A bibliometric review of oncolytic virus research as a novel approach for cancer therapy

Abstract Background In recent years, oncolytic viruses (OVs) have drawn attention as a novel therapy to various types of cancers, both in clinical and preclinical cancer studies all around the world. Consequently, researchers have been actively working on enhancing cancer therapy since the early twentieth century. This study presents a systematic review of the literature on OVs, discusses underlying research clusters and, presents future directions of OVs research. Methods A total of 1626 published articles related to OVs as cancer therapy were obtained from the Web of Science (WoS) database published between January 2000 and March 2020. Various aspects of OVs research, including the countries/territories, institutions, journals, authors, citations, research areas, and content analysis to find trending and emerging topics, were analysed using the bibliometrix package in the R-software. Results In terms of the number of publications, the USA based researchers were the most productive (n = 611) followed by Chinese (n = 197), and Canadian (n = 153) researchers. The Molecular Therapy journal ranked first both in terms of the number of publications (n = 133) and local citations (n = 1384). The most prominent institution was Mayo Clinic from the USA (n = 117) followed by the University of Ottawa from Canada (n = 72), and the University of Helsinki from Finland (n = 63). The most impactful author was Bell J.C with the highest number of articles (n = 67) and total local citations (n = 885). The most impactful article was published in the Cell journal. In addition, the latest OVs research mainly builds on four research clusters. Conclusion The domain of OVs research has increased at a rapid rate from 2000 to 2020. Based on the synthesis of reviewed studies, adenovirus, herpes simplex virus, reovirus, and Newcastle disease virus have shown potent anti-cancer activity. Developed countries such as the USA, Canada, the UK, and Finland were the most productive, hence, contributed most to this field. Further collaboration will help improve the clinical research translation of this therapy and bring benefits to cancer patients worldwide.

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Bibliometric analysis of the development of nanoscience research in South Africa

South African Journal of Science ◽

10.17159/sajs.2017/20160381 ◽

2017 ◽

Vol 113 (11/12) ◽

Cited By ~ 3

Author(s):

Xolani Makhoba ◽

Anastassios Pouris

Keyword(s):

South African ◽

Web Of Science ◽

Research Area ◽

Public Institutions ◽

Gauteng Province ◽

Research Areas ◽

The Usa ◽

Institutional Profile ◽

High Level ◽

The University

Nanotechnology is a fast-growing scientific research area internationally and is classified as an important emerging research area. In response to this importance, South African researchers and institutions have also increased their efforts in this area. A bibliometric study of articles as indexed in the Web of Science considered the development in this field with respect to the growth in literature, collaboration profile and the research areas that are more within the country’s context. We also looked at public institutions that are more active in this arena, including government policy considerations as guided by the National Nanotechnology Strategy launched in 2005. We found that the number of nanotechnology publications have shown a remarkable growth ever since the launch of the strategy. Articles on nanotechnology have been published in numerous journals, with Electrochimica Acta publishing the most, followed by Journal of Nanoscience and Nanotechnology. These publications fall within the traditional domains of chemistry and physics. In terms of the institutional profile and based on publication outputs over the period reviewed, the Council for Scientific and Industrial Research is a leading producer of publications in nanotechnology, followed by the University of the Witwatersrand – institutions that are both based in the Gauteng Province. There is a high level of international collaboration with different countries within this field – the most productive collaboration is with India, followed by the USA and China, as measured through co-authorship.

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Analysis of the Most-Cited Systematic Review or Meta-Analysis in Acupuncture Research

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2021/3469122 ◽

2021 ◽

Vol 2021 ◽

pp. 1-14

Author(s):

Ying He ◽

Yuxi Li ◽

Juan Li ◽

Ning Li ◽

Yonggang Zhang ◽

...

Keyword(s):

Systematic Reviews ◽

Meta Analysis ◽

Developed Countries ◽

Research Field ◽

Maryland School ◽

The Usa ◽

Acupuncture Research ◽

New Research ◽

Meta Analyses ◽

The University

Objectives. The aim of the current study was to analyze the 100 most-cited systematic reviews or meta-analyses in the field of acupuncture research. Methods. The Web of Science Core Collection was used to retrieve lists of 100 most-cited systematic reviews or meta-analyses in the field of acupuncture research. Two authors screened literature, extracted data, and analyzed the results. Results. The citation number of the 100 most-cited systematic reviews or meta-analyses varied from 65 to 577; they were published between 1989 and 2018. Fourteen authors published more than 1 study as the corresponding author and 10 authors published more than 1 study as the first author. In terms of the corresponding authors, Edzard Ernst and Linde Klaus published the most systematic reviews/meta-analyses (n = 7). The USA published most of the systematic reviews or meta-analyses (n = 24), followed by England (n = 23) and China (n = 14). Most institutions with more than 1 study were from England (4/13). The institutions with the largest numbers of most-cited systematic reviews or meta-analyses were the Technical University of Munich in Germany, the University of Maryland School of Medicine in the USA (n = 8), the Universities of Exeter and Plymouth in England (n = 6), and the University of Exeter in England (n = 6). The journal with the largest number of most-cited systematic reviews or meta-analyses was the Cochrane Database of Systematic Reviews (n = 20), followed by Pain (n = 6). Conclusion. Our study reveals that the 100 most-cited systematic reviews or meta-analyses in the acupuncture research field are mostly from high impact factor journals and developed countries. It will help researchers follow research hot spots, broaden their research scope, expand their academic horizons, and explore new research ideas, thereby improving the quality of acupuncture research.

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Metastatic Castration-Resistant Prostate Cancer: Academic Insights and Perspectives Analysis

10.21203/rs.2.10359/v1 ◽

2019 ◽

Author(s):

Lugeng He ◽

Hui Fang ◽

Chao Chen ◽

Yanqi Wu ◽

Yuyong Wang ◽

...

Keyword(s):

Prostate Cancer ◽

Developed Countries ◽

The United States ◽

Vital Role ◽

Cancer Center ◽

Castration Resistant Prostate Cancer ◽

Research Areas ◽

Castration Resistant ◽

The Usa ◽

Future Direction

Abstract Background In recent years, metastatic castration-resistant prostate cancer (MCRPC) and studies related to MCRPC have drawn global attention. The main objective of this bibliometric study was to provide an overview of MCRPC, explore clusters and trends in research and investigate the future direction of MCRPC research. Methods A total of 4,089 publications published between 1979 and 2018 were retrieved from the Web of Science (WoS) Core Collection database. Different aspects of MCRPC research, including the countries/territories, institutions, journals, authors, research areas, funding agencies and author keywords, were analyzed. Results The number of annual MCRPC publications increased rapidly after 2010. American researchers played a vital role in this increase, as they published the most publications. The most productive institution was Memorial Sloan Kettering Cancer Center. De Bono, JS (the United Kingdom [UK]) and Scher, HI (the United States of America [USA]) were the two most productive authors. The National Institutes of Health (NIH) funded the largest number of published papers. Analyses of keywords suggested that therapies (abiraterone, enzalutamide, etc.) would attracted global attention after US Food and Drug Administration (FDA) approval. Conclusions Developed countries, especially the USA,were the leading nations for MCRPC research because of their abundant funding and frequent international collaborations. Therapy was one of the most vital aspects of MCRPC research. Therapies targeting DNA repair or the androgen receptor (AR) signing pathway and new therapies especially prostate-specific membrane antigen (PSMA)-based radioligand therapy (RLT) would be the next focus of MCRPC research.

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Bibliometric Analysis and Systematic Review of Global Coronavirus Research Trends Before COVID-19: Prospects and Implications for COVID-19 Research

Frontiers in Medicine ◽

10.3389/fmed.2021.729138 ◽

2021 ◽

Vol 8 ◽

Author(s):

Peijing Yan ◽

Meixuan Li ◽

Jing Li ◽

Zhenxing Lu ◽

Xu Hui ◽

...

Keyword(s):

Systematic Review ◽

Hong Kong ◽

Bibliometric Analysis ◽

Research Trends ◽

Diagnosis And Treatment ◽

Ovid Medline ◽

Intestinal Infections ◽

The Usa ◽

Number Of Publications ◽

The University

Coronaviruses (CoV) cause respiratory and intestinal infections. We conducted this bibliometric analysis and systematical review to explore the CoV-related research trends from before COVID-19. We systematically searched the Ovid MEDLINE, Ovid Embase, and Web of Science (WOS) databases for published bibliometric analyses of CoV from database inception to January 24, 2021. The WOS Collection was searched from inception to January 31, 2020, to acquire the CoV-related publications before COVID-19. One-Way ANOVA and Bonferroni multiple-comparison tests were used to compare differences. Visualization mapping and keyword cluster graphs were made to illustrate the research topics and hotpots. We included 14,141 CoV-related publications for the bibliometric analysis and 16 (12 articles) CoV-related bibliometric analyses for the systematic review. Both the systematic review and bibliometric analysis showed (1) the number of publications showed two steep upward trajectories in 2003–2004 and in 2012–2014; (2) the research hotpots mainly focused on the mechanism, pathology, epidemiology, clinical diagnosis, and treatment of the coronavirus in MERS-CoV and SARS-Cov; (3) the USA, and China; the University of Hong Kong; and Yuen KY, came from the University of Hong Kong contributed most; (4) the Journal of Virology had the largest number of CoV related studies. More studies should focus on prevention, diagnosis, and treatment in the future.

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Hyperaccumulators for Potentially Toxic Elements: A Scientometric Analysis

Agronomy ◽

10.3390/agronomy11091729 ◽

2021 ◽

Vol 11 (9) ◽

pp. 1729

Author(s):

Dongming Zhang ◽

Miles Dyck ◽

Lana Filipović ◽

Vilim Filipović ◽

Jialong Lv ◽

...

Keyword(s):

Toxic Elements ◽

Environmental Science ◽

Low Cost ◽

Potentially Toxic Elements ◽

Collaboration Network ◽

Scientometric Analysis ◽

The Usa ◽

Using Data ◽

Number Of Publications ◽

The University

Phytoremediation is an effective and low-cost method for the remediation of soil contaminated by potentially toxic elements (metals and metalloids) with hyperaccumulating plants. This study analyzed hyperaccumulator publications using data from the Web of Science Core Collection (WoSCC) (1992-2020). We explored the research status on this topic by creating a series of scientific maps using VOSviewer, HistCite Pro, and CiteSpace. The results showed that the total number of publications in this field shows an upward trend. Dr. Xiaoe Yang is the most productive researcher on hyperaccumulators and has the broadest international collaboration network. The Chinese Academy of Sciences (China), Zhejiang University (China), and the University of Florida (USA) are the top three most productive institutions in the field. China, the USA, and India are the top three most productive countries. The most widely used journals were the International Journal of Phytoremediation, Environmental Science and Pollution Research, and Chemosphere. Co-occurrence and citation analysis were used to identify the most influential publications in this field. In addition, possible knowledge gaps and perspectives for future studies are also presented.

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Research Hotspots and Development Trends on Recycled Construction Materials in Pavement Engineering: A Bibliometric Evaluation

Materials ◽

10.3390/ma14092170 ◽

2021 ◽

Vol 14 (9) ◽

pp. 2170

Author(s):

Yue Xiao ◽

Qiankun Dong ◽

Xiwen Chang ◽

Peiqiang Cui ◽

Gang Liu

Keyword(s):

Performance Enhancement ◽

Construction Materials ◽

Road Construction ◽

Research Area ◽

Research Areas ◽

Publication Number ◽

Recycling Technology ◽

Pavement Engineering ◽

The Usa ◽

Number Of Publications

Road recycling technology is gradually becoming a research focus in road construction due to natural resource shortages. It is therefore necessary to carry out deep and extensive analysis of the huge amount of publications in the research area of recycling technology in road construction. Based on three databases (Web of Science, Compendex and Scopus) and VOSviewer visualization software, this study conducts a bibliometric analysis of the literature in the field of recycled construction materials in pavement engineering. The global research publications were reviewed to quantitatively identify the literature characteristics. A number of publications, document types, research areas and keywords were used to achieve the general statistics of this reviewed literature. H-index, publication number and citations per publication were used to evaluate the academic contributions by country, institution and journal. The results show that the most productive country and institution for publications are the USA and Chang’an University from China, respectively, followed by China and Wuhan University of Technology. In recent years, researchers have generally paid attention to two main approaches: the application of rubber modified asphalt and the performance enhancement of recycled pavement.

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Research Trends and Hotspots of Extracorporeal Membrane Oxygenation: A 10-Year Bibliometric Study and Visualization Analysis

Frontiers in Medicine ◽

10.3389/fmed.2021.752956 ◽

2021 ◽

Vol 8 ◽

Author(s):

Huaqin Wang ◽

Siqi Deng ◽

Xiaoyu Fan ◽

Jinxiu Li ◽

Li Tang ◽

...

Keyword(s):

Extracorporeal Membrane Oxygenation ◽

Visual Analysis ◽

Research Direction ◽

Developed Countries ◽

Membrane Oxygenation ◽

Management Of Complications ◽

Institutional Cooperation ◽

The Usa ◽

Number Of Publications ◽

Specialized Team

Objective: To determine the research hotspots and trends in the field of extracorporeal membrane oxygenation (ECMO), and to provide a reference for further and wider research in the future.Methods: The literatures on ECMO from January 2011 to July 2021 in the Web of Science Core Collection (WOSCC) database were searched, and Citespace5.8.R1 software was used to conduct bibliographic and visual analysis on the literature by country, institution, author and keywords.Results: A total of 5,986 articles were enrolled. According to an observation, the number of articles published in the past decade has increased, especially from 2019 to 2020. The USA had the largest number of publications, while less ECMO related studies were conducted among non-developed countries. The University of Michigan (Univ Michigan) was the institution that had the largest number of publications and the highest centrality, and Daniel B was the author who had the largest number of publications. However, more inter-institutional cooperation among author teams was needed. The focus of existing ECMO research has primarily been on the treatment of patients suffering from severe cardiopulmonary failure, and the prevention and management of complications during the application ECMO.Conclusion: Inter-regional and inter-institutional cooperation and exchanges should be carried out among ECMO research teams and institutions. The suggested research direction is to further broaden the application scope of ECMO, while determining the ways to reduce the incidence of complications and the cost, cultivate specialized team talents, and promote the application thereof.

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Engagement: bibliometric analysis

Nova Scientia ◽

10.21640/ns.v10i21.1438 ◽

2018 ◽

Vol 10 (21) ◽

pp. 524-551

Author(s):

Claudia Leticia Preciado Ortiz ◽

Juan Antonio Vargas Barraza ◽

Ainhize Gilsanz López

Keyword(s):

Bibliometric Analysis ◽

The United States ◽

User Engagement ◽

Brand Engagement ◽

Research Areas ◽

Communication Environments ◽

The Subject ◽

Online Environments ◽

Number Of Publications ◽

The University

Introduction: The objective of this paper was to carry out a bibliometric analysis by using the different names that engagement has had in marketing to know growth trends, current research areas and to discover potential future lines of research on this subject.Method: The Scopus database was the provider of the information, analyzing a sample of 1791 documents for the period from 1996 to March 10, 2018, the date on which the data was downloaded. Results: The results show that the development of research on the subject is growing. The country that leads in number of publications is the United States, however, the most productive institution is the University of Auckland, New Zealand; and the leading journal was Computers in Human Behavior. Similarly, the most productive authors are Hollebeek, Graffigna and Malthouse; but the author who had the greatest impact on citations per year and not per number of publications was Brodie. The main areas in which a particular interest has been given are customer / consumer engagement, social media engagement, user engagement and brand engagement. It is possible to emphasize the concentration in studies that are focused on online environments (social networks and brand communities) and recent studies related to mobile environments (apps). Discussion or Conclusion: It can be concluded that engagement is a frontier issue in the area of marketing, especially focused on online environments and recently on mobile applications. It is an area of research in which there is much to do, since brands are betting every day on using more interactive channels to keep their customers and attract new ones, by generating new communication environments, involvement and engagement between brands and customers.

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Application of Liposomes in Cancer Therapy: An Assessment of the Advancement of Technology Through Patent Documents

Recent Patents on Nanotechnology ◽

10.2174/1872210514666201223093321 ◽

2020 ◽

Vol 14 ◽

Author(s):

Danielle Devequi Gomes Nunes ◽

Ingrid Lessa Leal ◽

Fabricia Oliveira Oliveira ◽

Tatiara Lima Régis da Silva ◽

Valter de Senna ◽

...

Keyword(s):

Cancer Treatment ◽

Suppressor Activity ◽

Patent Classification ◽

Area Of Interest ◽

International Patent ◽

Tumor Suppressor Activity ◽

The Usa ◽

Patent Documents ◽

Number Of Publications ◽

The University

Background: Cancer is caused by mutations in oncogenes and loss of tumor suppressor activity. Despite the efforts of the pharmaceutical industry to fight cancer, it is necessary to investigate new methods to enhance the action against this disease. In this scenario, liposome technology has emerged as a drug delivery system for cancer treatment. The objective of this study was to evaluate the use of liposome technology in the treatment of cancer through analysis of patent documents. Methods: We analyzed prospective documents in the Derwent Innovation Index database. Results: A total of 203 patent documents were related to the area of interest, published between 2000 and 2020, and the USA and Japan were shown as countries with the largest number of publications. Moreover, most of these publications came from companies, however, also with representation of important universities, mainly the University of California.. According to the International Patent Classification, the codes most applicable to the documents were the area of human necessities and chemistry. Conclusion: The results of this study showed that the study and application of liposomes for the development of cancer treatment tended to grow, along with the number of related patents.

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Bibliometric Analysis of Current Drug Metabolism: The Twentieth Anniversary from 2000-2019

Current Drug Metabolism ◽

10.2174/1389200221666200826094233 ◽

2020 ◽

Vol 21 (9) ◽

pp. 685-703

Author(s):

Waseem Hassan ◽

Jean Paul Kamdem ◽

Mohammad Amjad Kamal ◽

Joao Batista Teixeira da Rocha

Keyword(s):

United States ◽

Drug Metabolism ◽

Bibliometric Analysis ◽

Continuous Growth ◽

H Index ◽

Current Drug ◽

The Usa ◽

Twentieth Anniversary ◽

Number Of Publications ◽

Number Of Citations

Background: Scopus is regularly covering Current Drug Metabolism from 2000 onwards. Objective: The major objective is to perform the 1st bibliometric analysis of Current Drug Metabolism (CDM). Methods: The data was retrieved from Scopus in April-May 2020 for detail analysis. Results: The total number of publications was found to be 1551, with 955 reviews (61.57%) and 466 articles (30.05%). From 2000 onwards, we calculated the relative growth rate and doubling time. Based on the number of publications, total 4418 authors, 3235 institutions and 83 countries were directly involved in all publications. M.A. Kamal is the highly productive scientist with fifty-three (53 or 3.73%) publications, King Abdulaziz University is the top university with the highest number of publications (58 or 4.13%) and the USA is the top-ranked country with 365 publications (25.96%). We also provided the h-index, total citations (TC), h-index without self-citations (WSC) and total WSC of the top ten authors, universities and countries. In citations analysis, Prof. Zhou S.F. was the top scientist with the highest (1594) number of citations. In institutional category Department of Drug Metabolism, Merck Research Laboratories, Rahway, United States, is the top ranked institutes with 654 total citations. While, United States is the top-ranked country with 18409 total citations. In co-words analysis, 3387, 30564 and 17333 terms in titles of the manuscripts, abstracts and keywords were recorded, respectively. This indicated that CDM principally focused on understanding drug development ranging from its efficacy to delivery, metabolism, distribution, safety and mechanism of actions. Similarly, various specific drugs were thoroughly discussed in publications. Various enzymatic, genetics, proteins and cancer-related aspects were also described. For data presentations, we used VOSviewer graphical maps. Conclusion: The data confirm that CDM showed continuous growth in the number of publications and citations. However significant measures are needed to make overall progress and improve the rankings in relevant categories.

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