scholarly journals The Effect of Free Androgen Index on the Quality of Life of Women With Polycystic Ovary Syndrome: A Cross-Sectional Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Mohammed Altigani Abdalla ◽  
Harshal Deshmukh ◽  
Irfaan Mohammed ◽  
Stephen Atkin ◽  
Marie Reid ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Free Androgen Index

Purpose: Free androgen index (FAI) and anti-Mullerian hormone (AMH) are independently associated with polycystic ovary syndrome (PCOS). This study aimed to describe the relationship between these two markers and health-related quality of life (HR-QoL) in women with PCOS.Methods: This cross-sectional study consisted of 81 women in the Hull PCOS biobank, who fulfilled the Rotterdam consensus criteria for the diagnosis of PCOS. The primary outcome was to measure the various domains of the QoL in the modified polycystic ovary syndrome questionnaire (MPCOSQ).Results: Mean age of the study participants was 28 ± 6.0 years, mean body mass index (BMI) 33.5 ± 7.8 kg/m2, mean FAI (6 ± 5.5), free testosterone (2.99 ± 0.75) and mean AMH (3.5 ± 0.8 units). In linear regression analysis, the FAI was associated with overall mean MPCOSQ score (Beta = 0.53, P-value = 0.0002), and with depression (Beta = 0.45, P-value = 0.01), hirsutism (Beta = 0.99, P-value = 0.0002) and menstrual irregularity (Beta = 0.31, P-value = 0.04). However, with adjustment for age and BMI, FAI was only associated with the hirsutism domain (Beta = 0.94, P-value = 0.001) of the MPCOSQ. FAI was also associated with the weight domain (Beta = 0.63 P-value = 0.005) of MPCOSQ. However, AMH was not associated with the overall mean MPCOSQ score or with any of its domains.Conclusion: FAI but not AMH was associated with QoL in women with PCOS, and this effect was mediated by BMI.

scholarly journals Prevalence of depression and quality of life in polycystic ovary syndrome patients at a tertiary care hospital: a cross-sectional study

2019 ◽  
Vol 8 (6) ◽  
pp. 2251
Author(s):  
Radhika Gollapudi ◽  
Venu Madhavi Lanke ◽  
Manaswini Namilakoda
Keyword(s):  
Quality Of Life ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Prevalence Of Depression ◽  
The Mean

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathy among women of reproductive age. Physical symptoms in PCOS cause depression and decrease the Quality of Life (QoL). The objective was to study the prevalence of depression in women suffering from PCOS and to assess its correlation with QoL.Methods: This was a cross sectional study conducted among one hundred patients diagnosed with PCOS. Women 18-40 years of age diagnosed with PCOS were included in the study. Patients with known psychiatric illness were excluded. Depression severity was assessed with Hamilton depression (HAM-D) scale. The quality of life (QoL) was assessed with Polycystic ovary syndrome questionnaire (PCOSQ). The data was analyzed using SPSS 20.0 for Windows.Results: The mean age and BMI was 25.64±3.25 years and 26.78±2.72 kg/m2 respectively. The mean depression score was 12.46±6.18. QoL domains showed that the lowest score was in the menstrual problem with a mean of 12.48±4.44 and the highest was in the emotional domain with a mean of 28.07±11.17. The negative correlations were between age and Hamilton score (p < 0.05). The Hamilton score was negatively correlated with the emotional score (p <0.01) and weight score was positively correlated with infertility score (p <0.01).Conclusions: PCOS was clearly associated with depression and reduced QoL. This should warrant health professionals to consider routine screening for depression and assess the impact of symptoms on their QoL to improve patient outcomes.

scholarly journals Quality of Life and Emotional States of Depression, Anxiety and Stress in Adolescents with Polycystic Ovary Syndrome: A Cross-Sectional Study

2020 ◽  
Vol Volume 13 ◽  
pp. 203-209 ◽  
Author(s):  
Marzieh Saei Ghare Naz ◽  
Fahimeh Ramezani Tehrani ◽  
Tahereh Behroozi Lak ◽  
Farnaz Mohammadzadeh ◽  
Malihe Nasiri ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Emotional States ◽  
Sectional Study ◽  
Ovary Syndrome ◽  
Cross Sectional

scholarly journals Glutathione-dependent enzymes in the follicular fluid of the first-retrieved oocyte and their impact on oocyte and embryos in polycystic ovary syndrome: A cross-sectional study

2020 ◽  
Author(s):  
Fatemeh Zal ◽  
Pardis Ahmadi ◽  
Maryam Davari ◽  
Fatemeh Khademi ◽  
Mojgan Akbarzadeh Jahromi ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Antioxidant System ◽  
Follicular Fluid ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
The Mean

Background: Oxidative stress and GSH-dependent antioxidant system plays a key role in the pathogenesis of polycystic ovary syndrome (PCOS). Objective: We compared glutathione peroxidase (GPx) and glutathione reductase activities and reduced glutathione (GSH) levels in serum and follicular fluid (FF) of the first-retrieved follicle and their impact on quality of oocyte and embryo in PCOS women undergoing IVF. Materials and Methods: This cross-sectional study was conducted on 80 pairs of blood samples and FF of the first-retrieved follicle from PCOS women, at the Infertility center of Ghadir Mother and Child Hospital. The mean activity of GPx and GR, also GSH levels in the serum and FF were compared to the quality of the first follicle and resultant embryo. Results: Retrieved oocytes included 53 (66.25%) MII, 17 (21.25%) MI, and 10 (12.5%) germinal vesicles; after IVF 42 (52.50%) embryos with grade I and 11 (13.75%) with grade II were produced. The mean values for all three antioxidants were higher in the FF compared to serum (p < 0.001). Also all of the mean measured levels were significantly higher in the FF of the MII oocytes compared to that of oocytes with lower grades (p = 0.012, 0.006 and 0.012, respectively). The mean GPX activity and GSH levels were significantly higher in the serum (p = 0.016 and 0.012, respectively) and FF (p = 0.001 for both) of the high-quality grade I embryos. Conclusion: GSH-dependent antioxidant system functions more efficiently in the FF of oocytes and embryos with higher quality. Key words: In vitro fertilization, Glutathione, Antioxidant, Oocyte, Embryo. 

scholarly journals Health related quality of life and psychological parameters in different polycystic ovary syndrome phenotypes: a comparative cross-sectional study

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Bahadori Fatemeh ◽  
Jahanian Sadatmahalleh Shahideh ◽  
Mirzaei Negin
Keyword(s):  
Quality Of Life ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Health Related Quality ◽  
Sectional Study ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Related Quality ◽  
Health Related

Abstract Background Polycystic Ovary Syndrome (PCOS) is associated with high levels of phsychological implications and detriments to Quality of Life (QoL). The aim of this study was to assess Health- Related Quality of Life (HRQoL), depression, and anxiety in Iranian women with different PCOS phenotypes. Methods The present observational, cross-sectional study was carried out on 239 PCOS women who were classified on the basis of Rotterdam criteria into four categories: A (n = 77), B (n = 38), C (n = 68), and D (n = 56). They asked to fill out three questionnaires, namely, HRQoL, SF-12, and HADS. Results No significant differences were observed between the four PCOS phenotypes for anxiety, depression and QoL, as well as HRQoL domains related to infertiliy, weight and emotional problems (P > 0.05). Phenotypes A and B had worse HRQoL related to hirsutism (13.98 ± 5.22, 14.13 ± 6.23, P < 0.001). In addition, no significant differences were observed between them for HRQoL domains. While the score of acne in phenotype D (19.60 ± 5.12, P = 0.003) and menstrual score in phenotype C were significantly higher comparing to the other PCOS groups (16.82 ± 3.87, P < 0.001). Conclusion Presenting similar psychological profiles in all phenotypes unveils the importance of pychological well-being screening, even in milder reproductive phenotypes.

scholarly journals Impact of polycystic ovary syndrome on eating behavior, depression and health related quality of life: A cross-sectional study in Riyadh

2020 ◽  
Vol 27 (12) ◽  
pp. 3342-3347
Author(s):  
Syed Mohammed Basheeruddin Asdaq ◽  
Shahamah Jomah ◽  
Reem Hasan ◽  
Danah Al-Baroudi ◽  
Mai Alharbi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Health Related Quality ◽  
Sectional Study ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Related Quality ◽  
Health Related

scholarly journals Health Related Quality of Life and Psychological Parameters in Different Polycystic Ovary Syndrome Phenotypes: A Comparative Cross-Sectional Study

2020 ◽  
Author(s):  
Fatemeh Bahadori ◽  
shahideh Jahanian Sadatmahalleh ◽  
Negin Mirzaei
Keyword(s):  
Quality Of Life ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Related Quality ◽  
Health Related ◽  
Rotterdam Criteria

Abstract Background: Polycystic ovary syndrome (PCOS) is associated with high levels of phsychological implications and detriments to quality of life (QoL). The aim of this study was to assess the quality of life (QoL), health related quality of life (HRQoL), depression, and anxiety in Iranian women with different PCOS phenotypes.Methods: The observational, cross-sectional study was carried out on 239 PCOS women PCOS which had been classified on the basis of Rotterdam criteria into four categories. Then they were classified into four groups according to the Rotterdam criteria: A (n=77), B (n=38), C (n=68), and D (n=56).Results: No significant differences were observed between the four PCOS phenotypes for anxiety, depression and QoL, likewise, HRQoL domains related to infertiliy, weight and emotional problems (P>0.05). Phenotypes A and B had worse HRQoL related to hirsutism (13.98±5.22, 14.13±6.23, P<0.001), also no significant differences were observed between them for HRQoL’s domains. While the score of acne in phenotype D (19.60±5.12, P=0.003) and menstrual score in phenotype C were significantly higher compare with the other PCOS groups (16.82±3.87, P<0.001). Conclusion: Presenting similar psychological profile in all phenotypes unveils the importance of pychological well-being screening, even in milder reproductive phenotypes.

scholarly journals Nutritional status and quality of life in diabetic patients on hemodialysis: a cross-sectional study from Palestine

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Eba’a Hafi ◽  
Ro’ya Soradi ◽  
Sarah Diab ◽  
Ahmad M. Samara ◽  
Marah Shakhshir ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Regression Analysis ◽  
Linear Regression ◽  
Nutritional Status ◽  
Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Sectional Study ◽  
Cross Sectional

Abstract Background End-stage renal disease (ESRD) is a leading cause of death and morbidity worldwide. Malnutrition is a common problem among hemodialysis (HD) patients that negatively impacts their prognosis and is linked to an increase in morbidity and mortality in these patients, as well as a decrease in their quality of life (QOL). In this study, we aimed to evaluate the QOL and to investigate factors that can influence it, including nutritional status, as well as socio-demographic factors, among Palestinian diabetic patients on HD therapy. Methods This was a cross-sectional study that occurred at a large hemodialysis center in Palestine. Malnutrition was assessed by the malnutrition-inflammation scale (MIS), and the quality of life was evaluated by using the EuroQoL five-dimensional instrument (EQ-5D). Multivariable linear regression analysis was carried out to look at the effect of multiple variables on QOL. Results A total of 118 diabetic patients on HD were included. Of these, 66.9% were male, and 60.2% were aged 60 years or higher. Having multiple comorbid diseases (p=0.004) and having been on HD for >4 years (p=0.003) were significantly associated with a higher MIS score, whereas living alone (p=0.037) and having been on HD for >4 years (p=0.002) was significantly associated with lower EQ-5D score. We also observed a significant association between the MIS score and the EQ-5D score(r=−0.616, p<0.001). Multiple linear regression analysis demonstrated that diabetic hemodialysis patients who lived within a family household were positively correlated with the QOL score (standardized coefficient, 0.178; 95% confidence interval (CI), 0.042 to 0.372; p = 0.015), and MIS score was significantly and negatively correlated with QOL scores (standardized coefficient, −0.587; 95% CI, −0.047 to −0.028; p < 0.001). Conclusions We found that malnutrition was associated with a lower QOL score among diabetic patients on HD. We recommend general practitioners, dietitians, nephrologists, and nurses to make plans that pay more attention to this group of patients who show evidence of malnutrition. Patients on dialysis for ≥ 4 years, patients who live alone, and those suffering from multiple co-morbid diseases should receive special care due to their higher risk of being impacted by this problem.

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