scholarly journals Analysis of 12 GWAS-Linked Loci With Parkinson’s Disease in the Chinese Han Population

2021 ◽  
Vol 12 ◽  
Author(s):  
Liyuan Fan ◽  
Changhe Shi ◽  
Xinchao Hu ◽  
Zhongxian Zhang ◽  
Huimin Zheng ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Large Scale ◽  
Genome Wide Association Study ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Asian Populations ◽  
Genome Wide ◽  
The Relationship

A recent large-scale European-originated genome-wide association study identified 38 novel independent risk signals in 37 loci for Parkinson's disease (PD). However, whether these new loci are associated with PD in Asian populations remains elusive. The present study aimed to explore the relationship between the 12 most relevant loci with larger absolute values for these new risk loci and PD in the Chinese Han population. We performed a case-control study including 527 PD patients and 435 healthy controls. In the allele model, it was found that rs10748818/GBF1 was associated with PD in the Chinese Han population [p = 0.035, odds ratio (OR) 1.221, 95% confidence interval (CI) 1.014–1.472

The prevalence of LRRK2 Gly2385Arg variant in Chinese Han population with Parkinson's disease

2007 ◽  
Vol 22 (16) ◽  
pp. 2439-2443 ◽  
Author(s):  
Li Cao ◽  
Ting Zhang ◽  
Qin Xiao ◽  
Ying Wang ◽  
Li Bai ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals HLA-DRB1 Alleles Are Associated with the Susceptibility to Sporadic Parkinson’s Disease in Chinese Han Population

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e48594 ◽  
Author(s):  
Congcong Sun ◽  
Lei Wei ◽  
Feifei Luo ◽  
Yi Li ◽  
Jiaobiao Li ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Sporadic Parkinson’S Disease

SNCA rs3822086 C>T Polymorphism Increases the Susceptibility to Parkinson's Disease in a Chinese Han Population

2015 ◽  
Vol 19 (9) ◽  
pp. 481-487 ◽  
Author(s):  
Chong-Dong Jian ◽  
Jian-Min Huang ◽  
Lan-Qing Meng ◽  
Xue-Bin Li ◽  
Rui-Ya Huang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

Association of VEGF gene polymorphisms with sporadic Parkinson’s disease in Chinese Han population

2016 ◽  
Vol 37 (12) ◽  
pp. 1923-1929 ◽  
Author(s):  
Yubin Wu ◽  
Yingying Zhang ◽  
Xun Han ◽  
Xiaoyuan Li ◽  
Li Xue ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gene Polymorphisms ◽  
Chinese Han Population ◽  
Vegf Gene ◽  
Chinese Han ◽  
Han Population ◽  
Sporadic Parkinson’S Disease

scholarly journals Rs2015 Polymorphism in miRNA Target Site of Sirtuin2 Gene Is Associated with the Risk of Parkinson’s Disease in Chinese Han Population

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Xiongjin Chen ◽  
Hui Mai ◽  
Xiaoting Chen ◽  
Yujie Cai ◽  
Qiufei Cheng ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Case Control Study ◽  
Mrna Level ◽  
Case Control ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Functional Assays ◽  
Control Study

Accumulating evidence reveals that the sirtuin family is involved in the pathology of Parkinson’s disease (PD). However, the association between the polymorphisms of the sirtuin gene and the risk of PD remains elusive. Here, we investigated the possible association of nine SIRT1 and SIRT2 SNPs with the risk of PD through a clinical case-control study from the Chinese Han population. Our results showed that rs12778366 in the promoter region of SIRT1 and rs2015 in the 3′untranslated region (3′UTR) of the SIRT2 were significantly associated with the risk of PD. Five SNPs related to SIRT1, rs3740051, rs7895833, rs7069102, rs2273773, and rs4746720 and two SNPs related to SIRT2, rs10410544, and rs45592833 did not show an association with PD risk in this study. Moreover, we found that mRNA level of SIRT2 was upregulated, and mRNA level of SIRT1 was downregulated in the peripheral blood of PD patients compared with healthy controls, and we also observed that SNPs rs12778366 and rs2015 influenced the SIRT1 and SIRT2 expression levels, respectively. Further functional assays suggest that rs2015 may affect the expression of SIRT2 by affecting the binding of miR-8061 to the 3′UTR of SIRT2, ultimately contributing to the risk of PD.

scholarly journals Analysis ofLRRK2,SNCA,andITGA8Gene Variants with Sporadic Parkinson’s Disease Susceptibility in Chinese Han Population

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Jie Fang ◽  
Kehui Yi ◽  
Mingwei Guo ◽  
Xingkai An ◽  
Hongli Qu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Chinese Han Population ◽  
Genotype Frequency ◽  
Nucleotide Polymorphisms ◽  
Chinese Han ◽  
Han Population ◽  
Age Related ◽  
Sporadic Parkinson’S Disease ◽  
Genetic And Environmental Factors

Background. Parkinson’s disease (PD) is an age-related neurodegenerative disease affected by multiple genetic and environmental factors. We performed a case-control study on candidate gene to scrutinize whether genetic variants inLRRK2,SNCA, andITGA8genes could be associated with sporadic PD in Chinese Han population.Methods. Five single-nucleotide polymorphisms (SNPs) ofLRRK2(rs1491942),SNCA(rs2301134, rs2301135, and rs356221), andITGA8(rs7077361) were selected and genotyped among 583 unrelated PD patients and 558 healthy controls.Results. Rs1491942 ofLRRK2gene had a significantly higher genotype frequency (P=3.543E-09) and allelic G/C frequencies (P=2.601E-10) in PD patients than controls. Rs2301135 ofSNCAgene also showed an obvious difference in genotype frequency (P=4.394E-07) and allelic G/C frequencies (P=9.116E-13) between PD patients and controls. SNPs rs2301134 and rs356221 ofSNCAgene and rs7077361 ofITGA8gene lacked the significant association with the susceptibility of PD in Chinese Han population.Conclusions. Our study firstly expresses that rs1491942 ofLRRK2and rs2301135 ofSNCAgene are substantially associated with sporadic Parkinson’s disease in Chinese Han population.

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