scholarly journals Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications

2021 ◽  
Vol 11 ◽  
Author(s):  
Hui Wang ◽  
Hongyi Zhang ◽  
Yihao Zhu ◽  
Zhonghang Wu ◽  
Chunhong Cui ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Clinical Applications ◽  
Therapeutic Drug ◽  
Invasion And Migration ◽  
Tumor Growth And Metastasis ◽  
And Migration ◽  
Prevent Tumor Growth ◽  
Inhibit Cell Proliferation

Breast cancer (BC) is the most frequent cancer among women worldwide and is the leading cause of cancer-related deaths in women. Cancer cells with stem cell-like features and tumor-initiating potential contribute to drug resistance, tumor recurrence, and metastasis. To achieve better clinical outcomes, it is crucial to eradicate both bulk BC cells and breast cancer stem cells (BCSCs). Salinomycin, a monocarboxylic polyether antibiotic isolated from Streptomyces albus, can precisely kill cancer stem cells (CSCs), particularly BCSCs, by various mechanisms, including apoptosis, autophagy, and necrosis. There is increasing evidence that salinomycin can inhibit cell proliferation, invasion, and migration in BC and reverse the immune-inhibitory microenvironment to prevent tumor growth and metastasis. Therefore, salinomycin is a promising therapeutic drug for BC. In this review, we summarize established mechanisms by which salinomycin protects against BC and discuss its future clinical applications.

scholarly journals Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis

Oncogene ◽  
2020 ◽  
Vol 39 (42) ◽  
pp. 6589-6605
Author(s):  
Daniel Doheny ◽  
Sherona Sirkisoon ◽  
Richard L. Carpenter ◽  
Noah Reeve Aguayo ◽  
Angelina T. Regua ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Tumor Growth ◽  
Breast Cancer Stem Cells ◽  
Tumor Growth And Metastasis

scholarly journals Role of ADAM17 in invasion and migration of CD133-expressing liver cancer stem cells after irradiation

Oncotarget ◽  
2016 ◽  
Vol 7 (17) ◽  
pp. 23482-23497 ◽  
Author(s):  
Sung Woo Hong ◽  
Wonhee Hur ◽  
Jung Eun Choi ◽  
Jung-Hee Kim ◽  
Daehee Hwang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Invasion And Migration ◽  
Liver Cancer Stem Cells ◽  
And Migration

scholarly journals MicroRNA-1 down-regulates proliferation and migration of breast cancer stem cells by inhibiting the Wnt/β-catenin pathway

Oncotarget ◽  
2015 ◽  
Vol 6 (39) ◽  
pp. 41638-41649 ◽  
Author(s):  
Tong Liu ◽  
Kebang Hu ◽  
Zuowei Zhao ◽  
Guanglei Chen ◽  
Xunyan Ou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Breast Cancer Stem Cells ◽  
And Migration ◽  
Proliferation And Migration

Eradicating the Roots: Advanced Therapeutic Approaches Targeting Breast Cancer Stem Cells

2020 ◽  
Vol 26 (17) ◽  
pp. 2009-2021 ◽  
Author(s):  
Lili He ◽  
Anran Yu ◽  
Li Deng ◽  
Hongwei Zhang
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Tumor Biology ◽  
Therapeutic Strategies ◽  
Proliferative Potential ◽  
Cancer Therapies ◽  
Breast Cancer Stem Cells ◽  
Self Renewal ◽  
Invasion And Migration

Accumulating evidences have demonstrated that the existence of breast cancer-initiating cells, which drives the original tumorigenicity, local invasion and migration propensity of breast cancer. These cells, termed as breast cancer stem cells (BCSCs), possess properties including self-renewal, multidirectional differentiation and proliferative potential, and are believed to play important roles in the intrinsic drug resistance of breast cancer. One of the reasons why BCBCs cause difficulties in breast cancer treating is that BCBCs can control both genetic and non-genetic elements to keep their niches safe and sound, which allows BCSCs for constant self-renewal and differentiation. Therapeutic strategies designed to target BCSCs may ultimately result in effective interventions for the treatment of breast cancer. Novel strategies including nanomedicine, oncolytic virus therapy, immunotherapy and induced differentiation therapy are emerging and proved to be efficient in anti-BCSCs therapy. In this review, we summarized breast tumor biology and the current challenges of breast cancer therapies, focused on breast cancer stem cells, and introduced promising therapeutic strategies targeting BCSCs.

E2F3 drives the epithelial-to-mesenchymal transition, cell invasion, and metastasis in breast cancer

2021 ◽  
pp. 153537022110356
Author(s):  
Shirley Jusino ◽  
Yainyrette Rivera-Rivera ◽  
Camille Chardón-Colón ◽  
Armando J Ruiz-Justiz ◽  
Jaleisha Vélez-Velázquez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Invasion ◽  
Epithelial To Mesenchymal Transition ◽  
Chromosome Instability ◽  
Metastatic Potential ◽  
Metastatic Progression ◽  
Mesenchymal Transition ◽  
Invasion And Migration ◽  
Tumor Growth And Metastasis ◽  
And Migration

E2F3 is a transcription factor that may initiate tumorigenesis if overexpressed. Previously, we demonstrated that E2F3 mRNA is overexpressed in breast cancer and that E2F3 overexpression results in centrosome amplification and unregulated mitosis, which can promote aneuploidy and chromosome instability to initiate and sustain tumors. Further, we demonstrated that E2F3 leads to overexpression of the mitotic regulator Shugoshin-1, which until recently had unknown roles in cancer. This study aims to evaluate the roles of E2F3 and Shugoshin-1 in breast cancer metastatic potential. Here we demonstrated that E2F3 and Shugoshin-1 silencing leads to reduced cell invasion and migration in two mesenchymal triple-negative breast cancer (TNBC) cell lines (MDA-MB-231 and Hs578t). Moreover, E2F3 and Shugoshin-1 modulate the expression of epithelial-to-mesenchymal transition-associated genes such as Snail, E-Cadherin, and multiple matrix metalloproteinases. Furthermore, E2F3 depletion leads to reductions in tumor growth and metastasis in NOD- scid Gamma mice. Results from this study suggest a key role for E2F3 and a novel role for Shugoshin-1 in metastatic progression. These results can further help in the improvement of TNBC targeted therapies by interfering with pathways that intersect with the E2F3 and Shugoshin-1 signaling pathways.

scholarly journals The potential therapeutic effect of melatonin on human ovarian cancer by inhibition of invasion and migration of cancer stem cells

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Maryam Akbarzadeh ◽  
Ali Akbar Movassaghpour ◽  
Hossein Ghanbari ◽  
Maryam Kheirandish ◽  
Nazila Fathi Maroufi ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Therapeutic Effect ◽  
Human Ovarian Cancer ◽  
Invasion And Migration ◽  
And Migration
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