The Changes in Concentration of Cerebral Oxygenated Hemoglobin During Single Event-Related Japanese Shiritori Task in Patients With Major Depression Disorder: Comparison With Healthy Subjects

Patients with major depressive disorder (MDD) have been reported to show cognitive impairments in attention, cognition control, and motivation. The purpose of this study is to compare and examine the characteristics of frontal and temporal cortical activity in outpatients with MDD during the word production task (Shiritori) using a single event-related Near-Infrared Spectroscopy (NIRS) measurement method that was originally devised. The subjects were 29 MDD patients and 29 age matched healthy controls. In this task, one session consisted of two contrasting conditions (word production task, control condition), and all subjects alternated between these conditions. Each word was visually presented by a monitor for 0.3 s as an activation task and a fixed circle was presented for 12 s. In the activation task, subjects had to immediately generate a noun that starts with the last syllable of the presented word and they were required to say only creatures. From the data obtained at each measurement point during the 20 trials, and averaged waveform during activation task (20 trials) was calculated for each channel. During the word production task, the MDD patients showed significantly smaller activation than the controls in the prefrontal cortex area and inferior parietal area, especially in the left area. In addition, there was a significant negative correlation between Δoxy-Hb at the bilateral temporal lobe area and HAM-D total score in the MDD patients. These findings suggest that a single event-related NIRS measurement during Japanese shiritori tasks may be useful tool for evaluating psychophysiological indices in MDD patients, that relationship between activation and symptom may be of help in predicting functional outcome in patients.

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Probing prefrontal cortex hemodynamic alterations during facial emotion recognition for major depression disorder through functional near-infrared spectroscopy

Journal of Neural Engineering ◽

10.1088/1741-2552/ab0093 ◽

2019 ◽

Vol 16 (2) ◽

pp. 026026 ◽

Cited By ~ 7

Author(s):

Lin Gao ◽

Yunli Cai ◽

Huaning Wang ◽

Gang Wang ◽

Quan Zhang ◽

...

Keyword(s):

Prefrontal Cortex ◽

Infrared Spectroscopy ◽

Major Depression ◽

Emotion Recognition ◽

Near Infrared Spectroscopy ◽

Near Infrared ◽

Facial Emotion ◽

Major Depression Disorder ◽

Functional Near Infrared Spectroscopy ◽

Depression Disorder

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Role of Behavioral Activation and Inhibition Systems in Symptoms of Major Depression Disorder Regarding the Mediating Role of Cognitive Bias

10.32592/ajnpp.2021.8.4.108 ◽

2020 ◽

pp. 215-221

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Cognitive Bias ◽

Behavioral Inhibition ◽

Behavioral Activation ◽

Major Depression Disorder ◽

Major Depressive ◽

Mediating Role ◽

Depression Disorder

Background: This study aimed to investigate the role of the behavioral activation and inhibition systems in symptoms of major depressive disorder, considering the mediating role of cognitive bias. Materials and Methods: The statistical population of this descriptive-correlational research was all the students of Ahvaz Azad University, Ahvaz, Iran during the academic year 2015-16. In total, 300 students were selected using the multistage sampling method, and finally, 279 students participated in this research. Data were collected using the Behavioral Inhibition/Activation Systems Scale, the Dysfunctional Attitudes Scale, and the Beck Depression Inventory. The collected data were analyzed using multiple regression analysis, coefficient correlation, and structural equation modeling in SPSS (version 22), Lisrel (version 8.80), and Mplus (version 6.12) software. Results: The results showed that cognitive bias mediated the influence of behavioral inhibition and activation systems on depressive disorder. Based on the findings, all of the direct and indirect effects of the model were significant. The model itself had a suitable index of fit, and cognitive bias significantly affected major depressive disorder symptoms. In the final model, the direct effect of the behavioral inhibition system was added to depression. Moreover, the indirect effect of the behavioral activation system on depression was not significant. Conclusion: The proposed model had an acceptable fitness to the result and was an essential step in recognition of the significant factors of major depressive disorder. It can be useful as a model for designing stress management programs and decreasing major depression disorder.

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Brainwaves Oscillations as a Potential Biomarker for Major Depression Disorder Risk

Clinical EEG and Neuroscience ◽

10.1177/1550059419876807 ◽

2019 ◽

Vol 51 (1) ◽

pp. 3-9 ◽

Cited By ~ 3

Author(s):

Patricia Fernández-Palleiro ◽

Tania Rivera-Baltanás ◽

Daniela Rodrigues-Amorim ◽

Sonia Fernández-Gil ◽

María del Carmen Vallejo-Curto ◽

...

Keyword(s):

Major Depressive Disorder ◽

Clinical Practice ◽

Cognitive Capacity ◽

Brain Electrical Activity ◽

Major Depression Disorder ◽

Major Depressive ◽

New Techniques ◽

Future Clinical Practice ◽

Potential Biomarker ◽

Depression Disorder

Major depressive disorder (MDD) is a multidimensional disorder that is characterized by the presence of alterations in mood, cognitive capacity, sensorimotor, and homeostatic functions. Given that about half of the patients diagnosed with MDD do not respond to the various current treatments, new techniques are being sought to predict not only the course of the disease but also the characteristics that differentiate responders from non-responders. Using the electroencephalogram, a noninvasive and inexpensive tool, most studies have proposed that patients with MDD have some lateralization in brain electrical activity, with alterations in alpha and theta rhythms being observed, which would be related to dysfunctions in emotional capacity such as the absence or presence of responses to the different existing treatments. These alterations help in the identification of subjects at high risk of suffering from depression, in the differentiation into responders and nonresponders to various therapies (pharmacological, electroconvulsive therapy, and so on), as well as to establish in which period of the disease the treatment will be more effective. Although the data are still inconclusive and more research is needed, these alpha and theta neurophysiological markers could support future clinical practice when it comes to establishing an early diagnosis and treating state disorders more successfully and accurately of mood disorders.

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Belastungen in der Kindheit und dissoziative Symptomatik bei Patienten mit psychischen Störungen

Zeitschrift für Klinische Psychologie und Psychotherapie ◽

10.1026/1616-3443/a000183 ◽

2013 ◽

Vol 42 (1) ◽

pp. 24-33 ◽

Cited By ~ 4

Author(s):

Johanna Fiess ◽

Astrid Steffen ◽

Christian Pietrek ◽

Brigitte Rockstroh

Keyword(s):

Major Depression ◽

Major Depression Disorder ◽

Dissoziative Symptome ◽

Kindheit Und Jugend ◽

Depression Disorder

Theoretischer Hintergrund: Dissoziative Symptome treten bei verschiedenen psychischen Störungen auf und werden bei einigen Störungen mit traumatischen Erfahrungen assoziiert. Fragestellung: Wird der Zusammenhang zwischen dissoziativer Symptomatik und belastenden Erfahrungen moduliert durch die Art der Erfahrung und das Alter zum Zeitpunkt der Belastung? Methode: Bei 82 Patienten (Borderline-Persönlichkeitsstörung, BPS; Major Depression Disorder, MDD) und 54 gesunden Kontrollpersonen wurden per Interview belastende Erfahrungen während Kindheit und Jugend (3 – 16 Jahre) ermittelt. Zusammenhänge zwischen Belastung und dissoziativer Symptomatik wurden regressionsanalytisch unter Berücksichtigung von Diagnose und komorbider Posttraumatischer Belastungsstörung (PTBS) untersucht. Ergebnisse: Dissoziative Symptomatik korreliert bei BPD und MDD (mit komorbider PTBS) positiv mit emotionalem (neben sexuellem) Missbrauch und mit Belastungen in der Pubertät. Schlussfolgerung: Therapeutische Berücksichtigung emotionaler und pubertärer Belastung könnte die (Behandlung erschwerende) dissoziative Symptomatik reduzieren.

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