scholarly journals Integrin-β6 Serves as a Potential Prognostic Serum Biomarker for Gastric Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Zequn Li ◽  
Yuqi Sun ◽  
Jianfei Xu ◽  
Hao Yang ◽  
Xiaodong Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Risk Stratification ◽  
Cancer Patients ◽  
Tumor Stage ◽  
Serum Biomarker ◽  
Clinicopathological Parameters ◽  
Novel Biomarkers ◽  
Prognostic Prediction ◽  
Tissue Specimens ◽  
Gastric Cancer Patients

Discovering novel biomarkers that easily accessed is a key step towards the personalized medicine approach for gastric cancer patients. Integrin-β6 (ITGB6) is a subtype of integrin that is exclusively expressed on the surface of epithelial cells and is up-regulated in various tumors. In the present study, a retrospective cohort with 135 gastric cancer patients and a prospective cohort with 34 gastric cancer patients were constructed, ITGB6 expression were detected in both the serum specimens and the tissue specimens. Detailed clinicopathological parameters as well as patients’ survival were recorded. A nomogram including ITGB6 expression was also constructed and validated to predict the prognosis of gastric cancer patients. Results showed that serum ITGB6 expression was obviously increased and associated with tumor stage in gastric cancer patients, serum ITGB6 expression was relatively high in patients with liver metastasis. High ITGB6 expression indicated a poor prognosis, and nomogram including serum ITGB6 expression could predict the prognosis of gastric cancer patients effectively. Moreover, serum ITGB6 expression was associated with ITGB6 expression in tumor tissues. Furthermore, combined serum ITGB6 and CEA levels contributed to the risk stratification and prognostic prediction for gastric cancer patients. In addition, the serum expression of ITGB6 decreased significantly after radical surgery, and a new rise in serum ITGB6 expression indicated tumor recurrence or progression. The present study identified a novel serum biomarker for the risk stratification, prognostic prediction and surveillance of gastric cancer patients.

scholarly journals Correlation between the Expression Levels of miR-21 and miR-192 and Clinicopatological Features in Plasma of Patients with Gastric Cancer in Iran

2021 ◽  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Area Under The Curve ◽  
Tumor Stage ◽  
Expression Levels ◽  
The North ◽  
Study Results ◽  
Noninvasive Biomarker ◽  
North Of Iran ◽  
Gastric Cancer Patients

Background: Gastric cancer (GC) is the most prevalent malignancy worldwide and a common cause of death in Iran. Studies have proved that a variety of dysregulated microRNAs is involved in the development and progression of gastric cancer. The present study aimed to evaluate the expression levels of plasma circulating oncogenic miR-21 and miR-192 and their association with clinical phenotypes of patients with gastric cancer in the north of Iran. Material and Methods: Clinico-pathological analysis was conducted using a standard protocol and pathological tests. The expression levels of miR-21 and miR-192 were measured using quantitative reverse transcription-polymerase chain reaction in the plasma of twenty pre/post-operative gastric cancer patients and twenty healthy subjects. The receiver operating characteristic (ROC) curve of these microRNAs was analyzed to investigate their diagnosis properties. Results: The study results indicated that plasma miR-21 expression was significantly associated with tumor stage and helicobacter pylori infection status (P=0.024, P=0.0004, respectively). However, no association was observed between clinic-pathological characteristics and miR-192 expression. The results showed that the plasma levels of miR-21 (P=0.0001) and miR-192 (P=0.0007) were significantly higher in GC patients compared to those in healthy individuals. Furthermore, the ROC analyses yielded the area under the curve (AUC) values of 0.9525±0.03 (P<0.0001) and 0.5925±0.09 (P=0.316) for miR-21and miR-192, respectively. Pearson regression analysis showed that there was no significant correlation between the expression of miR-21 and miR-192 (P=0.1507). Conclusion: Based on the obtained results, the expression of the plasma level of miR-21 was significantly higher in gastric cancer patients compared to that in the healthy group. Furthermore, the higher levels of AUC in miR-21 indicated the potential role of miR-21 as a noninvasive biomarker for the prognosis of gastric cancer in the population of the north of Iran.

Clinicopathological and Prognostic Value of S100A4 Expression in Gastric Cancer: A Meta-Analysis

2014 ◽  
Vol 29 (2) ◽  
pp. 99-111 ◽  
Author(s):  
Zhian Ling ◽  
Ruolin Li
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Tumor Grade ◽  
Pooled Analysis ◽  
Cochrane Library ◽  
Clinicopathological Parameters ◽  
S100a4 Expression ◽  
Gastric Cancer Patients

Purposes For several years S100A4 has been implicated in tumor progression and prognosis. However, the prognostic value of S100A4 overexpression in patients with gastric cancer remains unknown. Therefore, we performed a meta-analysis to assess the relationship between S100A4 overexpression and clinical outcome of gastric cancer. Methods and Results Candidate studies were searched from PubMed, Embase, Cochrane Library, and ISI Web of Science. We included studies that evaluated the prognostic value of S100A4 expression in gastric cancer patients with regard to survival and a series of clinicopathological parameters. The pooled hazard ratios (HR) and odds ratios (OR) with 95% confidence intervals (CI) were used to estimate the effects. Ten studies, all from Asia, were included in the meta-analysis. The pooled analysis showed that S100A4 overexpression was significantly associated with worse overall survival (OS) (HR=1.86, 95% CI: 1.45-2.38, p<0.00001) without heterogeneity in the data (I2=43.6%, p=0.131). Furthermore, our results showed that S100A4 overexpression was significantly correlated with some clinicopathological parameters such as tumor grade, stage, metastasis, invasion, and relapse. Conclusions The results of our meta-analysis indicate that S100A4 overexpression correlates with more adverse clinical features and a poor prognosis of gastric cancer patients in Asia, thus suggesting that S100A4 could be a useful marker to evaluate progression and prognosis of Asian gastric cancer patients. More studies from Western countries with a larger number of tumors and standardized methods are required before significant conclusions can be drawn.

scholarly journals Relationship of clinicopathological parameters and preoperative CA19-9 level in patients with gastric cancer

2015 ◽  
Vol 23 (1) ◽  
pp. 60-67
Author(s):  
Laila Shirin ◽  
Md Mizanur Rahman ◽  
Saifuddin Ahmed ◽  
Md Nabir Hossain
Keyword(s):  
Gastric Cancer ◽  
Gastric Carcinoma ◽  
Cancer Patients ◽  
Serum Levels ◽  
Lymph Node Involvement ◽  
Clinicopathological Parameters ◽  
Depth Of Invasion ◽  
Cutoff Value ◽  
Gastric Cancer Patients ◽  
Relationship Of

Objective: This study is an evaluation of serum level of the tumor marker CA 19-9 in gastric cancer patients in preoperative periods to assess the relationship of level of tumor markers in serum and clinicopathological parameters in gastric cancer. Methods: A prospective study was done of 61 patients diagnosed with gastric cancer treated at a single institution in Bangladesh National Institute of Cancer Research and Hospital (NICRH), Dhaka, from July 2010 to December 2011. Analyses were performed to identify patient and tumor-related characteristics in gastric cancer patients. The sera from 61patients with gastric cancer were measured for CA19-9 level using a commercial immunoradiometric assay. All the patients underwent diagnostic imaging with computed tomography (CT) or ultrasound (US) before laparotomy. Metastasis was confirmed by either by US or CT and direct visualization of metastatic deposits after laparotomy. Results: The serum levels of CA 19-9 e” the cutoff value of 40 U/ml was regarded as positive. The serum levels of CA 19-9 d” the cutoff value of 40 U/ml was considered as negative. Clinicopathological factors age, sex, tumor infiltration, N-classification, staging and grading was compared with CA19-9 level in gastric carcinoma. Preoperative levels of CA19-9 was above the cut-off levels in 23% of all cases. In the present study, we found CA 19-9 positivity was not significantly related with age (p.48) & sex (p.35) of the patients. There was no correlation with the histologic type and CA 19-9 positivity (P.19). CA 19-9 positivity had correlation with the proportions of depth of invasion (T stage) (P.007), lymph node involvement (P.000), metastasis (p .03); but no correlation with stage (P .4) in case of gastric carcinoma. DOI: http://dx.doi.org/10.3329/jdmc.v23i1.22696 J Dhaka Medical College, Vol. 23, No.1, April, 2014, Page 60-67

scholarly journals Histological and Pathological Assessment of miR-204 and SOX4 Levels in Gastric Cancer Patients

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Xiao Yuan ◽  
Shuanhu Wang ◽  
Mulin Liu ◽  
Zhen Lu ◽  
Yanqing Zhan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Patients ◽  
Clinicopathological Parameters ◽  
Ags Cells ◽  
Node Metastasis ◽  
Advanced Tumor ◽  
Tumor Stages ◽  
Gastric Cancer Patients

Gastric cancer is one of the most common cancers and the efficient therapeutic methods are limited. Further study of the exact molecular mechanism of gastric cancer to develop novel targeted therapies is necessary and urgent. We herein systematically examined that miR-204 suppressed both proliferation and metastasis of gastric cancer AGS cells. miR-204 directly targeted SOX4. In clinical tissue research, we determined that miR-204 was expressed much lower and SOX4 expressed much higher in gastric cancer tissues compared with normal gastric tissues. Associated analysis with clinicopathological parameters in gastric cancer patients showed miR-204 was associated with no lymph node metastasis and early tumor stages whereas SOX4 was associated with lymph node metastasis and advanced tumor stages. In addition, miR-204 and SOX4 were negatively correlated in tissues from gastric cancer patients. Our findings examined the important role of miR-204 and SOX4 played in gastric cancer, and they could be used as candidate therapeutic targets for gastric cancer therapy.

The correlations between the expression of FGFR4 protein and clinicopathological parameters as well as prognosis of gastric cancer patients

2012 ◽  
Vol 106 (7) ◽  
pp. 872-879 ◽  
Author(s):  
Yan-Wei Ye ◽  
Xiefu Zhang ◽  
Ye Zhou ◽  
Jianghong Wu ◽  
Chunlin Zhao ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Clinicopathological Parameters ◽  
Gastric Cancer Patients
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