scholarly journals Integrative Clinical, Molecular, and Computational Analysis Identify Novel Biomarkers and Differential Profiles of Anti-TNF Response in Rheumatoid Arthritis

2021 ◽  
Vol 12 ◽  
Author(s):  
Maria Luque-Tévar ◽  
Carlos Perez-Sanchez ◽  
Alejandra Mª Patiño-Trives ◽  
Nuria Barbarroja ◽  
Ivan Arias de la Rosa ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Machine Learning ◽  
Mixed Model ◽  
Learning Algorithms ◽  
Clinical Status ◽  
Machine Learning Algorithms ◽  
Supervised Machine Learning ◽  
Molecular Profile ◽  
Molecular Signatures ◽  
Molecular Profiles

Background: This prospective multicenter study developed an integrative clinical and molecular longitudinal study in Rheumatoid Arthritis (RA) patients to explore changes in serologic parameters following anti-TNF therapy (TNF inhibitors, TNFi) and built on machine-learning algorithms aimed at the prediction of TNFi response, based on clinical and molecular profiles of RA patients.Methods: A total of 104 RA patients from two independent cohorts undergoing TNFi and 29 healthy donors (HD) were enrolled for the discovery and validation of prediction biomarkers. Serum samples were obtained at baseline and 6 months after treatment, and therapeutic efficacy was evaluated. Serum inflammatory profile, oxidative stress markers and NETosis-derived bioproducts were quantified and miRNomes were recognized by next-generation sequencing. Then, clinical and molecular changes induced by TNFi were delineated. Clinical and molecular signatures predictors of clinical response were assessed with supervised machine learning methods, using regularized logistic regressions.Results: Altered inflammatory, oxidative and NETosis-derived biomolecules were found in RA patients vs. HD, closely interconnected and associated with specific miRNA profiles. This altered molecular profile allowed the unsupervised division of three clusters of RA patients, showing distinctive clinical phenotypes, further linked to the TNFi effectiveness. Moreover, TNFi treatment reversed the molecular alterations in parallel to the clinical outcome. Machine-learning algorithms in the discovery cohort identified both, clinical and molecular signatures as potential predictors of response to TNFi treatment with high accuracy, which was further increased when both features were integrated in a mixed model (AUC: 0.91). These results were confirmed in the validation cohort.Conclusions: Our overall data suggest that: 1. RA patients undergoing anti-TNF-therapy conform distinctive clusters based on altered molecular profiles, which are directly linked to their clinical status at baseline. 2. Clinical effectiveness of anti-TNF therapy was divergent among these molecular clusters and associated with a specific modulation of the inflammatory response, the reestablishment of the altered oxidative status, the reduction of NETosis, and the reversion of related altered miRNAs. 3. The integrative analysis of the clinical and molecular profiles using machine learning allows the identification of novel signatures as potential predictors of therapeutic response to TNFi therapy.

scholarly journals Crop price prediction using supervised machine learning algorithms

2021 ◽  
Vol 1916 (1) ◽  
pp. 012042
Author(s):  
Ranjani Dhanapal ◽  
A AjanRaj ◽  
S Balavinayagapragathish ◽  
J Balaji
Keyword(s):  
Machine Learning ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Supervised Machine Learning ◽  
Price Prediction

scholarly journals Performance Improvement of Decision Tree: A Robust Classifier Using Tabu Search Algorithm

2021 ◽  
Vol 11 (15) ◽  
pp. 6728
Author(s):  
Muhammad Asfand Hafeez ◽  
Muhammad Rashid ◽  
Hassan Tariq ◽  
Zain Ul Abideen ◽  
Saud S. Alotaibi ◽  
...  
Keyword(s):  
Machine Learning ◽  
Tabu Search ◽  
Decision Tree ◽  
Decision Trees ◽  
Search Algorithm ◽  
Learning Algorithms ◽  
Performance Comparison ◽  
Machine Learning Algorithms ◽  
Supervised Machine Learning ◽  
Tabu Search Algorithm

Classification and regression are the major applications of machine learning algorithms which are widely used to solve problems in numerous domains of engineering and computer science. Different classifiers based on the optimization of the decision tree have been proposed, however, it is still evolving over time. This paper presents a novel and robust classifier based on a decision tree and tabu search algorithms, respectively. In the aim of improving performance, our proposed algorithm constructs multiple decision trees while employing a tabu search algorithm to consistently monitor the leaf and decision nodes in the corresponding decision trees. Additionally, the used tabu search algorithm is responsible to balance the entropy of the corresponding decision trees. For training the model, we used the clinical data of COVID-19 patients to predict whether a patient is suffering. The experimental results were obtained using our proposed classifier based on the built-in sci-kit learn library in Python. The extensive analysis for the performance comparison was presented using Big O and statistical analysis for conventional supervised machine learning algorithms. Moreover, the performance comparison to optimized state-of-the-art classifiers is also presented. The achieved accuracy of 98%, the required execution time of 55.6 ms and the area under receiver operating characteristic (AUROC) for proposed method of 0.95 reveals that the proposed classifier algorithm is convenient for large datasets.

Spatial Roadway Condition-Assessment Mapping Utilizing Smartphones and Machine Learning Algorithms

2021 ◽  
pp. 036119812110061
Author(s):  
Charalambos Kyriakou ◽  
Symeon E. Christodoulou ◽  
Loukas Dimitriou
Keyword(s):  
Machine Learning ◽  
Learning Algorithms ◽  
Condition Assessment ◽  
Machine Learning Algorithms ◽  
Supervised Machine Learning ◽  
Geographical Information ◽  
Related Field ◽  
Pavement Surface ◽  
Automated Method ◽  
Smartphone Technology

The paper presents a data-driven framework and related field studies on the use of supervised machine learning and smartphone technology for the spatial condition-assessment mapping of roadway pavement surface anomalies. The study explores the use of data, collected by sensors from a smartphone and a vehicle’s onboard diagnostic device while the vehicle is in movement, for the detection of roadway anomalies. The research proposes a low-cost and automated method to obtain up-to-date information on roadway pavement surface anomalies with the use of smartphone technology, artificial neural networks, robust regression analysis, and supervised machine learning algorithms for multiclass problems. The technology for the suggested system is readily available and accurate and can be utilized in pavement monitoring systems and geographical information system applications. Further, the proposed methodology has been field-tested, exhibiting accuracy levels higher than 90%, and it is currently expanded to include larger datasets and a bigger number of common roadway pavement surface defect types. The proposed system is of practical importance since it provides continuous information on roadway pavement surface conditions, which can be valuable for pavement engineers and public safety.

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