scholarly journals Excessive Daytime Sleepiness Is Associated With Non-motor Symptoms of Multiple System Atrophy: A Cross-Sectional Study in China

2022 ◽  
Vol 12 ◽  
Author(s):  
Hui Wang ◽  
Xiangdong Tang ◽  
Junying Zhou ◽  
Yanming Xu
Keyword(s):  
Risk Factors ◽  
Multiple System Atrophy ◽  
Excessive Daytime Sleepiness ◽  
Disease Duration ◽  
Cross Sectional Study ◽  
Motor Dysfunction ◽  
Motor Symptoms ◽  
Sectional Study ◽  
Cross Sectional ◽  
Non Motor Symptoms

Objectives: Excessive daytime sleepiness (EDS) in multiple system atrophy (MSA) has received scant attention in the literature, thus the present cross-sectional study aimed to investigate the prevalence of EDS and its potential risk factors among Chinese patients with MSA.Methods: A total of 66 patients with MSA (60.6% males) were consecutively recruited. Eighteen patients (27.3%, 13 men) with Epworth Sleepiness Scale score >10 were defined as having EDS. Demographic, motor [Unified Multiple-System Atrophy (UMSARS)] and non-motor symptoms [Non-Motor Symptoms Scale (NMSS)], and sleep parameters [polysomnography (PSG)] were compared between patients with MSA with and without EDS. A logistic regression analysis was used to calculate the risk factors of EDS in patients with MSA.Results: There were no significant differences in age, sex, MSA onset age, disease duration, MSA sub-type, and motor symptom severity between MSA patients with and without EDS. However, compared with the MSA patients without EDS, their counterparts with EDS had higher scores of NMSS (65.3 ± 23.1 vs. 43.4 ± 25.3, P = .0002), Hamilton Anxiety (HAMA) [15.3 (10.3–20.0) vs. 9.5 (3.0–15.0), P = 0.006], Hamilton Depression (HAMD) [13.7 (12.5–17.8) vs. 9.0 (4.0–13.0), P = 0.015], and Fatigue Severity Scale (FSS) [29.8 (17.3–47.8) vs. 18.7 (10.3–21.8), P = 0.040]. Conversely, the patients with EDS had lower score of Mini-Mental State Examination (MMSE) [23.3 (20.3–27.0) vs. 25.7 (22.0–29.0), P = 0.023]. Similarly, there was a significantly lower percentage of N3 sleep (%) [0.3 (0–0) vs. 2.0 (0–0), P = 0.007] and a higher apnea-hypopnea index (AHI/h) [30.5 (14.5–47.8) vs. 19.3 (5.0–28.7), P = 0.034] in patients with EDS. After adjusting for age, sex, disease duration, MSA sub-type, and UMSARS score, the odds ratio (OR) (95% CI) of EDS was higher while increasing scores in FSS [1.06 (1.02–1.11)], HAMA [1.16 (1.04–1.28)], HAMD [1.13 (1.02–1.25)], NMSS [1.04 (1.01–1.07)], and AHI [1.03 (1.00–1.10)]. The OR of EDS was lower while the MMSE score was increasing [0.85 (0.72–1.00)].Conclusions: The presence and severity of EDS may be significantly associated with the non-motor dysfunction, including fatigue, anxiety, depression, cognitive dysfunction, and sleep-related breathing disorder, but not with the motor dysfunction in MSA.

scholarly journals Prevalence and Associated Factors of Diabetic Retinopathy in Quzhou, China: A Cross-Sectional Study

2021 ◽  
Author(s):  
Zian Cheng ◽  
Xianchen Jiang ◽  
Weifen Zhu ◽  
Xinxin Zhang ◽  
Xiaofang Ying ◽  
...  
Keyword(s):  
Risk Factors ◽  
Diabetic Retinopathy ◽  
Disease Duration ◽  
Cross Sectional Study ◽  
Zhejiang Province ◽  
Sectional Study ◽  
Good Glycemic Control ◽  
Cross Sectional ◽  
Duration Of Diabetes ◽  
High Risk Factors

Abstract Objectives To assess the prevalence and risk factors for fundus status among patients with type 2 diabetes mellitus (T2DM) using fundus screening in four towns of Quzhou city, Zhejiang province of China. Methods This cross-sectional study included 230 T2DM patients of four towns in Quzhou city, Zhejiang province of China. Participants were examined for the diabetes related fundus abnormalities and possible risk factors. Results Almost half of the T2DM patients (53.04%) reported with diabetic retinopathy (DR). Patients with diabetic retinopathy had longer duration of diabetes (P < 0.001) and higher HbA1c (P < 0.01). Risk factors for development of diabetic retinopathy included duration of diabetes and HbA1c. The prevalence of DR increased with the prolongation of the disease duration. The prevalence of DR was 28.79% in the group of disease duration < 5 years, 46.25% in the group of disease duration 5–10 years, 72.92% in the group of disease duration 10–15 years and 88.57% in the group of disease duration ≥ 15 years. What’s more, the prevalence of DR also increased with the increment of HbA1c levels. The prevalence of DR was 44.62% in the group of HbA1c < 7%, 53.13% in the group of HbA1c 7%-8%, 62.92% in the group of HbA1c ≥ 8%. Conclusion The prevalence of DR was disturbingly high. Risk factors for DR were similar to other studies and included duration of diabetes and HbA1c. Thus, good glycemic control remains the core foundation of managing DR.

Association among type D personality, non-motor symptoms, and quality of life in Parkinson's disease: A cross-sectional study

2017 ◽  
Vol 38 (5) ◽  
pp. 431-436 ◽  
Author(s):  
Sung Reul Kim ◽  
Ji Young Kim ◽  
Hyun Kyung Kim ◽  
Kyeung Eun Lim ◽  
Mi Sun Kim ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Cross Sectional Study ◽  
Type D Personality ◽  
Motor Symptoms ◽  
Sectional Study ◽  
Cross Sectional ◽  
Type D ◽  
Non Motor Symptoms

P1.171 Evolving non-motor symptoms in Parkinson disease patients. A cross-sectional study

2009 ◽  
Vol 15 ◽  
pp. S73
Author(s):  
L. Vela ◽  
M.D. Martin Rios ◽  
M. Baron ◽  
F.J. Barriga ◽  
J.L. Dobato ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Cross Sectional Study ◽  
Motor Symptoms ◽  
Sectional Study ◽  
Cross Sectional ◽  
Non Motor Symptoms

PRRSV: Risikofaktoren und Herdenprävalenz in Deutschland

2019 ◽  
Vol 47 (02) ◽  
pp. 132-132
Author(s):  
Sebastian Ganz
Keyword(s):  
Risk Factors ◽  
Cross Sectional Study ◽  
Respiratory Syndrome Virus ◽  
Sectional Study ◽  
Cross Sectional ◽  
Klinische Symptome

Nathues C, Janssen E, Duengelhoef A et al. Cross-sectional study on risk factors for Porcine Reproductive and Respiratory Syndrome virus sow herd instability in German breeding herds. Acta Vet Scand 2018; 60 (1): 1–8 In mit PRRSV (Porcine Reproductive and Respiratory Syndrom Virus) infizierten Schweinebeständen zeigen die Tiere oftmals ernsthafte klinische Symptome. Die Schwere der Symptomatik hängt von der Virulenz der jeweiligen Virusstämme ab. Deshalb ist die Impfung gegen diesen Erreger sinnvoll und wird empfohlen, auch wenn sie nicht immer klinische Fälle verhindert bzw. das Virus vollends eliminiert. Aufgrund dessen rückt die Prävention durch Verbesserung der innerbetrieblichen Abläufe zunehmend in den Fokus. Um solche Maßnahmen erfolgreich etablieren zu können, ist es wichtig, den epidemiologischen Status der Herde und mögliche Risikofaktoren zu kennen. Ziel der Studie war deshalb, die Prävalenz der Infektion in Sauenbetrieben in Norddeutschland zu eruieren und verschiedene Arbeitsabläufe hinsichtlich des Risikos der Erregerverbreitung zu untersuchen.

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