scholarly journals Estimating Global Prevalence of Metabolic Dysfunction-Associated Fatty Liver Disease in Overweight or Obese Children and Adolescents: Systematic Review and Meta-Analysis

2021 ◽  
Vol 66 ◽  
Author(s):  
Jiaye Liu ◽  
Chunyang Mu ◽  
Kewei Li ◽  
Han Luo ◽  
Yong Liu ◽  
...  
Keyword(s):  
Liver Disease ◽  
General Population ◽  
Fatty Liver ◽  
Children And Adolescents ◽  
Fatty Liver Disease ◽  
Child Obesity ◽  
Metabolic Dysfunction ◽  
Obese Children ◽  
Global Prevalence ◽  
Pooled Prevalence

Objectives: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a new terminology updated from non-alcoholic fatty liver disease (NAFLD). We aim to estimate the global prevalence of MAFLD in overweight or obese children and adolescents, by repurposing existing data on fatty liver disease.Methods: We screened relevant articles published up to December 2020. Pooled prevalence was calculated using Logit transformations.Results: Our search returned 35,441 records, of which 156 studies fulfilled the inclusion criteria. The overall prevalence of MAFLD was 33.78% in the general population and 44.94% in a special population based on child obesity clinics, regardless of the diagnostic techniques. For subgroup analysis, MAFLD prevalence was significantly higher in boys compared to girls (36.05 vs. 26.84% in the general population; 50.20 vs. 35.34% in the child obesity clinics-based population). Interestingly, based on study source, the pooled prevalence of MAFLD was 1.5-fold higher in other “fatty liver disease” studies compared to the classical “NAFLD” studies in the general population.Conclusion: MAFLD is highly prevalent in overweight or obese children and adolescents. Raising awareness and urgent actions are warranted to control the MAFLD pandemic across the globe.

scholarly journals Antioxidant vitamins in the context of nonalcoholic fatty liver disease in obese children and adolescents

2013 ◽  
Vol 31 (4) ◽  
pp. 523-530 ◽  
Author(s):  
Fábio da Veiga Ued ◽  
Virgínia Resende S. Weffort
Keyword(s):  
Liver Disease ◽  
Dietary Intake ◽  
Fatty Liver ◽  
Children And Adolescents ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Serum Levels ◽  
Antioxidant Vitamins ◽  
Obese Children ◽  
Nonalcoholic Fatty Liver

OBJECTIVE: To review the literature on the importance of antioxidant vitamins, analyzed in the context of dietary intake, its plasma levels, and its current use as a supplementation treatment in obese children and adolescents with nonalcoholic fatty liver disease. DATA SOURCES: The articles were identified in Lilacs, Ibecs, SciELO, PubMed/Medline, and Scopus databases. To conduct the survey, the "fatty liver" descriptor was associated to the following words: "children", "antioxidants" and "vitamins". The search was limited to articles written in Portuguese, Spanish and English, with publication date until December, 2012. DATA SYNTHESIS: Six studies were selected. The survey revealed a low dietary intake and low antioxidant vitamins serum levels in this population. The changes in lifestyle, with adequate dietary intake of vitamins, and the increase in physical activity were associated with a significant improvement in liver histology and in laboratory tests. Vitamin supplementation also improved the disease progression markers, as the alanine aminotransferase serum levels and the histological characteristics of lobular inflammation and hepatocellular damage. However, these improvements were not statistically significant in all studies. CONCLUSIONS: There is insufficient evidence to recommend or to refute antioxidant supplementation in patients with simple steatosis or steatohepatitis. The changes in lifestyle seem to be, at the present time, the more advisable therapy.

FATTY LIVER DISEASE AND INSULIN SENSIVITY INDEXES IN OBESE CHILDREN AND ADOLESCENTS

2005 ◽  
Vol 40 (5) ◽  
pp. 688
Author(s):  
H Ferreira Mansilha ◽  
S Rodrigues ◽  
I Valente ◽  
R Gouveia ◽  
J Louren??o Gomes
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Children And Adolescents ◽  
Fatty Liver Disease ◽  
Obese Children

Association Between Nonalcoholic Fatty Liver Disease and Cardiovascular Risk in Obese Children and Adolescents

2013 ◽  
Vol 29 (9) ◽  
pp. 1118-1125 ◽  
Author(s):  
Hayrullah Alp ◽  
Sevim Karaarslan ◽  
Beray Selver Eklioğlu ◽  
Mehmet Emre Atabek ◽  
Hakan Altın ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Liver Disease ◽  
Fatty Liver ◽  
Children And Adolescents ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Obese Children ◽  
Nonalcoholic Fatty Liver

Left ventricular dysfunction in obese children and adolescents with nonalcoholic fatty liver disease

Hepatology ◽  
2013 ◽  
Vol 59 (2) ◽  
pp. 461-470 ◽  
Author(s):  
Lucia Pacifico ◽  
Michele Di Martino ◽  
Antonio De Merulis ◽  
Mario Bezzi ◽  
John Frederick Osborn ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Children And Adolescents ◽  
Nonalcoholic Fatty Liver Disease ◽  
Left Ventricular Dysfunction ◽  
Fatty Liver Disease ◽  
Ventricular Dysfunction ◽  
Left Ventricular ◽  
Obese Children ◽  
Nonalcoholic Fatty Liver

scholarly journals Prevalence of Significant and Advanced Hepatic Fibrosis in Metabolic Dysfunction Associated Fatty Liver Disease (MAFLD)

2021 ◽  
Author(s):  
Mimi Kim ◽  
Eileen Laurel Yoon ◽  
Seon Cho ◽  
Chul-min Lee ◽  
Bo Kyeong Kang ◽  
...  
Keyword(s):  
Liver Disease ◽  
General Population ◽  
Fatty Liver ◽  
Hepatic Fibrosis ◽  
Fatty Liver Disease ◽  
Cross Sectional Study ◽  
Health Check ◽  
Metabolic Dysfunction ◽  
Advanced Fibrosis ◽  
Cross Sectional

Abstract Background: There are several reports on the prevalence of metabolic dysfunction associated fatty liver disease (MAFLD) in the general population. But the fibrosis burden of MAFLD in general population is largely unknown. We aimed to evaluate the prevalence of significant and advanced fibrosis associated with MAFLD in a health check-up cohort.Materials and methods: Participants who underwent magnetic resonance elastography (MRE) at nationwide thirteen health check-up centers were included in this cross-sectional study. Fatty liver was evaluated using ultrasonography. Significant (≥F2) and advanced (≥F3) hepatic fibrosis were defined by MRE thresholds of 3.0 kPa (range: 2.99–3.65 kPa) and 3.6 kPa (range: 3.4–3.9 kPa), respectively. The sex- and age-standardized prevalence of MAFLD and hepatic fibrosis were estimated.Results: Total 6,775 health check-up adults included analysis. The sex- and age-standardized prevalence of MAFLD was 33.9%. Prevalence of MAFLD was higher in males than in females, and increased with age. The prevalence of diabetes in MAFLD was 13.3%, and 73.6% of subjects with diabetes had MAFLD. The sex- and age-standardized prevalence of significant (≥F2) and advanced hepatic fibrosis (≥F3) was 9.7% (range: 3.0–9.8%) and 3.0% (range: 2.6–4.6%), respectively, in MAFLD subjects. The prevalence of advanced hepatic fibrosis in diabetic with MAFLD 9.5% (range: 7.5–12.7%).Conclusion: The sex- and age-standardized prevalence of advanced fibrosis was 3.0% (range: 2.6–4.6%) in subjects with MAFLD, respectively.

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