scholarly journals Radiotherapy-Induced Digestive Injury: Diagnosis, Treatment and Mechanisms

2021 ◽  
Vol 11 ◽  
Author(s):  
Guangxia Chen ◽  
Yi Han ◽  
Haihan Zhang ◽  
Wenling Tu ◽  
Shuyu Zhang
Keyword(s):  
Digestive System ◽  
Volume Effect ◽  
Novel Approach ◽  
Dose Volume ◽  
Assessment And Treatment ◽  
Physical Classification ◽  
Abdominal Radiotherapy ◽  
Radiation Induced ◽  
Lesion Level ◽  
Thoracic And Abdominal

Radiotherapy is one of the main therapeutic methods for treating cancer. The digestive system consists of the gastrointestinal tract and the accessory organs of digestion (the tongue, salivary glands, pancreas, liver and gallbladder). The digestive system is easily impaired during radiotherapy, especially in thoracic and abdominal radiotherapy. In this review, we introduce the physical classification, basic pathogenesis, clinical characteristics, predictive/diagnostic factors, and possible treatment targets of radiotherapy-induced digestive injury. Radiotherapy-induced digestive injury complies with the dose-volume effect and has a radiation-based organ correlation. Computed tomography (CT), MRI (magnetic resonance imaging), ultrasound (US) and endoscopy can help diagnose and evaluate the radiation-induced lesion level. The latest treatment approaches include improvement in radiotherapy (such as shielding, hydrogel spacers and dose distribution), stem cell transplantation and drug administration. Gut microbiota modulation may become a novel approach to relieving radiogenic gastrointestinal syndrome. Finally, we summarized the possible mechanisms involved in treatment, but they remain varied. Radionuclide-labeled targeting molecules (RLTMs) are promising for more precise radiotherapy. These advances contribute to our understanding of the assessment and treatment of radiation-induced digestive injury.

scholarly journals OC-0037: Low dose volume effect is a critical determinant for radiation-induced lung fibrosis

2017 ◽  
Vol 123 ◽  
pp. S14
Author(s):  
G. Defraene ◽  
M. La Fontaine ◽  
S. Van Kranen ◽  
B. Reymen ◽  
J. Belderbos ◽  
...  
Keyword(s):  
Lung Fibrosis ◽  
Low Dose ◽  
Volume Effect ◽  
Critical Determinant ◽  
Dose Volume ◽  
Radiation Induced

scholarly journals Potential Defects and Improvements of Equivalent Uniform Dose Prediction Model Based on the Analysis of Radiation-Induced Brain Injury

2022 ◽  
Vol 11 ◽  
Author(s):  
Qing-Hua Du ◽  
Jian Li ◽  
Yi-Xiu Gan ◽  
Hui-Jun Zhu ◽  
Hai-Ying Yue ◽  
...  
Keyword(s):  
Brain Injury ◽  
Dose Distribution ◽  
Predictive Ability ◽  
Volume Effect ◽  
Equivalent Uniform Dose ◽  
Critical Dose ◽  
Dose Volume ◽  
Radiation Induced ◽  
Effect Parameter ◽  
The Impact

PurposeTo study the impact of dose distribution on volume-effect parameter and predictive ability of equivalent uniform dose (EUD) model, and to explore the improvements.Methods and MaterialsThe brains of 103 nasopharyngeal carcinoma patients treated with IMRT were segmented according to dose distribution (brain and left/right half-brain for similar distributions but different sizes; VD with different D for different distributions). Predictive ability of EUDVD (EUD of VD) for radiation-induced brain injury was assessed by receiver operating characteristics curve (ROC) and area under the curve (AUC). The optimal volume-effect parameter a of EUD was selected when AUC was maximal (mAUC). Correlations between mAUC, a and D were analyzed by Pearson correlation analysis. Both mAUC and a in brain and half-brain were compared by using paired samples t-tests. The optimal DV and VD points were selected for a simple comparison.ResultsThe mAUC of brain/half-brain EUD was 0.819/0.821 and the optimal a value was 21.5/22. When D increased, mAUC of EUDVD increased, while a decreased. The mAUC reached the maximum value when D was 50–55 Gy, and a was always 1 when D ≥55 Gy. The difference of mAUC/a between brain and half-brain was not significant. If a was in range of 1 to 22, AUC of brain/half-brain EUDV55 Gy (0.857–0.830/0.845–0.830) was always larger than that of brain/half-brain EUD (0.681–0.819/0.691–0.821). The AUCs of optimal dose/volume points were 0.801 (brain D2.5 cc), 0.823 (brain V70 Gy), 0.818 (half-brain D1 cc), and 0.827 (half-brain V69 Gy), respectively. Mean dose (equal to EUDVD with a = 1) of high-dose volume (V50 Gy–V60 Gy) was superior to traditional EUD and dose/volume points.ConclusionVolume-effect parameter of EUD is variable and related to dose distribution. EUD with large low-dose volume may not be better than simple dose/volume points. Critical-dose-volume EUD could improve the predictive ability and has an invariant volume-effect parameter. Mean dose may be the case in which critical-dose-volume EUD has the best predictive ability.

scholarly journals Radiation-Induced Ocular Surface Disorders and Retinopathy: Ocular Structures and Radiation Dose-Volume Effect

2021 ◽  
Author(s):  
Ozlem Ozkaya Akagunduz ◽  
Suzan Guven Yilmaz ◽  
Emin Tavlayan ◽  
Mine Esen Baris ◽  
Filiz Afrashi ◽  
...  
Keyword(s):  
Radiation Dose ◽  
Ocular Surface ◽  
Volume Effect ◽  
Dose Volume ◽  
Radiation Induced

PO-1817: Kinetics and dose-volume effect of radiotherapy on leucocyte and platelet blood cell components

2020 ◽  
Vol 152 ◽  
pp. S1013-S1014
Author(s):  
C. Terrones Campos ◽  
B. Ledergerber ◽  
I. Vogelius ◽  
M. Helleberg ◽  
L. Specht ◽  
...  
Keyword(s):  
Blood Cell ◽  
Volume Effect ◽  
Dose Volume ◽  
Cell Components

OC-1045: Dose-volume effect relationships for rectal morbidity after brachytherapy for pediatric cancers.

2020 ◽  
Vol 152 ◽  
pp. S1096-S1097
Author(s):  
E. Romano ◽  
R. Simon ◽  
V. Martin ◽  
S. Bolle ◽  
M. Andraud ◽  
...  
Keyword(s):  
Volume Effect ◽  
Pediatric Cancers ◽  
Dose Volume

Dose Volume Parameter Analysis on Late Radiation Induced Pericardial Effusion

2015 ◽  
Vol 93 (3) ◽  
pp. E162
Author(s):  
Q. Liu ◽  
J. Wang ◽  
Y. Wang ◽  
Y.J. Wu ◽  
N. Li ◽  
...  
Keyword(s):  
Pericardial Effusion ◽  
Parameter Analysis ◽  
Dose Volume ◽  
Radiation Induced

scholarly journals Coconut Oil as a Novel Approach to Managing Radiation-Induced Xerostomia: A Primary Feasibility Study

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Alexandra E. Quimby ◽  
Debora Hogan ◽  
Diana Khalil ◽  
Matthew Hearn ◽  
Colette Nault ◽  
...  
Keyword(s):  
Feasibility Study ◽  
Total Duration ◽  
Coconut Oil ◽  
Patterns Of Use ◽  
Novel Approach ◽  
Significant Difference ◽  
Quality Of Life Scale ◽  
Life Scale ◽  
Related Quality ◽  
Radiation Induced

Background. Xerostomia is a common complication following radiation therapy for head and neck cancer (HNC), for which there is no single, universally accepted therapy. Coconut oil has been anecdotally suggested to provide relief for this complication. This study sought to examine the feasibility and effectiveness of coconut oil as a therapy for radiation-induced xerostomia. Methods. A feasibility study was performed among 30 patients with xerostomia subsequent to radiation for HNC. Coconut oil samples were provided along with a protocol for use over a 2-week period and the option to continue if they found it beneficial. Patients were also instructed to keep diaries to document their patterns of use. The Xerostomia-related Quality of Life Scale (XeQOLS) was administered at baseline and 3-month follow-up. Descriptive methods were used to summarize patterns of coconut oil use and paired t-tests were used to assess changes in XeQOLS scores over time. Results. The mean total duration of coconut oil use during the study period was 16 days (1–71). The average number of uses per day was 3 (1–5), with an average amount per use of 5 mL (1.2–8.5). Twelve patients (41.4%) continued coconut oil use beyond the advised period. There was no statistically significant difference in XeQOLS scores pre- and post-treatment. There were no adverse events during the study period. Conclusions. The use of coconut oil as a treatment strategy for xerostomia post-HNC radiation is feasible, inexpensive, and safe. This study demonstrates that there may be a group of HNC patients that benefit from its use.

Analyzing the association between dose-volume parameters and radiation-induced brain edema in patients with brain tumor receiving stereotactic radiosurgery

2020 ◽  
Vol 34 (22n24) ◽  
pp. 2040134
Author(s):  
Yang-Wei Hsieh ◽  
Chin-Shiuh Shieh ◽  
Tai-Lin Huang ◽  
Shyh-An Yeh ◽  
Yi-Kuan Tseng ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Stereotactic Radiosurgery ◽  
Brain Edema ◽  
Magnetic Resonance Images ◽  
Planning System ◽  
Volume Index ◽  
Treatment Planning System ◽  
Dose Volume ◽  
Study Results ◽  
Radiation Induced

In this paper, three-dimensional images were used to analyze the association between dose-volume parameters and radiation-induced brain edema in patients with a brain tumor after receiving stereotactic radiosurgery (SRS). The computed tomography (CT), magnetic resonance images (MRI) and treatment parameters were transferred through the treatment planning system (Multiplan, version 5.1.3). The correlation between the dose of radiation therapy and brain edema was evaluated by image processing methods, such as image normalization, registration, filtering, segmentation, and feature extraction. The association was evaluated by volume index and intersection index. The study results suggest that the volume receiving radiation dose above 30% of the prescribed dose is highly associated with the brain edema in brain tumor patients after SRS. The small number of patients limits the study. Further investigation with larger populations and long-term epidemiological studies are required.

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