scholarly journals Update on the Role of Neuropeptide Y and Other Related Factors in Breast Cancer and Osteoporosis

2021 ◽  
Vol 12 ◽  
Author(s):  
Shu-ting Lin ◽  
Yi-zhong Li ◽  
Xiao-qi Sun ◽  
Qian-qian Chen ◽  
Shun-fa Huang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neuropeptide Y ◽  
Treatment Strategies ◽  
Nuclear Factor Κb ◽  
Breast Cancer Patients ◽  
Related Factors ◽  
Osteogenic Response ◽  
The Relationship

Breast cancer and osteoporosis are common diseases that affect the survival and quality of life in postmenopausal women. Women with breast cancer are more likely to develop osteoporosis than women without breast cancer due to certain factors that can affect both diseases simultaneously. For instance, estrogen and the receptor activator of nuclear factor-κB ligand (RANKL) play important roles in the occurrence and development of these two diseases. Moreover, chemotherapy and hormone therapy administered to breast cancer patients also increase the incidence of osteoporosis, and in recent years, neuropeptide Y (NPY) has also been found to impact breast cancer and osteoporosis.Y1 and Y5 receptors are highly expressed in breast cancer, and Y1 and Y2 receptors affect osteogenic response, thus potentially highlighting a potential new direction for treatment strategies. In this paper, the relationship between breast cancer and osteoporosis, the influence of NPY on both diseases, and the recent progress in the research and treatment of these diseases are reviewed.

scholarly journals Key Factors Contributing to Quality of Life for Breast Cancer Patients in Latvia: Supplementing Quantitative Surveys with Qualitative Interviews

2012 ◽  
Vol 12 (1) ◽  
pp. 3-10 ◽  
Author(s):  
Agnese Dzērvīte ◽  
Maruta Pranka ◽  
Tana Lace ◽  
Ritma Rungule ◽  
Edvins Miklasevics ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Patients ◽  
Qualitative Interviews ◽  
Treatment Strategies ◽  
Well Being ◽  
University Hospital ◽  
Breast Cancer Patients ◽  
Key Factors

Summary Introduction. Health related quality of life is a much debated topic in medicine with much quantitative and qualitative research contributing to the understanding of how to improve the lives of patients, yet little has been published in relation to the quality of life of Latvian breast cancer patients. Aim of the Study. To gather base measurements of subjective and objective quality of life factors for breast cancer patients in Latvia and discover which key factors contribute most to quality of life of Latvian breast cancer patients at the start of treatment. Materials and Methods. This paper presents data collected from April 2010 to June 2011 at the Pauls Stradins Clinical University hospital on key factors influencing quality of life for breast cancer patients: health and physical well-being; state of surroundings and environment; social support and functionality; financial state, employment and leisure. Quantitative survey material has been supplemented with insight from qualitative in-depth interviews to better explain the objective and subjective implications for breast cancer patients’ quality of life. Results. Interviewed breast cancer patients rated their quality of life as being average or good at the beginning of treatment. Negative factors contributing to lowered quality of life were mainly linked to patient financial, social and emotional state at the first weeks of treatment and correspond to previous research done in Latvia on quality of life issues. Conclusions. Further follow-up surveys will contribute to the evaluation of breast cancer patients’ needs while undergoing treatment to further improve treatment strategies, especially if validated quality of life measurement surveys were to be implemented in Latvian hospitals.

scholarly journals A Study on Breast Cancer Patients’ Commitment to a Plan for Exercise based on Health Beliefs

2020 ◽  
Vol 27 (1) ◽  
pp. 64-72
Author(s):  
Hyoung Sook Park ◽  
Yun Seo Jung ◽  
Young Mi Kim ◽  
Jae Hyun Hwang
Keyword(s):  
Breast Cancer ◽  
Health Beliefs ◽  
Intervention Programs ◽  
Breast Cancer Patients ◽  
Breast Cancer Data ◽  
Cancer Data ◽  
Correlational Research ◽  
The Relationship ◽  
Structured Questionnaire

Purpose: The purpose of this study was to identify the factors relating to commitment to a plan for exercise in the breast cancer patient following a mastectomy and to examine the relationship between these factors.Methods: This study was a correlational research and the participants were 152 patients with breast cancer. Data were collected using a structured questionnaire from June to October, 2015.Results: The final regression model showed that income, experience of exercise and current exercise were significant predictors related to commitment to a plan for exercise in patients with breast cancer and explained for 65.9% of the variance in commitment to a plan for exercise.Conclusion: The findings indicate that patients in breast cancer-oriented intervention programs have an enhancing experience of exercise. Current exercise should be provided for patients with breast cancer in order to promote health and quality of life.

scholarly journals Research on the Relationship Between Self-Management Efficacy and Quality of Life for Breast Cancer Patients Receiving Endocrine Therapy

2022 ◽  
Author(s):  
Hongjie Yi ◽  
Haoran Jiang ◽  
Aiping Wang ◽  
Wei Zong ◽  
Yu Dong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Patients ◽  
Endocrine Therapy ◽  
Influencing Factors ◽  
The Self ◽  
Self Management ◽  
Breast Cancer Patients ◽  
The Relationship

Abstract Purpose To investigate the status quo and relationship between self-management efficacy and quality of life (QOL) of patients with breast cancer undergoing endocrine therapy, and to explore the influencing factors of QOL. Methods The convenience sampling method was used to select 240 patients who received endocrine therapy after breast cancer surgery in the First Hospital of China Medical University, the self-designed general data questionnaire, self-management efficacy questionnaire for breast cancer patients with endocrine therapy and quality of life scale for breast cancer patients were used to investigate. The frequency, percentage, mean ± standard deviation were used to describe patients' self-management efficacy and quality of life. Pearson correlation analysis was used to analyze the relationship between self-management efficacy and quality of life, and univariate analysis and multiple stepwise regression were used to analyze the influencing factors of QOL. Results The scores of self-management efficacy and QOL of patients with breast cancer endocrine therapy were 125.21 ± 25.57 and 153.33 ± 19.31 respectively, which were at the middle level; self-management efficacy was significantly positively correlated with quality of life ( p < 0.01 ) ; multiple stepwise regression results showed that self-management efficacy, the number of physical symptoms, monthly family income and recurrence and metastasis were the influencing factors of QOL. Conclusion The self-management efficacy of endocrine therapy was positively correlated with QOL in breast cancer patients. The higher the self-management efficacy of endocrine therapy, the better QOL in breast cancer patients. Self-management efficacy is the main factor affecting the quality of life of breast cancer patients undergoing endocrine therapy. Improving the level of self-management efficacy can improve their quality of life.

Role of breast surgery in T1-T3 breast cancer patients with synchronous bone metastases.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 1115-1115 ◽  
Author(s):  
Edoardo Botteri ◽  
Elisabetta Munzone ◽  
Vincenzo Bagnardi ◽  
Mattia Intra ◽  
Nicole Rotmensz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Bone Metastases ◽  
Breast Surgery ◽  
Treatment Strategies ◽  
Surgical Margins ◽  
Her2 Overexpression ◽  
Breast Cancer Patients ◽  
Ki 67

1115 Background: The role of breast surgery in advanced breast cancer (ABC) is controversial. The main potential advantage of removing the primary tumor is to eliminate the source of further metastatic spread. While previous studies addressed the question in very heterogeneous populations (e.g. patients with any local and distant extension), we have focused on a homogeneous series of ABC patients. Methods: From our institutional Tumor Registry we selected 191 consecutive women diagnosed between 2000 and 2008 with locally operable (T1-T3) ABC, synchronous bone metastases and no other distant sites involved. The progression free survival (PFS) was calculated from diagnosis to the date of progression, defined as either a new site of metastatic disease or clinical/radiographic evidence of increasing tumor burden at a previously known bone metastatic site. Results: Median age was 51 years and 92% of the women had an endocrine-responsive tumor. One-hundred and thirty patients out of 191 (68%) underwent surgery at the time of diagnosis, while 61 (32%) did not. Twenty-six of the operated patients (20%) had previously undergone neoadjuvant chemotherapy; 15 (12%) had positive or undetermined surgical margins. Operated and non-operated patients were similar with respect to age, tumor size, nodal involvement, estrogen and progesterone receptor status, HER2 overexpression and Ki-67, but differed in terms of number of bone metastatic sites: a single metastasis was detected in 34 (26%) operated and 7 (11%) non-operated cases (P=0.02). First-line treatment strategies with endocrine therapy, chemotherapy and Trastuzumab were similarly distributed between the two groups. The 5-year PFS was 22.0% and 10.4% in operated and non-operated patients, respectively. The multi-adjusted hazard ratio was 0.62 (95% confidence interval 0.39-0.98) in favor of surgery. The exclusion of the patients who had received neoadjuvant chemotherapy and patients with positive or undetermined surgical margins did not alter the results. Conclusions: In this large and homogeneous series of ABC patients with synchronous bone metastases, the role of breast surgery had a favorable impact on the progression of the disease, indicating a potential survival benefit.

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