scholarly journals Renal Diffusion-Weighted Imaging in Healthy Dogs: Reproducibility, Test-Retest Repeatability, and Selection of the Optimal b-value Combination

2021 ◽  
Vol 8 ◽  
Author(s):  
Sang-Kwon Lee ◽  
Juryeoung Lee ◽  
Seolyn Jang ◽  
Eunji Lee ◽  
Chang-Yeop Jeon ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Diffusion Weighted Imaging ◽  
Intraclass Correlation ◽  
B Value ◽  
Adc Value ◽  
B Values ◽  
Intraobserver Reproducibility ◽  
Diffusion Weighted ◽  
Pure Diffusion ◽  
Healthy Dogs

Diffusion-weighted imaging (DWI) magnetic resonance imaging can evaluate alterations in the microstructure of the kidney. The purpose of this study was to assess the apparent diffusion coefficient (ADC) and the intravoxel incoherent motion model (IVIM) parameters of a normal kidney in healthy dogs, to evaluate the effect of b-value combinations on the ADC value, and the reproducibility and test-retest repeatability in monoexponential and IVIM analysis. In this experimental study, the ADC, pure diffusion coefficient (D), pseudodiffusion coefficient (D*), and perfusion fraction (fp) were measured from both kidneys in nine healthy beagles using nine b-values (b = 0, 50, 70, 100, 150, 200, 500, 800, and 1,000 s/mm2) twice with a 1-week interval between measurements. Interobserver and intraobserver reproducibility, and test-retest repeatability of the measurements were calculated. ADC values were measured using 10 different b-value combinations consisting of three b-values each, and were compared to the ADC obtained from nine b-values. All the ADC, D, D*, and fp values measured from the renal cortex, medulla, and the entire kidney had excellent interobserver and intraobserver reproducibility, and test-retest repeatability. The ADC obtained from a b-value combination of 0, 100, and 800 s/mm2 had the highest intraclass correlation coefficient with the ADC from nine b-values. The results of this study indicated that DWI MRI using multiple b-values is feasible for the measurement of ADC and IVIM parameters with high reproducibility and repeatability in the kidneys of healthy dogs. A combination of b = 0, 100, and 800 s/mm2 can be used for ADC measurements when multiple b-values are not available in dogs.

scholarly journals Evaluation of Regional Variability and Measurement Reproducibility of Intravoxel Incoherent Motion Diffusion Weighted Imaging Using a Cardiac Stationary Phase Based ECG Trigger Method

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Zhiming Xiang ◽  
Zhu Ai ◽  
Jianke Liang ◽  
Guijin Li ◽  
Xiaolei Zhu ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Stationary Phase ◽  
Diffusion Weighted Imaging ◽  
Intravoxel Incoherent Motion ◽  
Regional Variability ◽  
Altman Plot ◽  
Bland Altman Plot ◽  
Hepatic Lobe ◽  
Diffusion Weighted ◽  
Pure Diffusion

Purpose. To evaluate the performance of an optimized ECG trigger diffusion weighted imaging (DWI) sequence in liver and its application in liver disease. Materials and Methods. Eighteen healthy volunteers underwent intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) scan of the liver twice in 1.5T MR scanner with signed informed consent approved by local ethic committees. A new method, called cardiac stationary phase based ECG trigger (CaspECG), and FB method were applied. The apparent diffusion coefficient (ADC) and the IVIM parameters, including pure diffusion coefficient (D), perfusion-related diffusion coefficient (D⁎), and perfusion fraction, (PF) were calculated, and then 18 region of interests were drawn on these parameter maps independently by two readers through whole hepatic lobe. The regional variability and reproducibility between two repeated scans were evaluated using interclass correlation coefficients (ICCs) and Bland-Altman plot, respectively, and compared between the CaspECG and FB methods. The signal-to-noise ratio (SNR) of DWI data was also evaluated. Result. Compared to the FB method, the proposed CaspECG method showed significant higher SNRs in DWI data, lower regional variability between left and right hepatic lobes, and higher reproducibility of ADC, PF, D, and D⁎ between repeat scans [left lobe, limit of agreement (LOA) of Bland-Altman plot: 10.1%, 18.3%, 19.8%, and 59.2%; right lobe, LOA: 10.25%, 14.15%, 16.45%, and 39.45%]. D⁎ showed the worst reproducibility in all parameters. Conclusion. The novel CaspECG method outperformed the FB method in compensating the cardiac motion induced artifacts in DWI data and generating more reliable quantitative parameters, with less regional variability and higher repeatability, especially in the left hepatic lobe.

scholarly journals The role of quantitative diffusion-weighted imaging in characterization of hypovascular liver lesions: A prospective comparison of intravoxel incoherent motion derived parameters and apparent diffusion coefficient

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0247301
Author(s):  
Jelena Djokić Kovač ◽  
Marko Daković ◽  
Aleksandra Janković ◽  
Milica Mitrović ◽  
Vladimir Dugalić ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Liver Metastases ◽  
Diffusion Weighted Imaging ◽  
Intraclass Correlation ◽  
Intravoxel Incoherent Motion ◽  
Liver Lesions ◽  
Diffusion Weighted ◽  
Significant Difference ◽  
Apparent Diffusion

Background The utility of intravoxel incoherent motion (IVIM) related parameters in differentiation of hypovascular liver lesions is still unknown. Purpose The purpose of this study was to evaluate the value of IVIM related parameters in comparison to apparent diffusion coefficient (ADC) for differentiation among intrahepatic mass-forming cholangiocarcinoma (IMC), and hypovascular liver metastases (HLM). Methods Seventy-four prospectively enrolled patients (21 IMC, and 53 HLM) underwent 1.5T magnetic resonance examination with IVIM diffusion-weighted imaging using seven b values (0–800 s/mm2). Two independent readers performed quantitative analysis of IVIM-related parameters and ADC. Interobserver reliability was tested using a intraclass correlation coefficient. ADC, true diffusion coefficient (D), perfusion-related diffusion coefficient (D*), and perfusion fraction (ƒ) were compared among the lesions using Kruskal-Wallis H test. The diagnostic accuracy of each parameter was assessed by receiver operating characteristic (ROC) curve analysis. Results The interobserver agreement was good for ADC (0.802), and excellent for D, D*, and ƒ (0.911, 0.927, and 0.942, respectively). ADC, and D values were significantly different among IMC and HLM (both p < 0.05), while there was no significant difference among these lesions for ƒ and D* (p = 0.101, and p = 0.612, respectively). ROC analysis showed higher diagnostic performance of D in comparison to ADC (AUC = 0.879 vs 0.821). Conclusion IVIM-derived parameters in particular D, in addition to ADC, could help in differentiation between most common hypovascular malignant liver lesions, intrahepatic mass—forming cholangiocarcinoma and hypovascular liver metastases.

The utility of diffusion-weighted imaging and ADC values in the characterization of mumps orchitis and seminoma

2021 ◽  
pp. 028418512199198
Author(s):  
Renwei Liu ◽  
Jianhua Li ◽  
Yixiang Jiang ◽  
Zhiqing Wu ◽  
Jiayin Ji ◽  
...  
Keyword(s):  
Diffusion Weighted Imaging ◽  
Testicular Tissue ◽  
B Value ◽  
Youden Index ◽  
Characteristic Analysis ◽  
Adc Value ◽  
High B Value ◽  
Diffusion Weighted ◽  
Hyperintense Signal ◽  
Adc Values

Background Diffusion-weighted imaging (DWI) can quantitatively reflect the diffusion characteristics of tissues, providing a theoretical basis for qualitative diagnosis and quantitative analysis of a disease. Purpose To characterize testicular lesions that present as a hypointense signal on magnetic resonance imaging (MRI) T2-weighted images using DWI. Material and Methods Study participants were divided into three groups. Group A were healthy controls (n = 35), group B included patients with mumps orchitis (n = 20), and group C included patients with seminoma (n = 15). DWI sequences used b-values of 0, 1000, and 2000 s/mm2. Apparent diffusion coefficient (ADC) values between 1000 and 2000 s/mm2 were calculated by MRI postprocessing software. The Kruskal–Wallis test and receiver operating characteristic analysis were performed to evaluate how well ADC values distinguished between mumps orchitis and seminoma. Results Normal testicular tissue showed a hyperintense signal on DWI and hypointensity on the ADC map: mean ADC value was 0.77 (0.69–0.85) ± 0.08 ×10−3 mm2/s. Mumps orchitis and seminoma showed slight hyperintensity on DWI: mean ADC values were 0.85 (0.71–0.99) ± 0.15 ×10−3 mm2/s and 0.43 (0.39–0.47) ± 0.04 × 10−3 mm2/s, respectively. There were statistically significant differences in mean ADC values between normal testicular tissue and seminoma and between mumps orchitis and seminoma. The cutoff ADC value for differentiating seminoma from mumps orchitis was 0.54 × 10−3 mm2/s. The sensitivity, specificity, and Youden Index for diagnosing seminoma were 99%, 31%, and 30%, respectively. Conclusion High b-value DWI has potential utility for differentiating mumps orchitis from seminoma in the clinical setting.

scholarly journals ADC-Based Stratification of Molecular Glioma Subtypes Using High b-Value Diffusion-Weighted Imaging

2021 ◽  
Vol 10 (16) ◽  
pp. 3451
Author(s):  
Nils C. Nuessle ◽  
Felix Behling ◽  
Ghazaleh Tabatabai ◽  
Salvador Castaneda Vega ◽  
Jens Schittenhelm ◽  
...  
Keyword(s):  
Diffusion Weighted Imaging ◽  
Mean Diffusivity ◽  
Area Under The Curve ◽  
B Value ◽  
Diffusion Kurtosis Imaging ◽  
B Values ◽  
High B Value ◽  
Diffusion Weighted ◽  
Apparent Diffusion

Purpose: To investigate the diagnostic performance of in vivo ADC-based stratification of integrated molecular glioma grades. Materials and methods: Ninety-seven patients with histopathologically confirmed glioma were evaluated retrospectively. All patients underwent pre-interventional MRI-examination including diffusion-weighted imaging (DWI) with implemented b-values of 500, 1000, 1500, 2000, and 2500 s/mm2. Apparent Diffusion Coefficient (ADC), Mean Kurtosis (MK), and Mean Diffusivity (MD) maps were generated. The average values were compared among the molecular glioma subgroups of IDH-mutant and IDH-wildtype astrocytoma, and 1p/19q-codeleted oligodendroglioma. One-way ANOVA with post-hoc Games-Howell correction compared average ADC, MD, and MK values between molecular glioma groups. A Receiver Operating Characteristic (ROC) analysis determined the area under the curve (AUC). Results: Two b-value-dependent ADC-based evaluations presented statistically significant differences between the three molecular glioma sub-groups (p < 0.001, respectively). Conclusions: High-b-value ADC from preoperative DWI may be used to stratify integrated molecular glioma subgroups and save time compared to diffusion kurtosis imaging. Higher b-values of up to 2500 s/mm2 may present an important step towards increasing diagnostic accuracy compared to standard DWI protocol.

Reproducibility of radiomics features derived from intravoxel incoherent motion diffusion-weighted MRI of cervical cancer

2020 ◽  
pp. 028418512093447 ◽  
Author(s):  
Hao Chen ◽  
Yaoyao He ◽  
Cecheng Zhao ◽  
Lili Zheng ◽  
Ning Pan ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Diffusion Coefficient ◽  
Intraclass Correlation ◽  
B Value ◽  
Intravoxel Incoherent Motion ◽  
Observer Variability ◽  
Multicenter Studies ◽  
Diffusion Weighted Images ◽  
Diffusion Weighted ◽  
Adc Map

Background The reproducibility of intravoxel incoherent motion (IVIM)-based radiomics studies in humans has not been reported. Purpose To determine the inter- and intra-observer variability on the reproducibility of IVIM-based radiomics features in cervical cancer (CC). Material and Methods The IVIM images of 25 patients with CC were retrospectively collected. Based on the high-resolution T2-weighted images, the regions of interest (ROIs) were independently delineated twice in diffusion-weighted images at a b value of 1000 s/mm2 (interval time was one month) by two radiologists. This was done at the largest transversal cross-sections of the tumors. The ROI was subsequently used in apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudo-diffusion coefficient (D*), and perfusion fraction (f) maps derived from IVIM images. In total, 105 radiomics features were then finally extracted from the IVIM-derived maps. The inter- and intra-observer reproducibility of IVIM-derived features was then evaluated using the intraclass correlation coefficient. Results Inter- and intra-observer variability affected the reproducibility of radiomics features. D* map had 100% and 95% reproducible features, ADC map had 89% and 93%, D map had 97% and 86%, while f map had 54% and 62% reproducible features with good to excellent reliability in the intra-observer analysis. Similarly, D* map had 90% and 94%, ADC map had 85% and 70%, D map had 81% and 78%, while f map had 41% and 93% reproducible features with good to excellent reliability in the inter-observer analysis. Conclusion Inter- and intra-observer variability can affect radiomics analysis. Cognizant to this, multicenter studies should pay more attention to intra- and inter-observer variability.

scholarly journals Diagnostic Benefit of High b-Value Computed Diffusion-Weighted Imaging in Patients with Hepatic Metastasis

2021 ◽  
Vol 10 (22) ◽  
pp. 5289
Author(s):  
Maxime Ablefoni ◽  
Hans Surup ◽  
Constantin Ehrengut ◽  
Aaron Schindler ◽  
Daniel Seehofer ◽  
...  
Keyword(s):  
Image Quality ◽  
Hepatic Metastasis ◽  
Diffusion Weighted Imaging ◽  
Hepatic Metastases ◽  
B Value ◽  
Primary Tumors ◽  
B Values ◽  
Lesion Detectability ◽  
High B Value ◽  
Diffusion Weighted

Diffusion-weighted imaging (DWI) has rapidly become an essential tool for the detection of malignant liver lesions. The aim of this study was to investigate the usefulness of high b-value computed DWI (c-DWI) in comparison to standard DWI in patients with hepatic metastases. In total, 92 patients with histopathologic confirmed primary tumors with hepatic metastasis were retrospectively analyzed by two readers. DWI was obtained with b-values of 50, 400 and 800 or 1000 s/mm2 on a 1.5 T magnetic resonance imaging (MRI) scanner. C-DWI was calculated with a monoexponential model with high b-values of 1000, 2000, 3000, 4000 and 5000 s/mm2. All c-DWI images with high b-values were compared to the acquired DWI sequence at a b-value of 800 or 1000 s/mm2 in terms of volume, lesion detectability and image quality. In the group of a b-value of 800 from a b-value of 2000 s/mm2, hepatic lesion sizes were significantly smaller than on acquired DWI (metastases lesion sizes b = 800 vs. b 2000 s/mm2: mean 25 cm3 (range 10–60 cm3) vs. mean 17.5 cm3 (range 5–35 cm3), p < 0.01). In the second group at a high b-value of 1500 s/mm2, liver metastases were larger than on c-DWI at higher b-values (b = 1500 vs. b 2000 s/mm2, mean 10 cm3 (range 4–24 cm3) vs. mean 9 cm3 (range 5–19 cm3), p < 0.01). In both groups, there was a clear reduction in lesion detectability at b = 2000 s/mm2, with hepatic metastases being less visible compared to c-DWI images at b = 1500 s/mm2 in at least 80% of all patients. Image quality dropped significantly starting from c-DWI at b = 3000 s/mm2. In both groups, almost all high b-values images at b = 4000 s/mm2 and 5000 s/mm2 were not diagnostic due to poor image quality. High c-DWI b-values up to b = 1500 s/mm2 offer comparable detectability for hepatic metastases compared to standard DWI. Higher b-value images over 2000 s/mm2 lead to a noticeable reduction in imaging quality, which could hamper diagnosis.

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