scholarly journals The High Immunity Induced by the Virus-Like Particles of Foot-and-Mouth Disease Virus Serotype O

2021 ◽  
Vol 8 ◽  
Author(s):  
Yan Xiao ◽  
Suling Zhang ◽  
He Yan ◽  
Xiaolin Geng ◽  
Yanwei Wang ◽  
...  
Keyword(s):  
Foot And Mouth Disease ◽  
Viral Disease ◽  
Mouth Disease ◽  
Dependent Manner ◽  
Virus Like Particles ◽  
Serotype O ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth ◽  
Cellular Immune

Foot-and-mouth disease (FMD), caused by FMD virus (FMDV), is a highly contagious and economically devastating viral disease of cloven-hoofed animals worldwide. In this study, the coexpression of small ubiquitin-like modifier (SUMO)–fused capsid proteins of FMDV serotype O by single plasmid in Escherichia coli was achieved with an optimal tandem permutation (VP0–VP3–VP1), showing a protein yield close to 1:1:1. After SUMO removal at a low level of protease activity (5 units), the assembled FMDV virus-like particles (VLPs) could expose multiple epitopes and have a size similar to the naive FMDV. Immunization of pigs with the FMDV VLPs could induce FMDV-specific humoral and cellular immune responses effectively, in a dose-dependent manner. These data suggested that the stable FMDV VLPs with multiple epitope exposure were effective for the induction of an immune response in pigs, which laid a foundation for the further development of the FMDV subunit vaccine.

Mutation in the VP2 gene of P1-2A capsid protein increases the thermostability of virus-like particles of foot-and-mouth disease virus serotype O

2018 ◽  
Vol 102 (20) ◽  
pp. 8883-8893 ◽  
Author(s):  
Vishweshwar Kumar Ganji ◽  
Jitendra K. Biswal ◽  
H. Lalzampuia ◽  
S. H. Basagoudanavar ◽  
P. Saravanan ◽  
...  
Keyword(s):  
Capsid Protein ◽  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Vp2 Gene ◽  
Virus Like Particles ◽  
Serotype O ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth

Antiviral potential of ivermectin against foot-and-mouth disease virus, serotype O, A and Asia-1

2021 ◽  
pp. 104914
Author(s):  
Zahra Naeem ◽  
Sohail Raza ◽  
Saba Afzal ◽  
Ali Ahmad Sheikh ◽  
Muhammad Muddassir Ali ◽  
...  
Keyword(s):  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Serotype O ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth

scholarly journals Hemato-Biochemical studies on Egyptian Buffaloes and Calves naturally infected with Foot and Mouth Disease Virus serotype SAT 2

2016 ◽  
Vol 73 (2) ◽  
pp. 230
Author(s):  
Essam A Mahmoud ◽  
Ahmed N.F Neamat-allah
Keyword(s):  
Clinical Signs ◽  
Foot And Mouth Disease ◽  
Viral Disease ◽  
Mouth Disease ◽  
Cardiac Markers ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth ◽  
Infected Adult ◽  
Apparently Healthy

Foot and mouth disease (FMD) is a highly contagious viral disease of all cloven footed domestic and wild animals. This work was planned to study the different markers for diagnosis of FMDV serotype Sat2 in adult buffaloes and calves including clinical, hematological and biochemical examinations. A total number of sixty animals were divided into four groups. The first group was apparently healthy adult buffaloes, while the second was naturally infected adult buffaloes, a third group was apparently healthy suckling calves and finally the fourth group was naturally infected suckling calves. The recorded clinical signs were fever, salivation, loss of appetite, depression, lameness, blisters or vesicles, erosions and ulcers in the mucosa of the mouth, tongue, lips, gums, pharynx, palate and between the claws. Anemia, leucopenia, lymphopenia and monocytopenia were recorded in infected adult buffaloes and calves. Myocardial injury proved by presence of degenerated myocardial fibers and lymphocyte cell infiltration with a significant increase in cardiac markers like cardiac torponin I, CPK and LDH in addition to a significant hyperkalemia, hypocalcaemia and hypomagnesemia in buffaloe calves. Moreover, electrophoresis showed hyoproteinemia, hypoalbuminemia and hypoglobulinemia in infected animals. It could be concluded that the elevation of cardiac markers emphasized that FMD is more severe in young calves than adult animals. Therefore, it is recommended to evaluate the prognosis of FMD infection in calves by these markers.

scholarly journals Pandemic Strain of Foot-and-Mouth Disease Virus Serotype O

2005 ◽  
Vol 11 (12) ◽  
pp. 1887-1893 ◽  
Author(s):  
Nick J. Knowles ◽  
Alan R. Samuel ◽  
Paul R. Davies ◽  
Rebecca J. Midgley ◽  
Jean-François Valarcher
Keyword(s):  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Pandemic Strain ◽  
Serotype O ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth

Emergence of antigenic variants of Foot-and-Mouth Disease Virus serotype O in Ecuador and preliminary evaluation of a field strain as a vaccine candidate

Vaccine ◽  
2014 ◽  
Vol 32 (21) ◽  
pp. 2446-2451 ◽  
Author(s):  
Eduardo Maradei ◽  
Viviana Malirat ◽  
Claudia Perez Beascoechea ◽  
Ana María Espinoza ◽  
Sabrina Galdo Novo ◽  
...  
Keyword(s):  
Disease Virus ◽  
Vaccine Candidate ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Field Strain ◽  
Preliminary Evaluation ◽  
Serotype O ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth

Application of a recombinant capsid polyprotein (P1) expressed in a prokaryotic system to detect antibodies against foot-and-mouth disease virus serotype O

2015 ◽  
Vol 215-216 ◽  
pp. 45-51 ◽  
Author(s):  
Jitendra K. Biswal ◽  
Punam Bisht ◽  
Jajati K. Mohapatra ◽  
Rajeev Ranjan ◽  
Aniket Sanyal ◽  
...  
Keyword(s):  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Serotype O ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth
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