scholarly journals Role of Dermoscopy in the Assessment of Basal Cell Carcinoma

2021 ◽  
Vol 8 ◽  
Author(s):  
Loredana Ungureanu ◽  
Ioana Cosgarea ◽  
Simona Şenilǎ ◽  
Alina Vasilovici
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Residual Disease ◽  
Invasive Technique ◽  
Continuous Increase ◽  
Non Invasive ◽  
Ablative Therapies ◽  
Vascular Structures

Basal cell carcinoma is one of the most common cancers in white people, with a continuous increase worldwide. Dermoscopy, a non-invasive technique, allows early diagnosis based on the presence of typical vascular structures, pigmented structures, and ulceration and the absence of specific melanocytic structures. Moreover, dermoscopy is useful in basal cell carcinoma management, enabling the differentiation between multiple histological subtypes, between pigmented and non-pigmented variants and allowing a more accurate assessment of surgical margins. After non-ablative therapies, dermoscopy allows the accurate detection of residual disease. The purpose of this review is to highlight the dermoscopic features encountered in basal cell carcinoma and to outline the role of dermoscopy for diagnosis and therapeutic response in this cancer.

scholarly journals Line-Field Confocal Optical Coherence Tomography May Enhance Monitoring of Superficial Basal Cell Carcinoma Treated with Imiquimod 5% Cream: A Pilot Study

Cancers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 4913
Author(s):  
Anna Elisa Verzì ◽  
Giuseppe Micali ◽  
Francesco Lacarrubba
Keyword(s):  
Optical Coherence Tomography ◽  
Pilot Study ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Invasive Technique ◽  
Optical Coherence ◽  
Line Field ◽  
Non Invasive ◽  
Superficial Basal Cell Carcinoma

Line-field confocal optical coherence tomography (LC-OCT) is a novel, non-invasive technique for real-time skin imaging. Imiquimod (IQ) 5% cream is an immune response modifier currently approved for the treatment of small, superficial basal cell carcinoma (BCC). The aim of this study was to investigate if LC-OCT may be useful to enhance the treatment monitoring of BCC. Twenty superficial BCCs from 12 patients were treated with IQ 5% cream once daily, five days a week, for six weeks. Clinical and LC-OCT evaluations were performed at baseline and 4 weeks after the end of treatment. At the end of the study, 13 lesions showed a complete clinical and LC-OCT response, 4 lesions a partial clinical and LC-OCT response, and 3 lesions a complete clinical response but residual tumoral signs at LC-OCT. Our pilot study suggests that LC-OCT may represent a promising tool able to enhance the evaluation of the treatment response of BCCs to non-invasive treatments. In our case series, its use highlighted, through a detailed, fast, and complete examination of the treated area, three cases of residual BCC that otherwise would have gone undetected at clinical examination. Future studies on larger series of patients treated with different modalities and with a longer follow-up are advisable.

scholarly journals Role of CRD-BP in the Growth of Human Basal Cell Carcinoma Cells

2014 ◽  
Vol 134 (6) ◽  
pp. 1718-1724 ◽  
Author(s):  
Felicite K. Noubissi ◽  
TaeWon Kim ◽  
Tisha N. Kawahara ◽  
William D. Aughenbaugh ◽  
Eric Berg ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Carcinoma Cells ◽  
Human Basal Cell Carcinoma

Parametric and empirical spectral analysis for non-invasive diagnosis of basal cell carcinoma

2010 ◽  
Author(s):  
Jingjing Sun ◽  
Narasimhan Rajaram ◽  
Tianyi Wang ◽  
Xianpei Wang ◽  
Michael R. Migden ◽  
...  
Keyword(s):  
Spectral Analysis ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Non Invasive

scholarly journals Diagnostic and pathogenetic role of café-au-lait macules in nevoid basal cell carcinoma syndrome

2012 ◽  
Vol 10 (1) ◽  
Author(s):  
Giovanni Ponti ◽  
Aldo Tomasi ◽  
Lorenza Pastorino ◽  
Cristel Ruini ◽  
Carmelo Guarneri ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Pathogenetic Role

scholarly journals The Role of Fine-Needle Aspiration Cytology in the Diagnosis of Basal Cell Carcinoma

2012 ◽  
Vol 2012 ◽  
pp. 1-2 ◽  
Author(s):  
Masoom Kassi ◽  
Pashtoon Murtaza Kasi ◽  
Abaseen Khan Afghan ◽  
Shah Mohammad Marri ◽  
Mahwash Kassi ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Background/Aims. Basal cell carcinoma (BCC) is the most common malignant tumor of the skin in humans. The diagnosis of BCC is made clinically, which can then be confirmed microscopically. Biopsy or surgical excision of the lesion provides the specimen for histopathological examination, which is the mainstay for diagnosis. Fine-needle aspiration cytology (FNAC) on the other hand is an even simpler procedure, which can provide accurate diagnosis to confirm or exclude the malignancy. Methods. Here, we present our experience on the role of FNAC in diagnosing BCC. We were able to recruit 37 patients, of which 35 had BCC. Both FNAC and biopsy were obtained and then interpreted independently of one another. Results. Cytology correlated with histopathology in all cases except for 2 in which the yield was deemed inadequate. The sensitivity and specificity of fine-needle aspiration cytology for basal cell carcinoma were 94.3% and 100%, respectively. Conclusions. We, therefore, recommend this technique for the initial evaluation of a patient with suspected BCC or in cases of recurrence. The technique is cheap, quick, less invasive, and highly accurate for the diagnosis of BCC. The limitation of the technique is low yield in some of the cases.

scholarly journals DDX5 Silencing Suppresses the Migration of Basal cell Carcinoma Cells by Downregulating JAK2/STAT3 Pathway

2019 ◽  
Vol 18 ◽  
pp. 153303381989225 ◽  
Author(s):  
Zhe Quan ◽  
Bei-bei Zhang ◽  
Fang Yin ◽  
Jiru Du ◽  
Yuan-ting Zhi ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Hedgehog Signaling ◽  
Human Cancer ◽  
Carcinoma Cells ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Migration And Invasion ◽  
Stat3 Pathway

Basal cell carcinoma is driven by the aberrant activation of hedgehog signaling. DEAD (Asp-Glu-Ala-Asp) box protein 5 is frequently overexpressed in human cancer cells and associated with the tumor growth and invasion. The purpose of this study was to investigate the role of DEAD (Asp-Glu-Ala-Asp) box protein 5 in the growth, migration, and invasion of basal cell carcinoma. The role of DEAD (Asp-Glu-Ala-Asp) box protein 5 was detected by quantitative real-time polymerase chain reaction, Western blot, and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling assay in basal cell carcinoma cells. The associations between JAK2/STAT3 pathway and DEAD (Asp-Glu-Ala-Asp) box protein 5 were analyzed in basal cell carcinoma cells. Results showed that DEAD (Asp-Glu-Ala-Asp) box protein 5 is overexpressed in basal cell carcinoma cells. DEAD (Asp-Glu-Ala-Asp) box protein 5 knockdown inhibited the migration and invasion of basal cell carcinoma cells. DEAD (Asp-Glu-Ala-Asp) box protein 5 knockdown increased the apoptosis of basal cell carcinoma cells induced by tunicamycin. Results found that DEAD (Asp-Glu-Ala-Asp) box protein 5 knockdown increased JAK2 and STAT3 expression in basal cell carcinoma cells. JAK2 inhibitor decreased STAT3 expression and abolished the inhibitory effects of DEAD (Asp-Glu-Ala-Asp) box protein 5 silencing on migration and invasion in basal cell carcinoma cells. In conclusion, these results indicate that DEAD (Asp-Glu-Ala-Asp) box protein 5 is a potential target for inhibiting basal cell carcinoma cells growth, migration, and invasion by downregulating JAK2/STAT3 pathway.

Role of adhesion molecules in basal cell carcinoma

1993 ◽  
Vol 3 ◽  
pp. 46
Author(s):  
M. E. Verhaegh ◽  
J. C. Veraart ◽  
R. -F. Hulsmans ◽  
J. -W. Arends ◽  
M. H. Neumann
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Adhesion Molecules ◽  
Basal Cell
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