scholarly journals A Systematic Review and Meta-Analysis Examining Whether Changing Ovarian Sex Steroid Hormone Levels Influence Cerebrovascular Function

2021 ◽  
Vol 12 ◽  
Author(s):  
Bethany D. Skinner ◽  
Rebecca J. Davies ◽  
Samuel R. Weaver ◽  
N. Tim Cable ◽  
Samuel J. E. Lucas ◽  
...  
Keyword(s):  
Systematic Review ◽  
Steroid Hormones ◽  
Steroid Hormone ◽  
Meta Analysis ◽  
Oral Contraception ◽  
Sex Steroid ◽  
Sex Steroid Hormone ◽  
Cerebrovascular Function ◽  
Menopausal Women ◽  
Post Menopausal

Sex differences in cerebrovascular disease rates indicate a possible role for ovarian sex steroid hormones in cerebrovascular function. To synthesise and identify knowledge gaps, a systematic review and meta-analysis was conducted to assess how ovarian sex steroid hormone changes across the lifespan affect cerebrovascular function in women. Three databases (EMBASE, MEDLINE and Web of Science) were systematically searched for studies on adult cerebrovascular function and ovarian sex steroid hormones. Forty-five studies met pre-defined inclusion criteria. Studied hormone groups included hormone replacement therapy (HRT; n = 17), pregnancy (n = 12), menstrual cycle (n = 7), menopause (n = 5), oral contraception (n = 2), and ovarian hyperstimulation (n = 2). Outcome measures included pulsatility index (PI), cerebral blood flow/velocity (CBF), resistance index (RI), cerebral autoregulation, and cerebrovascular reactivity. Meta-analysis was carried out on HRT studies. PI significantly decreased [−0.05, 95% CI: (−0.10, −0.01); p = 0.01] in post-menopausal women undergoing HRT compared to post-menopausal women who were not, though there was considerable heterogeneity (I2 = 96.8%). No effects of HRT were seen in CBF (p = 0.24) or RI (p = 0.77). This review indicates that HRT improves PI in post-menopausal women. However, there remains insufficient evidence to determine how changing ovarian sex steroid hormone levels affects cerebrovascular function in women during other hormonal phases (e.g., pregnancy, oral contraception).

scholarly journals Endogenous sex steroid hormones and colorectal cancer risk: a systematic review and meta-analysis

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Emmanouil Bouras ◽  
Christopher Papandreou ◽  
Ioanna Tzoulaki ◽  
Konstantinos K. Tsilidis
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Steroid Hormones ◽  
Meta Analysis ◽  
Epidemiological Studies ◽  
Sex Steroid Hormones ◽  
Sex Hormone Binding Globulin ◽  
Sex Steroid ◽  
Menopausal Women ◽  
Post Menopausal

AbstractPreclinical data suggest that endogenous sex steroid hormones may be implicated in colorectal cancer (CRC) development, however, findings from epidemiological studies are conflicting. The aim of this systematic review and meta-analysis was to investigate the associations between endogenous concentrations of sex hormones and CRC risk. PubMed and Scopus were searched until June 2020 for prospective studies evaluating the association between pre-diagnostic plasma/serum concentrations of estradiol, testosterone and sex-hormone binding globulin (SHBG) and CRC risk. Summary relative risks (RRs) and 95% confidence intervals (CIs) were estimated using the inverse-variance weighted random-effects model based on the DerSimonian-Laird estimator. Eight studies were included in the meta-analysis after evaluating 3,859 non-duplicate records. Four of the eight studies had a nested case–control design, one study was a case-cohort and the rest three studies were cohort studies, and they included on average 295 cases (range:48–732) and 2,105 controls. No associations were found for endogenous sex steroid hormones in men or post-menopausal women with CRC risk, with evidence for substantial heterogeneity observed among women. Findings from this meta-analysis do not support presence of associations between pre-diagnostic concentrations of testosterone, estradiol and SHBG with incident CRC risk in men and post-menopausal women.

scholarly journals Associations between female lung cancer risk and sex steroid hormones: a systematic review and meta-analysis of the worldwide epidemiological evidence on endogenous and exogenous sex steroid hormones

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hui Zeng ◽  
Zhuoyu Yang ◽  
Jiang Li ◽  
Yan Wen ◽  
Zheng Wu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Steroid Hormones ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Sex Steroid Hormone ◽  
Hormone Exposure ◽  
Female Lung Cancer

Abstract Background Published findings suggest sex differences in lung cancer risk and a potential role for sex steroid hormones. Our aim was to perform a meta-analysis to investigate the effects of sex steroid hormone exposure specifically on the risk of lung cancer in women. Methods The PubMed, MEDLINE, Web of Science, and EMBASE databases were searched. The pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) for female lung cancer risk associated with sex steroid hormones were calculated overall and by study design, publication year, population, and smoking status. Sensitivity analysis, publication bias, and subgroup analysis were performed. Results Forty-eight studies published between 1987 and 2019 were included in the study with a total of 31,592 female lung cancer cases and 1,416,320 subjects without lung cancer. Overall, higher levels of sex steroid hormones, both endogenous (OR: 0.92, 95% CI: 0.87–0.98) and exogenous (OR: 0.86, 95% CI: 0.80–0.93), significantly decreased the risk of female lung cancer by 10% (OR: 0.90, 95% CI: 0.86–0.95). The risk of lung cancer decreased more significantly with a higher level of sex steroid hormones in non-smoking women (OR: 0.88, 95% CI: 0.78–0.99) than in smoking women (OR: 0.98, 95% CI: 0.77–1.03), especially in Asia women (OR: 0.84, 95% CI: 0.74–0.96). Conclusions Our meta-analysis reveals an association between higher levels of sex steroid hormone exposure and the decreased risk of female lung cancer. Surveillance of sex steroid hormones might be used for identifying populations at high risk for lung cancer, especially among non-smoking women.

scholarly journals Racial variation in sex steroid hormone concentration in black and white men: a meta-analysis

Andrology ◽  
2014 ◽  
Vol 2 (3) ◽  
pp. 428-435 ◽  
Author(s):  
A. Richard ◽  
S. Rohrmann ◽  
L. Zhang ◽  
M. Eichholzer ◽  
S. Basaria ◽  
...  
Keyword(s):  
Steroid Hormone ◽  
Meta Analysis ◽  
White Men ◽  
Sex Steroid ◽  
Hormone Concentration ◽  
Racial Variation ◽  
Sex Steroid Hormone ◽  
Black And White

scholarly journals Endogenous and exogenous sex steroid hormones in asthma and allergy in females: A systematic review and meta-analysis

2018 ◽  
Vol 141 (4) ◽  
pp. 1510-1513.e8 ◽  
Author(s):  
Nicola McCleary ◽  
Bright I. Nwaru ◽  
Ulugbek B. Nurmatov ◽  
Hilary Critchley ◽  
Aziz Sheikh
Keyword(s):  
Systematic Review ◽  
Steroid Hormones ◽  
Meta Analysis ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Asthma And Allergy

scholarly journals Periconception endogenous and exogenous maternal sex steroid hormones and risk of asthma and allergy in offspring: protocol for a systematic review and meta-analysis

BMJ Open ◽  
2017 ◽  
Vol 7 (7) ◽  
pp. e014637 ◽  
Author(s):  
Merhunisa Talovic ◽  
Aziz Sheikh ◽  
Nicola McCleary ◽  
Maijaliisa Erkkola ◽  
Minna Kaila ◽  
...  
Keyword(s):  
Systematic Review ◽  
Steroid Hormones ◽  
Meta Analysis ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Asthma And Allergy

scholarly journals Changes in plasma steroid hormones and gonadal histology associated with sexual maturation in wild southern hake (Merluccius australis)

2017 ◽  
Vol 43 (4) ◽  
pp. 632-640
Author(s):  
Manuel Alvarado ◽  
Edison Serrano ◽  
Juan Carlos Sánchez ◽  
Luis Valladares
Keyword(s):  
Steroid Hormones ◽  
Steroid Hormone ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Sex Steroid Hormone ◽  
Asynchronous Development ◽  
Gonadal Histology ◽  
Males And Females ◽  
First Time

A detailed study of gametes development and characterization of plasma sex steroid hormones during the maturation cycle was performed for the first time in the southern hake (Merluccius australis). Fish were caught in the inland waters of the Reloncaví Sound, Interior Sea of Chiloé, Chile. Samples of gonads and blood were collected for histology and sex steroid hormone (17 β-estradiol, 11-ketotestosterone and 17,20 βdihydroxy-4-pregnen-3-one) analysis, respectively. Sex steroid hormone quantification was performed using enzyme-immunoassay (ELISA). Results showed that M. australis males and females have asynchronous development of testicles and ovaries, in all stages of maturation. Most spawning fish were found during the spring months. Regarding the sex steroid hormones, serological fluctuations of 17 β-estradiol and 11- ketotestosterone were found during gonadal maturation of M. australis. These hormones are the main hormones responsible for vitelogenesis and spermatogenesis processes, respectively. Conversely, 17,20 β-dihydroxy-4- pregnen-3-one did not show any serological fluctuation in females and males. Further studies involving gonadotropins, 17,20 β,21-trihydroxy-4-pregnen-3-one and vitellogenin quantification are required in order to obtain a more complete description of the reproductive physiology of wild and farmed M. australis.  

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