scholarly journals AltitudeOmics: Spontaneous Baroreflex Sensitivity During Acclimatization to 5,260 m: A Comparison of Methods

2019 ◽  
Vol 10 ◽  
Author(s):  
Nicolas Bourdillon ◽  
Sasan Yazdani ◽  
Jean-Marc Vesin ◽  
Andrew W. Subudhi ◽  
Andrew T. Lovering ◽  
...  
Keyword(s):  
Baroreflex Sensitivity ◽  
Comparison Of Methods ◽  
Spontaneous Baroreflex

Influence of Atrial Natriuretic Factor on Spontaneous Baroreflex Sensitivity for Heart Rate in Humans

Hypertension ◽  
1995 ◽  
Vol 25 (6) ◽  
pp. 1167-1171 ◽  
Author(s):  
Gary C. Butler ◽  
Beverley L. Senn ◽  
John S. Floras
Keyword(s):  
Heart Rate ◽  
Atrial Natriuretic Factor ◽  
Baroreflex Sensitivity ◽  
Natriuretic Factor ◽  
Spontaneous Baroreflex ◽  
Atrial Natriuretic

scholarly journals Resting spontaneous baroreflex sensitivity and cardiac autonomic control in anabolic androgenic steroid users

Clinics ◽  
2018 ◽  
Vol 73 ◽  
Author(s):  
MR Santos ◽  
AL Sayegh ◽  
R Armani ◽  
V Costa-Hong ◽  
FR Souza ◽  
...  
Keyword(s):  
Baroreflex Sensitivity ◽  
Autonomic Control ◽  
Anabolic Androgenic Steroid ◽  
Cardiac Autonomic Control ◽  
Androgenic Steroid ◽  
Spontaneous Baroreflex

scholarly journals With age spontaneous baroreflex sensitivity diminishes after acute fat ingestion

2015 ◽  
Vol 74 (OCE5) ◽  
Author(s):  
C.I. Wright ◽  
H. Ruediger ◽  
R. Draijer
Keyword(s):  
Baroreflex Sensitivity ◽  
Spontaneous Baroreflex

scholarly journals Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

10.3791/62101 ◽  
2021 ◽  
Author(s):  
René D. Rötzer ◽  
Verena F. Brox ◽  
Konstantin Hennis ◽  
Stefan B. Thalhammer ◽  
Martin Biel ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Baroreflex Sensitivity ◽  
Spontaneous Baroreflex

Abstract 422: Cardiovascular Regulation in Mice with Overexpression of the Gene of Vesicular Acetylcholine Transporter (VAChT)

Hypertension ◽  
2014 ◽  
Vol 64 (suppl_1) ◽  
Author(s):  
Geisa C Tezini ◽  
Silvia Guatimosim ◽  
Diogo A Guimarães ◽  
Mauro Oliveira ◽  
Rubens Fazan ◽  
...  
Keyword(s):  
Baroreflex Sensitivity ◽  
Fold Increase ◽  
Cardiovascular Regulation ◽  
Transgenic Animal ◽  
Vesicular Acetylcholine Transporter ◽  
Wild Type ◽  
Autonomic Blockade ◽  
Release Of Acetylcholine ◽  
Cardiovascular Autonomic Regulation ◽  
Spontaneous Baroreflex

It was recently developed a transgenic animal model with overexpression of cholinergic neurotransmission. This mouse, named ChAT-ChR2-EYFP, has several extra copies of the vesicular acetylcholine transporter (VAChT) gene and exhibits three-fold increase in the release of acetylcholine. However, the consequences of overexpression of VAChT protein to the cardiovascular system have not yet been characterized. Therefore, we have investigated the effects of the overexpression of the gene of VAChT on arterial pressure (AP) and heart rate (HR) as well as the autonomic cardiovascular regulation. Mice were assigned into two groups: Wild-type (WT, n=7) and ChAT-ChR2-EYFP (n=7). These animals were anesthetized (isoflurane) and implanted with probes to record AP by telemetry. After 10 days, the mice had basal AP and HR recorded continuously. Assessment of the autonomic function was conducted throughout the following approaches: 1) cardiac sympathovagal balance evaluated by HR responses to methylatropine and propranolol; 2) overall HR variability; 3) spontaneous baroreflex sensitivity by the sequence analysis. ChAT-ChR2-EYFP mice showed lower basal HR (461±8 vs. 502±14 bpm, p<0.01) but similar AP as compared to WT mice. ChAT-ChR2-EYFP mice exhibited higher vagal tone (Δbpm, 169±14 vs. 117±6, p=0.03) and lower HR after double autonomic blockade (IHR, 456±8 vs. 509±11 bpm, p<0.001). HR variability was similar between groups (SDNN: 88±16 vs. 65±7 ms; RMSSD: 11.4±1 vs. 9.7±0.5 ms). However, the baroreflex sensitivity (7.5±1.5 vs. 4.1±0.5 ms/mmHg, p=0.05) was higher in ChAT-ChR2-EYFP mice. Altogether, the results show that the cardiovascular autonomic regulation of ChAT-ChR2-EYFP mice is characterized by higher parasympathetic tone, combined with a lower basal HR and IHR. Moreover, these mice present greater baroreflex sensitivity.

Central actions of angiotensin II on spontaneous baroreflex sensitivity in the trout Onc orhynchus mykiss

2007 ◽  
Vol 138 (2-3) ◽  
pp. 94-102 ◽  
Author(s):  
Frédéric Lancien ◽  
Jean-Claude Le Mével
Keyword(s):  
Angiotensin Ii ◽  
Baroreflex Sensitivity ◽  
Central Actions ◽  
Spontaneous Baroreflex

Spontaneous baroreflex sensitivity in young normotensive African-American women

2013 ◽  
Vol 23 (4) ◽  
pp. 209-213 ◽  
Author(s):  
Peter Latchman ◽  
Gregory Gates ◽  
Robert Axtell ◽  
Jason Pereira ◽  
Matthew Bartels ◽  
...  
Keyword(s):  
African American ◽  
African American Women ◽  
Baroreflex Sensitivity ◽  
American Women ◽  
Spontaneous Baroreflex

Impaired serotonergic regulation of heart rate may underlie reduced baroreflex sensitivity in an animal model of depression

2008 ◽  
Vol 294 (1) ◽  
pp. H474-H480 ◽  
Author(s):  
Cara M. Hildreth ◽  
James R. Padley ◽  
Paul M. Pilowsky ◽  
Ann K. Goodchild
Keyword(s):  
Heart Rate ◽  
Animal Model ◽  
High Frequency ◽  
Neural Control ◽  
Baroreflex Sensitivity ◽  
Cardiac Risk ◽  
Sprague Dawley ◽  
Animal Model Of Depression ◽  
Spontaneous Baroreflex ◽  
Acute Changes

Serotonin (5-HT) is crucial to normal reflex vagal modulation of heart rate (HR). Reduced baroreflex sensitivity [spontaneous baroreflex sensitivity (sBRS)] and HR variability (HRV) reflect impaired neural, particularly vagal, control of HR and are independently associated with depression. In conscious, telemetered Flinders-Sensitive Line (FSL) rats, a well-validated animal model of depression, we tested the hypothesis that cardiovascular regulatory abnormalities are present and associated with deficient serotonergic control of reflex cardiovagal function. In FSL rats and control Flinders-Resistant (FRL) and Sprague-Dawley (SD) rat strains, diurnal measurements of HR, arterial pressure (AP), activity, sBRS, and HRV were made. All strains had normal and similar diurnal variations in HR, AP, and activity. In FRL rats, HR was elevated, contributing to the reduced HRV and sBRS in this strain. In FSL rats, sBRS and high-frequency power HRV were reduced during the night, indicating reduced reflex cardiovagal activity. The ratio of low- to high-frequency bands of HRV was increased in FSL rats, suggesting a relative predominance of cardiac sympathetic and/or reflex activity compared with FRL and SD rats. These data show that conscious FSL rats have cardiovascular regulatory abnormalities similar to depressed humans. Acute changes in HR, AP, temperature, and sBRS in response to 8-hydroxy-2-(di- n-propylamino)tetralin, a 5-HT1A, 5-HT1B, and 5-HT7 receptor agonist, were also determined. In FSL rats, despite inducing an exaggerated hypothermic effect, 8-hydroxy-2-(di- n-propylamino)tetralin did not decrease HR and AP or improve sBRS, suggesting impaired serotonergic neural control of cardiovagal activity. These data suggest that impaired serotonergic control of cardiac reflex function could be one mechanism linking reduced sBRS to increased cardiac risk in depression.

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