scholarly journals Estimation the Level of IL-6 in Pregnant Women Suffering from Urinary Tract Infections

2013 ◽  
Vol 24 (10) ◽  
pp. 55-63
Author(s):  
Abeer H. Al-Khafaf ◽  
Adeeba Y. Shareef
2021 ◽  
Vol 17 (1) ◽  
pp. 119-129
Author(s):  
R.H. Bello ◽  
Y.K.E. Ibrahim ◽  
B.O. Olayinka ◽  
A.A.G. Jimoh ◽  
N.B. Afolabi-Balogun ◽  
...  

Background: The emergence of multidrug- resistance Enterobacteriaceae especially in E. coli bacteria  associated with Urinary Tract Infections (UTIs) in pregnancy is a serious menace globally posing health challenges and confounding successful empirical treatment as well as increasing pregnancy – related  complications.Objectives: The aim of this study is to determine the phenotypic and genotypic characteristics of Extended Spectrum Beta – Lactamases (ESBLs) producing E. coli (ESBLs – EC) isolates in pregnant women attending ante – natal clinics within Ilorin - Kwara State, Nigeria.Materials and methods: A total of 53 non - repeated E. coli isolates from urine samples of pregnant women were presumptively identified using standard bacteriological method and confirmed by commercially available Microgen® Identification Kits. Phenotypic detection of ESBLs was determined using antibiotics susceptibility test and double disc synergy Method for screening and confirmation respectively. Polymerase Chain Reaction (PCR) was further used for the genotypic detection of ESBLs genes.Results: A total 88.67% (47/53) of E. coli exhibited resistance to the cephalosporins of which aztreonam was the highest (75.47%) and the least was cefpodoxime (35.84%) while 85.10% were confirmed positive for ESBL production. The genotypic detection showed the most occurring genotype was blaTEM (50%) blaOXA (27.7%), blaGES (22.5%), blaSHV (15%), blaCTXM and blaVEB (7.5%) while sixty – four (64%) of isolates co – harbored two or more gene. BlaTEM and blaOXA were dominant.Conclusion: This study showed high resistance of E. coli to the third generation cephalosporins harboring different ESBL genes which increases UTIs complexity and limit therapeutic options in pregnancy. Therefore, continuous monitoring of resistance in E. coli, effective appraisal of antibiotic control policies and rational use of antibiotics is therefore encouraged.


2007 ◽  
Vol 42 (2) ◽  
pp. 186-193 ◽  
Author(s):  
Ola Olén ◽  
Scott M. Montgomery ◽  
Anders Ekbom ◽  
Ingela Bollgren ◽  
Jonas F. Ludvigsson

2015 ◽  
Vol 5 (4) ◽  
pp. 198-204
Author(s):  
Raphael M Mordi ◽  
Moghene E Burke ◽  
Emmanuel E Odjadjare ◽  
Stephen A Enabulele ◽  
Onyinye Jecinta Umeh

1970 ◽  
Vol 8 (3P1) ◽  
pp. 298-303 ◽  
Author(s):  
Ireneusz Roszkowski ◽  
Janina Wojcicka ◽  
Danuta Pisarek-Miedzinska ◽  
Elzbieta Janczewska

2013 ◽  
Vol 10 (1) ◽  
pp. 47-54
Author(s):  
A.M. Ashshi ◽  
H. S. Faidah ◽  
A.A. Saati ◽  
G.A.A. El-Ella ◽  
Ahmad K. Al-Ghamdi ◽  
...  

1965 ◽  
Vol 80 (9) ◽  
pp. 805 ◽  
Author(s):  
Nathaniel D. Greenberg ◽  
Jeremiah Stamler ◽  
Jack Zackler ◽  
Samuel L. Andelman

Biomedika ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 148-154
Author(s):  
Satriya Manggala Liastra ◽  
Ninuk Dwi Ariningtyas ◽  
Yelvi Levani

Urinary tract infection or what is often called a UTI is an infectious disease of the urinary tract epithelium and is commonly caused by gram-positive bacteria, namely the Staphylococcus aureus, with a prevalence rate of 68 million patients in the world and 1.2 million patients in Indonesia. The diagnosis of UTI is established with a positive urine culture significance value ≥105 (CFU)/ml. The existing clinical management for cases of urinary tract infections in pregnant women uses amoxicillin to kill gram-positive bacteria, such as Staphylococcus aureus. However, there have been 469 cases of antibiotic resistance in pregnant women in Indonesia due to the non-compliance of using antibiotics for urinary tract infections. Vitis vinifera can be used as an alternative to natural bactericidal resveratrol containing anthocyanidin to kill gram-positive bacteria. This study used 28 white mice (Mus musculus) aged 6-21 weeks and weighing 120-200 grams injected with Staphylococcus aureus. The 28 subjects were divided into 4 groups, each of which consisted of 7 mice. The mice received K1 treatment with 250 mg/kgBW of amoxicillin and treatments with 200, 300, and 500 mg/KgBW red grape seed and skin extract. Before treatments were given, a pre-test was conducted to ensure that the results were not biased. Post-test was also performed after the Staphylococcus aureus injection, which was measured after 5 days of urine culture that reached 107 CFU/ml. The treatment in P3 using 500 mg/KgBW of red grape seed and skin extract contributed to the smallest result with 102 Cfu/ml, equals to the result produced by giving 250 ml/KgBW of amoxicillin.


2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Kekelwa Inyambo Yeta ◽  
Charles Michelo ◽  
Choolwe Jacobs

Introduction. Globally, there is a growing concern over antimicrobial resistance (AMR) which is currently estimated to account for more than 700,000 deaths per year worldwide. AMR undermines the management of infectious diseases in general especially in pregnancy where significant bacteriuria continues to be a serious cause of maternal and perinatal morbidity and mortality. We therefore aimed to determine the prevalence of AMR and the associated factors among pregnant women with urinary tract infections (UTIs) attending antenatal clinic at a selected hospital in Lusaka, Zambia. Methods. This was a hospital-based, cross-sectional study conducted between November 2018 and May 2019. Interviewer-administered questionnaire was used to assess the sociodemographic characteristics and behavioural characteristics. Laboratory tests were also conducted. Descriptive statistics of study participants were used to describe the characteristics of the respondents. Chi-square was used to assess the association between categorical variables. The logistic regression analysis was carried out to generate the adjusted odds ratio with 95% confidence interval. Results. Overall (n = 203), the prevalence of UTI was 60% (95% CI: 53.3%–66.7%). The most isolated bacteria were E. coli (59%) and Klebsiella (21%). The prevalence of AMR was found to be 53% (95% CI: 46.1%–59.8%). The drugs highly resistant to antimicrobials were nalidixic acid (88.3%), ampicillin (77.8%), and norfloxacin (58.5%), while the least resistant drug was chloramphenicol (20%). There were no important significant predictors to AMR among pregnant women observed in this study. Conclusion. We found high burden of AMR closely linked to observe high prevalence of UTI suggested in this small population. This suggests a need to develop integrated surveillance systems that aim for early and regular screening of pregnant women for UTI as well as concurrent determination of antibiotic susceptibility patterns. This is important to prevent complications that may endanger maternal and fetal health outcomes. Furthermore, further research is needed to explore reasons for this high prevalence of AMR including examining possible attribution to the misuse of drugs so as to inform, enforce, or adjust the prescription-only policies and enforce antimicrobial stewardship programs.


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