scholarly journals Nanocarriers for Inner Ear Disease Therapy

2021 ◽  
Vol 15 ◽  
Author(s):  
Xiaoxiang Xu ◽  
Jianwei Zheng ◽  
Yanze He ◽  
Kun Lin ◽  
Shuang Li ◽  
...  
Keyword(s):  
Side Effects ◽  
Inner Ear ◽  
High Efficiency ◽  
Delivery Systems ◽  
Sensory Loss ◽  
Common Disease ◽  
Efficient Treatment ◽  
Disease Therapy ◽  
Traditional Drug ◽  
Inner Ear Disease

Hearing loss is a common disease due to sensory loss caused by the diseases in the inner ear. The development of delivery systems for inner ear disease therapy is important to achieve high efficiency and reduce side effects. Currently, traditional drug delivery systems exhibit the potential to be used for inner ear disease therapy, but there are still some drawbacks. As nanotechnology is developing these years, one of the solutions is to develop nanoparticle-based delivery systems for inner ear disease therapy. Various nanoparticles, such as soft material and inorganic-based nanoparticles, have been designed, tested, and showed controlled delivery of drugs, improved targeting property to specific cells, and reduced systemic side effects. In this review, we summarized recent progress in nanocarriers for inner ear disease therapy. This review provides useful information on developing promising nanocarriers for the efficient treatment of inner ear diseases and for further clinical applications for inner ear disease therapy.

scholarly journals Inner Ear Disease and Benign Paroxysmal Positional Vertigo: A Critical Review of Incidence, Clinical Characteristics, and Management

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
M. Riga ◽  
A. Bibas ◽  
J. Xenellis ◽  
S. Korres
Keyword(s):  
Inner Ear ◽  
Clinical Characteristics ◽  
Efficient Treatment ◽  
Ear Diseases ◽  
Integrated Diagnosis ◽  
Positional Vertigo ◽  
Inner Ear Disease ◽  
Comprehensive Search ◽  
Suspicion Index ◽  
Paroxysmal Positional Vertigo

Background. This study is a review of the incidence, clinical characteristics, and management of secondary BPPV. The different subtypes of secondary BPPV are compared to each other, as well as idiopathic BPPV. Furthermore, the study highlights the coexistence of BPPV with other inner ear pathologies.Methods. A comprehensive search for articles including in the abstract information on incidence, clinical characteristics, and management of secondary BPPV was conducted within the PubMed library.Results. Different referral patterns, different diagnostic criteria used for inner ear diseases, and different patient populations have led to greatly variable incidence results. The differences regarding clinical characteristics and treatment outcomes may support the hypothesis that idiopathic BPPV and the various subtypes of secondary BPPV do not share the exact same pathophysiological mechanisms.Conclusions. Secondary BPPV is often under-diagnosed, because dizziness may be atypical and attributed to the primary inner ear pathology. Reversely, a limited number of BPPV patients may not be subjected to a full examination and characterized as idiopathic, while other inner ear diseases are underdiagnosed. A higher suspicion index for the coexistence of BPPV with other inner ear pathologies, may lead to a more integrated diagnosis and consequently to a more efficient treatment of these patients.

Protein profile of human perilymph: In search of markers for the diagnosis of perilymph fistula and other inner ear disease

1994 ◽  
Vol 111 (3) ◽  
pp. 273-280 ◽  
Author(s):  
I THALMANN ◽  
R KOHUT ◽  
J RYU ◽  
T COMEGYS ◽  
M SENARITA ◽  
...  
Keyword(s):  
Inner Ear ◽  
Protein Profile ◽  
Inner Ear Disease

Nanoparticle-based Drug Delivery Systems for Targeted Epigenetics Cancer Therapy

2020 ◽  
Vol 21 (11) ◽  
pp. 1084-1098
Author(s):  
Fengqian Chen ◽  
Yunzhen Shi ◽  
Jinming Zhang ◽  
Qi Liu
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Cancer Therapy ◽  
Drug Delivery Systems ◽  
Therapeutic Index ◽  
Delivery Systems ◽  
Epigenetic Therapy ◽  
Cancer Therapies ◽  
Therapeutic Benefits ◽  
High Therapeutic Index

This review summarizes the epigenetic mechanisms of deoxyribonucleic acid (DNA) methylation, histone modifications in cancer and the epigenetic modifications in cancer therapy. Due to their undesired side effects, the use of epigenetic drugs as chemo-drugs in cancer therapies is limited. The drug delivery system opens a door for minimizing these side effects and achieving greater therapeutic benefits. The limitations of current epigenetic therapies in clinical cancer treatment and the advantages of using drug delivery systems for epigenetic agents are also discussed. Combining drug delivery systems with epigenetic therapy is a promising approach to reaching a high therapeutic index and minimizing the side effects.

The pathogenesis of the secondary forms of autoimmune inner ear disease (AIED): advancing beyond the audiogram data

2021 ◽  
Author(s):  
Virginia Corazzi ◽  
Stavros Hatzopoulos ◽  
Chiara Bianchini ◽  
Magdalena B Skarżyńska ◽  
Stefano Pelucchi ◽  
...  
Keyword(s):  
Inner Ear ◽  
Inner Ear Disease ◽  
Autoimmune Inner Ear Disease

Improved efficacy and safety of low doses of benznidazole-loaded multiparticulate delivery systems in experimental Chagas disease therapy

2021 ◽  
pp. 105912
Author(s):  
Mónica C. García ◽  
Natalia Eberhardt ◽  
Liliana M. Sanmarco ◽  
Nicolás E. Ponce ◽  
Alvaro F. Jimenez-Kairuz ◽  
...  
Keyword(s):  
Chagas Disease ◽  
Delivery Systems ◽  
Low Doses ◽  
Efficacy And Safety ◽  
Disease Therapy

scholarly journals The Nanosystems Involved in Treating Lung Cancer

Life ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 682
Author(s):  
Andreea Crintea ◽  
Alina Gabriela Dutu ◽  
Gabriel Samasca ◽  
Ioan Alexandru Florian ◽  
Iulia Lupan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Side Effects ◽  
Chromosomal Rearrangements ◽  
Sirna Delivery ◽  
Delivery Systems ◽  
Inorganic Nanoparticles ◽  
New Methods ◽  
Different Types ◽  
Or Gene ◽  
The Many

Even though there are various types of cancer, this pathology as a whole is considered the principal cause of death worldwide. Lung cancer is known as a heterogeneous condition, and it is apparent that genome modification presents a significant role in the occurrence of this disorder. There are conventional procedures that can be utilized against diverse cancer types, such as chemotherapy or radiotherapy, but they are hampered by the numerous side effects. Owing to the many adverse events observed in these therapies, it is imperative to continuously develop new and improved strategies for managing individuals with cancer. Nanomedicine plays an important role in establishing new methods for detecting chromosomal rearrangements and mutations for targeted chemotherapeutics or the local delivery of drugs via different types of nano-particle carriers to the lungs or other organs or areas of interest. Because of the complex signaling pathways involved in developing different types of cancer, the need to discover new methods for prevention and detection is crucial in producing gene delivery materials that exhibit the desired roles. Scientists have confirmed that nanotechnology-based procedures are more effective than conventional chemotherapy or radiotherapy, with minor side effects. Several nanoparticles, nanomaterials, and nanosystems have been studied, including liposomes, dendrimers, polymers, micelles, inorganic nanoparticles, such as gold nanoparticles or carbon nanotubes, and even siRNA delivery systems. The cytotoxicity of such nanosystems is a debatable concern, and nanotechnology-based delivery systems must be improved to increase the bioavailability, biocompatibility, and safety profiles, since these nanosystems boast a remarkable potential in many biomedical applications, including anti-tumor activity or gene therapy. In this review, the nanosystems involved in treating lung cancer and its associated challenges are discussed.

scholarly journals Skin Side Effects of Inflammatory Bowel Disease Therapy

2013 ◽  
Vol 19 (5) ◽  
pp. 1086-1098 ◽  
Author(s):  
Joana Torres ◽  
Sébastien Buche ◽  
Emmanuel Delaporte ◽  
Jean-Frédéric Colombel
Keyword(s):  
Inflammatory Bowel Disease ◽  
Side Effects ◽  
Bowel Disease ◽  
Disease Therapy ◽  
Inflammatory Bowel ◽  
Skin Side Effects

Immune-mediated inner ear disease

2000 ◽  
Vol 12 (1) ◽  
pp. 32-40 ◽  
Author(s):  
John H. Stone ◽  
Howard W. Francis
Keyword(s):  
Inner Ear ◽  
Immune Mediated ◽  
Inner Ear Disease
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