Effect of Heat Stimulation on Circulating Irisin in Humans

High temperatures lead to oxidative stress. The aim of the study was to determine whether heat stimulation-induced hyperthermia can increase the level of circulating irisin. Twenty-one healthy female subjects (age, 26.3 ± 2.71 years; height, 162.1 ± 3.15 cm; weight, 54.2 ± 3.86 kg; and body surface area, 1.57 ± 0.11 m2) not taking contraceptives participated in this study. All experiments were performed individually for each participant when they were in the early proliferative menstrual phase. In an automated climate chamber (25 ± 0.5°C), the heat load was applied via half-body immersion into a hot water bath (42 ± 0.5°C). Five-minutes break was provided every after 5 min of immersion and the total passive heating time was 30 min. Tympanic temperature (Tty) and skin temperature (Ts) were measured. Mean body temperature (mTb) was calculated. Blood samples were collected before and immediately after immersion. Levels of irisin, cortisol, creatine kinase (CK), and lactate dehydrogenase (LDH) were analyzed. Tty, mTb and serum irisin levels increased after hot water immersion. The blood levels of cortisol, CK, and LDH were also elevated after hot water immersion. Heat stimulation might increase the levels of circulating irisin in humans in response to oxidative stress.

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A comparison of heat acclimation by post-exercise hot water immersion and exercise in the heat

Journal of Science and Medicine in Sport ◽

10.1016/j.jsams.2021.05.008 ◽

2021 ◽

Author(s):

Robert D. McIntyre ◽

Michael J. Zurawlew ◽

Samuel J. Oliver ◽

Andrew T. Cox ◽

Jessica A. Mee ◽

...

Keyword(s):

Water Immersion ◽

Heat Acclimation ◽

Hot Water ◽

Post Exercise ◽

Hot Water Immersion

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Local cooling during hot water immersion improves perceptions without inhibiting the acute interleukin-6 response

European Journal of Applied Physiology ◽

10.1007/s00421-021-04616-5 ◽

2021 ◽

Author(s):

R. G. Mansfield ◽

S. P. Hoekstra ◽

J. J. Bill ◽

Christof A. Leicht

Keyword(s):

Thermal Comfort ◽

Interleukin 6 ◽

Water Immersion ◽

Hot Water ◽

Upper Body ◽

Healthy Male ◽

Local Cooling ◽

Blood Samples ◽

Body Cooling ◽

Hot Water Immersion

Abstract Purpose Passive elevation of body temperature can induce an acute inflammatory response that has been proposed to be beneficial; however, it can be perceived as uncomfortable. Here, we investigate whether local cooling of the upper body during hot water immersion can improve perception without inhibiting the interleukin-6 (IL-6) response. Methods Nine healthy male participants (age: 22 ± 1 years, body mass: 83.4 ± 9.4 kg) were immersed up to the waist for three 60-min water immersion conditions: 42 °C hot water immersion (HWI), 42 °C HWI with simultaneous upper-body cooling using a fan (FAN), and 36 °C thermoneutral water immersion (CON). Blood samples to determine IL-6 plasma concentration were collected pre- and post-water immersion; basic affect and thermal comfort were assessed throughout the intervention. Results Plasma IL-6 concentration was higher for HWI and FAN when compared with CON (P < 0.01) and did not differ between HWI and FAN (P = 0.22; pre to post, HWI: 1.0 ± 0.6 to 1.5 ± 0.7 pg·ml−1, FAN: 0.7 ± 0.5 to 1.1 ± 0.5 pg·ml−1, CON: 0.5 ± 0.2 to 0.5 ± 0.2 pg·ml−1). At the end of immersion, basic affect was lowest for HWI (HWI: − 1.8 ± 2.0, FAN: 0.2 ± 1.6, CON 1.0 ± 2.1, P < 0.02); thermal comfort for HWI was in the uncomfortable range (3.0 ± 1.0, P < 0.01 when compared with FAN and CON), whereas FAN (0.7 ± 0.7) and CON (-0.2 ± 0.7) were in the comfortable range. Conclusion Local cooling of the upper body during hot water immersion improves basic affect and thermal comfort without inhibiting the acute IL-6 response.

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Hot-Water Immersion as a Potential Quarantine Treatment Against Pseudaulacaspis cockerelli (Homoptera: Diaspididae)

Journal of Economic Entomology ◽

10.1093/jee/86.4.1167 ◽

1993 ◽

Vol 86 (4) ◽

pp. 1167-1170 ◽

Cited By ~ 15

Author(s):

Arnold H. Hara ◽

Trent Y. Hata ◽

Benjamin K. S. Hu ◽

Victoria L. Tenbrink

Keyword(s):

Water Immersion ◽

Hot Water ◽

Hot Water Immersion

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Hot water immersion v icepacks for treating pain of Chironex fleckeri stings: a randomised controlled trial

The Medical Journal of Australia ◽

10.5694/mja17.00675 ◽

2017 ◽

Vol 207 (8) ◽

pp. 362-362

Author(s):

Geoffrey K Isbister ◽

Bart J Currie

Keyword(s):

Randomised Controlled Trial ◽

Controlled Trial ◽

Water Immersion ◽

Hot Water ◽

Chironex Fleckeri ◽

Randomised Controlled ◽

Hot Water Immersion

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Lower-limb hot-water immersion acutely induces beneficial hemodynamic and cardiovascular responses in peripheral arterial disease and healthy, elderly controls

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.00404.2016 ◽

2017 ◽

Vol 312 (3) ◽

pp. R281-R291 ◽

Cited By ~ 35

Author(s):

Kate N. Thomas ◽

André M. van Rij ◽

Samuel J. E. Lucas ◽

James D. Cotter

Keyword(s):

Blood Pressure ◽

Lower Limb ◽

Water Immersion ◽

Duplex Ultrasound ◽

Arterial Disease ◽

Hot Water ◽

Healthy Elderly ◽

Limb Perfusion ◽

Peripheral Arterial ◽

Hot Water Immersion

Passive heat induces beneficial perfusion profiles, provides substantive cardiovascular strain, and reduces blood pressure, thereby holding potential for healthy and cardiovascular disease populations. The aim of this study was to assess acute responses to passive heat via lower-limb, hot-water immersion in patients with peripheral arterial disease (PAD) and healthy, elderly controls. Eleven patients with PAD (age 71 ± 6 yr, 7 male, 4 female) and 10 controls (age 72 ± 7 yr, 8 male, 2 female) underwent hot-water immersion (30-min waist-level immersion in 42.1 ± 0.6°C water). Before, during, and following immersion, brachial and popliteal artery diameter, blood flow, and shear stress were assessed using duplex ultrasound. Lower-limb perfusion was measured also using venous occlusion plethysmography and near-infrared spectroscopy. During immersion, shear rate increased ( P < 0.0001) comparably between groups in the popliteal artery (controls: +183 ± 26%; PAD: +258 ± 54%) and brachial artery (controls: +117 ± 24%; PAD: +107 ± 32%). Lower-limb blood flow increased significantly in both groups, as measured from duplex ultrasound (>200%), plethysmography (>100%), and spectroscopy, while central and peripheral pulse-wave velocity decreased in both groups. Mean arterial blood pressure was reduced by 22 ± 9 mmHg (main effect P < 0.0001, interaction P = 0.60) during immersion, and remained 7 ± 7 mmHg lower 3 h afterward. In PAD, popliteal shear profiles and claudication both compared favorably with those measured immediately following symptom-limited walking. A 30-min hot-water immersion is a practical means of delivering heat therapy to PAD patients and healthy, elderly individuals to induce appreciable systemic (chronotropic and blood pressure lowering) and hemodynamic (upper and lower-limb perfusion and shear rate increases) responses.

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