Abstract. The intensity and/or extent of the northeastern Pacific Oxygen Minimum Zone (OMZ) varied in-phase with the Northern Hemisphere high latitude climate on millennial timescales during the last glacial period, indicating the presence of atmospheric and oceanic connections under glacial conditions. While millennial variability was observed for both the Greenland ice core and the northern Atlantic during the last interglacial period, the relationship with the northeastern Pacific OMZ has not yet been observed under warm interglacial conditions. Here we present a~new geochemical dataset, spanning the past 120 kyr, for major components (terrigenous fraction, marine organic matter, biogenic opal, and carbonates) by X-ray fluorescence scanning alongside with biological productivity and redox sensitive trace element content (Mo, Ni, Cd) of sediment core MD02-2508 at 23° N, retrieved from the northern limit of the modern OMZ. We evidenced high biological productivity from opal based on Si/Ti, and from Cd/Al, and Ni/Al ratios during last interglacial period. Highly resolved opal reconstruction presents millennial variability corresponding to all the Dansgaard–Oeschger interstadial events over the last interglacial, while the Mo/Al ratio indicates reduced oxygenation during these intervals. Extremely high opal content during warm interstadials suggests high diatom productivity. Despite the different climatic and oceanic background between glacial and interglacial periods, rapid variability in the northeastern Pacific OMZ seems to be tightly related to Northern Hemisphere high latitude climate mainly via atmospheric processes.