ovary Syndrome ◽  
Linear Dose ◽  
Deletion Rate

BackgroundPolycystic ovary syndrome (PCOS) is a common endocrine disorder worldwide. We aimed to examine the associations of two mitochondrial DNA (mtDNA) biomarkers in the peripheral blood, mtDNA copy number (CN), and mtDNA4977 deletion rate (DR), with PCOS in a clinical setting.MethodsWe performed a study involving 263 women with PCOS and 326 age-matched controls between June 2015 and June 2019. The mtDNA CN and mtDNA4977 DR were measured using multiplex probe-based qPCR. The associations of the mtDNA CN and mtDNA4977 DR with the risk of PCOS were estimated using logistic regression.ResultsAnalysis of the associations between mtDNA biomarkers and PCOS indicate that the mtDNA CN (P = 0.003) and mtDNA4977 DR (P < 0.001) in PCOS patients were significantly higher than those in the controls. After adjusting for the body mass index, luteinizing hormone/follicle-stimulating hormone ratio, and testosterone level, only higher mtDNA4977 DR was associated with PCOS (odds ratio 1.053, 95% confidence interval 1.024 to 1.083; P < 0.001). The linear dose-response trends of the mtDNA4977 DR were also supported by the quartile analysis.ConclusionMultivariable models suggest that mtDNA4977 DR levels are strongly associated with PCOS and represent an independent risk factor for PCOS. Further investigation of the utility of mtDNA as a biomarker for PCOS is warranted.

Mitochondrial DNA copy number in peripheral blood in polycystic ovary syndrome

Metabolism ◽  
2011 ◽  
Vol 60 (12) ◽  
pp. 1677-1682 ◽  
Author(s):  
Sang-Hee Lee ◽  
Da-Jung Chung ◽  
Hee-Sun Lee ◽  
Tae-June Kim ◽  
Myung-Hee Kim ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Polycystic Ovary Syndrome ◽  
Peripheral Blood ◽  
Copy Number ◽  
Polycystic Ovary ◽  
Dna Copy Number ◽  
Ovary Syndrome ◽  
Mitochondrial Dna Copy Number

scholarly journals The potential diagnostic use of clinical characteristics and mitochondrial DNA copy numbers of peripheral blood and ovarian tissue in polycystic ovary syndrome (PCOS) patient

2021 ◽  
Author(s):  
Yi Song ◽  
Yan Deng ◽  
Pui Wah Jacqueline Chung ◽  
Tin Chiu Li ◽  
Chi Chiu Wang ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Peripheral Blood ◽  
Copy Number ◽  
Polycystic Ovary ◽  
Ovarian Tissue ◽  
Clinical Parameters ◽  
Mtdna Copy Number ◽  
Ovary Syndrome ◽  
Copy Numbers ◽  
Dna Copy Numbers

Abstract Polycystic ovary syndrome (PCOS) is a complex, heterogeneous syndrome of uncertain etiology characterized by hyperandrogenemia, hyperinsulinemia, chronic anovulation, and polycystic ovaries. Recent studies showed that the abnormalities of mitochondrial metabolism are related to PCOS. We hypothesized that mtDNA copy number is an important marker that can reflect mitochondrial function. In this study, 135 PCOS patients and 57 age-matched healthy participants were studied. Mitochondrial DNA copy number in peripheral blood and PCOS ovarian tissues, and some clinical parameters were assessed. From the single factor analysis, we can find some clinical parameters are different between PCOS and healthy women and the mitochondrial DNA copy numbers in peripheral blood in PCOS women were significantly lower than in healthy women. We also found that there was no correlation between mtDNA copy numbers in peripheral blood and in ovarian tissue. After multiple logistic regressions, we identified the occurrence of PCOS was significantly positively correlated with BMI and pulse, and negatively correlated with mitochondrial DNA copy numbers in peripheral blood. We also found the decreased mtDNA copy numbers in PCOS patients are independent of these clinical parameters. We constructed the ROC curve based on these risk factors and found if they have potential to predict the patient’s outcome. In conclusion, the changes in mtDNA copy number and some clinical parameters may provide new ideas for PCOS diagnosis. More studies are necessary for further validation of their use in PCOS diagnosis.

scholarly journals Mitochondrial DNA 4977 bp Deletion in Peripheral Blood is Associated with Polycystic Ovary Syndrome.

2020 ◽  
Author(s):  
Mujin Ye ◽  
Weihui Shi ◽  
Bin Hu ◽  
Fei Guo ◽  
Xianhua Lin ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Risk Factor ◽  
Peripheral Blood ◽  
Odds Ratio ◽  
Independent Risk Factor ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Endocrine Disorder ◽  
Linear Dose ◽  
Multivariable Models

Abstract Background PCOS is a common worldwide endocrine disorder. We aimed to examine the associations of two mtDNA biomarkers in the peripheral blood, mtDNA CN and mtDNA4977 DR, with PCOS in a clinical setting.Methods We performed a study involving 263 women with PCOS and 326 age-matched controls between January 2016 and December 2018. The mtDNA CN and mtDNA4977 DR were measured via a multiplex probe-based qPCR. The associations of mtDNA CN and mtDNA DR with the risk of PCOS were estimated by logistic regression.Results In the analysis between mtDNA biomarkers and PCOS, the mtDNA CN (P = 0.003) and mtDNA4977 DR (P < 0.001) levels in PCOS patients were significantly higher than those in the controls. After adjusting for BMI, LH/FSH, and T, only higher mtDNA4977 DR was associated with PCOS (odds ratio 1.053, 95% confidence interval 1.024 to 1.083, P < 0.001). The linear dose-response trends of mtDNA4977 DR were also supported by the quartile analyses.Conclusions Multivariable models suggest that mtDNA4977 DR levels are strongly associated with PCOS and represent an independent risk factor for PCOS. Future investigation of the utility of mtDNA as a biomarker for PCOS is warranted.

scholarly journals Use of Inositols in Polycystic Ovary Syndrome

2020 ◽  
Vol 16 (28) ◽  
pp. 24-34
Author(s):  
O.A. Pustotina ◽  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Ovarian Function ◽  
Polycystic Ovary ◽  
The Body ◽  
Metabolic Parameters ◽  
Ovary Syndrome ◽  
Pathogenetic Role

The article presents key data on the physiology of inositols in the body, their pathogenetic role in the development of polycystic ovary syndrome, and the possibilities of myo-inositol and D-chiro-inositol in the restoration of ovarian function, metabolic parameters, and overcoming of infertility.

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