scholarly journals Association Between 18-FDG Positron Emission Tomography and MRI Biomarkers of Plaque Vulnerability in Patients With Symptomatic Carotid Stenosis

2021 ◽  
Vol 12 ◽  
Author(s):  
Nicola Giannotti ◽  
Jonathan McNulty ◽  
Shane Foley ◽  
John McCabe ◽  
Marey Barry ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Carotid Stenosis ◽  
Emission Tomography ◽  
Inclusion Criteria ◽  
Plaque Vulnerability ◽  
Plaque Instability ◽  
Symptomatic Carotid ◽  
Non Invasive ◽  
Positron Emission ◽  
Symptomatic Carotid Stenosis

Purpose: Pathologic studies suggest that unstable plaque morphology and inflammation are associated with cerebrovascular events. 18F-fluorodeoxyglucose positron emission tomography (18FDG-PET) is a validated technique for non-invasive imaging of inflammation-related plaque metabolism, and MRI can identify morphologic features of plaque instability. The aim of this study was to investigate the association of selected imaging characteristics of plaque vulnerability measured with MRI and PET in patients with symptomatic carotid stenosis.Methods: Patients from the BIOVASC study were selected based on the following inclusion criteria: (1) age ≥ 50 years; (2) recent (<30 days) ischaemic stroke (modified Rankin scale ≤3) or motor/speech/vision TIA; (3) ipsilateral internal carotid artery stenosis (≥5 0% lumen-narrowing); (4) carotid PET/CTA and MRI completed. Semi-automated plaque analysis of MRI images was performed to quantify morphologic features of plaque instability. PET images were co-registered with CTA and inflammation-related metabolism expressed as maximum standardised uptake value (SUVmax).Results: Twenty-five patients met inclusion criteria (72% men, mean age 65 years). MRI-measured plaque volume was greater in men (1,708–1,286 mm3, p = 0.03), patients who qualified with stroke (1,856–1,440 mm3, p = 0.05), and non-statin users (1,325–1,797 mm3, p = 0.03). SUVmax was associated with MRI-measured plaque lipid-rich necrotic core (LRNC) in the corresponding axial slice (rs = 0.64, p < 0.001) and was inversely associated with whole-plaque fibrous cap thickness (rs = −0.4, p = 0.02) and calcium volume (rs = −0.4, p = 0.03).Conclusion: This study demonstrated novel correlations of non-invasive imaging biomarkers of inflammation-related plaque metabolism with morphological MRI markers of plaque instability. If replicated, our findings may support the application of combined MRI and PET to detect vulnerable plaque in future clinical practise and randomised trials.

scholarly journals Cre/lox-assisted non-invasive in vivo tracking of specific cell populations by positron emission tomography

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Martin Thunemann ◽  
Barbara F. Schörg ◽  
Susanne Feil ◽  
Yun Lin ◽  
Jakob Voelkl ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Emission Tomography ◽  
Cell Populations ◽  
Specific Cell ◽  
Non Invasive ◽  
Positron Emission

scholarly journals Positron Emission Tomography in Animal Models of Alzheimer’s Disease Amyloidosis

2021 ◽  
Author(s):  
Ruiqing Ni
Keyword(s):  
Positron Emission Tomography ◽  
Animal Models ◽  
Amyloid Beta ◽  
Emission Tomography ◽  
Imaging Biomarkers ◽  
Preclinical Research ◽  
Non Invasive ◽  
Positron Emission ◽  
Cerebral Amyloid ◽  
On Chip

Animal models of Alzheimer’s disease amyloidosis that recapitulate cerebral amyloid-beta pathology have been widely used in preclinical research, and have greatly enabled the mechanistic understanding of Alzheimer’s disease and the development of therapeutics. Comprehensive deep phenotyping of the pathophysiological and biochemical features in these animal models are essential. Recent advances in positron emission tomography have allowed the non-invasive visualization of the alterations in the brain of animal models as well as in patients with Alzheimer’s disease, These tools have facilitated our understanding of disease mechanisms, and provided longitudinal monitoring of treatment effect in animal models of Alzheimer’s disease amyloidosis. In this review, we focus on recent positron emission tomography studies of cerebral amyloid-beta accumulation, hypoglucose metabolism, synaptic and neurotransmitter receptor deficits (cholinergic and glutamatergic system), blood-brain barrier impairment and neuroinflammation (microgliosis and astrocytosis) in animal models of Alzheimer’s disease amyloidosis. We further propose the emerging targets and tracers for reflecting the pathophysiological changes, and discuss outstanding challenges in disease animal models and future outlook in on-chip characterization of imaging biomarkers towards clinical translation.

scholarly journals Vulnerable plaque imaging using 18F-sodium fluoride positron emission tomography

2020 ◽  
Vol 93 (1113) ◽  
pp. 20190797 ◽  
Author(s):  
Jacek Kwiecinski ◽  
Piotr J Slomka ◽  
Marc R Dweck ◽  
David E Newby ◽  
Daniel S Berman
Keyword(s):  
Coronary Artery Disease ◽  
Positron Emission Tomography ◽  
Coronary Artery ◽  
Sodium Fluoride ◽  
Imaging Modality ◽  
Emission Tomography ◽  
Plaque Morphology ◽  
Non Invasive ◽  
Positron Emission ◽  
Artery Disease

Positron emission tomography (PET) with 18F-sodium fluoride (18F-NaF) has emerged as a promising non-invasive imaging modality to identify high-risk and ruptured atherosclerotic plaques. By visualizing microcalcification, 18F-NaF PET holds clinical promise in refining how we evaluate coronary artery disease, shifting our focus from assessing disease burden to atherosclerosis activity. In this review, we provide an overview of studies that have utilized 18F-NaF PET for imaging atherosclerosis. We discuss the associations between traditional coronary artery disease measures (risk factors) and 18F-NaF plaque activity. We also present the data on the histological validation as well as show how 18F-NaF uptake is associated with plaque morphology on intravascular and CT imaging. Finally, we discuss the technical challenges associated with 18F-NaF coronary PET highlighting recent advances in this area.

Positron emission tomography imaging of vascular endothelial growth factor with 64Cu-labeled bevacizumab for non-invasive diagnosis of endometriosis

2019 ◽  
Vol 11 (4) ◽  
pp. 194-200
Author(s):  
Tumenjargal Amartuvshin ◽  
Hirofumi Hanaoka ◽  
Aiko Yamaguchi ◽  
Yoshito Tsushima
Keyword(s):  
Positron Emission Tomography ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Positron Emission Tomography Imaging ◽  
Emission Tomography ◽  
Vascular Endothelial ◽  
Tomography Imaging ◽  
Non Invasive ◽  
Positron Emission ◽  
Endothelial Growth Factor

Introduction: Non-invasive diagnosis of endometriosis remains challenging. A promising approach for diagnosing endometriosis is the molecular imaging of vascular endothelial growth factor because angiogenesis plays a role in the establishment of endometriosis. This study aimed to evaluate the potential of copper-64-labeled bevacizumab, an anti–vascular endothelial growth factor antibody, for endometriosis imaging. Methods: Mouse endometriosis model was prepared by autologous transplantation. The vascular endothelial growth factor expression was evaluated by immunohistochemical staining. Biodistribution study and positron emission tomography imaging were performed at 1, 24, and 48 h after the injection of radiolabeled bevacizumab. Results: The immunohistochemical staining revealed that vascular endothelial growth factor is expressed around the stroma and glandular epithelial cells in the endometriosis lesion. The biodistribution study showed a high uptake of indium-111 bevacizumab in the endometriosis lesion. Positron emission tomography imaging with copper-64-labeled bevacizumab clearly visualized the endometriosis lesions at 24 and 48 h after injection. Conclusion: These results indicate the potential usefulness of copper-64-labeled bevacizumab for endometriosis imaging.

Symptomatic carotid atherosclerosis detection by positron emission tomography imaging

2017 ◽  
Vol 263 ◽  
pp. e144
Author(s):  
Jeong -Min Kim ◽  
Woo Hyun Paik ◽  
Byeong Jun Song ◽  
Eun Seoung Lee ◽  
Kwang -Yeol Park ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Carotid Atherosclerosis ◽  
Positron Emission Tomography Imaging ◽  
Emission Tomography ◽  
Tomography Imaging ◽  
Symptomatic Carotid ◽  
Positron Emission
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