Relationship Between Blood Cytokine Levels, Psychological Comorbidity, and Widespreadness of Pain in Chronic Pelvic Pain

Background: Low-grade inflammation has been implicated in the etiology of depression, long-term fatigue and chronic pain. TNFα and IL-6 are perhaps the most studied pro-inflammatory cytokines in the field of psychoneuroimmunology. The purpose of our study was to further investigate these relationships in patients with chronic pelvic pain specifically. Using plasma samples from a large, well-described cohort of patients with pelvic pain and healthy controls via the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network, we examined the relationship between TNFα and IL-6 and comorbid psychological symptoms. We also investigated the relationship between IL-8 and GM-CSF, and widespreadness of pain.Methods: We included baseline blood samples in the analyses, 261 patients (148 women) and 110 healthy controls (74 women). Fourteen pro- and anti-inflammatory or regulatory cytokines were analyzed in a Luminex® xMAP® high-sensitivity assay. We used regression models that accounted for known factors associated with the outcome variables to determine the relationship between cytokine levels and clinical measures.Results: There were no statistical differences in cytokine levels between patients and healthy controls when controlling for age. In patients, TNFα was significantly associated with levels of fatigue (p = 0.026), but not with pain intensity or depression. IL-6 was not significantly related to any of the outcome variables. Women with pelvic pain showed a negative relationship between IL-8 and widespreadness of pain, while men did not (p = 0.003). For both sexes, GM-CSF was positively related to widespreadness of pain (p = 0.039).Conclusion: Our results do not suggest low-grade systemic inflammation in chronic pelvic pain. Higher TNFα blood levels were related to higher fatigue ratings, while higher systemic GM-CSF levels predicted more widespread pain. Our study further suggests a potentially protective role of IL-8 with regard to with regard to the widepreadness of pain in the body, at least for women.

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Complementary Approaches for Military Women with Chronic Pelvic Pain: A Randomized Trial

10.21203/rs.3.rs-760730/v1 ◽

2021 ◽

Author(s):

Carol D Crisp ◽

Robert Baldi ◽

Matthew Fuller ◽

Eduardo Abreu ◽

Andrea G Nackley

Keyword(s):

Pelvic Pain ◽

Stress Reduction ◽

Chronic Pelvic Pain ◽

Behavioral Treatment ◽

Pain Perception ◽

Healthy Lifestyle ◽

Military Women ◽

Gm Csf ◽

Non Invasive ◽

Cytokine Levels

Abstract Introduction: Active-duty (AD) women suffer with chronic pelvic pain (CPP) while providers tackle diagnoses and treatments to keep them functional without contributing to the opioid epidemic. The purpose of this study was to determine the effectiveness of non-invasive, self-explanatory mindfulness-based stress reduction (MBSR) or self-paced healthy lifestyle (HL) interventions on CPP in AD women.Methods: We conducted a six-week interventional prospective study with AD women aged 21–55 at Mountain Home (MTHM), Idaho. Women were randomly assigned to MBSR (N = 21) or HL (N = 20) interventions. The primary outcome was pain perception. Secondary outcomes were depression and circulating cytokine levels.Results: Women in the MBSR group exhibited reduced pain interference (P < .01) and depression (P < .05) alongside decreased IL-4 (P < .05), IL-6 (P < .05), eotaxin (P < .05), MCP-1 (P = .06), and IL-1ra (P < .01) and increased VEGF (P < .05). Those in the HL group did not have changes in pain, however, did exhibit reduced depression (P < .05) alongside decreased GM-CSF (P < .05) and increased TNFα (P < .05), SDF-1 (P < .01), and IL-1ra (P < .01).Conclusion: AD women receiving MBSR or HL had reduced depression scores and altered circulating cytokine levels, however only those receiving MBSR had reduced pain perception. Findings support MBSR as an effective and viable behavioral treatment for AD women suffering from CPP.

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MP74-06 DIFFERENCES IN SEXUAL FUNCTION IN PATIENTS WITH UROLOGIC CHRONIC PELVIC PAIN SYNDROMES (UCPPS) AND INDIVIDUALS WITH OTHER CHRONIC PAIN CONDITIONS AND HEALTHY CONTROLS IN THE MAPP RESEARCH NETWORK

The Journal of Urology ◽

10.1016/j.juro.2018.02.2390 ◽

2018 ◽

Vol 199 (4S) ◽

Author(s):

Renee Rolston ◽

Alisa Stephens-Shields ◽

J. Quentin Clemens ◽

John Krieger ◽

Craig Newcomb ◽

...

Keyword(s):

Chronic Pain ◽

Sexual Function ◽

Pelvic Pain ◽

Chronic Pelvic Pain ◽

Research Network ◽

Healthy Controls ◽

Pain Syndromes ◽

Chronic Pain Conditions

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Voluntary exercise improves voiding function and bladder hyperalgesia in an animal model of stress‐induced visceral hypersensitivity: A multidisciplinary approach to the study of urologic chronic pelvic pain syndrome research network study

Neurourology and Urodynamics ◽

10.1002/nau.24270 ◽

2020 ◽

Vol 39 (2) ◽

pp. 603-612 ◽

Cited By ~ 2

Author(s):

Melissa T. Sanford ◽

Jih‐chao Yeh ◽

Jackie J. Mao ◽

Yumei Guo ◽

Zhuo Wang ◽

...

Keyword(s):

Animal Model ◽

Pelvic Pain ◽

Chronic Pelvic Pain ◽

Multidisciplinary Approach ◽

Chronic Pelvic Pain Syndrome ◽

Pain Syndrome ◽

Voluntary Exercise ◽

Research Network ◽

Pelvic Pain Syndrome ◽

Voiding Function

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“The Urinary Proteomic Profile Implicates Key Regulators for Urologic Chronic Pelvic Pain Syndrome (UCPPS): A MAPP Research Network Study”

Molecular & Cellular Proteomics ◽

10.1016/j.mcpro.2021.100176 ◽

2021 ◽

pp. 100176

Author(s):

John W. Froehlich ◽

Hsin-Hsaio Scott Wang ◽

Tanya Logvinenko ◽

Stephen Kostel ◽

Shannon DiMartino ◽

...

Keyword(s):

Pelvic Pain ◽

Chronic Pelvic Pain ◽

Chronic Pelvic Pain Syndrome ◽

Pain Syndrome ◽

Research Network ◽

Pelvic Pain Syndrome ◽

Proteomic Profile

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The expression and significance of inflammatory cytokines and MMP-9 in the tears of the infected eye and contralateral uninfected eye in patients with fungal keratitis

10.21203/rs.3.rs-269176/v1 ◽

2021 ◽

Author(s):

Shuang Zhang ◽

Hui-Min Wu ◽

Xiang-Ni Cao ◽

Xian-Qi Zhang ◽

Gui-ping Gao

Keyword(s):

Tear Film ◽

Fungal Keratitis ◽

Enzyme Linked Immunosorbent Assay ◽

Control Group ◽

Healthy Controls ◽

Tnf Α ◽

Cytokine Levels ◽

Healthy Control ◽

The Relationship ◽

Tear Film Function

Abstract Background: We investigated bilateral tear cytokine levels including interleukin (IL)-1β, IL-10, IL-17, tumor necrosis factor (TNF)-α and Matrix metalloproteinase-9 (MMP-9) in patients with fungal keratitis(FK). Meanwhile, we evaluated the relationship between the changes of tear cytokines with corneal perception and pain in infected eyes, and the relationship between tear cytokines and tear film function in contralateral uninfected eyes .Methods : A total of 60(20 FK, 20 contralateral, 20 healthy controls) tear samples were collected prospectively and analyzed by enzyme linked immunosorbent assay(ELISA). Approximately 50 to 60 ul of tear samples in each case were collected. Meanwhile ,we analyzed the changes of visual analogue scale(VAS), tear breakup time (TBUT), Schirmer I test (SIT) and corneal perception compared with healthy controls. Results :The concentrations of IL-1β, IL-10 and IL-17 increased in bilateral eyes compared with healthy controls(P<0.05). The tear concentrations of MMP-9 , TNF-α only significantly increased in affected eyes (P <0.05). Patients with FK showed significant reduction in corneal perception of infected eyes compared with controls(P<0.05). Corneal perception of the normal eyes in FK patients was slightly lower than that of control group, but there was not statistical difference (P>0.05).TBUT and SIT of contralateral uninfected eyes were significantly lower than that of control group(P<0.05), which were significantly correlated with levels of IL-1β, IL-17(P<0.05). SIT were also negatively correlated with MMP-9(P<0.05), while the levels of IL-1β, IL-10, IL-17, TNF-α and MMP-9 in the tears of the healthy control group had no significant correlation with TBUT and SIT indicators(P>0.05).The corneal perception and VAS score of the affected FK eyes showed correlation with IL-1β, IL-17 and TNF-α(P<0.05).In addition, concentration of IL-10 inversely was correlated with VAS (P<0.05). Conclusion: Proinflammatory tear cytokines are elevated in bilateral eyes with unilateral FK as associated with tear film function ,pain and corneal sensitivity.

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