scholarly journals Psychiatric Symptoms of Children and Adolescents With Mitochondrial Disorders: A Descriptive Case Series

2021 ◽  
Vol 12 ◽  
Author(s):  
Elise Riquin ◽  
Thomas Le Nerzé ◽  
Natwin Pasquini ◽  
Magalie Barth ◽  
Clément Prouteau ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Children And Adolescents ◽  
Rating Scale ◽  
Psychiatric Symptoms ◽  
Case Series ◽  
Mitochondrial Disorders ◽  
Psychiatric Interview ◽  
Neuropsychological Profile ◽  
Quality Of Life Scale

Background: Mitochondrial disorders (MD) are a group of clinically heterogeneous genetic disorders resulting from dysfunction of the mitochondrial respiratory chain. Cognitive impairment is a common feature in adults with MD and psychiatric symptoms are associated with MD in up to 70% of the adult population. The aim of this study is to describe the psychiatric profile in children and adolescents with MD by focusing on the description of psychiatric symptoms.Methods: A cohort of 12 children and adolescents was prospectively recruited between February 2019 and February 2020 in the Reference Center for Mitochondrial Disorders of Angers (France). Participants and their parents completed an anamnestic form to provide socio-demographic data and completed the Global Assessment of Functioning scale, the Brief Psychiatric Rating Scale, the Child Depression Inventory, the Revised Children's Manifest Anxiety Scale, and the Conner's Rating Scale to evaluate the inattention/hyperactivity symptoms as well as the Quality of Life scale.Results: Four children (33.3%) were diagnosed with depressive symptoms. With regarding to anxiety, 6 children (50%) reported anxiety issues during the psychiatric interview and 3 children (25%) were suffering from anxiety according to the RCMAS scale. Compared to other children with chronic illnesses, the individuals in our cohort reported a lower overall quality of life score and lower scores in physical and social subscales.Conclusion: Our study shows that MD can lead to psychiatric disorders in children and adolescents, in particular anxiety and depression, as well as poor quality of life. This highlights the need for regular psychiatric assessments in individuals with developing brains, such as children and adolescents. We do not, however, have data regarding the neuropsychological profile of this population.

Association of Progressive Supranuclear Palsy Rating Scale with Progressive Supranuclear Palsy Quality of Life Scale

2021 ◽  
pp. 1-8
Author(s):  
Alexander Pantelyat ◽  
Lenora Higginbotham ◽  
Liana Rosenthal ◽  
Diane Lanham ◽  
Vanessa Nesspor ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trials ◽  
Progressive Supranuclear Palsy ◽  
Rating Scale ◽  
Linear Regression Analysis ◽  
Disease Evolution ◽  
Quality Of Life Scale ◽  
Patient Reported ◽  
Scale Scores

<b><i>Introduction:</i></b> There is growing interest in using patient-reported outcomes as end points in clinical trials, such as the progressive supranuclear palsy quality of life (PSP-QoL) scale. However, this tool has not been widely validated and its correlation with validated motor scales has not been explored. To evaluate the potential utility of using PSP-QoL as an outcome, it is important to examine its relationship with a standard scale used to evaluate neurologic parameters, such as the PSP Rating Scale. <b><i>Methods:</i></b> PSP-QoL and PSP Rating Scale scores were gathered from 60 clinically diagnosed PSP patients, including patients with Richardson syndrome PSP (PSP-RS, <i>n</i> = 43) and those with non-RS PSP variants (<i>n</i> = 17). Linear regression analysis adjusted for age, sex, and disease duration was used to evaluate the cross-sectional relationship between the total and subscale scores of the 2 instruments. <b><i>Results:</i></b> Among 60 PSP patients, there was a significant correlation between total PSP-QoL and PSP Rating Scale scores. The physical and mentation subscales of each instrument also demonstrated significant correlations. Comparisons among PSP subtypes indicated that worsening PSP-QoL Total and Physical subscale scores correlated with worsening PSP Rating Scale gait subscale scores more strongly for the non-RS PSP variants than for PSP-RS. <b><i>Discussion:</i></b> There is a significant association between the total scores and many of the subscale scores of the PSP-QoL and the PSP Rating Scale. Additionally, the relationship between these measures may differ for PSP-RS and non-RS variants. These findings suggest that the PSP-QoL may be useful in clinical trials as a patient-reported outcome measure. Large prospective multicenter studies utilizing the PSP-QoL are necessary to examine its relationship to disease evolution and changes in the PSP Rating Scale.

scholarly journals Correlations Between Clinical Trial Outcomes Based on Symptoms, Functional Impairments, and Quality of Life in Children and Adolescents With ADHD

2017 ◽  
Vol 23 (13) ◽  
pp. 1578-1591 ◽  
Author(s):  
David R. Coghill ◽  
Alain Joseph ◽  
Vanja Sikirica ◽  
Mark Kosinski ◽  
Caleb Bliss ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Children And Adolescents ◽  
Rating Scale ◽  
Controlled Trial ◽  
Pearson Correlation ◽  
Correlation Coefficients ◽  
Parent Report ◽  
Functional Impairments ◽  
Risk Avoidance

Objective: To assess relationships between treatment-associated changes in measures of ADHD symptoms, functional impairments, and health-related quality of life in children and adolescents with ADHD. Method: Pearson correlation coefficients were calculated post hoc for changes from baseline to endpoint in outcomes of one randomized, placebo- and active-controlled trial of lisdexamfetamine (osmotic-release methylphenidate reference) and one of guanfacine extended-release (atomoxetine reference). Results: Changes in ADHD Rating Scale IV (ADHD-RS-IV) total score generally correlated moderately with changes in Child Health and Illness Profile−Child Edition: Parent Report Form (CHIP-CE:PRF) Achievement and Risk Avoidance ( r ≈ .4), but weakly with Resilience, Satisfaction, and Comfort ( r ≈ .2); and moderately with Weiss Functional Impairment Rating Scale–Parent (WFIRS-P) total score ( r ≈ .5). CHIP-CE:PRF Achievement and Risk Avoidance correlated moderately to strongly with WFIRS-P total score ( r ≈ .6). Conclusion: The ADHD-RS-IV, CHIP-CE:PRF, and WFIRS-P capture distinct but interconnected aspects of treatment response in individuals with ADHD.

The Menopause Rating Scale (MRS): comparison with Kupperman index and quality-of-life scale SF-36

Climacteric ◽  
2000 ◽  
Vol 3 (1) ◽  
pp. 50-58 ◽  
Author(s):  
H. P. G. Schneider ◽  
L. A. J. Heinemann ◽  
H.-P. Rosemeier ◽  
P. Potthoff ◽  
H. M. Behre
Keyword(s):  
Quality Of Life ◽  
Rating Scale ◽  
Kupperman Index ◽  
Sf 36 ◽  
Quality Of Life Scale ◽  
Life Scale ◽  
Menopause Rating Scale

scholarly journals The Gilles De La Tourette Syndrome-Quality of Life Scale for Children and Adolescents (C&A-GTS-QOL): Development and Validation of the Italian Version

2013 ◽  
Vol 27 (1) ◽  
pp. 95-103 ◽  
Author(s):  
Andrea E. Cavanna ◽  
Chiara Luoni ◽  
Claudia Selvini ◽  
Rosanna Blangiardo ◽  
Clare M. Eddy ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Children And Adolescents ◽  
Tourette Syndrome ◽  
Rating Scales ◽  
Self Report ◽  
Principal Component Factor Analysis ◽  
Quality Of Life Scale ◽  
Life Scale ◽  
Disease Specific

Background:Gilles de la Tourette syndrome (GTS) is a chronic childhood-onset neuropsychiatric disorder with a significant impact on patients’ health-related quality of life (HR-QOL). Cavanna et al. (Neurology 2008; 71: 1410–1416) developed and validated the first disease-specific HR-QOL assessment tool for adults with GTS (Gilles de la Tourette Syndrome-Quality of Life Scale, GTS-QOL). This paper presents the translation, adaptation and validation of the GTS-QOL for young Italian patients with GTS.Methods:A three-stage process involving 75 patients with GTS recruited through three Departments of Child and Adolescent Neuropsychiatry in Italy led to the development of a 27-item instrument (Gilles de la Tourette Syndrome-Quality of Life Scale in children and adolescents, C&A-GTS-QOL) for the assessment of HR-QOL through a clinician-rated interview for 6–12 year-olds and a self-report questionnaire for 13–18 year-olds.Results:The C&A-GTS-QOL demonstrated satisfactory scaling assumptions and acceptability. Internal consistency reliability was high (Cronbach’s alpha > 0.7) and validity was supported by interscale correlations (range 0.4–0.7), principal-component factor analysis and correlations with other rating scales and clinical variables.Conclusions:The present version of the C&A-GTS-QOL is the first disease-specific HR-QOL tool for Italian young patients with GTS, satisfying criteria for acceptability, reliability and validity.

scholarly journals EFFECT OF BEHAVIORAL PROBLEMS OF CHILDREN WITH AUTISM ON THEIR MOTHER’S QUALITY OF LIFE

2020 ◽  
Vol 70 (6) ◽  
pp. 1666-70
Author(s):  
Ayesha Waheed ◽  
Mussarat Jabeen Khan ◽  
Maryam Khurshid
Keyword(s):  
Quality Of Life ◽  
Study Design ◽  
Behavioral Problems ◽  
Working Mothers ◽  
Rating Scale ◽  
Negative Relationship ◽  
Children With Autism ◽  
Joint Family ◽  
Quality Of Life Scale

Object: The aim of the present study was to assess effect of behavioral problems of children with Autism on their mother’s quality of life. Study Design: Cross-sectional study design Place and Duration of Study: The sample was selected from different special education institutes of Islamabad and Rawalpindi. Duration of study was from March 2017 to September 2017. Participants and Methods: The Study was conducted on 100 participants (N=100, n= 50 mothers, n=50 diagnosed children with Autism). Convenient and snowball sampling technique was used to collect data. Two questionnaires were administered to assess Quality of life (WHO Quality of life scale -BREF) and behavior problems of children with Autism (Childhood Autism Rating Scale-CARS). Results: Results showed that quality of life of mothers has a significant negative relationship with their children’s autism related behavioral problems. Quality of life was found high in postgraduate mothers, while autism related behavioral problems were less in children with postgraduate mothers. Mothers living in joint family scored high on quality of, whereas child with Autism belonging to joint family system had fewer behavioral problems. Quality of life among working mothers was found high and children of working mothers exhibited less autism related behavioral problems than children of non-working mothers. Conclusion: Present study highlighted the importance of behavioral problems of children with Autism on their mother’s quality of life. The study would be helpful for the professionals for devising educational programs for mothers and treatment plans for their children with Autism. Keywords: Quality of life, Autism, behavioral problems

Welfare of cats 5–29 months after perineal urethrostomy: 74 cases (2015–2017)

2019 ◽  
Vol 22 (6) ◽  
pp. 582-588 ◽  
Author(s):  
Margaret R Slater ◽  
Sharon Pailler ◽  
J’mai M Gayle ◽  
Illoneete Cohen ◽  
Erin L Galloway ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Case Series ◽  
Life Outcomes ◽  
Retrospective Case ◽  
Quality Of Life Scale ◽  
Life Scale ◽  
Potential Factors ◽  
American Society

Objectives The objective of this study was to evaluate the long-term quality of life in cats following perineal urethrostomy. Methods This study comprised a retrospective case series of 74 cats with urinary obstructions that received perineal urethrostomies at the American Society for the Prevention of Cruelty to Animals (ASPCA) Animal Hospital between September 2015 and July 2017. Medical records were reviewed for information on the number of obstructions prior to surgery, urinary tract problems at the time of surgery and other potential factors influencing long-term welfare. Owners were surveyed by telephone and text 5–29 months after their cat’s surgery. Responses were compiled and analyzed to determine owner perception of welfare postsurgery, and to identify patterns in medical history and welfare outcomes. Results In total, 105 cat owners were eligible for the survey; 74 responded. Altogether, 100% of responding individuals reported at least the same quality of life postsurgery compared with the cat’s quality of life before demonstrating urinary problems (48% reported better). On a quality-of-life scale of 1–10 (10 = excellent), 100% of responding cat owners reported at least 7; 75% reported 10. Conclusions and relevance Quality-of-life outcomes for cats 5–29 months after receiving perineal urethrostomy surgery were reported to be very good. Given this finding, and that perineal urethrostomy surgery should mitigate future blockages, we suggest considering perineal urethrostomy surgery as a standard tool to manage urinary obstructions in cats. The needs of the specific client and patient, including risks, costs and welfare of the cats, should drive the options for management of urinary obstructions in male cats.

scholarly journals Te.M.P.O., an app for using temporal musical mismatch in post-stroke neurorehabilitation: A preliminary randomized controlled study

2020 ◽  
Vol 47 (2) ◽  
pp. 201-208
Author(s):  
Valeria Verna ◽  
Daniela De Bartolo ◽  
Marco Iosa ◽  
Lucia Fadda ◽  
Gianluca Pinto ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Acute Phase ◽  
Rating Scale ◽  
Controlled Study ◽  
Clinical Scales ◽  
Disability Rating Scale ◽  
Quality Of Life Scale ◽  
Life Scale ◽  
Disability Rating

BACKGROUND: Recently, the potential rehabilitation value of music has been examined and music-based interventions and techniques such as the Negative Mismatch (MMN) have been increasingly investigated in the neurological rehabilitation context. OBJECTIVE: The aim of this study was to investigate the effectiveness of a negative mismatch-based therapy on the disability and quality of life in patients with stroke in sub-acute phase. METHODS: Thirty patients with a stroke diagnosis in sub-acute phase were randomly assigned to one of two groups: Mismatch (Mg) or Control (CTRLg) group. Both groups used an innovative Android application: Temporal Musical Patterns Organisation (Te.M.P.O). The Disability Rating Scale (DRS), the Modified Barthel Index (MBI) and the Stroke Specific Quality of Life scale (SSQoL) were used at the baseline (T0) and after four weeks of training (T1), in order to assess changes over time. RESULTS: Statistical analysis was performed using the data of 24 (Mg = 12, CTRLg = 12) subjects. The results show a major improvement of the Mg with respect to the CTRLg in all clinical scales score. CONCLUSION: The temporal negative mismatch-based therapy performed with the Te.M.P.O. application could be useful in improving the disability and the quality of life in stroke survivors in a sub-acute phase.

scholarly journals Effective strategies for nurses empowering the life quality and antipsychotic adherence of patients with schizophrenia

2018 ◽  
Vol 8 (10) ◽  
pp. 106 ◽  
Author(s):  
Saida I. El-Azzab ◽  
Entisar M. Abu-Salem
Keyword(s):  
Quality Of Life ◽  
Rating Scale ◽  
Demographic Data ◽  
Life Quality ◽  
Structured Interview ◽  
Psychiatric Nursing ◽  
Effective Strategies ◽  
Quality Life ◽  
Quality Of Life Scale

Background and objective: Schizophrenia requires preservation of treatment with psychotropic medication and psycho-educational therapy. The nurse uses effective strategies to train those patients about stress management; relaxation technique and increase self-awareness, to improve their quality of life and enhance antipsychotic adherence. The study aimed to assess the effective strategies for nurses empowering the life quality and antipsychotic adherence of patients with schizophrenia.Methods: Quasi-experimental research design was utilized in this study. The present study was achieved at the outpatient departments of the Mental Hospital in Beni-Suef, Egypt. A non-probability sampling of 60 patients with schizophrenia were recruited for the study. Tools of this study included: A structured interview questionnaire related to soci-demographic data, the quality of life scale, and the medication adherence rating scale. The training program consisted of 8 sessions.Results: The study indicated that there were statistically significant improvements in the life quality and antipsychotic adherence for patients with schizophrenia after application of psychiatric nursing instructions.Conclusions and recommendations: The results of this study concluded that psychiatric nursing approaches were effective in the improvement the quality life and adherence to antipsychotic of patients with schizophrenic disorders. Recommendations: This study recommended that a psychiatric nurse must use the effective strategies for empowering the life quality and antipsychotic adherence of patients with schizophrenia.

Analisis of quality of life long-term hospitalized schizophrenic patients

2011 ◽  
Vol 26 (S2) ◽  
pp. 1513-1513 ◽  
Author(s):  
G. Tasic ◽  
S. Anakiev ◽  
D. Milosevic ◽  
M. Cvetanovic
Keyword(s):  
Quality Of Life ◽  
Rating Scale ◽  
Length Of Hospital Stay ◽  
Hospital Treatment ◽  
Quality Of Life Scale ◽  
Life Scale ◽  
Icd 10 ◽  
Schizophrenic Patients

IntroductionLong term hospitalization are often caused by social reasons wich significantly affects the quality of the patients.AimComparing the quality of long-term hospitalized schizophrenic patients in relation to sex.MethodWe have used following rating scale: a brief psychiatric assessment scale BPRS, QLS Quality of life scale, “Lancashir” profile quality of life scale LQOLP, a short questionnaire for the “needs assessment Cambersels” scale CANSAS. Analysis included 80 inpatients, 40 male and 40 female, with Schizophrenia according to ICD 10 criteria. All patients were hospitalized according to ICD 10 criteria. All patients were hospitalized in a Special Hospital For Psychiatric Illness G. Toponica more than two years.ResultsSignificant differences in quality of life between male and female patients about what is discussed in further study.ConclusionsResearch has shown that long-term hospitalizing has adverse effects on quality of life of schizophrenic patients of both sexes. His essential that the length of hospital stay should be reduced to the period reduced to the period for reduction of symptoms and provide the patient a stable life in the community after hospital treatment.

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