Detraining Slows and Maintenance Training Over 6 Years Halts Parkinsonian Symptoms-Progression

Introduction: There are scant data to demonstrate that the long-term non-pharmaceutical interventions can slow the progression of motor and non-motor symptoms and lower drug dose in Parkinson's disease (PD).Methods: After randomization, the Exercise-only (E, n = 19) group completed an initial 3-week-long, 15-session supervised, high-intensity sensorimotor agility exercise program designed to improve the postural stability. The Exercise + Maintenance (E + M, n = 22) group completed the 3-week program and continued the same program three times per week for 6 years. The no exercise and no maintenance control (C, n = 26) group continued habitual living. In each patient, 11 outcomes were measured before and after the 3-week initial exercise program and then, at 3, 6, 12, 18, 24, 36, 48, 60, and 72 months.Results: The longitudinal linear mixed effects modeling of each variable was fitted with maximum likelihood estimation and adjusted for baseline and covariates. The exercise program strongly improved the primary outcome, Motor Experiences of Daily Living, by ~7 points and all secondary outcomes [body mass index (BMI), disease and no disease-specific quality of life, depression, mobility, and standing balance]. In E group, the detraining effects lasted up to 12 months. E+M group further improved the initial exercise-induced gains up to 3 months and the gains were sustained until year 6. In C group, the symptoms worsened steadily. By year 6, levodopa (L-dopa) equivalents increased in all the groups but least in E + M group.Conclusion: A short-term, high-intensity sensorimotor agility exercise program improved the PD symptoms up to a year during detraining but the subsequent 6-year maintenance program was needed to further increase or sustain the initial improvements in the symptoms, quality of life, and drug dose.

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Can High-Intensity Functional Suspension Training over Eight Weeks Improve Resting Blood Pressure and Quality of Life in Young Adults? A Randomized Controlled Trial

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph16245062 ◽

2019 ◽

Vol 16 (24) ◽

pp. 5062 ◽

Cited By ~ 2

Author(s):

Florian A. Engel ◽

Ludwig Rappelt ◽

Steffen Held ◽

Lars Donath

Keyword(s):

Quality Of Life ◽

Blood Pressure ◽

Young Adults ◽

Cardiorespiratory Fitness ◽

High Intensity ◽

Life Questionnaire ◽

Leg Press ◽

Resting Blood Pressure ◽

Before And After

The present study examined the effects of a functional high-intensity suspension training (FunctionalHIIT) on resting blood pressure, psychological well-being as well as on upper body and core strength and cardiorespiratory fitness in moderately trained participants. Twenty healthy, moderately trained adults (10 males and 10 females; age: 36.2 ± 11.1 years, BMI: 23.9 ± 3.7) were randomly assigned to a FunctionalHIIT training group or passive control group (CON). FunctionalHIIT performed 16 sessions (2× week for eight weeks, 30 min per session), whereas CON maintained their habitual lifestyle using a physical activity log. Before and after FunctionalHIIT intervention, resting blood pressure and quality of life (short version of the WHO Quality of Life questionnaire (WHOQOL-BREF)) were assessed. Furthermore, maximum-repetition (leg press, chest press, pulldown, back extension) and trunk muscle strength (Bourban test) as well as cardiorespiratory fitness (Vameval test), were measured before and after the intervention. Both systolic and diastolic blood pressure and WHOQOL-BREF did not change significantly but both showed moderate training-induced effects (0.62 < standardized mean difference (SMD) < 0.82). Significant improvements in the FunctionalHIIT group were evident on leg press (p < 0.01), chest press (p < 0.05), and left side Bourban test (p < 0.05). Cardiorespiratory fitness did not reveal any time effects or time × group interactions. The present study revealed that eight weeks of FunctionalHIIT represents a potent stimulus to improve health-related parameters in young adults, whereas FunctionalHIIT was not sufficient to improve cardiorespiratory fitness.

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HIGH INTENSITY PHYSICAL TRAINING AND QUALITY OF LIFE IN A YOUNG CORONARY PATIENT BEFORE AND AFTER MESENTERIC THOMBOSIS

Journal of Cardiopulmonary Rehabilitation ◽

10.1097/00008483-199509000-00064 ◽

1995 ◽

Vol 15 (5) ◽

pp. 377

Author(s):

E. Ortíz ◽

P. Femández de la Vega ◽

J. Ruíz Meza

Keyword(s):

Quality Of Life ◽

Physical Training ◽

High Intensity ◽

Coronary Patient ◽

Before And After

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Effect of a therapeutic exercise program (FisioPausa) on the quality of life of employees from CESPU

European Journal of Public Health ◽

10.1093/eurpub/ckaa040.007 ◽

2020 ◽

Vol 30 (Supplement_2) ◽

Author(s):

P Rocha ◽

F Araújo ◽

E Lafourcade ◽

N Callais ◽

M Gabriele ◽

...

Keyword(s):

Quality Of Life ◽

Mental Health ◽

Functional Capacity ◽

Exercise Program ◽

Therapeutic Exercise ◽

Before And After ◽

Health Related ◽

General Improvement ◽

Positive Effect

Abstract Introduction In the context of work, labouring time is mainly spent in the sitting position and in a continuous way. This reality contributes for the increase of a sedentary lifestyle of workers, leading to health-related diseases and consequently decreasing they quality of life (QoL). Objectives Verify the effect of a therapeutic exercise program in quality of life, and evaluate the association between different components of QoL, with back pain, physical activity and Body Mass Index (BMI). Methodology A pré-post interventional study was realized in workers from the Cooperativa de Ensino Superior Politécnico Universitário. Fourteen participants were included and submitted to evaluations with a preliminary survey, the SF-36v2 (before and after 8 weeks of intervention) to assess the effects of the program in QoL. All the participants were submitted to a specific therapeutic exercise program of 20 minutes, twice a week, and during 8 weeks. Results There was a general improvement in Health-Related Physical and Mental Quality of Life. These improvements were especially observed in the functional capacity with a higher median of 5.00 (p = 0,015). Although it was less evident, Vitality was the domain with higher improvements amongst all the four Mental domains (increase of 10.00 points across time, p = 0.341). Associations were observed between pain and functional capacity (p = 0,027) BMI and Mental Health (p = 0,027) and finally between Age and Mental Health (p = 0,028). Conclusion Our therapeutic exercise program seems to have positive effect on quality of life, especially regarding functional capacity of workers. Participants with the highest pain were associated with decreased functional capacity and older people or those with higher BMI showed weaker mental health.

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153 Quality of life in typical atrial flutter patients before and after radiofrequency catheter ablation using irrigational and conventional techniques

EP Europace ◽

10.1016/s1099-5129(05)80070-4 ◽

2005 ◽

Vol 7 ◽

pp. 25-25

Keyword(s):

Quality Of Life ◽

Catheter Ablation ◽

Atrial Flutter ◽

Radiofrequency Catheter Ablation ◽

Typical Atrial Flutter ◽

Before And After

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Strategic Role of Zakat in Multidimensional Quality of Life in Sijunjung, Indonesia

The Journal of Muamalat and Islamic Finance Research ◽

10.33102/jmifr.v15i1.101 ◽

2018 ◽

Vol 15 (1) ◽

pp. 55-72

Author(s):

Herlin Hamimi ◽

Abdul Ghafar Ismail ◽

Muhammad Hasbi Zaenal

Keyword(s):

Quality Of Life ◽

Positive Impact ◽

Wealth Distribution ◽

Absolute Poverty ◽

Before And After ◽

The Status ◽

Being There ◽

The Impact

Zakat is one of the five pillars of Islam which has a function of faith, social and economic functions. Muslims who can pay zakat are required to give at least 2.5 per cent of their wealth. The problem of poverty prevalent in disadvantaged regions because of the difficulty of access to information and communication led to a gap that is so high in wealth and resources. The instrument of zakat provides a paradigm in the achievement of equitable wealth distribution and healthy circulation. Zakat potentially offers a better life and improves the quality of human being. There is a human quality improvement not only in economic terms but also in spiritual terms such as improving religiousity. This study aims to examine the role of zakat to alleviate humanitarian issues in disadvantaged regions such as Sijunjung, one of zakat beneficiaries and impoverished areas in Indonesia. The researcher attempted a Cibest method to capture the impact of zakat beneficiaries before and after becoming a member of Zakat Community Development (ZCD) Program in material and spiritual value. The overall analysis shows that zakat has a positive impact on disadvantaged regions development and enhance the quality of life of the community. There is an improvement in the average of mustahik household incomes after becoming a member of ZCD Program. Cibest model demonstrates that material, spiritual, and absolute poverty index decreased by 10, 5, and 6 per cent. Meanwhile, the welfare index is increased by 21 per cent. These findings have significant implications for developing the quality of life in disadvantaged regions in Sijunjung. Therefore, zakat is one of the instruments to change the status of disadvantaged areas to be equivalent to other areas.

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