scholarly journals Case Report: Ninjin'yoeito May Improve Quality of Life After Hospitalization for Acute Illness in Patients With Frailty

2021 ◽  
Vol 8 ◽  
Author(s):  
Masayuki Kashima
Keyword(s):  
Quality Of Life ◽  
Short Form ◽  
Acute Illness ◽  
Chronic Obstructive ◽  
Total Quality ◽  
Obstructive Pulmonary Disease ◽  
Frail Patients ◽  
Traditional Japanese Medicine ◽  
Sf 36

Introduction: Frail patients are susceptible to a large number of diseases, and frailty particularly is known to develop after acute illness. No conventional drugs are known to prevent such exacerbation after acute illness. However, traditional Japanese medicine, Kampo, is thought to confer efficacious energy and nutritional supplements and serve to improve malaise after acute illness. Ninjin'yoeito is a representative Kampo medicine for such situation.Cases: We describe three frail patients hospitalized for acute illness who started taking ninjin'yoeito at the time of discharge.Case 1: An 87-year-old man admitted with acute prostatitis complicated by hypertension and chronic obstructive pulmonary disease (COPD). His 36-Item Short Form Health Survey (SF-36) score, which is representative of total quality of life and comprises eight components, showed consistent improvements after 4 and 12 weeks of ninjin'yoeito administration, especially for body pain (BP; scores from 41 to 51 and 100, respectively), social function (SF; 50, 100, 100), and mental health (MH; 75, 75, 90).Case 2: A 65-year-old man admitted with urinary tract infection complicated by primary sclerosing cholangitis and COPD. All SF-36 component scores showed improvement 12 weeks later: physical function (PF; 70–95), role physical (RP; 75–100), BP (72–84), general health (GH; 45–52), vitality (VT; 37.5–75), SF 75–100, role emotional (RE; 75–100), and MH (70–90).Case 3: An 80-year-old man admitted for pneumonia complicated with hypertension. SF-36 score was improved 4 weeks later for RP (68.8–100), BP (52–61), GH (52–72), VT (43.8–62.5), SF (37.5–100), and RE (58.3–91.7).Conclusion: Patients with frailty often have a worsened SF-36 score after discharge following acute illness, but the score may be improved by taking ninjin'yoeito.

scholarly journals Haemoglobin as a biomarker for clinical outcomes in chronic obstructive pulmonary disease

2021 ◽  
pp. 00068-2021
Author(s):  
Aparna Balasubramanian ◽  
Robert J. Henderson ◽  
Nirupama Putcha ◽  
Ashraf Fawzy ◽  
Sarath Raju ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Obstructive Pulmonary Disease ◽  
Physical Health ◽  
Pulmonary Disease ◽  
Functional Performance ◽  
Chronic Obstructive ◽  
Diffusing Capacity ◽  
Obstructive Pulmonary Disease ◽  
Sf 36

In Chronic Obstructive Pulmonary Disease (COPD), anaemia is associated with increased morbidity, but the relationship between haemoglobin over its entire observed range and morbidity is poorly understood. Such an understanding could guide future therapeutic targeting of haemoglobin in COPD management. Leveraging the COPDGene® study, we conducted a cross-sectional analysis of haemoglobin from COPD participants, examining symptoms, quality of life, functional performance, and acute exacerbations of COPD (AECOPD). Haemoglobin was analysed both as a continuous variable and categorized into anaemia, normal haemoglobin, and polycythaemia groups. Fractional polynomial modelling was used for continuous analyses; categorical models were multivariable linear or negative binomial regressions. Covariates included demographics, comorbidities, emphysema, diffusing capacity, and airflow obstruction. From 2539 participants, 366(14%) were identified as anaemic and 125(5%) as polycythaemic. Compared to normal haemoglobin, anaemia was significantly associated with increased symptoms (CAT score: p=0.006, mMRC: p=0.001), worse quality of life (SGRQ score: p<0.001, SF-36 General Health: p=0.002, SF-36 Physical Health: p<0.001), decreased functional performance (6MWD: p<0.001), and severe AECOPD (p=0.01), while polycythaemia was not. Continuous models however demonstrated increased morbidity at both ends of the haemoglobin distribution (p<0.01 for mMRC, SGRQ, SF-36 Physical Health, 6MWD, and severe AECOPD). Evaluating interactions, both diffusing capacity and haemoglobin were independently associated with morbidity. We present novel findings that haemoglobin derangements towards either extreme of the observed range are associated with increased morbidity in COPD. Further investigation is necessary to determine whether haemoglobin derangement drives morbidity or merely reflects systemic inflammation and whether correcting haemoglobin towards the normal range improves morbidity.

scholarly journals COMPARATIVE STUDY OF THE IMPACT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE ON THE QUALITY OF LIFE OF PATIENTS WITH PULMONARY TUBERCULOSIS BASED ON THE MOS SF-36 QUESTIONNAIRE

2021 ◽  
Vol 14 (3) ◽  
pp. 63-69
Author(s):  
MARAT F. YAUSHEV ◽  
◽  
ALEXEY P. ALEXEEV ◽  
ILGIZYAR F. MAKHMUTOV ◽  
BORIS M. PETROV ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Tuberculosis ◽  
Pulmonary Disease ◽  
Negative Impact ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Sf 36 ◽  
The Impact

Pulmonary tuberculosis (TBL), as well as chronic obstructive pulmonary disease (COPD), have a diverse negative impact on the quality of life (QOL) of patients. In this regard, a detailed study of the quality of life of patients with pulmonary tuberculosis in combination with chronic obstructive pulmonary disease retains its importance and relevance.

scholarly journals Evaluation of the quality of life in patients with chronic obstructive pulmonary disease in combination with cardiovascular disease.

2017 ◽  
Vol 95 (7) ◽  
pp. 629-633
Author(s):  
A. A. Nizov ◽  
V. N. Abrosimov ◽  
Anna N. Vyunova ◽  
I. B. Ponomareva
Keyword(s):  
Quality Of Life ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Bodily Pain ◽  
Well Being ◽  
Role Playing ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Sf 36

This article reports the results of evaluation of the quality of life in patients with chronic obstructive pulmonary disease (COPD) and its combination with coronary heart disease (CHD) or essential hypertension (HD) based on the SF-36 questionnaire designed for the non-specific assessment of the patient's quality of life and widely used in clinical studies to characterize theirgeneral well-being and the degree of satisfaction with those aspects of human activity that affect health. SF-36 consists of 36 questions, grouped into eight scales: physical functioning, role-playing activity, bodily pain, general health, vitality, social functioning, emotional well-being and mental health. The scales are combined in such a way that the higher the value (from 0 to 100) the better results of evaluation based on a given scale. They were used to derive two parameters characterizing psychological and physical components of health.

Generic versus Disease-specific Instruments in Quality-of-life Assessment of Chronic Obstructive Pulmonary Disease

2006 ◽  
Vol 45 (02) ◽  
pp. 211-215 ◽  
Author(s):  
V. Vondra ◽  
M. Malý
Keyword(s):  
Quality Of Life ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Well Being ◽  
Life Assessment ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Sf 36 ◽  
Disease Specific

Summary Objectives: Chronic respiratory diseases may alter a patient’s social life and well-being. Measures of health-related quality of life have been proven to bring complementary information to functional assessments. The aim of the study was to describe the questionnaires that are most frequently used to measure this subjective construct in patients with chronic obstructive pulmonary disease (COPD) and to compare the responses obtained via administering one generic (SF-36) and one disease-specific questionnaire (St. George’s Respiratory Questionnaire; SGRQ) to patients with COPD. Methods: One group of patients (46 individuals) was used to evaluate the questionnaire’s performance in repeated administrations under unchanged conditions (reproducibility) and to study the correlations of corresponding domains of respective questionnaires. Responsiveness of both questionnaires was tested on another group of 129 patients measured before and after the therapeutic stay at the spa. Methods of cor-relational analysis (Spearman, intraclass, and canonical correlation coefficients) as well as the Wilcoxon rank test were used for statistical analysis. Results: Both questionnaires seem to be comprehensive outcome measures for patients with COPD, but some particular areas may not be covered with the same intensity (e.g. emotional problems). Reproducibility of both questionnaires was good and only small non-significant shifts were seen, particularly in physical and social functioning domains. In repeated measurement, the SGRQ seemed to be slightly more responsive to change than the SF-36. Conclusions: The idea of using generic and disease-specific questionnaires together probably represents the best approach to this topic. It may improve our knowledge and explain better the relationship between disease-specific changes in patient status and both disease-specific treatment and general functional status.

scholarly journals Depression is a major determinant of both disease-specific and generic health-related quality of life in people with severe COPD

2018 ◽  
Vol 16 ◽  
pp. 147997231877542 ◽  
Author(s):  
Sun Mi Jang ◽  
Ki Uk Kim ◽  
Hae Jung Na ◽  
Seung Eun Song ◽  
Sang Hee Lee ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Short Form ◽  
Chronic Obstructive ◽  
Health Related Quality ◽  
Sf 36 ◽  
Related Quality ◽  
Health Related ◽  
Severe Copd ◽  
Disease Specific

The quality of life of patients with chronic obstructive pulmonary disease (COPD) decreases significantly as the disease progresses; those with severe COPD are affected most. This article investigates predictors of the disease-specific and generic health-related quality of life (HRQL) in patients with severe COPD. This multicentre prospective cross-sectional study enrolled 80 patients with severe COPD. At enrolment, all patients completed a disease-specific instrument, the St George’s Respiratory Questionnaire (SGRQ), and a generic instrument, the Short Form 36 Health Survey Questionnaire (SF-36). The data were analyzed by Pearson’s correlation and multiple linear regression. The mean age of the patients was 66 ± 8 years; 93% were males. The SGRQ and SF-36 scores were not influenced by age or sex. Depression, dyspnea, the number of exacerbations, and exercise capacity significantly predicted the total SGRQ score ( p < 0.05). Depression was the strongest determinant of the total SGRQ score. The SF-36 physical component summary scores were related to depression, dyspnea, and the number of exacerbations ( p < 0.05). In comparison, the SF-36 mental component summary scores were related to depression and anxiety ( p < 0.05). Depression is a significant determinant of both the disease-specific and generic HRQL in patients with severe COPD. Screening and early intervention for depression in patients with severe COPD could improve the HRQL.

Quality of life of patients with Sjogren’s disease with ongoing therapy with diseasemodifying antirheumatic drugs

2020 ◽  
pp. 33-38
Author(s):  
E. Yu. Gan ◽  
L. P. Evstigneeva
Keyword(s):  
Quality Of Life ◽  
Short Form ◽  
Life Quality ◽  
Well Being ◽  
Disease Modifying Antirheumatic Drugs ◽  
Antirheumatic Drugs ◽  
Sf 36 ◽  
Disease Modifying ◽  
Sjögren’S Disease

Purpose of the study. Assessing the association between the life quality of patients with Sjogren’s Disease and ongoing therapy with various disease-modifying antirheumatic drugs.Material and methods. The study was conducted on the basis of the regional rheumatology center of the consultative diagnostic clinic of the Sverdlovsk Regional Clinical Hospital No. 1. This work is based on the results of a simultaneous study of 74 patients with primary Sjogren’s Disease (SD), distributed in three comparison groups receiving various disease-modifying antirheumatic drugs chlorambucil, methotrexate and hydroxychloroquine. The diagnosis of SD was carried out according to European-American criteria AECGC (2002) [18]. In order to analyze the quality of life of patients with SD, the 36-Item Short Form Health Survey (SF‑36) was used. Statistical data processing was carried out using Statistica 7.0 program.Results. Assessment of the quality of life of patients with SD, which is an integrative criterion of human health and well-being, revealed the absence of statistically significant differences (p > 0.05) on eight scales and two health components of the SF‑36 questionnaire in the analyzed groups that differ in the treatment of disease-modifying antirheumatic drugs chlorambucil, methotrexate and hydroxychloroquine.Conclusions. The obtained data indicate an equivalent quality of life in SD patients treated with different disease-modifying antirheumatic drugs methotrexate, chlorambucil and hydroxychloroquine, and therefore hydroxychloroquine can be considered as an alternative basic therapy in patients with SD with certain limitations and contraindications methotrexate and chlorambucil.

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