scholarly journals Case Report: Pulmonary Metastases From Epithelioid Sarcoma in Extremity Favourably Responding to Immunotherapy With Camrelizumab

2021 ◽  
Vol 11 ◽  
Author(s):  
Tao-Jun Gong ◽  
Fan Tang ◽  
Chuan-Xi Zheng ◽  
Jie Wang ◽  
Yi-Tian Wang ◽  
...  
Keyword(s):  
Local Recurrence ◽  
Lymph Nodes ◽  
Pulmonary Metastases ◽  
Epithelioid Sarcoma ◽  
Wound Dehiscence ◽  
Left Knee ◽  
Extensive Resection ◽  
Inguinal Lymph Nodes ◽  
Lymph Nodes Dissection ◽  
Alternative Choice

Epithelioid sarcoma (ES) is a rare soft tissue sarcoma (STS), with limited therapies available for metastatic disease. Here, we describe a case of a 30-year-old male with ES of the left knee and underwent surgery and radiation therapy for the primary disease. After 2 years, he had local recurrence and underwent extensive resection surgery; however, adjuvant chemotherapies were delayed due to recurrent wound infection. Nine months after the second surgery, progressive disease was confirmed after detection of metastases to the lungs and inguinal lymph nodes. Amputation was performed for the local recurrence, followed by inguinal lymph nodes dissection. Pazopanib was transiently administered but discontinued as a result of wound dehiscence. The tumour specimens were detected with unexpected high level of PD-L1 expression and tumoural infiltrating lymphocytes. Subsequently, he received camrelizumab 2.0 mg/kg every 21 days for 18 cycles with rapid remission of the pulmonary metastases. This promising response to camrelizumab indicates that immunotherapies may be an alternative choice for patients with metastatic ES in lung based on analysing the tumour immune microenvironment.

scholarly journals Clear Cell Carcinoma of the Abdominal Wall as a Rare Complication of General Obstetric and Gynecologic Surgeries: 15 Years of Experience at a Large Academic Institution

2019 ◽  
Vol 16 (4) ◽  
pp. 552 ◽  
Author(s):  
Yen-Ling Lai ◽  
Heng-Cheng Hsu ◽  
Kuan-Ting Kuo ◽  
Yu-Li Chen ◽  
Chi-An Chen ◽  
...  
Keyword(s):  
Adjuvant Chemotherapy ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Abdominal Wall ◽  
Surgical Intervention ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Primary Treatment ◽  
Inguinal Lymph Nodes ◽  
Lymph Nodes Dissection

The objective of this article was to report the clinicopathological characteristics, treatment modalities, and outcomes of patients with clear cell carcinoma (CCC) of the abdominal wall. Medical records of six patients diagnosed with CCC of the abdominal wall between May 2003 and May 2018 at the National Taiwan University Hospital were reviewed. All patients had prior obstetric or gynecologic surgeries. The primary clinical presentation was enlarging abdominal masses at previous surgical scars. Four patients underwent initial/primary surgeries with/without adjuvant chemotherapy. One patient received neoadjuvant chemotherapy followed by surgical intervention and adjuvant chemotherapy, the other received chemotherapy and sequential radiotherapy without any surgical intervention. Two of four patients undergoing initial/primary surgeries had disease recurrence and the remaining two cases without initial surgery experienced disease progression during primary treatment. Inguinal lymph nodes were the most frequent sites of recurrence. In conclusion, previous obstetric or gynecologic surgery can be a risk factor for CCC of the abdominal wall. Complete resection of abdominal wall tumor and suspected intra-abdominal lesions with hysterectomy and bilateral inguinal lymph nodes dissection may be the primary treatment. Adjuvant chemotherapy would be considered for potential benefits. For patients without bilateral inguinal lymph nodes dissection, careful inguinal lymph node palpation during postoperative surveillance is necessary. More cases are still needed to elucidate the clinical management of this disease.

scholarly journals A Malignant Melanoma of the Penile : A Very Rare Case Report and Literature Review

2021 ◽  
Vol 8 (1) ◽  
pp. 124-128
Author(s):  
Yanuar Hendra Wijaya ◽  
Nanda Daniswara ◽  
Ardy Santosa ◽  
Mohamad Adi Soedarso ◽  
Eriawan Agung Nugroho ◽  
...  
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
Physical Examination ◽  
Lymph Nodes ◽  
Vital Signs ◽  
Surgical Excision ◽  
Primary Treatment ◽  
Inguinal Lymph Nodes ◽  
Rare Case Report ◽  
Lymph Nodes Dissection

Background: Malignant melanoma of the penis is very rare, accounting for approximately 1.4% of all primary penile carcinomas. With a small prevalence of penile melanoma, there is lack of data about quality of the therapy. The primary treatment of melanoma of the penile is surgical, although there is a lack of consensus regarding the extent of treatment that is indicated. Case Report: A 60-year-old Caucasian man came to Division of Urology, Department of Surgery, Dr. Kariadi General Hospital Semarang with chief complaint painless and fast growing lesions on his penile. His general condition was fine, and has a normal vital signs. On the physical examination of penile region, there were found lesions on the ventral of the glans and penile foreskin and covered with blood and pus, with bilateral inguinal lymph nodes and lung metastasis from Multi Slice Computed Tomography. We already performed partial penectomy and bilateral inguinal lymph nodes dissection with histopathological results a malignant melanoma Clark IV. The final stage of penile melanoma was pT2N1M1. We follow-up the patient until 1 year after procedure, and there wasn’t any recurrence. Conclusion: Malignant melanoma of the penis is rare. Penile melanoma is highly treatable with surgical excision in its early stages because of resistant to both chemotherapy and radiotherapy. Delay in diagnosed and surgical treatment can lead to an adverse prognosis. The anamnesis, physical examination, and imaging studies must be done appropriately to improve the survival.

scholarly journals Videoendoscopic Inguinal Lymph Node Dissection: Our First Experience

2019 ◽  
Vol 13 (1) ◽  
pp. 21
Author(s):  
Rinto Hariwibowo ◽  
Agus Rizal Hamid ◽  
Chaidir Arif Mochtar ◽  
Rainy Umbas
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Inguinal Lymph Node ◽  
Open Approach ◽  
Inguinal Lymph Node Dissection ◽  
Inguinal Lymph Nodes ◽  
Lymph Nodes Dissection

Background: Inguinal lymph nodes dissection has been the mainstay treatment for penile squamous cell carcinoma with resectable inguinal lymph nodes metastasis. Traditionally, inguinal lymph node dissections were performed with a classical open approach with high complications and morbidity rate. We are reporting our first experience with videoendoscopic inguinal lymph nodes dissection as an alternative to the classic open approach in our center.Case Presentation: This article reports a case of squamous cell carcinoma of the penis. A case report of post partial penectomy with pT3N2M0 squamous cell carcinoma of the penis and palpable bilateral inguinal lymph nodes in a 52-year-old male. In this patient, we perform our first experience with videoendoscopic inguinal lymph nodes dissection as an alternative to the traditional classic open approach inguinal lymph node dissections.Conclusions: Videoendoscopic approach for inguinal lymph nodes dissection in penile cancer is feasible and has been demonstrated to have a better outcome on complications & morbidity compared to the traditional open approach. In the end, we propose that the videoendoscopic approach, if available, could be the main choice for inguinal lymph nodes dissections for the future.

Radiation synovectomy of the knee joint

2006 ◽  
Vol 45 (01) ◽  
pp. 57-61
Author(s):  
M. Puille ◽  
D. Steiner ◽  
R. Bauer ◽  
R. Klett
Keyword(s):  
Knee Joint ◽  
Lymph Nodes ◽  
Geometric Mean ◽  
Radiation Synovectomy ◽  
Real Activity ◽  
Anterior View ◽  
Inguinal Lymph Nodes ◽  
The Real ◽  
Therapeutic Modalities ◽  
Real Value

Summary Aim: Multiple procedures for the quantification of activity leakage in radiation synovectomy of the knee joint have been described in the literature. We compared these procedures considering the real conditions of dispersion and absorption using a corpse phantom. Methods: We simulated different distributions of the activity in the knee joint and a different extra-articular spread into the inguinal lymph nodes. The activity was measured with a gammacamera. Activity leakage was calculated by measuring the retention in the knee joint only using an anterior view, using the geometric mean of anterior and posterior views, or using the sum of anterior and posterior views. The same procedures were used to quantify the activity leakage by measuring the activity spread into the inguinal lymph nodes. In addition, the influence of scattered rays was evaluated. Results: For several procedures we found an excellent association with the real activity leakage, shown by an r² between 0.97 and 0.98. When the real value of the leakage is needed, e. g. in dosimetric studies, simultaneously measuring of knee activity and activity in the inguinal lymph nodes in anterior and posterior views and calculation of the geometric mean with exclusion of the scatter rays was found to be the procedure of choice. Conclusion: When measuring of activity leakage is used for dosimetric calculations, the above-described procedure should be used. When the real value of the leakage is not necessary, e. g. for comparing different therapeutic modalities, several of the procedures can be considered as being equivalent.

Mediastinal Lymph Nodes Dissection under Complete VATS

2011 ◽  
Vol 62 (2) ◽  
pp. 135-135
Author(s):  
S. Yamashita ◽  
T. Hashimoto ◽  
T. Moroga ◽  
M. Kamei ◽  
K. Tokuishi ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Mediastinal Lymph Nodes ◽  
Lymph Nodes Dissection

scholarly journals Long-term survival with multiple metastasectomies for pulmonary osteosarcoma: a case report

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Satoshi Takamori ◽  
Hiroyuki Oizumi ◽  
Jun Suzuki ◽  
Katsuyuki Suzuki
Keyword(s):  
Case Report ◽  
Pulmonary Metastases ◽  
Multidisciplinary Treatment ◽  
Underlying Disease ◽  
Pulmonary Metastasectomy ◽  
Extensive Resection ◽  
Term Survival ◽  
Long Term Survival ◽  
Primary Surgery

Abstract Background Repeat pulmonary metastasectomy (PM) considerably improves the prognosis of patients with pulmonary metastases of osteosarcoma. Reports have demonstrated a significantly improved prognosis in patients who have undergone repeat metastasectomy for osteosarcoma; however, there have been no reports with more than six metastasectomies. Herein, we describe the long-term survival of a patient following resection of multiple tumors and other treatments for metastatic osteosarcoma. Case presentation A 28-year-old woman underwent extensive resection and postoperative adjuvant chemotherapy for right tibial sarcoma. Over the years, she developed repeated pulmonary metastases. First, 116 metastases were removed from the bilateral lungs. After that, multiple PMs of approximately 250 tumors and other treatments for deep metastatic lesions were performed. The patient died of the underlying disease 24 years after the primary surgery. Conclusions This case report demonstrates the long-term survival benefit of a multidisciplinary treatment centered on multiple metastasectomies.

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