B-Mode and Contrast Enhanced Ultrasonography Features of Gastric Inflammatory and Neoplastic Diseases in Cats

Alimentary lymphoma (AL) is the most common malignancy of the feline gastrointestinal tract and may cause variable mild to severe alteration of the gastric wall on ultrasonography (US) that can be very similar to those caused by inflammation (INF). The aim of this prospective study is to establish the value of B-mode and contrast-enhanced US (CEUS) in describing specific features of normal, inflammatory, and neoplastic gastric diseases in feline species. B-mode US and CEUS of the stomach were performed in anesthetized cats with or without gastric disorders. Gastric wall qualitative and quantitative parameters were evaluated on B-mode US and CEUS examination. A total of 29 cats were included: six healthy (HEA) cats as the control group; nine INF; three low-grade lymphoma (LGAL); 10 high-grade lymphoma (HGAL). On B-mode US, there were significant differences in thickness, the wall’s layer definition and echogenicity between HGAL and all the other groups (<0.001). For CEUS, statistical differences between groups were found in the following: HGAL vs. HEA, HGAL vs. INF; HGAL vs. LGAL; INF vs. HEA. Diagnostic accuracy (AUC) and cut-off value were calculated and found to be significant for thickness (3.8 mm) for INF vs. LGAL (AUC > 0.70) and “benign” vs. “malignant” (AUC > 0.90) as well as peak enhancement (34.87 dB) for “benign” vs. “malignant” (AUC > 0.70). INF and LGAL showed an overlap of qualitative and quantitative parameters both on B-mode and CEUS, while HGAL usually appears as a severe wall thickening with absent layer definition, high-contrast uptake, a specific enhancement pattern, regional lymphadenopathy and local steatitis. Thickness and peak enhancement can be useful parameters in the characterization of gastric infiltrates in cats.

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B-Mode and Contrast Enhanced Ultrasonography Features of Gastric Inflammatory and Neoplastic Diseases in Dogs

Animals ◽

10.3390/ani11030670 ◽

2021 ◽

Vol 11 (3) ◽

pp. 670

Author(s):

Francesco Simeoni ◽

Francesca Del Signore ◽

Giovanni Aste ◽

Paolo Bargellini ◽

Giuseppe Rubini ◽

...

Keyword(s):

Imaging Modality ◽

Gastric Wall ◽

Rapid Identification ◽

Gastric Neoplasms ◽

Control Group ◽

Undifferentiated Sarcoma ◽

Contrast Enhanced ◽

Anesthetized Dogs ◽

Contrast Enhanced Ultrasonography ◽

Identification And Characterization

Canine gastric disorders are common in veterinary clinical practice and among these neoplasms require rapid identification and characterization. Standard ultrasound (US) is the imaging modality of choice for gastric wall assessment. The aim of this prospective study is to describe the specific B-mode and contrast enhanced US (CEUS) features of normal, inflammatory, and neoplastic gastric wall in dogs. B-mode US and CEUS of the stomach were performed in anesthetized dogs with or without gastric disorders. Gastric wall qualitative and quantitative parameters were evaluated on B-mode US and CEUS examination. A total of 41 dogs were included: 6 healthy (HEA) as the control group; 9 gastritis (INF); 8 adenocarcinoma (AC); 8 alimentary lymphoma (AL); 4 leiomyosarcoma (LEIS); 2 gastrointestinal stromal tumor (GIST); 2 leiomyoma; 1 undifferentiated sarcoma; 1 metastatic gastric hemangiosarcoma. Gastric tumors appear as a marked wall thickness with absent layers definition and possible regional lymphadenopathy (AC and AL) and steatitis (AC) while gastritis generally shows no/mild thickening and no other alterations on B-mode US. On CEUS, neoplasm shows a higher and faster wash in if compared to that of gastritis. B-mode and CEUS assessment may be useful in the evaluation of canine gastric disorders in the distinction between gastritis and gastric neoplasms, even if there are no specific features able to discriminate between the different tumor histotypes.

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Endoscopic ultrasound (EUS) in staging and follow-up of patients with malt lymphoma treated conservatively

Acta chirurgica iugoslavica ◽

10.2298/aci0501083p ◽

2005 ◽

Vol 52 (1) ◽

pp. 83-89 ◽

Cited By ~ 5

Author(s):

A.R. Pavlovic ◽

M. Krstic ◽

D. Tomic ◽

Milos Bjelovic ◽

R. Jesic ◽

...

Keyword(s):

Helicobacter Pylori ◽

Malt Lymphoma ◽

Gastric Wall ◽

Gastric Lymphoma ◽

Eradication Therapy ◽

Muscularis Propria ◽

Wall Thickening ◽

Low Grade ◽

Ann Arbor

Background: Endoscopic ultrasonography (EUS) is an important tool for diagnosis and pretreatment staging of primary gastric lymphoma. The aim of the study was to evaluate the diagnostic importance of endosonography (EUS)in gastric lymphoma; to assess the depth of tumoral infiltration in low-grade gastric lymphoma of mucosa-associated lymphoid tissue (MALT) and to assess EUS response to medical treatment (Cyclophosphamid/Mabtera and/or anti-Helicobacter pylori therapy). Methods: 26 patients with MALT gastric lymphoma were investigated by EUS. Six of them were evaluated after the eradication of Helicobacter pylori infection and 20 after and during the cyclophosphamide/Mabtera and anti H.pylori treatment. EUS staging was compared with histopathology. Tumors were staged according to the 2000 TNM and modified Ann Arbor classification. Results: Six patients were treated with anti - Helicobacter pylori eradication therapy. Full regression of lymphoma was observed in 2 of 6 (33.3%) patients, which was endoscopicaly and histologicaly proved. EUS correlated with histology in all (6/6). In 20 patients treated with cyclophosphamide/Mabtera therapy, EUS revealed regression of lymphoma in 14 cases. Positive correlation with histology was found in 11 patients (11/14; 78%). The initial EUS showed an increased wall thickness more than 5mm in 24 of 26 patients (92%). The thickening was predominantly of mucosa and submucosa and in 11 patients extended the muscularis propria. After the therapy, the gastric wall thickening returned to normal in 14 patients, however, 3 of them still had positive histology findings. In 2 cases, during the follow-up, the EUS showed remained thickening of gastric wall, whereas biopsies were negative. Six months later histology revealed progressive low-grade MALT lymphoma in this cases. Conclusion: EUS appears to be a sensitive procedure for initial staging and assessment of treatment response and long-term follow up in patients with gastric lymphoma. The importance of EUS lies in ability to detect relapse early, too.

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Contrast-enhanced ultrasonography features of hepatobiliary neoplasms in cats

Veterinary Record ◽

10.1136/vr.105453 ◽

2019 ◽

Vol 186 (10) ◽

pp. 320-320 ◽

Cited By ~ 2

Author(s):

Tommaso Banzato ◽

Silvia Burti ◽

Giuseppe Rubini ◽

Riccardo Orlandi ◽

Paolo Bargellini ◽

...

Keyword(s):

Bile Duct ◽

Diagnostic Accuracy ◽

Large Range ◽

Liver Parenchyma ◽

Qualitative And Quantitative ◽

Hepatocellular Carcinomas ◽

Contrast Enhanced ◽

Contrast Enhanced Ultrasonography ◽

Malignant Lesions

BackgroundContrast-enhanced ultrasonography (CEUS) features of primary hepatobiliary neoplasms have been reported in dogs but no information is available in cats.MethodsQualitative and quantitative features of bile duct adenomas (BDAs, n=20), bile duct carcinomas (BDCs, n=16), and hepatocellular carcinomas (HCCs, n=8) are described in 44 cats.ResultsThere was an overlap in CEUS qualitative features between different histotypes, both in wash-in and wash-out phases. Distinction between different neoplasms based only on the CEUS qualitative features was not possible. At peak of enhancement, the BDAs, BDCs and HCCs showed a large range of echogenicities, from hypoenhancement to hyperenhancement, in comparison to the liver parenchyma. Eight of 20 BDAs showed inhomogeneous hyperenhancement during wash-in, which is a feature reported as typical of malignant lesions in dogs. BDC had a significantly faster wash-in compared with both BDA and HCC but the diagnostic accuracy of all the included quantitative variables was only moderate. No significant differences in the wash-out quantitative features of BDA and BDC were evident.ConclusionThere is poor evidence that CEUS may be used to distinguish between different primary hepatobiliary neoplasms in cats.

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Neurosurgical tools to extend tumor resection in hemispheric low-grade gliomas: conventional and contrast enhanced ultrasonography

Child s Nervous System ◽

10.1007/s00381-016-3186-z ◽

2016 ◽

Vol 32 (10) ◽

pp. 1907-1914 ◽

Cited By ~ 15

Author(s):

Luca Mattei ◽

Francesco Prada ◽

Federico Giuseppe Legnani ◽

Alessandro Perin ◽

Alessandro Olivi ◽

...

Keyword(s):

Tumor Resection ◽

Low Grade ◽

Low Grade Gliomas ◽

Contrast Enhanced ◽

Contrast Enhanced Ultrasonography

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Dynamic contrast-enhanced (DCE) MR imaging: the role of qualitative and quantitative parameters for evaluating prostate tumors stratified by Gleason score and PI-RADS v2

Abdominal Radiology ◽

10.1007/s00261-019-02234-6 ◽

2019 ◽

Vol 45 (7) ◽

pp. 2225-2234 ◽

Cited By ~ 1

Author(s):

Sohrab Afshari Mirak ◽

Amirhossein Mohammadian Bajgiran ◽

Kyunghyun Sung ◽

Nazanin H. Asvadi ◽

Daniela Markovic ◽

...

Keyword(s):

Mr Imaging ◽

Gleason Score ◽

Prostate Tumors ◽

Qualitative And Quantitative ◽

Dynamic Contrast Enhanced ◽

Quantitative Parameters ◽

Contrast Enhanced

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Quantitative parameters of contrast-enhanced ultrasonography for assessment of renal pathology: A preliminary study in chronic kidney disease

Clinical Hemorheology and Microcirculation ◽

10.3233/ch-170303 ◽

2018 ◽

Vol 68 (1) ◽

pp. 71-82 ◽

Cited By ~ 2

Author(s):

Wen-qi Yang ◽

Shan Mou ◽

Yao Xu ◽

Li Xu ◽

Feng-hua Li ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Renal Pathology ◽

Quantitative Parameters ◽

Contrast Enhanced ◽

Contrast Enhanced Ultrasonography ◽

Preliminary Study

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Effects of artery input function on dynamic contrast-enhanced MRI for determining grades of gliomas

British Journal of Radiology ◽

10.1259/bjr.20200699 ◽

2020 ◽

pp. 20200699

Author(s):

Lin Jia ◽

Xia Wu ◽

Qian Wan ◽

Liwen Wan ◽

Wenxiao Jia ◽

...

Keyword(s):

Cerebral Artery ◽

Input Function ◽

P Value ◽

Low Grade ◽

High Grade ◽

Dce Mri ◽

Dynamic Contrast Enhanced ◽

Quantitative Parameters ◽

Contrast Enhanced ◽

High Grade Gliomas

Objective: To evaluate the effect of artery input function (AIF) derived from different arteries for pharmacokinetic modeling on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters in the grading of gliomas. Methods: 49 patients with pathologically confirmed gliomas were recruited and underwent DCE-MRI. A modified Tofts model with different AIFs derived from anterior cerebral artery (ACA), ipsilateral and contralateral middle cerebral artery (MCA) and posterior cerebral artery (PCA) was used to estimate quantitative parameters such as Ktrans (volume transfer constant) and Ve (fractional extracellular-extravascular space volume) for distinguishing the low grade glioma from high grade glioma. The Ktrans and Ve were compared between different arteries using Two Related Samples Tests (TRST) (i.e. Wilcoxon Signed Ranks Test). In addition, these parameters were compared between the low and high grades as well as between the grade II and III using the Mann-Whitney U-test. A p-value of less than 0.05 was regarded as statistically significant. Results: All the patients completed the DCE-MRI successfully. Sharp wash-in and wash-out phases were observed in all AIFs derived from the different arteries. The quantitative parameters (Ktrans and Ve) calculated from PCA were significant higher than those from ACA and MCA for low and high grades, respectively (p < 0.05). Despite the differences of quantitative parameters derived from ACA, MCA and PCA, the Ktrans and Ve from any AIFs could distinguish between low and high grade, however, only Ktrans from any AIFs could distinguish grades II and III. There was no significant correlation between parameters and the distance from the artery, which the AIF was extracted, to the tumor. Conclusion: Both quantitative parameters Ktrans and Ve calculated using any AIF of ACA, MCA, and PCA can be used for distinguishing the low- from high-grade gliomas, however, only Ktrans can distinguish grades II and III. Advances in knowledge: We sought to assess the effect of AIF on DCE-MRI for determining grades of gliomas. Both quantitative parameters Ktrans and Ve calculated using any AIF of ACA, MCA, and PCA can be used for distinguishing the low- from high-grade gliomas.

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Qualitative and Quantitative Contrast Enhanced Ultrasonography of the Pancreas Using Bolus Injection and Continuous Infusion Methods in Normal Dogs

Journal of Veterinary Medical Science ◽

10.1292/jvms.13-0199 ◽

2013 ◽

Vol 75 (12) ◽

pp. 1601-1607 ◽

Cited By ~ 16

Author(s):

Sue Yee LIM ◽

Kensuke NAKAMURA ◽

Keitaro MORISHITA ◽

Noboru SASAKI ◽

Masahiro MURAKAMI ◽

...

Keyword(s):

Continuous Infusion ◽

Bolus Injection ◽

Qualitative And Quantitative ◽

Contrast Enhanced ◽

Contrast Enhanced Ultrasonography

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Risk Factors of Large Artery Atherosclerotic Ischemic Stroke Based on Carotid Contrast-Enhanced Ultrasonography

10.21203/rs.3.rs-23692/v1 ◽

2020 ◽

Author(s):

Shaoqi Chen ◽

Xiya Du ◽

Zhongkeng Yao ◽

Qingzi Chen ◽

Xuerui Tan

Keyword(s):

Risk Factors ◽

Ischemic Stroke ◽

Sensitivity And Specificity ◽

Roc Curve ◽

Control Group ◽

Large Artery ◽

Operating Characteristics ◽

Carotid Artery Plaque ◽

Contrast Enhanced ◽

Contrast Enhanced Ultrasonography

Abstract Background Ischemic stroke is a serious public health issue with a continuously increasing incidence worldwide. This study explores the risk factors of large artery atherosclerotic (LAA) ischemic stroke based on carotid contrast-enhanced ultrasonography (CEUS). Methods A total of 110 patients with LAA ischemic stroke and 34 patients without stroke were included. All participants underwent standard ultrasonography and CEUS, from which carotid artery plaque characteristics were obtained. The predicted performance of artery plaques was evaluated using the area under the receiver operating characteristics (ROC) curve and sensitivity and specificity at the optimal cut-off point. Results Subjects with LAA ischemic stroke were more likely to have a history of hypertension than the control group (P = 0.009). The area under the ROC curve (AUROC) for plaque echogenicity was 0.609 (95% CI, 0.524–0.689). With a cut-off value of ≤ class II (echolucent or predominantly hypoechogenic plaque), the sensitivity and specificity were 84.55% and 32.35%, respectively. The AUROC for plaque thickness was 0.676 (95% CI, 0.593–0.751). With a cut-off value of > 2.4 mm, the sensitivity and specificity were 41.82% and 88.24%, respectively. The AUROC for intraplaque neovascularization was 0.807 (95% CI, 0.733–0.868). With a cut-off value of > grade 2 (extensive appearance of bubbles within plaque), the sensitivity and specificity were 70.91% and 82.35%, respectively. Conclusions Hypertension, echolucent (or predominantly hypoechogenic) plaque, plaque thickness, and degree of intraplaque neovascularization are significantly relevant to LAA ischemic stroke in adults. These results may be helpful for clinical prediction of ischemic stroke risk.

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