scholarly journals Case Report: Management of Malignancy-Exacerbated Pemphigus Vulgaris During COVID-19 Pandemic

2021 ◽  
Vol 8 ◽  
Author(s):  
Alberto Corrà ◽  
Francesca Cammelli ◽  
Lavinia Quintarelli ◽  
Giuseppe Barbato ◽  
Ornella Le Rose ◽  
...  
Keyword(s):  
Immunosuppressive Treatment ◽  
Surgical Excision ◽  
Pemphigus Vulgaris ◽  
Intravenous Immunoglobulins ◽  
Diagnostic Process ◽  
Trigger Factors ◽  
Blistering Disease ◽  
Oncologic Diseases ◽  
Bridge Therapy ◽  
Rule Out

Pemphigus vulgaris is an intraepidermal autoimmune mucocutaneous blistering disease whose etiopathogenesis includes various trigger factors, i.e., drugs and malignancies. We present a case of malignancy-exacerbated pemphigus vulgaris which required a careful diagnostic process in order to rule out paraneoplastic pemphigus, along with the challenges posed by the need of treating both cutaneous and oncologic diseases. Possible post-operative complications post-poned the start of first-line immunosuppressive treatment of pemphigus. Moreover, the infective risks had to be minimized during the peak of the COVID-19 pandemic in Italy. Intravenous immunoglobulins were chosen as “bridge” therapy before the tumor surgical excision, followed by rituximab in post-operative phase.

scholarly journals Serum Levels of Autoantibodies to Desmoglein 3 in Patients with Therapy-resistant Pemphigus Vulgaris Successfully Treated with Adjuvant Intravenous Immunoglobulins

2003 ◽  
Vol 84 (1) ◽  
pp. 48-52
Author(s):  
Detlef Zillikens ◽  
Susanne Herzog ◽  
Enno Schmidt ◽  
Matthias Goebeler ◽  
Bröcker Eva-B.
Keyword(s):  
Pemphigus Vulgaris ◽  
Serum Levels ◽  
Intravenous Immunoglobulins ◽  
Desmoglein 3

scholarly journals A rare clinical case: schwannoma of tongue

2019 ◽  
Vol 5 (3) ◽  
pp. 789
Author(s):  
Chandra Veer Singh ◽  
Sheetal Radia ◽  
Saalim Sheikh ◽  
Vijay Haribhakti
Keyword(s):  
Head And Neck ◽  
Rare Case ◽  
Neck Region ◽  
Surgical Excision ◽  
Imaging Studies ◽  
Head And Neck Tumours ◽  
Head And Neck Region ◽  
Complete Surgical Excision ◽  
Slow Growing ◽  
Rule Out

<p class="abstract">Schwannoma are slow growing tumours, which can arise from any peripheral nerve. 10% of schwannomas that occur in the head and neck region mostly originate from the vagus or sympathetic nervous system. Extracranial schwannomas in the head and neck region are rare neoplasm. Intraoral schwannoma are only 1% of the all head and neck tumours. Diagnosis is established by imaging studies such as magnetic resonance imaging or computed tomography, while FNAC is used to rule out other conditions. We report a rare case of lingual schwannomas generally present as a painless lump schwannoma of the tongue in a 27-year-old male complaining of asymptomatic swelling over a posterolateral surface of the tongue, treated by complete surgical excision. The diagnosis was established on the basis of clinical, histopathological, and immunohistochemical examination. We report a rare case of schwannoma over the posterolateral surface of tongue. Prognosis is good for the patient when this condition is correctly diagnosed as the condition rarely recurs after complete resection.</p>

scholarly journals Anterior scleritis in a patient of pemphigus vulgaris while on immunosuppressive treatment

2019 ◽  
Vol 64 (6) ◽  
pp. 499
Author(s):  
Brijesh Takkar ◽  
Mihika Dube ◽  
DineshP Asati ◽  
Sourabh Jain
Keyword(s):  
Immunosuppressive Treatment ◽  
Pemphigus Vulgaris ◽  
Anterior Scleritis

scholarly journals Alternative Therapeutic Approach in the Treatment of Oral Pyogenic Granuloma

2015 ◽  
Vol 8 (3) ◽  
pp. 493-497 ◽  
Author(s):  
Amr Bugshan ◽  
Harsh Patel ◽  
Karen Garber ◽  
Timothy F. Meiller
Keyword(s):  
Oral Cavity ◽  
Malignant Tumors ◽  
Surgical Excision ◽  
Pyogenic Granuloma ◽  
Hormonal Imbalance ◽  
Choice Of Treatment ◽  
Chronic Irritation ◽  
Multiple Recurrences ◽  
And Behavior ◽  
Rule Out

Pyogenic granulomas (PGs) in the oral cavity present as an inflammatory hyperplasia usually caused by trauma, hormonal imbalance, chronic irritation, or as the response to a wide variety of drugs. PGs with atypical presentation and behavior may clinically mimic malignant tumors. Thus, histological examination is required to rule out cancer development. Lesions in the oral cavity have been described to be either an isolated entity or present in multiple forms and with multiple recurrences. Conservative surgical excision is the standard choice of treatment in almost every scenario. However, the severity of the lesions and the affected sites often challenge surgical treatment. In this report, we describe the clinical scenario of a recurrent PG, where surgical excision of the lesion was questioned. As an alternative, we describe a noninvasive approach with lesional steroid injections.

Sweet Syndrome and Pemphigus Vulgaris

2012 ◽  
Vol 16 (2) ◽  
pp. 128-130 ◽  
Author(s):  
Ashley O'toole ◽  
Maureen O'malley
Keyword(s):  
Clinical Presentation ◽  
Pemphigus Vulgaris ◽  
Neutrophilic Dermatosis ◽  
Rare Presentation ◽  
Sweet Syndrome ◽  
Autoimmune Blistering Disease ◽  
Mucous Membranes ◽  
Blistering Disease ◽  
Erythematous Plaques ◽  
New Onset

Background: Pemphigus vulgaris is an autoimmune blistering disease of the skin and mucous membranes. Sweet syndrome is an uncommon reactive neutrophilic dermatosis. Objective: This case report describes the rare presentation of a 58-year-old female patient with newly diagnosed pemphigus vulgaris who later presented with erythematous plaques and leukocytosis highly suggestive of Sweet syndrome. Methods: Review of the literature using the PubMed and Medline databases. Results: The clinical presentation of new-onset Sweet syndrome in a patient with pemphigus has been reported in the literature only on one other occasion. Conclusion: The observation of an association between Sweet syndrome and autoimmune diseases, such as pemphigus vulgaris, may ultimately lead to better understanding of the pathophysiology of this disease.

A Rare Case of Nasopharyngeal Glial Heterotopia in a Neonate

2021 ◽  
pp. 097321792110425
Author(s):  
Viveka Singh ◽  
Neha Nabar ◽  
Sanjiv Badhwar ◽  
Preetha Joshi
Keyword(s):  
Gold Standard ◽  
Rare Case ◽  
Neural Tissue ◽  
Surgical Excision ◽  
Intracranial Extension ◽  
Resonance Imaging ◽  
Radiological Studies ◽  
Rule Out ◽  
Glial Heterotopia

Nasopharyngeal glial heterotopias is an extremely rare, nonhereditary, developmental malformation manifesting as a mass composed of mature neural tissue with no intracranial continuity. Glial heterotopia is a rare, non-neoplastic, extracranial midline malformation. Nasal glioma is the most frequently encountered entity among congenital nasal masses. Cases which are associated with intracranial extension are termed as encephalocele. It must be considered in the differential diagnosis of airway obstruction in neonates. Magnetic resonance imaging is mandatory to rule out intracranial extension. We report a rare case of heterotopic brain tissue in nasopharynx with no intracranial extension to attract attention to the diagnostic workup of nasopharyngeal obstruction in a neonate with respiratory distress. Clinical examination and radiological studies are diagnostic while early surgical excision and histopathological confirmation is the gold standard. This baby underwent complete intranasal endoscopic excision of mass on day 20 of life. The postoperative course was uneventful and the baby is growing well on follow-up. This case would be one of the few cases reported from India.

scholarly journals Ocular Myasthenia Gravis with Severe Blepharitis and Ocular Surface Disease: A Case Report

2020 ◽  
Vol 11 (2) ◽  
pp. 322-329
Author(s):  
Roee Arnon ◽  
Tal Yahalomi ◽  
Irit Rozen-Knisbacher ◽  
Joseph Pikkel ◽  
Dina Mostovoy
Keyword(s):  
Myasthenia Gravis ◽  
Ocular Surface ◽  
Immunosuppressive Treatment ◽  
Intravenous Immunoglobulins ◽  
Ocular Surface Disease ◽  
Topical Steroids ◽  
Conjunctival Hyperemia ◽  
Tea Tree ◽  
Ocular Myasthenia ◽  
Ocular Myasthenia Gravis

Ocular myasthenia gravis (OMG) is an autoimmune disease of the neuromuscular junction and commonly associated with other immune diseases. We describe a 16-year-old female who presented to our clinic with 1-month complaints of diplopia and strabismus, visual acuity deterioration, and ocular irritation. Her examination showed crossed diplopia and alternating exotropia of 25 prism diopters, severe blepharitis, conjunctival hyperemia, corneal pannus, epithelial irregularities, and subepithelial opacities. Workup included pediatric neurologic examination, laboratory tests, imaging, and electrophysiological tests. Diagnoses of OMG and blepharitis with ocular surface disease were made. Topical treatment included eyelid hygiene, tea tree oil scrubbing, topical steroids, and tacrolimus ointment. Systemic treatment included corticosteroids, pyridostigmine, azathioprine, intravenous immunoglobulins, amitriptyline, and doxycycline. Both diseases were refractory to intensive immunosuppressive treatment and had simultaneous relapses and an intertwined course. Our hypothesis is that a shared immune mechanism may be the cause of both OMG and ocular surface disease in our patient.

Treatment of temporal artery pseudoaneurysms

Vascular ◽  
2013 ◽  
Vol 22 (4) ◽  
pp. 274-279 ◽  
Author(s):  
Irene Thomassen ◽  
Elisabeth G Klompenhouwer ◽  
Edith M Willigendael ◽  
Joep AW Teijink
Keyword(s):  
Superficial Temporal Artery ◽  
Surgical Excision ◽  
Temporal Artery ◽  
Primary Treatment ◽  
Treatment Modalities ◽  
Diagnostic Process ◽  
Thrombin Injection ◽  
Invasive Treatment ◽  
Artery Pseudoaneurysm ◽  
Primary Treatment Modality

Purpose To give an overview of the etiology and diagnostic process of superficial temporal artery pseudoaneurysms and to evaluate different treatment modalities. Basic methods PubMed was used for searching multiple databases for relevant clinical studies. Principal findings A total of 62 studies were included, harboring 82 patients. Surgical excision is the most frequently described treatment, but less invasive treatment modalities as coiling and thrombin injections are gaining popularity. Surgical treatment was successful in all cases (67/67). Endovascular treatment was successful in 69% (9/13); the five cases treated with thrombin injection were all successful. Complementary, a description of our experience with thrombin injection is given. Conclusions Limited evidence of minimal invasive treatment for superficial temporal artery pseudoaneurysm is available. Based on this review combined with our limited experience, we suggest thrombin injections to be considered as the future primary treatment modality. In the case of unsuccessful exclusion of the aneurysm, surgical excision can be performed.

Pemphigus Vulgaris: Update on Etiopathogenesis, Oral Manifestations, and Management

2002 ◽  
Vol 13 (5) ◽  
pp. 397-408 ◽  
Author(s):  
Crispian Scully ◽  
Stephen J. Challacombe
Keyword(s):  
Pemphigus Vulgaris ◽  
Intravenous Immunoglobulins ◽  
Current Treatment ◽  
Enzyme Linked Immunosorbent Assay ◽  
Ashkenazi Jews ◽  
Normal Human Skin ◽  
Autoimmune Blistering Disease ◽  
Systemic Corticosteroids ◽  
Life Threatening ◽  
Systemic Infections

Pemphigus is a group of potentially life-threatening diseases characterized by cutaneous and mucosal blistering. There is a fairly strong genetic background to pemphigus with linkage to HLA class II alleles. Certain ethnic groups, such as Ashkenazi Jews and those of Mediterranean origin, are especially liable to pemphigus. Pemphigus vulgaris (PV), the most common and important variant, is an autoimmune blistering disease characterized by circulating pathogenic IgG antibodies against desmoglein 3 (Dsg3), about half the patients also having Dsg1 autoantibodies. Oral lesions are initially vesiculobullous but readily rupture, new bullae developing as the older ones rupture and ulcerate. Biopsy of perilesional tissue, with histological and immunostaining examinations, is essential to the diagnosis. Serum autoantibodies to either Dsg1 or Dsg3 are best detected by both normal human skin and monkey esophagus or by enzyme-linked immunosorbent assay (ELISA). Before the introduction of corticosteroids, pemphigus vulgaris was typically fatal mainly from dehydration or secondary systemic infections. Current treatment is largely based on systemic immunosuppression using systemic corticosteroids, with azathioprine, dapsone, methotrexate, cyclophosphamide, and gold as adjuvants or alternatives, but mycophenolate mofetil and intravenous immunoglobulins also appear promising.

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