Long Noncoding RNAs: Novel Important Players in Adipocyte Lipid Metabolism and Derivative Diseases

Obesity, a global public health issue, is characterized by excessive adiposity and is strongly related to some chronic diseases including cardiovascular diseases and diabetes. Extra energy intake-induced adipogenesis involves various transcription factors and long noncoding RNAs (lncRNAs) that control lipogenic mRNA expression. Currently, lncRNAs draw much attention for their contribution to adipogenesis and adipose tissue function. Increasing evidence also manifests the pivotal role of lncRNAs in modulating white, brown, and beige adipose tissue development and affecting the progression of the diseases induced by adipose dysfunction. The aim of this review is to summarize the roles of lncRNAs in adipose tissue development and obesity-caused diseases to provide novel drug targets for the treatment of obesity and metabolic diseases.

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Long non-coding RNAs in regulation of adipogenesis and adipose tissue function

eLife ◽

10.7554/elife.59053 ◽

2020 ◽

Vol 9 ◽

Author(s):

Tiziana Squillaro ◽

Gianfranco Peluso ◽

Umberto Galderisi ◽

Giovanni Di Bernardo

Keyword(s):

Gene Expression ◽

Adipose Tissue ◽

Drug Targets ◽

Metabolic Diseases ◽

Tissue Development ◽

Cellular Functions ◽

Adipose Tissue Development ◽

And Function

Complex interaction between genetics, epigenetics, environment, and nutrition affect the physiological activities of adipose tissues and their dysfunctions, which lead to several metabolic diseases including obesity or type 2 diabetes. Here, adipogenesis appears to be a process characterized by an intricate network that involves many transcription factors and long noncoding RNAs (lncRNAs) that regulate gene expression. LncRNAs are being investigated to determine their contribution to adipose tissue development and function. LncRNAs possess multiple cellular functions, and they regulate chromatin remodeling, along with transcriptional and post-transcriptional events; in this way, they affect gene expression. New investigations have demonstrated the pivotal role of these molecules in modulating white and brown/beige adipogenic tissue development and activity. This review aims to provide an update on the role of lncRNAs in adipogenesis and adipose tissue function to promote identification of new drug targets for treating obesity and related metabolic diseases.

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GROWTH AND DEVELOPMENT SYMPOSIUM: STEM AND PROGENITOR CELLS IN ANIMAL GROWTH: Long noncoding RNAs in adipogenesis and adipose development of meat animals12

Journal of Animal Science ◽

10.1093/jas/skz114 ◽

2019 ◽

Vol 97 (6) ◽

pp. 2644-2657

Author(s):

Shengjuan Wei ◽

Anning Li ◽

Lifan Zhang ◽

Min Du

Keyword(s):

Adipose Tissue ◽

Noncoding Rnas ◽

Growth Efficiency ◽

Long Noncoding Rnas ◽

Farm Animals ◽

Sequencing Technology ◽

Key Factor ◽

Stem And Progenitor Cells ◽

Adipose Tissue Development ◽

Animal Growth

Abstract Sequencing technology, especially next-generation RNA sequencing, has greatly facilitated the identification and annotation of long noncoding RNAs (lncRNAs). In mammals, a large number of lncRNAs have been identified, which regulate various biological processes. An increasing number of lncRNAs have been identified which could function as key regulators of adipogenesis (adipocyte formation), a key step of the development of adipose tissue. Because proper adipose tissue development is a key factor affecting animal growth efficiency, lean/fat ratio, and meat quality, summarizing the roles and recent advances of lncRNAs in adipogenesis is needed in order to develop strategies to effectively manage fat deposition. In this review, we updated lncRNAs contributed to the regulation of adipogenesis, focusing on their roles in fat development of farm animals.

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