scholarly journals Relationship of clinicopathological parameters and preoperative CA19-9 level in patients with gastric cancer

2015 ◽  
Vol 23 (1) ◽  
pp. 60-67
Author(s):  
Laila Shirin ◽  
Md Mizanur Rahman ◽  
Saifuddin Ahmed ◽  
Md Nabir Hossain
Keyword(s):  
Gastric Cancer ◽  
Gastric Carcinoma ◽  
Cancer Patients ◽  
Serum Levels ◽  
Lymph Node Involvement ◽  
Clinicopathological Parameters ◽  
Depth Of Invasion ◽  
Cutoff Value ◽  
Gastric Cancer Patients ◽  
Relationship Of

Objective: This study is an evaluation of serum level of the tumor marker CA 19-9 in gastric cancer patients in preoperative periods to assess the relationship of level of tumor markers in serum and clinicopathological parameters in gastric cancer. Methods: A prospective study was done of 61 patients diagnosed with gastric cancer treated at a single institution in Bangladesh National Institute of Cancer Research and Hospital (NICRH), Dhaka, from July 2010 to December 2011. Analyses were performed to identify patient and tumor-related characteristics in gastric cancer patients. The sera from 61patients with gastric cancer were measured for CA19-9 level using a commercial immunoradiometric assay. All the patients underwent diagnostic imaging with computed tomography (CT) or ultrasound (US) before laparotomy. Metastasis was confirmed by either by US or CT and direct visualization of metastatic deposits after laparotomy. Results: The serum levels of CA 19-9 e” the cutoff value of 40 U/ml was regarded as positive. The serum levels of CA 19-9 d” the cutoff value of 40 U/ml was considered as negative. Clinicopathological factors age, sex, tumor infiltration, N-classification, staging and grading was compared with CA19-9 level in gastric carcinoma. Preoperative levels of CA19-9 was above the cut-off levels in 23% of all cases. In the present study, we found CA 19-9 positivity was not significantly related with age (p.48) & sex (p.35) of the patients. There was no correlation with the histologic type and CA 19-9 positivity (P.19). CA 19-9 positivity had correlation with the proportions of depth of invasion (T stage) (P.007), lymph node involvement (P.000), metastasis (p .03); but no correlation with stage (P .4) in case of gastric carcinoma. DOI: http://dx.doi.org/10.3329/jdmc.v23i1.22696 J Dhaka Medical College, Vol. 23, No.1, April, 2014, Page 60-67

The correlation among tissue, serum adiponectin levels and histopathological variables in gastric cancer patients

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e22199-e22199
Author(s):  
A. Bilici ◽  
D. O. Guler ◽  
M. Seker ◽  
B. O. Ustaalioglu ◽  
B. Sonmez ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Perineural Invasion ◽  
Tumor Tissue ◽  
Inverse Correlation ◽  
Serum Levels ◽  
Serum Adiponectin ◽  
Tissue Levels ◽  
Gastric Cancer Patients ◽  
Demographic Features

e22199 Background: Adiponectin is a new peptide hormone secreted from the adipose tissue, affecting the proliferation and insulin sensitivity in different cell types.The previous studies showed that the serum levels of adiponectin are decreased in patients with endometrial and breast cancer.In our study, demographic features and histopathological variables and the relationship among adiponectin levels of serum and gastric tissue were analyzed in gastric cancer patients. Methods: Thirty-five consecutive patients with gastric cancer included in this study.The serum levels of glucose, insulin, c-peptide, HbA1c, lipids and adiponectin were measured in patients.In addition, normal and tumor tissue levels of adiponectin were also detected.We analyzed the correlation among these parameters and patients demographic features, such as age, gender, body mass index (BMI) and histopathological variables. Results: Patients characteristics included 24 males (68.5%), 11 females (31.5%); median age was 64 (range:41–85). The mean serum, normal and tumor tissue levels of adiponectin were 49.4±0.8, 48.2±4.2, 48.6±2.9 ng/ml, respectively. There was no relationship among serum, normal and tumor tissue adiponectin levels (p>0.05).There was inverse correlation between the normal tissue levels of adiponectin and insulin (p=0.002).The serum adiponectin levels were significantly associated with tumor localization (p=0.03).However, there was inverse correlation between serum adiponectin levels and perineural invasion (p=0.02).In subgroup analysis, the serum, normal and tumor tissue levels of adiponectin in woman were not different compared with those in male patients (p>0.05).No relations were detected among tumor stage, grade, nodal status, lymphatic and vascular invasion, the other insulin-resistant status parameters and the levels of serum, normal and tumor tissue adiponectin (p>0.05). Conclusions: Our results suggest that no correlations among the levels of serum adiponectin,normal tissue and tumor tissue adiponectin levels,patients demographic features and histopathological variables except for the association of serum adiponectin with tumor localization and perineural invasion detected in gastric cancer patients. No significant financial relationships to disclose.

scholarly journals Integrin-β6 Serves as a Potential Prognostic Serum Biomarker for Gastric Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Zequn Li ◽  
Yuqi Sun ◽  
Jianfei Xu ◽  
Hao Yang ◽  
Xiaodong Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Risk Stratification ◽  
Cancer Patients ◽  
Tumor Stage ◽  
Serum Biomarker ◽  
Clinicopathological Parameters ◽  
Novel Biomarkers ◽  
Prognostic Prediction ◽  
Tissue Specimens ◽  
Gastric Cancer Patients

Discovering novel biomarkers that easily accessed is a key step towards the personalized medicine approach for gastric cancer patients. Integrin-β6 (ITGB6) is a subtype of integrin that is exclusively expressed on the surface of epithelial cells and is up-regulated in various tumors. In the present study, a retrospective cohort with 135 gastric cancer patients and a prospective cohort with 34 gastric cancer patients were constructed, ITGB6 expression were detected in both the serum specimens and the tissue specimens. Detailed clinicopathological parameters as well as patients’ survival were recorded. A nomogram including ITGB6 expression was also constructed and validated to predict the prognosis of gastric cancer patients. Results showed that serum ITGB6 expression was obviously increased and associated with tumor stage in gastric cancer patients, serum ITGB6 expression was relatively high in patients with liver metastasis. High ITGB6 expression indicated a poor prognosis, and nomogram including serum ITGB6 expression could predict the prognosis of gastric cancer patients effectively. Moreover, serum ITGB6 expression was associated with ITGB6 expression in tumor tissues. Furthermore, combined serum ITGB6 and CEA levels contributed to the risk stratification and prognostic prediction for gastric cancer patients. In addition, the serum expression of ITGB6 decreased significantly after radical surgery, and a new rise in serum ITGB6 expression indicated tumor recurrence or progression. The present study identified a novel serum biomarker for the risk stratification, prognostic prediction and surveillance of gastric cancer patients.

Influence of age on soluble E-cadherin serum levels prevents its utility as a disease marker in gastric cancer patients

2008 ◽  
Vol 43 (6) ◽  
pp. 765-766 ◽  
Author(s):  
Corrado Pedrazzani ◽  
Stefano Caruso ◽  
Giovanni Corso ◽  
Daniele Marrelli ◽  
Alessandro Neri ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Serum Levels ◽  
Disease Marker ◽  
Gastric Cancer Patients ◽  
E Cadherin

scholarly journals Prognostic significance of the preoperative serum levels of soluble form of endoglin in gastric cancer patients

2013 ◽  
Vol 114 (10) ◽  
pp. 566-568
Author(s):  
I. Gomceli ◽  
M. Tez ◽  
E. B. Bostanci ◽  
A. S. Kemik ◽  
B. Demiriz ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Prognostic Significance ◽  
Serum Levels ◽  
Soluble Form ◽  
Preoperative Serum ◽  
Gastric Cancer Patients

Clinicopathological and Prognostic Value of S100A4 Expression in Gastric Cancer: A Meta-Analysis

2014 ◽  
Vol 29 (2) ◽  
pp. 99-111 ◽  
Author(s):  
Zhian Ling ◽  
Ruolin Li
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Tumor Grade ◽  
Pooled Analysis ◽  
Cochrane Library ◽  
Clinicopathological Parameters ◽  
S100a4 Expression ◽  
Gastric Cancer Patients

Purposes For several years S100A4 has been implicated in tumor progression and prognosis. However, the prognostic value of S100A4 overexpression in patients with gastric cancer remains unknown. Therefore, we performed a meta-analysis to assess the relationship between S100A4 overexpression and clinical outcome of gastric cancer. Methods and Results Candidate studies were searched from PubMed, Embase, Cochrane Library, and ISI Web of Science. We included studies that evaluated the prognostic value of S100A4 expression in gastric cancer patients with regard to survival and a series of clinicopathological parameters. The pooled hazard ratios (HR) and odds ratios (OR) with 95% confidence intervals (CI) were used to estimate the effects. Ten studies, all from Asia, were included in the meta-analysis. The pooled analysis showed that S100A4 overexpression was significantly associated with worse overall survival (OS) (HR=1.86, 95% CI: 1.45-2.38, p<0.00001) without heterogeneity in the data (I2=43.6%, p=0.131). Furthermore, our results showed that S100A4 overexpression was significantly correlated with some clinicopathological parameters such as tumor grade, stage, metastasis, invasion, and relapse. Conclusions The results of our meta-analysis indicate that S100A4 overexpression correlates with more adverse clinical features and a poor prognosis of gastric cancer patients in Asia, thus suggesting that S100A4 could be a useful marker to evaluate progression and prognosis of Asian gastric cancer patients. More studies from Western countries with a larger number of tumors and standardized methods are required before significant conclusions can be drawn.

scholarly journals Histological and Pathological Assessment of miR-204 and SOX4 Levels in Gastric Cancer Patients

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Xiao Yuan ◽  
Shuanhu Wang ◽  
Mulin Liu ◽  
Zhen Lu ◽  
Yanqing Zhan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Patients ◽  
Clinicopathological Parameters ◽  
Ags Cells ◽  
Node Metastasis ◽  
Advanced Tumor ◽  
Tumor Stages ◽  
Gastric Cancer Patients

Gastric cancer is one of the most common cancers and the efficient therapeutic methods are limited. Further study of the exact molecular mechanism of gastric cancer to develop novel targeted therapies is necessary and urgent. We herein systematically examined that miR-204 suppressed both proliferation and metastasis of gastric cancer AGS cells. miR-204 directly targeted SOX4. In clinical tissue research, we determined that miR-204 was expressed much lower and SOX4 expressed much higher in gastric cancer tissues compared with normal gastric tissues. Associated analysis with clinicopathological parameters in gastric cancer patients showed miR-204 was associated with no lymph node metastasis and early tumor stages whereas SOX4 was associated with lymph node metastasis and advanced tumor stages. In addition, miR-204 and SOX4 were negatively correlated in tissues from gastric cancer patients. Our findings examined the important role of miR-204 and SOX4 played in gastric cancer, and they could be used as candidate therapeutic targets for gastric cancer therapy.

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