Research Trends and Hotspots of Extracorporeal Membrane Oxygenation: A 10-Year Bibliometric Study and Visualization Analysis

Objective: To determine the research hotspots and trends in the field of extracorporeal membrane oxygenation (ECMO), and to provide a reference for further and wider research in the future.Methods: The literatures on ECMO from January 2011 to July 2021 in the Web of Science Core Collection (WOSCC) database were searched, and Citespace5.8.R1 software was used to conduct bibliographic and visual analysis on the literature by country, institution, author and keywords.Results: A total of 5,986 articles were enrolled. According to an observation, the number of articles published in the past decade has increased, especially from 2019 to 2020. The USA had the largest number of publications, while less ECMO related studies were conducted among non-developed countries. The University of Michigan (Univ Michigan) was the institution that had the largest number of publications and the highest centrality, and Daniel B was the author who had the largest number of publications. However, more inter-institutional cooperation among author teams was needed. The focus of existing ECMO research has primarily been on the treatment of patients suffering from severe cardiopulmonary failure, and the prevention and management of complications during the application ECMO.Conclusion: Inter-regional and inter-institutional cooperation and exchanges should be carried out among ECMO research teams and institutions. The suggested research direction is to further broaden the application scope of ECMO, while determining the ways to reduce the incidence of complications and the cost, cultivate specialized team talents, and promote the application thereof.

Download Full-text

Acute Kidney Injury in Extracorporeal Membrane Oxygenation Patients: National Analysis of Impact of Age

Blood Purification ◽

10.1159/000518346 ◽

2021 ◽

pp. 1-10

Author(s):

Ankit Sakhuja ◽

Paul McCarthy ◽

Jeremiah A. Hayanga ◽

Steven Turley ◽

Gordon Smith ◽

...

Keyword(s):

Acute Kidney Injury ◽

Extracorporeal Membrane Oxygenation ◽

Independent Predictor ◽

Kidney Injury ◽

International Classification Of Diseases ◽

Ecmo Support ◽

Membrane Oxygenation ◽

Nationwide Inpatient Sample Database ◽

The Usa ◽

National Analysis

Background: The aim of this study was to determine epidemiology and outcomes of acute kidney injury (AKI) in patients on extracorporeal membrane oxygenation (ECMO) and to assess if age modifies the effect of AKI on mortality. Methods: Using National (Nationwide) Inpatient Sample Database for hospitalizations in the USA from 2003 to 2014, we identified adult patients on ECMO support. Using International Classification of Diseases 9th Revision, we assessed the rates of AKI and AKI requiring dialysis (AKI-D) among them and associated survival. We used a multivariable logistic regression to identify risk factors of and differential effect of age on mortality from AKI. Results: AKI was seen in 63.9% of 17,942 ECMO hospitalizations: 21.9% of those with AKI required dialysis. The percentage of those with AKI increased steadily. Mortality was higher in those with AKI, with highest in those with AKI-D (70.8% vs. 61.7%; p < 0.001). While both age and AKI were independent predictors of mortality, age was neither a risk factor for AKI nor did it modify the effect of AKI on mortality. Conclusions: AKI is common and is increasing among patients on ECMO support. Patients on ECMO have high mortality and AKI is an independent predictor of mortality. Though age is also an independent predictor of mortality in patients on ECMO, it is neither a predictor of AKI nor does not modify the relationship between AKI and mortality.

Download Full-text

National estimates of the use and outcomes of extracorporeal membrane oxygenation after acute trauma

Trauma Surgery & Acute Care Open ◽

10.1136/tsaco-2018-000209 ◽

2019 ◽

Vol 4 (1) ◽

pp. e000209 ◽

Cited By ~ 1

Author(s):

Parker J Hu ◽

Lauren Griswold ◽

Lauren Raff ◽

Rachel Rodriguez ◽

Gerald McGwin Jr ◽

...

Keyword(s):

Extracorporeal Membrane Oxygenation ◽

Statistical Significance ◽

Trauma Patients ◽

Level Of Evidence ◽

Traumatic Injuries ◽

Membrane Oxygenation ◽

Diagnostic Codes ◽

The Usa ◽

Ninth Edition ◽

National Estimates

BackgroundThe use of extracorporeal membrane oxygenation (ECMO) as salvage therapy for patients with severe acute respiratory distress syndrome is gaining greater acceptance among trauma intensivists. The objective of this study was to review ECMO usage in trauma patients in the USA.MethodsThe National Inpatient Sample (NIS) from years 2002 to 2012 was queried for patients aged 15 and older treated with ECMO who had one or more acute traumatic injuries as defined by the International Diagnostic Codes, Ninth Edition (ICD-9). The primary outcomes of interest were incidence of ECMO and overall inpatient mortality.ResultsA total of 1347 patients were identified in the NIS database who had both ECMO performed and ICD-9 codes consistent with trauma. Patients were predominantly aged 15 to 29 years (31.4%) and were male (65.5%). The incidence of ECMO for patients after traumatic injuries has increased 66-fold during the 10-year period. In-hospital mortality was 48.0% overall, with a decreasing trend during the study period that approached statistical significance (p=0.06).DiscussionAlthough ECMO use in patients in the post-trauma setting remains controversial, there is an increasing trend to use ECMO nationwide, suggesting an increasing acceptance and/or increased availability at trauma centers. Given the decrease in mortality during the study period, ECMO as a salvage method in trauma patients remains a potentially viable option. Evaluation in a prospective manner may clarify risks and benefits.Level of evidenceLevel IV, epidemiological.

Download Full-text

Choosing a Pump for Extracorporeal Membrane Oxygenation in the USA

Artificial Organs ◽

10.1111/aor.12215 ◽

2014 ◽

Vol 38 (1) ◽

pp. 1-4 ◽

Cited By ~ 22

Author(s):

David A. Palanzo ◽

Larry D. Baer ◽

Aly El-Banayosy ◽

Shigang Wang ◽

Akif Ündar ◽

...

Keyword(s):

Extracorporeal Membrane Oxygenation ◽

Membrane Oxygenation ◽

The Usa

Download Full-text

Respiratory failure caused by tuberculous pneumonia requiring extracorporeal membrane oxygenation

Perfusion ◽

10.1177/026765910101600613 ◽

2001 ◽

Vol 16 (6) ◽

pp. 525-529 ◽

Cited By ~ 9

Author(s):

Toni M Petrillo ◽

Micheal L Heard ◽

James D Fortenberry ◽

Jana A Stockwell ◽

Michael K Leonard

Keyword(s):

Mycobacterium Tuberculosis ◽

Respiratory Failure ◽

Extracorporeal Membrane Oxygenation ◽

Treatment Option ◽

Antimicrobial Therapy ◽

Ventilatory Support ◽

Developed Countries ◽

Membrane Oxygenation ◽

Common Pathogen

While a common pathogen, Mycobacterium tuberculosis (TB) pneumonitis is only rarely reported as a cause for respiratory failure in developed countries. We report an adolescent with TB pneumonitis and respiratory failure requiring extracorporeal membrane oxygenation (ECMO) with eventual survival. With the incidence of TB rising globally, TB should be suspected and treated as early as possible. ECMO should be considered as a treatment option if conventional ventilatory support is inadequate. ECMO survival with TB pneumonia and anti-TB antimicrobial therapy is possible.

Download Full-text

A bibliometric review of oncolytic virus research as a novel approach for cancer therapy

Virology Journal ◽

10.1186/s12985-021-01571-7 ◽

2021 ◽

Vol 18 (1) ◽

Author(s):

Amir Sasan Mozaffari Nejad ◽

Tehjeeb Noor ◽

Ziaul Haque Munim ◽

Mohammad Yousef Alikhani ◽

Amir Ghaemi

Keyword(s):

Cancer Therapy ◽

Developed Countries ◽

Oncolytic Viruses ◽

Molecular Therapy ◽

Research Translation ◽

Novel Therapy ◽

Research Areas ◽

The Usa ◽

Number Of Publications ◽

The University

Abstract Background In recent years, oncolytic viruses (OVs) have drawn attention as a novel therapy to various types of cancers, both in clinical and preclinical cancer studies all around the world. Consequently, researchers have been actively working on enhancing cancer therapy since the early twentieth century. This study presents a systematic review of the literature on OVs, discusses underlying research clusters and, presents future directions of OVs research. Methods A total of 1626 published articles related to OVs as cancer therapy were obtained from the Web of Science (WoS) database published between January 2000 and March 2020. Various aspects of OVs research, including the countries/territories, institutions, journals, authors, citations, research areas, and content analysis to find trending and emerging topics, were analysed using the bibliometrix package in the R-software. Results In terms of the number of publications, the USA based researchers were the most productive (n = 611) followed by Chinese (n = 197), and Canadian (n = 153) researchers. The Molecular Therapy journal ranked first both in terms of the number of publications (n = 133) and local citations (n = 1384). The most prominent institution was Mayo Clinic from the USA (n = 117) followed by the University of Ottawa from Canada (n = 72), and the University of Helsinki from Finland (n = 63). The most impactful author was Bell J.C with the highest number of articles (n = 67) and total local citations (n = 885). The most impactful article was published in the Cell journal. In addition, the latest OVs research mainly builds on four research clusters. Conclusion The domain of OVs research has increased at a rapid rate from 2000 to 2020. Based on the synthesis of reviewed studies, adenovirus, herpes simplex virus, reovirus, and Newcastle disease virus have shown potent anti-cancer activity. Developed countries such as the USA, Canada, the UK, and Finland were the most productive, hence, contributed most to this field. Further collaboration will help improve the clinical research translation of this therapy and bring benefits to cancer patients worldwide.

Download Full-text