scholarly journals Signaling Potential Therapeutic Herbal Medicine Prescription for Treating COVID-19 by Collaborative Filtering

2021 ◽  
Vol 12 ◽  
Author(s):  
Fan Yang ◽  
Qi Zhang ◽  
Zhongshang Yuan ◽  
Saisai Teng ◽  
Lizhen Cui ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Collaborative Filtering ◽  
Domain Knowledge ◽  
Clinical Manifestations ◽  
Treatment Protocol ◽  
Syndrome Differentiation ◽  
Medicine Prescription ◽  
Syndrome Differentiation And Treatment ◽  
And Control ◽  
Filtering Approach

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has aggressed in more than 200 countries and territories since Dec 2019, and 30 million cases of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 have been reported, including 950,000 deaths. Supportive treatment remains the mainstay of therapy for COVID-19. There are no small-molecule–specific antiviral drugs available to prevent and treat COVID-19 until recently. Herbal medicine can facilitate syndrome differentiation and treatment according to the clinical manifestations of patients and has demonstrated effectiveness in epidemic prevention and control. The National Health Commission (NHC) of China has recommended “three TCM prescriptions and three medicines,” as a group of six effective herbal formulas against COVID-19 in the released official file “Diagnosis and Treatment Protocol for COVID-19 Patients: Herbal Medicine for the Priority Treatment of COVID-19.” This study aimed to develop a collaborative filtering approach to signaling drug combinations that are similar to the six herbal formulas as potential therapeutic treatments for treating COVID-19. The results have been evaluated by herbal medicine experts’ domain knowledge.

scholarly journals Potential Therapeutic Effect of Traditional Chinese Medicine on Coronavirus Disease 2019: A Review

2020 ◽  
Vol 11 ◽  
Author(s):  
Qin Qiu ◽  
Yuge Huang ◽  
Xiaohua Liu ◽  
Fangfang Huang ◽  
Xiaoling Li ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Severe Acute Respiratory Syndrome ◽  
Small Molecules ◽  
Prevention And Control ◽  
Clinical Manifestations ◽  
Syndrome Differentiation ◽  
Treatment Measures ◽  
Syndrome Differentiation And Treatment ◽  
And Control

The Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 has been rapidly spreading globally and has caused worldwide social and economic disruption. Currently, no specific antiviral drugs or clinically effective vaccines are available to prevent and treat COVID-19. Traditional Chinese medicine (TCM) can facilitate syndrome differentiation and treatment according to the clinical manifestations of patients and has demonstrated effectiveness in epidemic prevention and control. In China, TCM intervention has helped to control the epidemic; however, TCM has not been fully recognized worldwide. In this review, we summarize the epidemiology and etiological characteristics of severe acute respiratory syndrome coronavirus 2 and the prevention and treatment measures of COVID-19. Additionally, we describe the application of TCM in the treatment of COVID-19 and the identification of small molecules of TCM that demonstrate anti-coronavirus activity. We also analyze the current problems associated with the recognition of TCM. We hope that, through the contribution of TCM, combined with modern technological research and the support of our international counterparts, COVID-19 can be effectively controlled and treated.

scholarly journals Retrospective Review of Traditional Chinese Medicine Treatment of COVID-19 in China: Clinical Practice and Researches

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Han Lai ◽  
Hui Zhang
Keyword(s):  
Chinese Medicine ◽  
Herbal Medicine ◽  
Traditional Chinese Medicine ◽  
Western Medicine ◽  
Treatment Protocol ◽  
Medical Community ◽  
Critical Conditions ◽  
Syndrome Differentiation ◽  
National Guidance ◽  
Prevention And Treatment

In the fight against COVID-19 in China, traditional Chinese medicine (TCM) has played an important role in relieving symptoms, preventing deterioration, improving cure rate, reducing death rate, and promoting recovery. Since the third edition of the Diagnosis and Treatment Protocol for COVID-19 (simply referred to as the National Protocol), TCM has been included in the national guidance to tackle the epidemic. In order to make the international medical community fully understand the experience of TCM in the prevention and treatment of COVID-19, we comprehensively reviewed the history, etiology and pathogenesis, prevention and treatment, rehabilitation, and clinical and pharmacological research of TCM used in the endemic. The COVID-19 is under the category of plague or pestilence in TCM. Herbal medicine treatment for COVID-19 is mainly performed based on the syndrome differentiation of three stages and four types. The method also applies to acupuncture and moxibustion treatments. Herbal medicine granules and injections are used flexibly, and Western medicine is adopted to rescue patients in critical conditions. In rehabilitation, the integration of Chinese and Western medicine can be used to improve the respiratory and somatic function of patients. The role TCM has been playing in fighting this epidemic is a further proof of the effect of TCM in preventing and treating infectious diseases, and the relevant experience has been summarized and sublimated.

scholarly journals The clinical application of a traditional Chinese medicine prescription issued by Professor Liangduo Jiang in the prevention of coronavirus disease 2019 (COVID-19)

2020 ◽  
Vol 03 (01) ◽  
pp. 65-69
Author(s):  
Jinfang Yao ◽  
Jian Yang ◽  
Zhenping Yu ◽  
Jinwei Chui ◽  
Simin Lee ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Prevention And Control ◽  
Close Contact ◽  
Clinical Manifestations ◽  
Preventive Treatment ◽  
Temperature Changes ◽  
Medicine Prescription ◽  
Chinese Medicine Prescription ◽  
And Control ◽  
Observation Period

Objective: To summarize the clinical experience of Professor Liangduo Jiang in the prevention and control of the new coronavirus disease COVID-19. Methods: Between January 2020 and February 2020, 87 subjects who have had contact with patients tested positive for COVID-19 in an isolated observation site in Tianjin were given the Chinese medicine prescription for prevention prescribed by Professor Liangduo Jiang continuously for three days. Their basic information, clinical manifestations and medication adherence were statistically analyzed, and the clinical manifestations, temperature changes and infection status after medication were summarized. Results: After the 14-day isolation observation period, only one patient who had close contact with confirmed patients developed a positive test for COVID-19 after taking the preventive Chinese medicine prescription, with the infection rate of 1.149%. Conclusion: The preventive treatment by Professor Liangduo Jiang is effective in the prevention and control of the epidemic.

Clinical and molecular epidemic characterization of rotavirus infection among children under five years old in Shandong province, China.

2021 ◽  
Author(s):  
Shixiao Dong ◽  
Deyu Huang ◽  
Zheng Wang ◽  
Guanyou Zhang ◽  
Fengjuan Zhang ◽  
...  
Keyword(s):  
Lower Incidence ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Shandong Province ◽  
Rotavirus Infection ◽  
National Immunization ◽  
Significant Difference ◽  
The Mean ◽  
And Control

Abstract Rotavirus was the an important causative agent of acute gastroenteritis in children. In China, rotavirus was positive in approximately 30% of the diarrhea children and become a serious public problem. This study was carried out to investigate the clinical and molecular epidemic characterization of rotavirus infection among children under 5 years old with acute diarrhea in Shandong province, China. From July 2017 to June 2018, a total of 1211 fecal specimens were detected and the prevalence of rotavirus infection was 32.12%. The mean age of positive children was 12.2 ± 10.9 months and the highest infection rate was observed in children aged 7–12 months with a rate of 41.64%. G9P[8] (76.61%) was the most prevalent combinations followed by G2P[4] (7.20%), G3P[8] (3.60%) and G9P[4] (2.06%). In addition to diarrhea, vomiting, fever and dehydration were the most common accompanied symptoms. In general, there was no significant difference in clinical manifestations among different age groups. However, the clinical manifestations between vaccinated and unvaccinated children were significantly different. Vaccinated children showed lower incidence and frequency of vomiting, lower incidence and degree of dehydration, lower incidence of severe cases than unvaccinated children. The findings suggested necessary to continue rotavirus strains surveillance in order to monitor the change of prevalent genotype. Moreover, introducing vaccine into national immunization program to prevent and control rotavirus infections is needed in China.

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