scholarly journals Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application

2020 ◽  
Vol 11 ◽  
Author(s):  
Jinfeng Shi ◽  
Jiaxin Li ◽  
Ziyi Xu ◽  
Liang Chen ◽  
Ruifeng Luo ◽  
...  
Keyword(s):  
Side Effects ◽  
Therapeutic Window ◽  
Future Research ◽  
Anticancer Activities ◽  
Research Directions ◽  
Anticancer Efficacy ◽  
Cancer Breast ◽  
Future Research Directions ◽  
Micro Systems ◽  
Anticancer Compound

Celastrol, a natural bioactive ingredient derived from Tripterygium wilfordii Hook F, exhibits significant broad-spectrum anticancer activities for the treatment of a variety of cancers including liver cancer, breast cancer, prostate tumor, multiple myeloma, glioma, etc. However, the poor water stability, low bioavailability, narrow therapeutic window, and undesired side effects greatly limit its clinical application. To address this issue, some strategies were employed to improve the anticancer efficacy and reduce the side-effects of celastrol. The present review comprehensively focuses on the various challenges associated with the anticancer efficiency and drug delivery of celastrol, and the useful approaches including combination therapy, structural derivatives and nano/micro-systems development. The specific advantages for the use of celastrol mediated by these strategies are presented. Moreover, the challenges and future research directions are also discussed. Based on this review, it would provide a reference to develop a natural anticancer compound for cancer treatment.

Psychiatric Side Effects of Interferon Therapy: Prevalence, Proposed Mechanisms, and Future Directions

2000 ◽  
Vol 18 (11) ◽  
pp. 2316-2326 ◽  
Author(s):  
Peter C. Trask ◽  
Peg Esper ◽  
Michelle Riba ◽  
Bruce Redman
Keyword(s):  
Side Effects ◽  
Case Studies ◽  
Psychiatric Symptoms ◽  
Future Research ◽  
Future Directions ◽  
Research Directions ◽  
Symptoms Of Depression ◽  
Future Research Directions ◽  
Ifn Therapy ◽  
Psychiatric Side Effects

ABSTRACT: The increasing use of interferon (IFN) in treating a variety of disorders including, malignant melanoma and hepatitis C, has resulted in the identification and increasing concern about the psychiatric side effects that can result from treatment. These effects can occur either shortly after beginning IFN therapy or later as a result of continued treatment. Studies have reported the incidence of later side effects, which include symptoms of depression, anxiety, and occasional suicidal ideation, to be from 0% to 70%. Case studies have demonstrated that pharmacologic interventions are beneficial in reducing iatrogenic psychiatric symptoms while allowing patients to maintain IFN therapy. The present article provides an overview of the psychiatric effects of IFN therapy, the proposed mechanisms of these side effects, and case studies that provide mechanistic support. In addition, limitations of the current literature are provided with suggestions for treating physicians and a discussion of possible future research directions.

Biomechanics of oral implants: future research directions

1988 ◽  
Vol 52 (12) ◽  
pp. 775-787 ◽  
Author(s):  
JB Brunski
Keyword(s):  
Future Research ◽  
Research Directions ◽  
Oral Implants ◽  
Future Research Directions

School Consultation Research: Methodological Critique and Future Research Directions

1987 ◽  
Vol 16 (3) ◽  
pp. 306-316 ◽  
Author(s):  
Frank M. Gresham ◽  
Ginger K. Kendell
Keyword(s):  
Future Research ◽  
School Consultation ◽  
Research Directions ◽  
Future Research Directions

Managing the risks from petroleum hydrocarbons at contaminated sites: achievements and future research directions

2005 ◽  
Vol 13 (2) ◽  
pp. 115-122 ◽  
Author(s):  
S.J.T. Pollard ◽  
R. Duarte-Davidson ◽  
K. Askari ◽  
E. Stutt
Keyword(s):  
Petroleum Hydrocarbons ◽  
Contaminated Sites ◽  
Future Research ◽  
Research Directions ◽  
Future Research Directions

Developing Management from Islamic Perspectives (MIP) as a Formal Academic Discipline

2009 ◽  
Vol 26 (1) ◽  
pp. 46-69
Author(s):  
Shamas-Ur-Rehman Toor
Keyword(s):  
Literature Review ◽  
Academic Discipline ◽  
Real Life ◽  
Growth Potential ◽  
Future Research ◽  
Business Practices ◽  
Research Directions ◽  
International Consortium ◽  
Future Research Directions ◽  
Scholarly Attention

Management from Islamic Perspectives (MIP) is an emerging field that has begun to attract scholarly attention. However, the research undertaken so far has been rather fragmented and lack a clear agenda. This paper presents a literature review of the field and the areas of current focus. Although the field has a huge growth potential, I argue that it faces several challenges and problems as it develops further. I outline these potential pitfalls, suggest how to develop MIP as a formal discipline, and explain how to integrate it within real-life business practices. The article closes with a call for research to be conducted in a more organized fashion through an international consortium of researchers as well as recommendations for future research directions.

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