scholarly journals Does Longer Leukocyte Telomere Length and Higher Physical Fitness Protect Master Athletes From Consequences of Coronavirus (SARS-CoV-2) Infection?

2020 ◽  
Vol 2 ◽  
Author(s):  
Herbert Gustavo Simões ◽  
Thiago Santos Rosa ◽  
Caio Victor Sousa ◽  
Samuel da Silva Aguiar ◽  
Daisy Motta-Santos ◽  
...  
2015 ◽  
Vol 47 (12) ◽  
pp. 2525-2534 ◽  
Author(s):  
LUISA SOARES-MIRANDA ◽  
FUMIAKI IMAMURA ◽  
DAVID SISCOVICK ◽  
NANCY SWORDS JENNY ◽  
ANNETTE L. FITZPATRICK ◽  
...  

2020 ◽  
Vol 29 (3) ◽  
pp. 256-263
Author(s):  
Yun-Cheol Shin ◽  
Yongchul Jang ◽  
Joon-Yong Cho

PURPOSE: This study is to investigate the effects of combined exercise on body composition, physical fitness and leukocyte telomere length in elderly women.METHODS: Twenty-six elderly women were randomly divided into two group: combined exercise group (EXE, n=14) and control group (CON, n=12). EXE group performed combined exercise for 60 mintues per day, 2days/week for 12 weeks.RESULTS: There was significant interaction between groups and time points in body composition (e.g., skeletal muscle mass, visceral fat area, and Inbody score). EXE group was no significant changes in skeletal muscle mass, visceral fat area and Inbody score, but the CON group showed significant decrease in skeletal muscle mass and Inbody score. Furthermore, increased in visceral fat area. Among the measurement variable of physical fitness, there was significant interaction between group and time in 6 minutes walking test, chair sit test, and knee flexion muscle endurance. In EXE group, 6 minutes walking test and chair test was significantly increased, and there were no significant differences in knee flexion muscle endurance, whereas CON group, the 6 minutes walking test and knee flexion muscle endurance significantly decreased, and there was no significant difference in chair test. In addition, there was significant interaction between groups and time points in leukocyte telomere length. EXE group was no significant changes, but CON group significantly decreased.CONCLUSIONS: Our study suggest that combined exercise-induced improvement of body composition and physical fitness may have had a positive effect on leukocyte telomere length in elderly women.


2021 ◽  
Author(s):  
Resham L Gurung ◽  
Rajkumar Dorajoo ◽  
Yiamunaa M ◽  
Ling Wang ◽  
Sylvia Liu ◽  
...  

Abstract Background Chronic kidney disease (CKD) is common among type 2 diabetes (T2D) and increases the risk of kidney failure and cardiovascular diseases. Shorter leukocyte telomere length is associated with CKD in patients with T2D. We previously reported single nucleotide polymorphisms (SNPs) associated with leukocyte telomere length in Asian population. In this study, we elucidated the association of these SNPs with CKD in patients with T2D using Mendelian randomization (MR) approach. Methods The cross-sectional association of 16 leukocyte telomere length SNPs with CKD, defined as an estimated glomerular filtration rate of less than 60 ml/min/1.73m2 was assessed among 4,768 (1,628 cases, 3,140 controls) participants in the Singapore Study of Macro-angiopathy and Micro-vascular Reactivity in Type 2 Diabetes and Diabetic Nephropathy cohorts. MR analysis was performed using the random-effect inverse-variance weighted (IVW) method, the weighted median, MR-Egger and Radial MR adjusted for age and sex-stratified by cohorts and ethnicity (Chinese and Malays), then meta-analysed. Results Genetically determined shorter leukocyte telomere length was associated with increased risk of CKD in patients with T2D (meta-IVW adjusted odds ratio = 1.51 [95% confidence interval, 1.12 - 2.12; P = 0.007; Phet= 0.547]). Similar results were obtained following sensitivity analysis. MR-Egger analysis (intercept) suggested no evidence of horizontal pleiotropy (β  =  0.010, P = 0.751). Conclusions Our findings suggest that genetically determined leukocyte telomere length is associated with CKD in patients with T2D. Further studies are warranted to elucidate the causal role of telomere length in CKD progression.


Author(s):  
Fernanda Gutierrez-Rodrigues ◽  
Raquel M. Alves-Paiva ◽  
Natália F. Scatena ◽  
Edson Z. Martinez ◽  
Priscila S. Scheucher ◽  
...  

2020 ◽  
Vol 14 (11) ◽  
pp. 933-941
Author(s):  
Ying Sun ◽  
Wei Wang ◽  
Yue-Ru Jiao ◽  
Jian Ren ◽  
Lei Gao ◽  
...  

Aim: This study aimed to explore the prognostic value of leukocyte telomere length (LTL) in patients with coronary artery disease (CAD). Materials & methods: We enrolled 366 CAD patients and 76 healthy subjects in this study. LTL was measured. All subjects were followed up for 6 months for further analysis regarding major adverse cardiac events (MACEs). Results: CAD patients had a significantly shortened LTL compared with healthy subjects (p < 0.05). The area under the curve for LTL prediction of MACEs was 0.769 (p < 0.001), with a shorter LTL being an independent predictor of MACEs (Cox proportional hazards regression, hazard ratio: 2.866; p < 0.001). Conclusion: LTL could be considered as an independent predictor of short-term MACEs in CAD.


2015 ◽  
Vol 66 ◽  
pp. 25-31 ◽  
Author(s):  
Barbara Rubek Nielsen ◽  
Allan Linneberg ◽  
Laila Bendix ◽  
Maria Harboe ◽  
Kaare Christensen ◽  
...  

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