scholarly journals Predicting Post-operative Blood Inflammatory Biomarkers Using Pre-operative Heart Rate Variability in Patients With Cervical Cancer

2021 ◽  
Vol 12 ◽  
Author(s):  
Jian Liu ◽  
Shiqi Liu ◽  
Longfei Gao ◽  
Guangqiao Li ◽  
Jie Xu ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Gynecologic Oncology ◽  
Venous Blood ◽  
Inflammatory Biomarkers ◽  
Poincaré Plot ◽  
Lymphocyte Ratio ◽  
Lymphocyte To Monocyte Ratio ◽  
Unit Increase

Blood inflammatory biomarkers, including the neutrophil-to-lymphocyte ratio (NLR), the lymphocyte-to-monocyte ratio (LMR), and the platelet-to-lymphocyte ratio (PLR), play a significant role in determining the prognosis of patients with cervical cancer (CC). Currently, no methods are available to predict these indexes pre-operatively. Cardiac autonomic function is determined based on the heart rate variability (HRV), which is also associated with a progressive inflammatory response and cancer. Thus, the main aim of this study was to evaluate the feasibility of using pre-operative HRV parameters in CC patients to predict post-operative blood inflammation biomarkers as a means of determining prognosis. Between 2020 and 2021, 56 patients who were diagnosed with CC and then underwent hysterectomy surgery at the Department of Gynecologic Oncology, First Affiliated Hospital, Bengbu Medical College were enrolled in this study. Five-minute electrocardiogram data were collected 1 day before the operation for analysis of HRV parameters, including frequency domain parameters (LF, HF, and LF/HF) and Poincaré plot parameters (SD1, SD2, and SD2/SD1). Venous blood was collected 2 days post-operatively and inflammatory biomarkers were evaluated, with the NLR, LMR, and PLR determined. Pre-operative SD2 was significantly associated with post-operative PLR, with each 1-unit increase in SD2 decreasing the PLR value by 2.4 ± 0.9 (P < 0.05). Besides, LF/HF was significantly correlated with NLR, with each 1-unit increase in LF/HF increasing the NLR value by 1.1 ± 0.5 (P < 0.05). This association was independent of patient age and body mass index. These results suggest that the pre-operative autonomic nervous system plays a role in the regulation of post-operative cancer inflammation and that pre-operative HRV parameters can potentially predict post-operative inflammation and facilitate clinical treatment decisions.

scholarly journals Heart Rate Variability Monitoring during Interferential Current Application in the Lower Back Area: A Cross-Sectional Study

2021 ◽  
Vol 18 (7) ◽  
pp. 3394
Author(s):  
Blanca De-la-Cruz-Torres ◽  
Eva Martínez-Jiménez ◽  
Emmanuel Navarro-Flores ◽  
Patricia Palomo-López ◽  
Vanesa Abuín-Porras ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Placebo Group ◽  
Intervention Group ◽  
Lumbar Pain ◽  
Poincaré Plot ◽  
Current Application ◽  
Cross Sectional ◽  
Vasovagal Reactions ◽  
Interferential Current

Vasovagal reactions may occur occasionally during electrical stimulation using interferential current (IFC). The purpose of this study was to examine variations in autonomic activity during the application of IFC in asymptomatic participants by analysis of their heart rate variability (HRV). Seventy-three male volunteers were randomly assigned to a placebo group (n = 36; HRV was documented for 10 min, both at rest and during a placebo intervention) and an intervention group (n = 37; HRV was documented for 10 min in two conditions labelled as (1) rest and (2) application of IFC technique on the lumbar segment). The diameters of the Poincaré plot (SD1, SD2), stress score (SS), and the ratio between sympathetic and parasympathetic activity (S/PS) were measured. After interventions, differences amongst the placebo group and the IFC group were found in SD2 (p < 0.001), SS (p = 0.01) and S/PS ratio (p = 0.003). The IFC technique was associated with increased parasympathetic modulation, which could induce a vasovagal reaction. Monitorization of adverse reactions should be implemented during the application of IFC technique. HRV indicators might have a part in prevention of vasovagal reactions. Further studies in patients with lumbar pain are needed to explore possible differences in HRV responses due to the presence of chronic pain.

scholarly journals Cardiac Parasympathetic Withdrawal and Sympathetic Activity: Effect of Heat Exposure on Heart Rate Variability

2021 ◽  
Vol 18 (11) ◽  
pp. 5934
Author(s):  
Oriol Abellán-Aynés ◽  
Pedro Manonelles ◽  
Fernando Alacid
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Environmental Conditions ◽  
Sympathetic Activity ◽  
Heat Exposure ◽  
Repeated Measurements ◽  
Control Group ◽  
Poincaré Plot ◽  
Activity Effect ◽  
And Control

(1) Background: Research on heart rate variability has increased in recent years and the temperature has not been controlled in some studies assessing repeated measurements. This study aimed to analyze how heart rate variability may change based on environmental temperature during measurement depending on parasympathetic and sympathetic activity variations. (2) Methods: A total of 22 volunteers participated in this study divided into an experimental (n = 12) and control group (n = 10). Each participant was assessed randomly under two different environmental conditions for the experimental group (19 °C and 35 °C) and two identical environmental conditions for the control group (19 °C). During the procedure, heart rate variability measurements were carried out for 10 min. (3) Results: Significantly changes were observed for time and frequency domains as well as Poincaré plot variables after heat exposure (p < 0.05). These findings were not observed in the control group, whose conditions between measurements did not change. (4) Conclusions: The reduction of heart rate variability due to exposure to hot conditions appears to be produced mostly by a parasympathetic withdrawal rather than a sympathetic activation. Therefore, if consecutive measurements have to be carried out, these should always be done under the same temperature conditions.

scholarly journals Heart Rate Variability is an Independent Predictor of Lymph Node Metastasis in Patients with Cervical Cancer

2021 ◽  
Vol Volume 13 ◽  
pp. 8821-8830
Author(s):  
Jingfeng Wang ◽  
Jian Liu ◽  
Longfei Gao ◽  
Guangqiao Li ◽  
Yilin Sun ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Independent Predictor ◽  
Node Metastasis

Characterization of HRV by Poincare Plot Analysis among the Female Tea Garden Workers of Northern Hilly Regions of West Bengal

2012 ◽  
pp. 206-215
Author(s):  
Somsirsa Chatterjee ◽  
Ankur Ganguly ◽  
Saugat Bhattacharya
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Standard Deviation ◽  
West Bengal ◽  
Mean Value ◽  
Short Term ◽  
Poincaré Plot ◽  
Plot Analysis ◽  
Tea Garden

Recent research on Heart Rate Variability (HRV) has proven that Poincare Plot is a powerful tool to mark Short Term and Long Term Heart Rate Variability. This study focuses a comprehensive characterization of HRV among the Tea Garden Workers of the Northern Hilly Regions of West Bengal. The characterization, as available from the data sets, projects the average values of SD1 characteristics, that is, Short Term HRV in females as 58.265ms and SD2 as 149.474. The SDRR shows a mean value of 87.298 with a standard deviation of 119.669 and the S Characterization as 16505.99 ms and Standard deviation of 45882.31 ms. The SDRR shows a mean value of 87.298 with a standard deviation of 119.669 and the S Characterization as 16505.99 ms and Standard deviation of 45882.31 ms. ApEn Characterization showed mean value of 0.961 and standard deviation of 0.274.

Characterization of HRV by Poincare Plot Analysis among the Female Tea Garden Workers of Northern Hilly Regions of West Bengal

2010 ◽  
Vol 5 (2) ◽  
pp. 49-59 ◽  
Author(s):  
Somsirsa Chatterjee ◽  
Ankur Ganguly ◽  
Saugat Bhattacharya
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Standard Deviation ◽  
West Bengal ◽  
Mean Value ◽  
Data Sets ◽  
Short Term ◽  
Poincaré Plot ◽  
Tea Garden

Recent research on Heart Rate Variability (HRV) has proven that Poincare Plot is a powerful tool to mark Short Term and Long Term Heart Rate Variability. This study focuses a comprehensive characterization of HRV among the Tea Garden Workers of the Northern Hilly Regions of West Bengal. The characterization, as available from the data sets, projects the average values of SD1 characteristics, that is, Short Term HRV in females as 58.265ms and SD2 as 149.474. The SDRR shows a mean value of 87.298 with a standard deviation of 119.669 and the S Characterization as 16505.99 ms and Standard deviation of 45882.31 ms. The SDRR shows a mean value of 87.298 with a standard deviation of 119.669 and the S Characterization as 16505.99 ms and Standard deviation of 45882.31 ms. ApEn Characterization showed mean value of 0.961 and standard deviation of 0.274.

scholarly journals Investigating effects of preoperative inflammatory biomarkers on predicting survival outcomes of intrahepatic cholangiocarcinoma after curative resection

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Zeyu Zhang ◽  
Yufan Zhou ◽  
Kuan Hu ◽  
Yun Huang
Keyword(s):  
Intrahepatic Cholangiocarcinoma ◽  
Survival Data ◽  
Roc Curves ◽  
Inflammatory Biomarkers ◽  
Free Survival ◽  
Lymphocyte Ratio ◽  
Lymphocyte To Monocyte Ratio ◽  
Kaplan Meier ◽  
Patient Prognosis ◽  
Curative Hepatectomy

Abstract Introduction Intrahepatic cholangiocarcinoma (ICC) stands as the second most common malignant tumor in the liver with poor patient prognosis. Increasing evidences have shown that inflammation plays a significant role in tumor progression, angiogenesis, and metastasis. However, the prognosis significance of inflammatory biomarkers on recurrence-free survival (RFS) and overall survival (OS) in ICC patients is poorly recognized. Methods ICC patients who underwent curative hepatectomy and diagnosed pathologically were retrospectively analyzed. Inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII), were investigated. Results Receiver operating characteristic (ROC) curves showed no significance in NLR, PLR, and LMR in RFS and OS, while significant results were shown on SII in both RFS (P = 0.035) and OS (P = 0.034) with areas under ROC curve as 0.63 (95%CI 0.52–0.74) and 0.62 (95%CI 0.51–0.72), respectively. Kaplan-Meier curves revealed a statistically significant better survival data in SII-low groups on both RFS (P < 0.001) and OS (P < 0.001). The univariate and multivariate analyses revealed that higher level of SII was independently associated with both poorer RFS time and OS time. However, no significant result was shown on NLR, PLR, or LMR. Conclusion SII is an effective prognostic factor for predicting the prognosis of ICC patient undergone curative hepatectomy, while NLR, PLR, and LMR are not associated with clinical outcomes of these patients.

Segmented Poincaré Plot Analysis for Risk Stratification in Patients with Dilated Cardiomyopathy

2010 ◽  
Vol 49 (05) ◽  
pp. 511-515 ◽  
Author(s):  
C. Fischer ◽  
R. Schroeder ◽  
H. R. Figulla ◽  
M. Goernig ◽  
A. Voss
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Risk Stratification ◽  
Dilated Cardiomyopathy ◽  
Heart Rate Variability Analysis ◽  
Poincaré Plot ◽  
Plot Analysis ◽  
Interval Time Series ◽  
Nonlinear Features ◽  
Cloud Of Points

Summary Background: The prognostic value of heart rate variability in patients with dilated cardiomyopathy (DCM) is limited and does not contribute to risk stratification although the dynamics of ventricular repolarization differs considerably between DCM patients and healthy subjects. Neither linear nor nonlinear methods of heart rate variability analysis could discriminate between patients at high and low risk for sudden cardiac death. Objective: The aim of this study was to analyze the suitability of the new developed segmented Poincaré plot analysis (SPPA) to enhance risk stratification in DCM. Methods: In contrast to the usual applied Poincaré plot analysis the SPPA retains nonlinear features from investigated beat-to-beat interval time series. Main features of SPPA are the rotation of cloud of points and their succeeded variability depended segmentation. Results: Significant row and column probabilities were calculated from the segments and led to discrimination (up to p < 0.005) between low and high risk in DCM patients. Conclusion: For the first time an index from Poincaré plot analysis of heart rate variability was able to contribute to risk stratification in patients suffering from DCM.

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